当前蛋白身份:P62837 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
2CLW Crystal structure of human ubiquitin-conjugating enzyme UbcH5B 提交 2006-05-02 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
非标准单体:是(mmCIF未提供具体位点) SO4 SULFATE ION × 1 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 4.6;150 MM AMMONIUM SULPHATE, 100 MM SODIUM ACETATE TRIHYDRATE [PH 4.6], 25% W/V PEG MME 2000
分辨率 1.95 Å R-free 0.255
2CLW Crystal structure of human ubiquitin-conjugating enzyme UbcH5B 提交 2006-05-02 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 4.6;150 MM AMMONIUM SULPHATE, 100 MM SODIUM ACETATE TRIHYDRATE [PH 4.6], 25% W/V PEG MME 2000
分辨率 1.95 Å R-free 0.255
2CLW Crystal structure of human ubiquitin-conjugating enzyme UbcH5B 提交 2006-05-02 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 4.6;150 MM AMMONIUM SULPHATE, 100 MM SODIUM ACETATE TRIHYDRATE [PH 4.6], 25% W/V PEG MME 2000
分辨率 1.95 Å R-free 0.255
2CLW Crystal structure of human ubiquitin-conjugating enzyme UbcH5B 提交 2006-05-02 Assembly 4 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 1–147(147 aa)
未记录 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 4.6;150 MM AMMONIUM SULPHATE, 100 MM SODIUM ACETATE TRIHYDRATE [PH 4.6], 25% W/V PEG MME 2000
分辨率 1.95 Å R-free 0.255
2ESK Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type 提交 2005-10-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.5;294 K;NaCl, PEG 6000, Sodium Acetate, temperature 294K, pH 4.5, VAPOR DIFFUSION, HANGING DROP
分辨率 1.36 Å R-free 0.224
2ESO Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ile37Ala 提交 2005-10-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
突变:I37A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.5;294 K;NaCl, PEG 6000, Sodium Acetate, temperature 294K, pH 4.5, VAPOR DIFFUSION, HANGING DROP
分辨率 1.50 Å R-free 0.219
2ESP Human ubiquitin-conjugating enzyme (E2) UbcH5b mutant Ile88Ala 提交 2005-10-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
突变:I88A CL CHLORIDE ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.5;294 K;NaCl, PEG 6000, Sodium Acetate, temperature 294K, pH 4.5, VAPOR DIFFUSION, HANGING DROP
分辨率 1.52 Å R-free 0.233
2ESQ Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ser94Gly 提交 2005-10-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
突变:S94G 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.5;294 K;NaCl, PEG 6000, Sodium Acetate, temperature 294K, pH 4.5, VAPOR DIFFUSION, HANGING DROP
分辨率 1.44 Å R-free 0.205
3A33 UbcH5b~Ubiquitin Conjugate 提交 2009-06-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–147(147 aa)
突变:C85S GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.1;293 K;2.0M NaCl, 0.1M Potassium acetate, pH 4.1, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.20 Å R-free 0.280
3JVZ E2~Ubiquitin-HECT 提交 2009-09-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 2–147(146 aa)
突变:L3S, C85S, T98K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.1;277 K;0.1 M sodium citrate, pH 5.1-5.2, 2.4-2.5 M sodium chloride, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 3.30 Å R-free 0.267
3JVZ E2~Ubiquitin-HECT 提交 2009-09-17 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 2–147(146 aa)
突变:L3S, C85S, T98K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.1;277 K;0.1 M sodium citrate, pH 5.1-5.2, 2.4-2.5 M sodium chloride, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 3.30 Å R-free 0.267
3JW0 E2~Ubiquitin-HECT 提交 2009-09-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 2–147(146 aa)
突变:L3S, C85S, T98K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.1;277 K;0.1 M sodium citrate, 2.4M sodium chloride, pH 5.1, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 3.10 Å R-free 0.287
3JW0 E2~Ubiquitin-HECT 提交 2009-09-17 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 2–147(146 aa)
突变:L3S, C85S, T98K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.1;277 K;0.1 M sodium citrate, 2.4M sodium chloride, pH 5.1, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 3.10 Å R-free 0.287
3L1Y Crystal structure of human UBC4 E2 conjugating enzyme 提交 2009-12-14 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa) 片段:residues 1-147
