Current Protein Identity：P53355
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1IG1 1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn. Deposited 2001-04-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | MN MANGANESE (II) ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；pH 7.5
|
Resolution 1.80 Å R-free 0.213 |
| 1JKK 2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG. Deposited 2001-07-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | MG MAGNESIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；PROTEIN, AMPPnP, AMMONIUM SULFATE, TRIS-HL (pH 8), MGCL2 SOAKING, pH 7.5
|
Resolution 2.40 Å R-free 0.239 |
| 1JKL 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE Deposited 2001-07-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；PROTEIN, AMPPNP, AMMONIUM SULFATE, TRIS-HL, pH 7.5
|
Resolution 1.62 Å R-free 0.218 |
| 1JKS 1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE Deposited 2001-07-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；pH 7.50
|
Resolution 1.50 Å R-free 0.202 |
| 1JKT TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE Deposited 2001-07-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；pH 7.00
|
Resolution 3.50 Å R-free 0.297 |
| 1JKT TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE Deposited 2001-07-13 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；pH 7.00
|
Resolution 3.50 Å R-free 0.297 |
| 1P4F DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT Deposited 2003-04-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：CATALYTIC DOMAIN, PROTEIN KINASE DOMAIN
|
Not recorded | 86Q 5,6-Dihydro-benzo[H]cinnolin-3-ylamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；Ammonium sulfate, Tris, MgCl2, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 1.90 Å R-free 0.233 |
| 1WVW Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors Deposited 2004-12-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–278（278 aa）
Fragment：catalytic domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；283 K；sodium cacodylate, PEG8000, magnesium acetate, glycerol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 283K
|
Resolution 2.40 Å R-free 0.270 |
| 1WVX Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors Deposited 2004-12-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–278（278 aa）
Fragment：catalytic domain
|
Not recorded | BD4 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；283 K；Tris-HCl, PEG400, PEG8000, glycerol, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 283K
|
Resolution 2.60 Å R-free 0.270 |
| 1WVY Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors Deposited 2004-12-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–278（278 aa）
Fragment：catalytic domain
|
Not recorded | STU STAUROSPORINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；283 K；Tris-HCl, PEG400, PEG8000, glycerol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 283K
|
Resolution 2.80 Å R-free 0.274 |
| 1YR5 1.7-A structure of calmodulin bound to a peptide from DAP kinase Deposited 2005-02-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
302–320（19 aa）
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；295 K；PEG 8000, sodium acetate, calcium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.70 Å R-free 0.257 |
| 2W4J X-ray structure of a DAP-Kinase 2-277 Deposited 2008-11-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–277（277 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-277
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 ACT ACETATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.30 Å R-free 0.159 |
| 2W4K X-ray structure of a DAP-Kinase 2-302 Deposited 2008-11-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–302（302 aa）
Fragment：CATALYTIC AUTOINHIBITORY DOMAIN, RESIDUES 1-302
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å R-free 0.228 |
| 2X0G X-RAY STRUCTURE OF A DAP-KINASE CALMODULIN COMPLEX Deposited 2009-12-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–334（334 aa）
Fragment：CATALYTIC AND AUTOINHIBITORY DOMAIN, RESIDUES 1- 334
|
Not recorded | SO4 SULFATE ION × 2 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.2；0.17M AMMONIUM SULFATE, 25% (W/V) PEG 4000, 15% GLYCEROL, pH 7.2
|
Resolution 2.20 Å R-free 0.267 |
| 2XUU Crystal structure of a DAP-kinase 1 mutant Deposited 2010-10-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–334（334 aa）
Fragment：CATALYTIC AND AUTOINHIBITORY DOMAIN, RESIDUES 1-334
|
Mutation：YES | ADP ADENOSINE-5'-DIPHOSPHATE × 1 SO4 SULFATE ION × 3 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.5；0.2 M LISO4 0.1 M BIS-TRIS PH 5.5 25% PEG 4000 0.002% NAN3
|
Resolution 1.80 Å R-free 0.226 |
