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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q15306 New Search
18PDB entries
21Biological assembly
30chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
21IE The MIDN Catch-IRF4 (A8S) fusion protein Deposited 2025-12-13 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–226（22 aa）
Mutation：A222M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；4%(v/v) tacsimate (pH 4.0) and 12%(w/v) PEG 3,350
Resolution 3.24 Å R-free 0.294
21IK The MIDN Catch-IRF4 (V2T) fusion protein Deposited 2025-12-13 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：V216T No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；4% (v/v) tacsimate (pH 4.0) and 20% (w/v) polyethylene glycol (PEG) 3,350.
Resolution 2.99 Å R-free 0.281
21IP The MIDN Catch-IRF4 (A8C) fusion protein Deposited 2025-12-14 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：A222C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；4% (v/v) tacsimate (pH 4.0) and 12% (w/v) PEG 3,350
Resolution 3.30 Å R-free 0.291
2DLL Solution structure of the IRF domain of human interferon regulator factors 4 Deposited 2006-04-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 22–130（109 aa） Fragment：IRF domain, residues 8-115
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；293 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition 1.23mM 13C, 15N-labeled protein; 20mM d-Tris-HCl(pH7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
6TD4 IRF4 DNA-binding domain surface entropy mutant apo structure Deposited 2019-11-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 20–132（113 aa）
Mutation：E45A E46A K47A C99A CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；25 % PEG 3350, 0.1 M HEPES pH 7.5
Resolution 1.71 Å R-free 0.245
7JM4 IRF Transcription Factor Deposited 2020-07-31 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 21–129（109 aa）
Chain B 21–129（109 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；10 % PEG 4000, 0.1 M Na acetate pH 4.6
Resolution 2.95 Å R-free 0.205
7JM4 IRF Transcription Factor Deposited 2020-07-31 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain G 21–129（109 aa）
Chain H 21–129（109 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；10 % PEG 4000, 0.1 M Na acetate pH 4.6
Resolution 2.95 Å R-free 0.205
7O56 X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element solved by Phosphorus and Sulphur SAD methods Deposited 2021-04-07 Assembly 1 Protein–DNA Homooligomer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 20–139（120 aa）
Chain B 20–139（120 aa）
Chain C 20–139（120 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.2；293 K；0.1M sodium acetate, 5% PEG 4000, 10mM EDTA
Resolution 2.60 Å R-free 0.241
7OGS X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element Deposited 2021-05-07 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 20–139（120 aa）
Chain B 20–139（120 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1M Bis Tris pH 5.5, 0.2M ammonium acetate, 25% PEG 3350
Resolution 2.37 Å R-free 0.249
7OGS X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element Deposited 2021-05-07 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain E 20–139（120 aa）
Chain F 20–139（120 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1M Bis Tris pH 5.5, 0.2M ammonium acetate, 25% PEG 3350
Resolution 2.37 Å R-free 0.249
7OOT X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element Deposited 2021-05-28 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 20–139（120 aa）
Chain B 20–139（120 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；0.1M Tris HCl pH 8.5, 30% PEG 4000, 0.2M lithium sulfate
Resolution 2.25 Å R-free 0.238
9TOY Investigating the binding mechanism of Interferon Regulatory Factor 4 to DNA in the context of Multiple Myeloma Deposited 2025-12-17 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 20–139（120 aa）
Chain B 20–139（120 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.2M Calcium Acetate, 0.1M MES pH 6, 20% PEG 8000
Resolution 2.10 Å R-free 0.258
9TOY Investigating the binding mechanism of Interferon Regulatory Factor 4 to DNA in the context of Multiple Myeloma Deposited 2025-12-17 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain D 20–139（120 aa）
Chain F 20–139（120 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.2M Calcium Acetate, 0.1M MES pH 6, 20% PEG 8000
Resolution 2.10 Å R-free 0.258
9VE3 The MIDN Catch-IRF4 (V2L) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：V216L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；2% (v/v) tacsimate (pH 5.0), 0.1 M sodium citrate, and 16% (w/v) PEG 3,350
Resolution 2.10 Å R-free 0.263
9VE4 The MIDN Catch-IRF4 fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；6% (v/v) tacsimate (pH 4.0) and 12% (w/v) polyethylene glycol (PEG) 3,350
Resolution 2.55 Å R-free 0.281
9VE5 The MIDN Catch-IRF4 (V2Y) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：V216Y No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.15 M cesium chloride and 15% (w/v) PEG 3,350
Resolution 3.20 Å R-free 0.276
9VE6 The MIDN Catch-IRF4 (F6Y) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：F220Y No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；6% (v/v) tacsimate (pH 4.0) and 12% (w/v) polyethylene glycol (PEG) 3,350
Resolution 2.80 Å R-free 0.296
9VE7 The MIDN Catch-IRF4 (A8V) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：A222V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.2 M sodium malonate (pH 4.0) and 12% (w/v) PEG 3,350
Resolution 2.15 Å R-free 0.254
9VE8 The MIDN Catch-IRF4 (A8L) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：A222L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；4% (v/v) tacsimate (pH 4.0) and 12% (w/v) PEG 3,350
Resolution 2.85 Å R-free 0.274
9VEA The MIDN Catch-IRF4 (A8I) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：A222I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.1 M ammonium tartrate (pH 7.0) and 12% (w/v) PEG 3,350
Resolution 3.60 Å R-free 0.272
9VEH The MIDN Catch-IRF4 (A8M) fusion protein Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 205–227（23 aa）
Mutation：A222M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.1 M ammonium tartrate (pH 7.0) and 12% (w/v) PEG 3,350
Resolution 2.00 Å R-free 0.287

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.