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.6;295 K;2M sodium formate, 0.1M sodium acetate trihydrate, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 295K
分辨率 1.60 Å R-free 0.229
3TGD Crystal structure of the human ubiquitin-conjugating enzyme (E2) UbcH5b 提交 2011-08-17 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;293 K;0.8M potassium phosphate, 0.8M sodium phosphate, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
分辨率 1.80 Å R-free 0.203
3ZNI Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex 提交 2013-02-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 C 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES ZN ZINC ION × 2 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 0.1 M BICINE, PH 9.0, 8-11% (W/V) PEG 3350 AND 0.1 M SODIUM FORMATE
分辨率 2.21 Å R-free 0.211
3ZNI Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex 提交 2013-02-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 G 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES ZN ZINC ION × 2 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 0.1 M BICINE, PH 9.0, 8-11% (W/V) PEG 3350 AND 0.1 M SODIUM FORMATE
分辨率 2.21 Å R-free 0.211
3ZNI Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex 提交 2013-02-14 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 K 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES ZN ZINC ION × 2 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 0.1 M BICINE, PH 9.0, 8-11% (W/V) PEG 3350 AND 0.1 M SODIUM FORMATE
分辨率 2.21 Å R-free 0.211
3ZNI Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex 提交 2013-02-14 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 O 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES ZN ZINC ION × 2 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 0.1 M BICINE, PH 9.0, 8-11% (W/V) PEG 3350 AND 0.1 M SODIUM FORMATE
分辨率 2.21 Å R-free 0.211
4A49 Structure of phosphoTyr371-c-Cbl-UbcH5B complex 提交 2011-10-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–147(147 aa)
未记录 ZN ZINC ION × 2 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 291 K;20% (W/V) PEG 3350 AND 0.2 M POTASSIUM THIOCYANATE AT 18 DEGREES CELSIUS.
分辨率 2.21 Å R-free 0.205
4A4B Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex 提交 2011-10-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–147(147 aa)
未记录 ZN ZINC ION × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 7.5;31-35% PENTAERYTHRITOL PROPOXYLATE (5/4 PO/OH), 0.2 M KCL, 50 MM HEPES, PH 7.5
分辨率 2.79 Å R-free 0.267
4A4C Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex 提交 2011-10-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–147(147 aa)
未记录 ZN ZINC ION × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 277 K;50 MM HEPES, PH 7.5, 0.2 M KCL AND 31-35% (V/V) PENTAERYTHRITOL PROPOXYLATE (5/4 PO/OH) AT 4 DEGREES CELSIUS.
分辨率 2.70 Å R-free 0.268
4AUQ Structure of BIRC7-UbcH5b-Ub complex. 提交 2012-05-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–147(147 aa) 片段:UBCH5B, RESIDUES 1-147
链 D 1–147(147 aa) 片段:UBCH5B, RESIDUES 1-147
突变:YES 突变:YES ZN ZINC ION × 4 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.18 Å R-free 0.249
4DDG Crystal structure of human OTUB1/UbcH5b~Ub/Ub 提交 2012-01-18 Assembly 1 信息不足 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 A 1–147(147 aa)
链 B 1–147(147 aa)
链 C 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;293 K;25% PEG1500, 0.1 M SPG, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
分辨率 3.30 Å R-free 0.280
4DDG Crystal structure of human OTUB1/UbcH5b~Ub/Ub 提交 2012-01-18 Assembly 2 信息不足 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 J 1–147(147 aa)
链 K 1–147(147 aa)
链 L 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;293 K;25% PEG1500, 0.1 M SPG, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
分辨率 3.30 Å R-free 0.280
4DDI Crystal structure of human OTUB1/UbcH5b~Ub/Ub 提交 2012-01-18 Assembly 1 信息不足 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 A 1–147(147 aa)
链 B 1–147(147 aa)
链 C 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8;293 K;25% PEG1500, 0.1 M SPG, pH 8.0, VAPOR DIFFUSION, temperature 293K
