← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q8TD43 New Search
38PDB entries
38Biological assembly
134chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
30KW Human Trpm4 at 8 degrees Celsius Deposited 2026-05-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.10 Å
30KZ Human trpm4 in complex with PBA at 8 degrees Celsius Deposited 2026-05-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.40 Å
30LA Human Trpm4 with calcium at 37 degrees celsius Deposited 2026-05-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.00 Å
30LD Human Trpm4 with calcium and PBA at 37 degrees celsius Deposited 2026-05-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.00 Å
5WP6 Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate Deposited 2017-08-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded DVT DECAVANADATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6BQR Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state Deposited 2017-11-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 75–1168（1094 aa）
Chain B 75–1168（1094 aa）
Chain C 75–1168（1094 aa）
Chain D 75–1168（1094 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
6BQV Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state Deposited 2017-11-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1214（1213 aa）
Chain B 2–1214（1213 aa）
Chain C 2–1214（1213 aa）
Chain D 2–1214（1213 aa）
Not recorded CA CALCIUM ION × 4 Y01 CHOLESTEROL HEMISUCCINATE × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8RCR human TRPM4 in SMA apo Deposited 2023-12-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 421–1168（748 aa）
Chain B 421–1168（748 aa）
Chain C 421–1168（748 aa）
Chain D 421–1168（748 aa）
Not recorded CLR CHOLESTEROL × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
8RCU human TRPM4 in SMA IBA Deposited 2023-12-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 421–1168（748 aa）
Chain B 421–1168（748 aa）
Chain C 421–1168（748 aa）
Chain D 421–1168（748 aa）
Not recorded A1HZ5 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid × 4 CLR CHOLESTEROL × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8RD9 human TRPM4 in SMA NBA Deposited 2023-12-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 420–1168（749 aa）
Chain C 420–1168（749 aa）
Chain D 420–1168（749 aa）
Chain E 420–1168（749 aa）
Not recorded A1H0C 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid × 4 CLR CHOLESTEROL × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
9B8W Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9B8X Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9B8Y Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 8 DVT DECAVANADATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9B8Z Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 2 DVT DECAVANADATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9B90 Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 8 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9B91 Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9B92 Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9B93 Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9B94 Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius Deposited 2024-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Mutation：E396A Mutation：E396A Mutation：E396A Mutation：E396A CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9I3R Human TRPM4 ion channel in MAASTY copolymer lipid nanodisc in a calcium-bound state Deposited 2025-01-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1214（1213 aa）
Chain B 2–1214（1213 aa）
Chain C 2–1214（1213 aa）
Chain D 2–1214（1213 aa）
Not recorded CLR CHOLESTEROL × 12 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
9MRT Cryo-EM structure of the human TRPM4 channel in a calcium and PI(4,5)P2 bound open state Deposited 2025-01-08 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.44 Å
9MT8 Cryo-EM structure of the human TRPM4 channel in a calcium bound putative desensitized state Deposited 2025-01-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.19 Å
9MTA Cryo-EM structure of the human TRPM4 channel in an apo closed state Deposited 2025-01-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.78 Å
9MTC Cryo-EM structure of the human TRPM4 channel in a ATP bound inhibited state Deposited 2025-01-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.63 Å
9SMK Human TRPM4 ion channel in MSP2N2 lipid nanodisc in a calcium-bound state Deposited 2025-09-08 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1214（1213 aa）
Chain B 2–1214（1213 aa）
Chain C 2–1214（1213 aa）
Chain D 2–1214（1213 aa）
Not recorded CA CALCIUM ION × 4 Y01 CHOLESTEROL HEMISUCCINATE × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9Y2A Cryo-EM structure of the human TRPM4 channel in complex with calcium and DAB at 37 degrees Celsius Deposited 2025-08-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 8 A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9Y2B Cryo-EM structure of the human TRPM4 channel in complex with EGTA and DAB at 37 degrees Celsius Deposited 2025-08-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9Y2C Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and DAB at 37 degrees Celsius Deposited 2025-08-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded CA CALCIUM ION × 2 A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9Z1W Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.86 Å
9Z1Z Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 18 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.63 Å
9Z20 Cryo-EM structure of human TRPM4 channel in complex with EGTA and TPPO at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.51 Å
9Z21 Cryo-EM structure of human TRPM4 channel in complex with calcium and NC1 at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.83 Å
9Z22 Cryo-EM structure of human TRPM4 channel in complex with EGTA and NC1 at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.58 Å
9Z23 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.59 Å
9Z24 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved CBA density) Deposited 2025-11-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.10 Å
9Z25 Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.64 Å
9Z26 Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density) Deposited 2025-11-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.90 Å
9Z27 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA and DVT at 37 degrees Celsius (consensus) Deposited 2025-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1214（1214 aa）
Chain B 1–1214（1214 aa）
Chain C 1–1214（1214 aa）
Chain D 1–1214（1214 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.76 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.