| 2XZS Death associated protein kinase 1 residues 1-312 Deposited 2010-11-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–312（311 aa）
Fragment：KINASE CATALYTIC DOMAIN, RESIDUES 1-312
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；0.2 M MAGNESIUM ACETATE TETRAHYDRATE, 0.1 M SODIUM CACODYLATE, PH 6.5 AND 10% PEG 8000
|
Resolution 2.00 Å R-free 0.225 |
| 2XZS Death associated protein kinase 1 residues 1-312 Deposited 2010-11-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–312（311 aa）
Fragment：KINASE CATALYTIC DOMAIN, RESIDUES 1-312
|
Not recorded | MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；0.2 M MAGNESIUM ACETATE TETRAHYDRATE, 0.1 M SODIUM CACODYLATE, PH 6.5 AND 10% PEG 8000
|
Resolution 2.00 Å R-free 0.225 |
| 2Y0A Structure of DAPK1 construct residues 1-304 Deposited 2010-12-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–304（303 aa）
Fragment：KINASE CATALYTIC DOMAIN, RESIDUES 2-304
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；5% PEG 6000, 0.1M MES, PH 6.0
|
Resolution 2.60 Å R-free 0.259 |
| 2Y4P Dimeric structure of DAPK-1 catalytic domain Deposited 2011-01-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
Chain D
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8；0.1 M TRIS PH 8.0, 0.1 M MGCL2, 15% (W/V) PEG 4000, 0.5 MM AMPPCP, 0.5 MM PMSF.
|
Resolution 2.65 Å R-free 0.312 |
| 2Y4P Dimeric structure of DAPK-1 catalytic domain Deposited 2011-01-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
Chain B
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8；0.1 M TRIS PH 8.0, 0.1 M MGCL2, 15% (W/V) PEG 4000, 0.5 MM AMPPCP, 0.5 MM PMSF.
|
Resolution 2.65 Å R-free 0.312 |
| 2Y4V CRYSTAL STRUCTURE OF HUMAN CALMODULIN IN COMPLEX WITH A DAP KINASE-1 MUTANT (W305Y) PEPTIDE Deposited 2011-01-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
302–320（19 aa）
Fragment：RESIDUES 302-320
|
Mutation：YES | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1 M HEPES PH 7.5, 25(W/V) PEG 3000
|
Resolution 1.80 Å R-free 0.238 |
| 2YAK Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) Deposited 2011-02-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：AA, RESIDUES 1-285
|
Not recorded | OSV RUTHENIUM OCTASPORINE 4 × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
100 MM TRIS PH 7.2, 7.5-10% PEG 6000.
|
Resolution 2.20 Å R-free 0.260 |
| 3DFC Crystal structure of a glycine-rich loop mutant of the death associated protein kinase catalytic domain with AMPPNP Deposited 2008-06-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–285（285 aa）
Fragment：Protein kinase catalytic domain
|
Mutation：Q23K | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2M lithium nitrate, 2.2 M ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.90 Å R-free 0.230 |
| 3DGK Crystal structure of a glycine-rich loop mutant of the death associated protein kinase catalytic domain Deposited 2008-06-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：Protein kinase catalytic domain
|
Mutation：Q23K | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；100 mM Tris pH 7.5, 0.8 M Ammonium Sulfate, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.70 Å R-free 0.220 |
| 3EH9 Crystal structure of death associated protein kinase complexed with ADP Deposited 2008-09-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：Protein kinase domain, UNP residues 2-285
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；.2 M ammonium iodide
2.2 M ammonium sulfate , VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.70 Å R-free 0.217 |
| 3EHA Crystal structure of death associated protein kinase complexed with AMPPNP Deposited 2008-09-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：Protein kinase domain, UNP residues 2-285
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2 M ammonium bromide
2.2 M ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.60 Å R-free 0.210 |
| 3F5G Crystal structure of death associated protein kinase in complex with ADP and Mg2+ Deposited 2008-11-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：UNP residues 2-285, protein kinase domain,catalytic domain
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
295 K；0.2 M ammonium chloride, 2.2 M ammonium sulfate , VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.85 Å R-free 0.244 |
| 3F5U Crystal structure of the death associated protein kinase in complex with AMPPNP and Mg2+ Deposited 2008-11-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP residues 1-285, Protein kinase domain,Catalytic domain
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
295 K；0.2 M NaCl, 2.2 M ammonium sulfate , VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.245 |