分辨率 3.80 Å R-free 0.273
4LDT The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub 提交 2013-06-25 Assembly 1 信息不足 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 C 1–147(147 aa)
突变:C85S EDO 1,2-ETHANEDIOL × 4 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;293.15 K;1:1 mix of 12 mg/mL purified complex and well solution (100 mM Bis-Tris, pH 6.0, 200 mM magnesium chloride, 22% PEG3350), crystals appeared in about 2 to 3 days, cryoprotection with well solution + 10% ethylene glycol, flash frozen in liquid nitrogen, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K
分辨率 1.90 Å R-free 0.223
4V3K RNF38-UbcH5B-UB complex 提交 2014-10-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES CL CHLORIDE ION × 3 EDO 1,2-ETHANEDIOL × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 50 MM TRIS-HCL, PH 8.5 AND 2.3 M AMMONIUM SULFATE
分辨率 2.04 Å R-free 0.223
4V3K RNF38-UbcH5B-UB complex 提交 2014-10-20 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES CL CHLORIDE ION × 3 EDO 1,2-ETHANEDIOL × 3 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 50 MM TRIS-HCL, PH 8.5 AND 2.3 M AMMONIUM SULFATE
分辨率 2.04 Å R-free 0.223
4V3L RNF38-UB-UbcH5B-Ub complex 提交 2014-10-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 2–147(146 aa) 片段:RESIDUES 2-147
突变:YES EDO 1,2-ETHANEDIOL × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 50 MM HEPES, PH 7.5, 0.2 M MAGNESIUM ACETATE AND 13% (W/V) PEG 8K
分辨率 1.53 Å R-free 0.193
4WZ3 Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2 提交 2014-11-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
突变:C85S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;15 mg/ml of E2D2.(C85S)-Ub conjugate and an equimolar concentration of LubX (1-186), 0.2 M sodium tartrate, 0.1 M Tris-Cl (pH 8.5) and 25% PEG3350
分辨率 2.70 Å R-free 0.223
5D0K Structure of UbE2D2:RNF165:Ub complex 提交 2015-08-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291.15 K;MES, sodium chloride, PEG 6000
分辨率 2.65 Å R-free 0.238
5D0K Structure of UbE2D2:RNF165:Ub complex 提交 2015-08-03 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–147(147 aa)
突变:C21S, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291.15 K;MES, sodium chloride, PEG 6000
分辨率 2.65 Å R-free 0.238
5D0K Structure of UbE2D2:RNF165:Ub complex 提交 2015-08-03 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 G 1–147(147 aa)
突变:C21S, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291.15 K;MES, sodium chloride, PEG 6000
分辨率 2.65 Å R-free 0.238
5D0K Structure of UbE2D2:RNF165:Ub complex 提交 2015-08-03 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 J 1–147(147 aa)
突变:C21S, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291.15 K;MES, sodium chloride, PEG 6000
分辨率 2.65 Å R-free 0.238
5D0M Structure of UbE2D2:RNF165:Ub complex 提交 2015-08-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S PO4 PHOSPHATE ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291.15 K;SPG buffer, PEG 1500
分辨率 1.91 Å R-free 0.213
5D1K Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 提交 2015-08-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 EDO 1,2-ETHANEDIOL × 3 PEG DI(HYDROXYETHYL)ETHER × 1 OXL OXALATE ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;292 K;20% PEG-10000, 8% ethylene glycol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
分辨率 1.78 Å R-free 0.202
5D1L Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) 提交 2015-08-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 PEG DI(HYDROXYETHYL)ETHER × 1 OXL OXALATE ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;292 K;15% PEG 20000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
分辨率 1.62 Å R-free 0.200
5D1M Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) 提交 2015-08-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 OXL OXALATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;292 K;20% PEG 10000, 8% Ethylene glycol, 0.1M HEPS, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
分辨率 1.58 Å R-free 0.223
5EDV Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex 提交 2015-10-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 C 2–147(146 aa)
