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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P51787 New Search
27PDB entries
28Biological assembly
99chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
12DK structure of human KCNQ1-CaM-PIP2 intermediate state Deposited 2026-03-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Mutation：I145C, E160R, R231E Mutation：I145C, E160R, R231E Mutation：I145C, E160R, R231E Mutation：I145C, E160R, R231E PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.47 Å
3BJ4 The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction Deposited 2007-12-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 574–622（49 aa） Fragment：C-terminal Helix D
Chain B 574–622（49 aa） Fragment：C-terminal Helix D
Not recorded NI NICKEL (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；292 K；12-16% PEG 8K, 0.1M Tris, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 292K
Resolution 2.00 Å R-free 0.255
3HFC A trimeric form of the Kv7.1 A domain Tail, L602M/L606M mutant Semet Deposited 2009-05-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 583–611（29 aa） Fragment：UNP residues 583-611
Chain B 583–611（29 aa） Fragment：UNP residues 583-611
Chain C 583–611（29 aa） Fragment：UNP residues 583-611
Mutation：L602M Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：L602M Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：L602M Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；1.6M sodium citrate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 2.45 Å R-free 0.269
3HFE A trimeric form of the Kv7.1 A domain Tail Deposited 2009-05-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 583–611（29 aa） Fragment：UNP residues 583-611
Chain B 583–611（29 aa） Fragment：UNP residues 583-611
Chain C 583–611（29 aa） Fragment：UNP residues 583-611
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；1.6M sodium citrate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.70 Å R-free 0.251
4UMO Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin Deposited 2014-05-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 352–396（45 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396,502-539
Chain A 502–539（38 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396,502-539
Chain B 352–396（45 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396,502-539
Chain B 502–539（38 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396,502-539
Mutation：YES Mutation：YES Mutation：YES Mutation：YES K POTASSIUM ION × 4 SCN THIOCYANATE ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 277 K；0.3 M POTASSIUM THIOCYANATE, 0.1 M SODIUM ACETATE TRIHYDRATE PH=5.6, 1 MM EGTA AT 4 DEGREES CELSIUS
Resolution 3.00 Å R-free 0.247
4V0C Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin Deposited 2014-09-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 352–396（45 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396 AND RESIDUES 502-539
Chain A 502–539（38 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396 AND RESIDUES 502-539
Chain B 352–396（45 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396 AND RESIDUES 502-539
Chain B 502–539（38 aa） Fragment：PROXIMAL C-TERMINAL DOMAIN, RESIDUES 352-396 AND RESIDUES 502-539
Mutation：YES Mutation：YES Mutation：YES Mutation：YES SCN THIOCYANATE ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 0.3 M POTASSIUM THIOCYANATE, 0.1 M SODIUM ACETATE TRIHYDRATE PH=5.6, 5 MM CACL2
Resolution 2.86 Å R-free 0.268
6MIE Solution NMR structure of the KCNQ1 voltage-sensing domain Deposited 2018-09-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 100–249（150 aa） Fragment：UNP residues 100-249
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；323 K；Ionic strength (raw mmCIF value) 4 % (w/v) LMPG；Pressure 1
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N; U-80% 2H] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v Deuterated LMPG, 100% D2O | 100% D2O
NMR sample composition 0.4 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 mM LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 mM LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.2 mM [U-100% 15N] KCNQ1-VSD, 50 mM MES, 0.5 mM EDTA, 2 mM TCEP, 4 % w/v LMPG, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6UZZ structure of human KCNQ1-CaM complex Deposited 2019-11-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6V00 structure of human KCNQ1-KCNE3-CaM complex Deposited 2019-11-16 Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 76–620（545 aa）
Chain D 76–620（545 aa）
Chain G 76–620（545 aa）
Chain J 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6V01 structure of human KCNQ1-KCNE3-CaM complex with PIP2 Deposited 2019-11-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 76–620（545 aa）
Chain D 76–620（545 aa）