| 3GU4 Crystal structure of DAPKQ23V-AMPPNP Deposited 2009-03-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：Q23V | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；295 K；0.1 M MES, 1.8 M Ammonium sulfate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.35 Å R-free 0.211 |
| 3GU5 Crystal structure of DAPKQ23V-AMPPNP-Mg2+ Deposited 2009-03-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：Q23V | MG MAGNESIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2M CH3COOLi, 2.2 Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.65 Å R-free 0.219 |
| 3GU6 Crystal structure of DAPKQ23V-ADP Deposited 2009-03-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：Q23V | ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；295 K；0.1 M Tris, 1.8 M Ammonium sulfate, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.49 Å R-free 0.213 |
| 3GU7 Crystal structure of DAPKQ23V-ADP-Mg2+ Deposited 2009-03-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：Q23V | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2M NaI, 2.2M ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.90 Å R-free 0.228 |
| 3GU8 Crystal structure of DAPKL93G with N6-cyclopentyladenosine Deposited 2009-03-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：L93G | 3GU N6-cyclopentyladenosine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；100 mM Tris, 1.1 ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.60 Å R-free 0.239 |
| 3GUB Crystal structure of DAPKL93G complexed with N6-(2-Phenylethyl)adenosine Deposited 2009-03-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：protein kinase domain
|
Mutation：L93G | GUB 9-alpha-L-lyxofuranosyl-N-(2-phenylethyl)-9H-purin-6-amine × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；100mM Tris, 1.1 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.71 Å R-free 0.239 |
| 3ZXT Dimeric structure of DAPK-1 catalytic domain in complex with AMPPCP- Mg Deposited 2011-08-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
Chain B
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
|
Not recorded | ACP PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 2 MG MAGNESIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
0.1 M HEPES PH7.0, 0.1M MGCL2, 15% PEG4000
|
Resolution 2.65 Å R-free 0.285 |
| 3ZXT Dimeric structure of DAPK-1 catalytic domain in complex with AMPPCP- Mg Deposited 2011-08-15 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
Chain D
1–285（285 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-285
|
Not recorded | ACP PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 2 MG MAGNESIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
0.1 M HEPES PH7.0, 0.1M MGCL2, 15% PEG4000
|
Resolution 2.65 Å R-free 0.285 |
| 4B4L CRYSTAL STRUCTURE OF AN ARD DAP-KINASE 1 MUTANT Deposited 2012-07-31 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–334（334 aa）
Fragment：CATALYTIC AND AUTOREGULATORY DOMAIN, RESIDUES 1-334
|
Mutation：YES | 1PE PENTAETHYLENE GLYCOL × 3 SO4 SULFATE ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.5；0.2M AMMONIUM SULFATE, 0.1M BIS-TRIS PH 5.5, 25%(W/V) POLYETHYLENE GLYCOL 3350
|
Resolution 1.75 Å R-free 0.220 |
| 4PF4 1.1A X-RAY STRUCTURE OF THE APO CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE 1, aa 1-277 Deposited 2014-04-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count |
Chain A
1–277（277 aa）
|
Not recorded | SO4 SULFATE ION × 4 NA SODIUM ION × 2 GOL GLYCEROL × 6 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；0.1 M HEPES, Ph=7, 2M Ammonium sulfate
|
Resolution 1.13 Å R-free 0.149 |
| 4TL0 Crystal structure of death-associated protein kinase 1 with a crucial phosphomimicking mutation Deposited 2014-05-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–334（334 aa）
Fragment：UNP residues 1-334
|
Mutation：S289E | MG MAGNESIUM ION × 1 NH4 AMMONIUM ION × 3 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.15 ammonium sulfate, 0.1M TRIS, pH 8.0, 15%(w/v) PEG 4000
|
Resolution 2.70 Å R-free 0.218 |
| 4TXC Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor Deposited 2014-07-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | 38G 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol × 1 EDO 1,2-ETHANEDIOL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；20% PEG6000, 10% ethylene glycol, 0.1M HEPES pH 7.0, 0.2M sodium chloride, 293K,
using previously frozen protein
|
Resolution 1.95 Å R-free 0.216 |
| 4UV0 Structure of a semisynthetic phosphorylated DAPK Deposited 2014-08-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–321（321 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 1-321
|
Mutation：YES | PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