突变:S22R, C85K ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;285 K;0.06M Tris, 0.04M Bicine, 0.02 M 1,6-Hexanediol, 0.02 M 1-Butanol, 0.02 M 1,2- Propanediol (racemic), 0.02 M 2-Propanol, 0.02 M 1,4-Butanediol, 0.02 M 1,3-Propanediol, 20% PEG550MME, 10% PEG20K, 8% glycerol
分辨率 3.48 Å R-free 0.303
5EDV Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex 提交 2015-10-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 C 2–147(146 aa)
链 D 2–147(146 aa)
突变:S22R, C85K 突变:S22R, C85K ZN ZINC ION × 16 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;285 K;0.06M Tris, 0.04M Bicine, 0.02 M 1,6-Hexanediol, 0.02 M 1-Butanol, 0.02 M 1,2- Propanediol (racemic), 0.02 M 2-Propanol, 0.02 M 1,4-Butanediol, 0.02 M 1,3-Propanediol, 20% PEG550MME, 10% PEG20K, 8% glycerol
分辨率 3.48 Å R-free 0.303
5EDV Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex 提交 2015-10-22 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 D 2–147(146 aa)
突变:S22R, C85K ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;285 K;0.06M Tris, 0.04M Bicine, 0.02 M 1,6-Hexanediol, 0.02 M 1-Butanol, 0.02 M 1,2- Propanediol (racemic), 0.02 M 2-Propanol, 0.02 M 1,4-Butanediol, 0.02 M 1,3-Propanediol, 20% PEG550MME, 10% PEG20K, 8% glycerol
分辨率 3.48 Å R-free 0.303
5EDV Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex 提交 2015-10-22 Assembly 4 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 I 2–147(146 aa)
突变:S22R, C85K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;285 K;0.06M Tris, 0.04M Bicine, 0.02 M 1,6-Hexanediol, 0.02 M 1-Butanol, 0.02 M 1,2- Propanediol (racemic), 0.02 M 2-Propanol, 0.02 M 1,4-Butanediol, 0.02 M 1,3-Propanediol, 20% PEG550MME, 10% PEG20K, 8% glycerol
分辨率 3.48 Å R-free 0.303
5MNJ Structure of MDM2-MDMX-UbcH5B-ubiquitin complex 提交 2016-12-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–147(147 aa)
突变:S22R, C85K ZN ZINC ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;292 K;0.1 M Tris-HCl, pH 8.5, 0.175 M Li2SO4 and 16-20 %(v/v) PEG 3350
分辨率 2.16 Å R-free 0.231
5MNJ Structure of MDM2-MDMX-UbcH5B-ubiquitin complex 提交 2016-12-13 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 E 1–147(147 aa)
突变:S22R, C85K ZN ZINC ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;292 K;0.1 M Tris-HCl, pH 8.5, 0.175 M Li2SO4 and 16-20 %(v/v) PEG 3350
分辨率 2.16 Å R-free 0.231
5ULF Crystal Structure of a UbcH5b~Ub conjugate 提交 2017-01-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;289 K;100 mM bis-Tris pH 5.5, 150 mM ammonium sulfate, 20% PEG 3350
分辨率 1.80 Å R-free 0.261
5ULF Crystal Structure of a UbcH5b~Ub conjugate 提交 2017-01-24 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;289 K;100 mM bis-Tris pH 5.5, 150 mM ammonium sulfate, 20% PEG 3350
分辨率 1.80 Å R-free 0.261
5ULH Structure of RNF165 in complex with a UbcH5b~Ub conjugate 提交 2017-01-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, C85K, C107S, C111S GOL GLYCEROL × 2 SCN THIOCYANATE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;289 K;200 mM potassium thiocyanate, 20% PEG 3350
分辨率 1.95 Å R-free 0.217
5ULK Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate 提交 2017-01-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;289 K;200 mM ammonium nitrate, 20% PEG 3350
分辨率 2.38 Å R-free 0.267
5VZW TRIM23 RING domain in complex with UbcH5-Ub 提交 2017-05-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–147(147 aa)
链 B 1–147(147 aa)
突变:S22R,C85K 突变:S22R,C85K ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;290 K;0.1 M Bis-Tris, pH 5.5, 0.2 M calcium chloride, 17% w/v PEG3350
分辨率 2.28 Å R-free 0.237
5ZBU Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub 提交 2018-02-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–147(147 aa)
突变:C85K ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;293 K;0.1M MES monohydrate, 14% PEG 4000
分辨率 3.20 Å R-free 0.262
5ZBU Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub 提交 2018-02-12 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 1–147(147 aa)
突变:C85K ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;293 K;0.1M MES monohydrate, 14% PEG 4000