Chain G 76–620（545 aa）
Chain J 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7VVD Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P Deposited 2021-11-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 364–397（34 aa） Fragment：C-terminal Domain
Chain A 503–533（31 aa） Fragment：C-terminal Domain
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；25% PEG 1500, 0.1M MMT pH 8.0
Resolution 3.13 Å R-free 0.274
7VVD Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P Deposited 2021-11-05 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 364–397（34 aa） Fragment：C-terminal Domain
Chain D 503–533（31 aa） Fragment：C-terminal Domain
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；25% PEG 1500, 0.1M MMT pH 8.0
Resolution 3.13 Å R-free 0.274
7VVH Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E140G Deposited 2021-11-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 364–397（34 aa） Fragment：C-terminal Domain
Chain A 503–533（31 aa） Fragment：C-terminal Domain
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；291 K；25% PEG 1500, 0.1M MMT pH 9.0
Resolution 2.30 Å R-free 0.272
7XNI human KCNQ1-CaM in apo state Deposited 2022-04-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–676（676 aa）
Chain B 1–676（676 aa）
Chain D 1–676（676 aa）
Chain G 1–676（676 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
7XNK human KCNQ1-CaM in complex with ML277 Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–676（676 aa）
Chain C 1–676（676 aa）
Chain E 1–676（676 aa）
Chain G 1–676（676 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
7XNL human KCNQ1-CaM-ML277-PIP2 complex in state A Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–676（676 aa）
Chain C 1–676（676 aa）
Chain E 1–676（676 aa）
Chain G 1–676（676 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7XNN human KCNQ1-CaM-ML277-PIP2 complex in state B Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–676（676 aa）
Chain C 1–676（676 aa）
Chain E 1–676（676 aa）
Chain G 1–676（676 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8SIK KCNQ1 with voltage sensor in the up conformation Deposited 2023-04-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8SIM KCNQ1 with voltage sensor in the intermediate conformation Deposited 2023-04-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.20 Å
8SIN KCNQ1 with voltage sensor in the down conformation Deposited 2023-04-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.80 Å
9U7F structure of human KCNQ1-KCNE1-CaM complex Deposited 2025-03-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–676（676 aa）
Chain D 1–676（676 aa）
Chain G 1–676（676 aa）
Chain J 1–676（676 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9UC8 structure of human KCNQ1-KCNE1-CaM complex with PIP2 Deposited 2025-04-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–676（676 aa）
Chain D 1–676（676 aa）
Chain G 1–676（676 aa）
Chain J 1–676（676 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 8 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
9UJ4 Structure of human KCNQ1-CaM complex Deposited 2025-04-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–676（676 aa）
Chain C 1–676（676 aa）
Chain E 1–676（676 aa）
Chain G 1–676（676 aa）
Not recorded K POTASSIUM ION × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.59 Å
9VEC structure of human KCNQ1-KCNE1-CaM complex Deposited 2025-06-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain A 76–620（545 aa）
Chain D 76–620（545 aa）
Chain G 76–620（545 aa）
Chain J 76–620（545 aa）
Mutation：I145C Mutation：I145C Mutation：I145C Mutation：I145C CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9VEI structure of human KCNQ1-KCNE1-CaM complex with PIP2 Deposited 2025-06-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain A 76–620（545 aa）
Chain D 76–620（545 aa）
Chain G 76–620（545 aa）
Chain J 76–620（545 aa）
Mutation：I145C Mutation：I145C Mutation：I145C Mutation：I145C PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
9VEN structure of human KCNQ1-CaM-PIP2 complex with bent conformation Deposited 2025-06-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9VEO structure of human KCNQ1-CaM-PIP2 complex with straight conformation Deposited 2025-06-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 76–620（545 aa）
Chain C 76–620（545 aa）
Chain E 76–620（545 aa）
Chain G 76–620（545 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
9WD8 structure of human KCNQ1-KCNE3-CaM complex with two PIP2 Deposited 2025-08-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 76–620（545 aa）
Chain D 76–620（545 aa）
Chain G 76–620（545 aa）
Chain J 76–620（545 aa）
Not recorded CA CALCIUM ION × 8 A1BBG (2R)-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl di[(9Z)-octadec-9-enoate] × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.