5MM HEPES, 30 MM NACL, 10 MM NA2SO4,0.5 MMDTT,25% (W/V) PEGMME2000
|
Resolution 2.49 Å R-free 0.242 |
| 4YO4 Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment phthalazine Deposited 2015-03-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：protein kinase domain (UNP residues 2-285)
|
Not recorded | CL CHLORIDE ION × 4 ACT ACETATE ION × 1 SO4 SULFATE ION × 1 4FT phthalazine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2 M sodium chloride, 0.1 M HEPES, 1.6 M ammonium sulfate
|
Resolution 1.60 Å R-free 0.185 |
| 4YPD Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment 4-methylpyridazine Deposited 2015-03-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：protein kinase domain (UNP residues 2-285)
|
Not recorded | CL CHLORIDE ION × 1 SO4 SULFATE ION × 1 DKG 4-methylpyridazine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES, 1.7 M ammonium sulfate
|
Resolution 1.40 Å R-free 0.177 |
| 5AUT Crystal structure of DAPK1 in complex with ANS. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | 2AN 8-ANILINO-1-NAPHTHALENE SULFONATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.70 Å R-free 0.202 |
| 5AUU Crystal structure of DAPK1 in complex with luteolin. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | LU2 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.70 Å R-free 0.216 |
| 5AUV Crystal structure of DAPK1 in complex with apigenin. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | AGI 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.50 Å R-free 0.194 |
| 5AUW Crystal structure of DAPK1 in complex with quercetin. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | QUE 3,5,7,3',4'-PENTAHYDROXYFLAVONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.50 Å R-free 0.211 |
| 5AUX Crystal structure of DAPK1 in complex with kaempferol. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | KMP 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.50 Å R-free 0.208 |
| 5AUY Crystal structure of DAPK1 in complex with morin. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | MRI 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 2.00 Å R-free 0.249 |
| 5AUZ Crystal structure of DAPK1 in complex with genistein. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | GEN GENISTEIN × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.60 Å R-free 0.206 |
| 5AV0 Crystal structure of DAPK1 in complex with 7,3',4'-trihydroxyisoflavone. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | 47X 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.85 Å R-free 0.220 |
| 5AV1 Crystal structure of DAPK1 in the presence of bromide ions. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | BR BROMIDE ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.50 Å R-free 0.215 |
| 5AV2 Crystal structure of DAPK1-kaempferol complex in the presence of bromide ions. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | KMP 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE × 1 BR BROMIDE ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.50 Å R-free 0.209 |
| 5AV3 Crystal structure of DAPK1-kaempferol complex in the presence of iodide ions. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | KMP 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE × 1 IOD IODIDE ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.90 Å R-free 0.233 |
| 5AV4 Crystal structure of DAPK1-genistein complex in the presence of bromide ions. Deposited 2015-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
Fragment：UNP RESIDUES 1-285
|
Not recorded | GEN GENISTEIN × 1 BR BROMIDE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2 M ammonium sulfate, 0.1 M MES
|
Resolution 1.40 Å R-free 0.228 |
| 6AAR Crystal structure of DAPK1 in complex with purpurin Deposited 2018-07-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | 9TF Purpurin × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.6 M ammonium sulfate, 0.1 M MES pH 6.5
|
Resolution 1.95 Å R-free 0.220 |
| 6FHA Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289A and S308A mutations Deposited 2018-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–334（333 aa）
|
Mutation：S289A S308A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292.15 K；22% PEG 4000, 0.2M ammonium sulfate, 0.1M sodium sulfate
|
Resolution 2.30 Å R-free 0.267 |
| 6FHB Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289A and S308E mutations Deposited 2018-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–334（333 aa）
|
Mutation：S289A S308E | CL CHLORIDE ION × 5 ACT ACETATE ION × 1 MG MAGNESIUM ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292.15 K；10% PEG 8000, 0.2M magnesium acetate
|
Resolution 1.75 Å R-free 0.222 |