分辨率 3.20 Å R-free 0.262
6HPR Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub 提交 2018-09-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 C 1–147(147 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;292 K;0.2 M ammonium fluoride and 15% (w/v) PEG 3350
分辨率 1.70 Å R-free 0.197
6M2C Distinct mechanism of MUL1-RING domain simultaneously recruiting E2 enzyme and the substrate p53-TAD domain 提交 2020-02-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;291 K;4% v/v Tacsimate pH 6.0, 12% w/v Polyethylene glycol 3350
分辨率 2.70 Å R-free 0.258
6M2C Distinct mechanism of MUL1-RING domain simultaneously recruiting E2 enzyme and the substrate p53-TAD domain 提交 2020-02-27 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–147(147 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;291 K;4% v/v Tacsimate pH 6.0, 12% w/v Polyethylene glycol 3350
分辨率 2.70 Å R-free 0.258
6M2C Distinct mechanism of MUL1-RING domain simultaneously recruiting E2 enzyme and the substrate p53-TAD domain 提交 2020-02-27 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–147(147 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;291 K;4% v/v Tacsimate pH 6.0, 12% w/v Polyethylene glycol 3350
分辨率 2.70 Å R-free 0.258
6M2C Distinct mechanism of MUL1-RING domain simultaneously recruiting E2 enzyme and the substrate p53-TAD domain 提交 2020-02-27 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–147(147 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;291 K;4% v/v Tacsimate pH 6.0, 12% w/v Polyethylene glycol 3350
分辨率 2.70 Å R-free 0.258
6SQO Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub 提交 2019-09-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 B 2–147(146 aa)
链 E 2–147(146 aa)
突变:S22R, C85K 突变:S22R, C85K ZN ZINC ION × 4 CL CHLORIDE ION × 4 NO3 NITRATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;292 K;0.1 M SPG, pH 7.0, 10% (w/v) PEG Smear Broad, 0.15 M NH4NO3
分辨率 1.41 Å R-free 0.173
6SQR Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub 提交 2019-09-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 12 PDB 声明:dodecameric(12) 与蛋白数一致
链 B 2–147(146 aa)
链 E 2–147(146 aa)
链 H 2–147(146 aa)
链 K 2–147(146 aa)
突变:S22R, C85K 突变:S22R, C85K 突变:S22R, C85K 突变:S22R, C85K EDO 1,2-ETHANEDIOL × 12 ZN ZINC ION × 8 NO3 NITRATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;292 K;0.1 M Tris-HCl, pH 8.5, 20% (v/v) PEG Smear High
分辨率 2.18 Å R-free 0.227
6SQS Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub 提交 2019-09-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 B 2–147(146 aa)
链 E 2–147(146 aa)
突变:S22R, C85K 突变:S22R, C85K ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;292 K;0.1 M Tris-HCl, pH 8.0, 15% (w/v) PEG 2000 MME and 0.1 M KCl
分辨率 1.83 Å R-free 0.242
6TTU Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 提交 2019-12-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 D 1–147(147 aa)
未记录 ZN ZINC ION × 3 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.8
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.70 Å
6W7Z RNF12 RING domain in complex with Ube2d2 提交 2020-03-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 GOL GLYCEROL × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;289 K;15-20% PEG 3350, 100-200 mM ammonium formate
分辨率 1.80 Å R-free 0.211
6W9D RNF12 RING domain in complex with a Ube2d2~Ub conjugate 提交 2020-03-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S ZN ZINC ION × 2 IOD IODIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;289 K;15-20% PEG 3350, 200-400 mM NaI
分辨率 3.19 Å R-free 0.281
6W9D RNF12 RING domain in complex with a Ube2d2~Ub conjugate 提交 2020-03-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S ZN ZINC ION × 2 IOD IODIDE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;289 K;15-20% PEG 3350, 200-400 mM NaI
分辨率 3.19 Å R-free 0.281
6W9D RNF12 RING domain in complex with a Ube2d2~Ub conjugate 提交 2020-03-22 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 G 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S ZN ZINC ION × 2 IOD IODIDE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;289 K;15-20% PEG 3350, 200-400 mM NaI
分辨率 3.19 Å R-free 0.281
7AI0 Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) 提交 2020-09-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 BBB 1–147(147 aa)
突变:S22R, C85K CL CHLORIDE ION × 4 ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;292 K;0.1 M Tris, 0.075 M NaOAc, 0.1 M NaCl, 15 % w/v PEG Smear Medium
分辨率 1.56 Å R-free 0.185
7AI0 Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) 提交 2020-09-25 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 EEE 1–147(147 aa)
突变:S22R, C85K CL CHLORIDE ION × 1 ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;292 K;0.1 M Tris, 0.075 M NaOAc, 0.1 M NaCl, 15 % w/v PEG Smear Medium
分辨率 1.56 Å R-free 0.185
7AI1 Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) 提交 2020-09-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 BBB 1–147(147 aa)
突变:S22R, C85K CL CHLORIDE ION × 1 ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;292 K;0.1 M HEPES, 0.2 M NH4NO3, 20 % w/v PEG Smear Broad
分辨率 2.07 Å R-free 0.266
7AI1 Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) 提交 2020-09-25 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 EEE 1–147(147 aa)
突变:S22R, C85K CL CHLORIDE ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;292 K;0.1 M HEPES, 0.2 M NH4NO3, 20 % w/v PEG Smear Broad
分辨率 2.07 Å R-free 0.266
7BOL ubiquitin-conjugating enzyme, Ube2D2 提交 2020-03-19 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291 K;0.5 M Ammonium sulfate 0.1 M Sodium citrate pH 5.6 1.0 M Lithium sulfate
分辨率 1.80 Å R-free 0.219
7R71 Crystal Structure of the UbArk2C-UbcH5b~Ub complex 提交 2021-06-24 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–147(147 aa)
突变:C21S, S22R, C85K, C107S, C111S ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;289.15 K;0.1 M MMT pH 6.0, 25% w/v PEG 1500
分辨率 2.80 Å R-free 0.271
8B3I CRL4CSA-E2-Ub (state 2) 提交 2022-09-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 7 PDB 声明:heptameric(7) 与蛋白数一致
链 D 1–147(147 aa)
未记录 ZN ZINC ION × 3 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.50 Å
8GBQ Structure of RNF125 in complex with UbcH5b 提交 2023-02-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 GOL GLYCEROL × 1 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 9.5;289 K;0.1 M CHES 9.5 20% PEG 8000
分辨率 1.74 Å R-free 0.201
8GCB Structure of RNF125 in complex with a UbcH5b~Ub conjugate 提交 2023-03-01 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;pH 9;289 K;0.1 M BICINE pH 9.0, 20% PEG 6000
分辨率 2.39 Å R-free 0.271
8JWJ PHD Finger Protein 7 (PHF7) in complex with UBE2D2 提交 2023-06-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–147(147 aa)
突变:S22R, C85K ZN ZINC ION × 7 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.3;277 K;MPD, Tris
分辨率 2.96 Å R-free 0.222
8JWJ PHD Finger Protein 7 (PHF7) in complex with UBE2D2 提交 2023-06-29 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–147(147 aa)
突变:S22R, C85K ZN ZINC ION × 7 SO4 SULFATE ION × 1 GOL GLYCEROL × 4 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.3;277 K;MPD, Tris
分辨率 2.96 Å R-free 0.222
8JWU PHD Finger Protein 7 (PHF7) fused to UBE2D2 via a (GSGG)3 linker 提交 2023-06-29 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–147(147 aa)
突变:S346R,C409K ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;277 K;PEG8000, DMSO, MOPS
分辨率 3.58 Å R-free 0.265
8JWU PHD Finger Protein 7 (PHF7) fused to UBE2D2 via a (GSGG)3 linker 提交 2023-06-29 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–147(147 aa)
突变:S346R,C409K ZN ZINC ION × 7 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;277 K;PEG8000, DMSO, MOPS
分辨率 3.58 Å R-free 0.265
8JWU PHD Finger Protein 7 (PHF7) fused to UBE2D2 via a (GSGG)3 linker 提交 2023-06-29 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 1–147(147 aa)
突变:S346R,C409K ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;277 K;PEG8000, DMSO, MOPS
分辨率 3.58 Å R-free 0.265
8V0D Ubch5B-RING3 of MIB1 fusion structure 提交 2023-11-17 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
链 B 1–147(147 aa)
未记录 ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;291 K;4% v/v TacsimateTM pH 6.0, 12% w/v Polyethylene glycol 3,350