| 6IN4 Crystal structure of apo DAPK1 in the presence of 18-crown-6 Deposited 2018-10-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.8 M ammonium sulfate, 0.1 M MES pH 6.5, 100 mM 18-crown-6
|
Resolution 1.80 Å R-free 0.218 |
| 6QMO Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289E and S308A mutations Deposited 2019-02-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–310（309 aa）
|
Mutation：S289E S308A | GOL GLYCEROL × 6 CL CHLORIDE ION × 5 PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292.15 K；20% PEG 3350, 0.2M magnesium formate
|
Resolution 1.87 Å R-free 0.224 |
| 6QN4 Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289E and S308E mutations Deposited 2019-02-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–310（309 aa）
|
Mutation：S289E S308E | ACT ACETATE ION × 7 GOL GLYCEROL × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292.15 K；16% PEG 4000, 0.1 M Tris pH 8.5, 0.2 M sodium acetate
|
Resolution 2.50 Å R-free 0.266 |
| 7CCU Crystal structure of death-associated protein kinase 1 in complex with resveratrol Deposited 2020-06-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | STL RESVERATROL × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.4 M ammonium sulfate, 0.1 M Tris-HCl pH 8.0, 14.4 mg/mL DAPK1, 2 mM resveratrol
|
Resolution 1.65 Å R-free 0.199 |
| 7CCV Crystal structure of death-associated protein kinase 1 in complex with piceatannol Deposited 2020-06-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | PIT PICEATANNOL × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M ammonium sulfate, 0.1 M Tris-HCl pH 7.0, 14.4 mg/mL DAPK1, 2 mM piceatannol
|
Resolution 1.75 Å R-free 0.208 |
| 7CCW Crystal structure of death-associated protein kinase 1 in complex with resveratrol and MES Deposited 2020-06-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | STL RESVERATROL × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.8 M ammonium sulfate, 0.1 M MES-NaOH pH 6.5, 14.4 mg/mL DAPK1, 2 mM resveratrol
|
Resolution 1.40 Å R-free 0.188 |
| 8IE5 Crystal structure of DAPK1 in complex with oxyresveratrol Deposited 2023-02-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | EZE trans-oxyresveratrol × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG 400, ammonium sulfate, Bis-tris pH 6.5
|
Resolution 1.80 Å R-free 0.210 |
| 8IE6 Crystal structure of DAPK1 in complex with pinostilbene Deposited 2023-02-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | 8KZ 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG 400, ammonium sulfate, Bis-tris pH 6.5
|
Resolution 1.70 Å R-free 0.195 |
| 8IE7 Crystal structure of DAPK1 in complex with pterostilbene Deposited 2023-02-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | 3RL Pterostilbene × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG400, ammonium sulfate, Bis-tris pH 6.5
|
Resolution 1.85 Å R-free 0.211 |
| 8IE8 Crystal structure of DAPK1 in complex with isorhapontigenin Deposited 2023-02-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | P5O 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG400, ammonium sulfate, Bis-tris pH 6.5
|
Resolution 1.75 Å R-free 0.216 |
| 8ODZ Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). Deposited 2023-03-10 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
300–319（20 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
|
Resolution 3.60 Å |
| 8OE0 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). Deposited 2023-03-10 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
300–319（20 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
|
Resolution 4.60 Å |
| 8OE4 Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. Deposited 2023-03-10 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain D
301–319（19 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 4.5 s. blotting time.
|
Resolution 3.60 Å |
| 8PB1 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. Deposited 2023-06-08 | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
300–319（20 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
|
Resolution 3.50 Å |
| 9DUB Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound SRM-25-071 Deposited 2024-10-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：protein kinase domain (UNP residues 2-285)
|
Not recorded | A1BB7 4-(pyridin-4-yl)pyridazine × 1 CL CHLORIDE ION × 1 SO4 SULFATE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；Protein: 6.6 mg/ml, 0.25M Sodium chloride, 0.1M Tris-HCl (pH 8.0);
Screen: 1.8M Ammomium sulfate, 0.2M Ammonium chloride;
Soak: 24h, 1mM SRM-25-071, 10% DMSO, 1.8M Ammonium sulfate, 0.2M Ammonium chloride;
Cryo: 1.8M Ammonium sulfate, 25% sucrose.