分辨率 2.40 Å R-free 0.243
8VK8 Structure of UbV.d2.1 in complex with Ube2d2 提交 2024-01-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, C107S, and C111S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;289 K;0.1 M Sodium citrate pH 5.6, 20% w/v PEG 4000, 20% v/v 2-Propanol
分辨率 2.99 Å R-free 0.295
8VK8 Structure of UbV.d2.1 in complex with Ube2d2 提交 2024-01-08 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–147(147 aa)
突变:C21S, C107S, and C111S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;289 K;0.1 M Sodium citrate pH 5.6, 20% w/v PEG 4000, 20% v/v 2-Propanol
分辨率 2.99 Å R-free 0.295
8VK8 Structure of UbV.d2.1 in complex with Ube2d2 提交 2024-01-08 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 1–147(147 aa)
突变:C21S, C107S, and C111S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;289 K;0.1 M Sodium citrate pH 5.6, 20% w/v PEG 4000, 20% v/v 2-Propanol
分辨率 2.99 Å R-free 0.295
8VK9 Structure of UbV.d2.3 in complex with Ube2d2-S22R 提交 2024-01-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
突变:C21S, S22R, C107S, C111S GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;289 K;0.1 M Sodium HEPES pH 7.0, 15% w/v PEG 20,000
分辨率 2.00 Å R-free 0.224
8VK9 Structure of UbV.d2.3 in complex with Ube2d2-S22R 提交 2024-01-08 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–147(147 aa)
突变:C21S, S22R, C107S, C111S GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;289 K;0.1 M Sodium HEPES pH 7.0, 15% w/v PEG 20,000
分辨率 2.00 Å R-free 0.224
8VK9 Structure of UbV.d2.3 in complex with Ube2d2-S22R 提交 2024-01-08 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 1–147(147 aa)
突变:C21S, S22R, C107S, C111S GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;289 K;0.1 M Sodium HEPES pH 7.0, 15% w/v PEG 20,000
分辨率 2.00 Å R-free 0.224
8VK9 Structure of UbV.d2.3 in complex with Ube2d2-S22R 提交 2024-01-08 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 1–147(147 aa)
突变:C21S, S22R, C107S, C111S GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;289 K;0.1 M Sodium HEPES pH 7.0, 15% w/v PEG 20,000
分辨率 2.00 Å R-free 0.224
9DNS Cryo-EM structure of Tom1-UBE2D2-ubiquitin complex 提交 2024-09-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 7 PDB 声明:heptameric(7) 与蛋白数一致
链 D 1–147(147 aa)
链 E 1–147(147 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.2;30 mM HEPES pH 7.2, 200 mM NaCl, 0.5 mM TCEP, 0.2 mM CHAPSO
cryo-EM玻璃化条件 冷冻剂 ETHANE;CHAPSO detergent added to final conc. of 0.2 mM. Sample applied twice.
分辨率 2.80 Å
9GLS Crystal Structure of Human UBCH5B C85E 提交 2024-08-28 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 AAA 1–147(147 aa)
突变:C85E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;293 K;10% PEG 200, 0.1 M Bis-Tris propane, pH 9, 15% PEG 8000
分辨率 1.25 Å R-free 0.211
9Q8Y Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub 提交 2025-02-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 2–147(146 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.6;293 K;0.2 M Sodium acetate trihydrate, 0.1 M Imidazole pH 8.0, 10% PEG 8000
分辨率 2.63 Å R-free 0.275
9Q8Y Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub 提交 2025-02-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 2–147(146 aa)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.6;293 K;0.2 M Sodium acetate trihydrate, 0.1 M Imidazole pH 8.0, 10% PEG 8000
分辨率 2.63 Å R-free 0.275
9YE9 Structure of UbcH5b in complex with the U-box domain of the E3 ubiquitin ligase CHIP 提交 2025-09-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–147(147 aa)
突变:M1K, C85K BME BETA-MERCAPTOETHANOL × 5 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.1 M Magnesium chloride hexahydrate, 0.1 M Potassium chloride, 0.1 M PIPES, 20 % v/v PEG Smear Medium
分辨率 2.01 Å R-free 0.288
9YEA Structure of the isopeptide bond-linked UbcH5b~Ubiquitin conjugate complex for an M1K/C85K UbcH5b mutant 提交 2025-09-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–147(147 aa)
突变:M1K, C85K 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;298 K;0.1 M Sodium Citrate, 20 % (w/v) PEG 3000
分辨率 1.83 Å R-free 0.239