|
Resolution 1.50 Å R-free 0.183 |
| 9DUE Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound SRM-07-081a Deposited 2024-10-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：protein kinase domain (UNP residues 2-285)
|
Not recorded | A1BB6 3-chloro-6-(4-methylpiperazin-1-yl)-4-(pyridin-4-yl)pyridazine × 1 BO3 BORIC ACID × 1 SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；Protein: 6.6 mg/ml, 0.25M Sodium chloride, 0.1M Tris-HCl (pH 8.0);
Screen: 1.8M Ammomium sulfate, 0.2M Ammonium chloride;
Soak: 24h, 1mM SRM-7-081a, 10% DMSO, 1.8M Ammonium sulfate, 0.2M Ammonium chloride;
Cryo: 1.8M Ammonium sulfate, 25% sucrose.
|
Resolution 1.65 Å R-free 0.184 |
| 9INV Crystal structure of DAPK1 in complex with isoliquiritigenin Deposited 2024-07-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | HCC 2',4,4'-TRIHYDROXYCHALCONE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG 400, ammonium sulfate, MES pH 6.5
|
Resolution 1.61 Å R-free 0.205 |
| 9INW Crystal structure of DAPK1 in complex with compound 9 Deposited 2024-07-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | A1L2V (~{E})-1-[2,4-bis(oxidanyl)phenyl]-3-(3-chloranyl-4-oxidanyl-phenyl)prop-2-en-1-one × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG 400, ammonium sulfate, MES pH 6.5
|
Resolution 1.52 Å R-free 0.207 |
| 9INX Crystal structure of DAPK1 in complex with compound 10 Deposited 2024-07-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–285（285 aa）
|
Not recorded | A1L2W (~{E})-1-[2,4-bis(oxidanyl)phenyl]-3-(3-bromanyl-4-oxidanyl-phenyl)prop-2-en-1-one × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；PEG 400, ammonium sulfate, MES pH 6.5
|
Resolution 1.72 Å R-free 0.211 |
| 9MIU Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound MW01-9-039SRM. Deposited 2024-12-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
|
Not recorded | A1BLJ 6-chloro-N,N-dimethyl-5-(pyridin-4-yl)pyridazin-3-amine × 1 SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；Protein: 6.6 mg/ml, 0.25M Sodium chloride, 0.1M Tris-HCl (pH 8.0);
Screen: 1.8M Ammomium sulfate, 0.2M Ammonium chloride;
Soak: 24h, 1mM MW01-9-039SRM, 10% DMSO, 1.8M Ammonium sulfate, 0.2M Ammonium chloride;
Cryo: 1.8M Ammonium sulfate, 25% sucrose.
|
Resolution 1.90 Å R-free 0.197 |
| 9N1T Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound SRM-26-100 Deposited 2025-01-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
|
Not recorded | SO4 SULFATE ION × 1 A1BU8 3-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)pyridazine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；Protein: 6.6 mg/ml, 0.25M Sodium chloride, 0.1M Tris-HCl (pH 8.0); Screen: 1.8M Ammomium sulfate, 0.2M Ammonium chloride; Soak: 24h, 1mM SRM-25-071, 10% DMSO, 1.8M Ammonium sulfate, 0.2M Ammonium chloride; Cryo: 1.8M Ammonium sulfate, 25% sucrose.
|
Resolution 1.43 Å R-free 0.176 |
| 9N2M Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound MW01-30-047SRM Deposited 2025-01-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
|
Not recorded | SO4 SULFATE ION × 1 A1BVM 5-(pyridin-4-yl)-3-[4-(pyridin-4-yl)piperazin-1-yl]pyridazine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；2M LiSO4, 5% DMSO
|
Resolution 1.35 Å R-free 0.177 |
| 9N2O Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound MW01-27-040SRM Deposited 2025-01-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
|
Not recorded | A1BVL 5-(pyridin-4-yl)-3-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine × 1 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；3.6M Ammonium Sulfate
|
Resolution 1.49 Å R-free 0.191 |
| 9O73 Crystal Structure of Human DAPK1 Catalytic Subunit Complexed with Compound MW01-30-035SRM Deposited 2025-04-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–285（284 aa）
Fragment：protein kinase domain (UNP residues 2-285)
|
Not recorded | 86Q 5,6-Dihydro-benzo[H]cinnolin-3-ylamine × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；2M LiSO4, 5mM MW01-30-035SRM
|
Resolution 1.49 Å R-free 0.191 |