当前蛋白身份:Q96T88 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
2FAZ Ubiquitin-Like Domain of Human Nuclear Zinc Finger Protein NP95 提交 2005-12-08 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–76(76 aa) 片段:UBIQUITIN-LIKE DOMAIN
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;298 K;Well Solution: 20.0% P3350, 0.2 M tri-Li Citrate; Protein Buffer: 20 mM Tris pH 8.0, 100 mM NaCl, 5 mM beta- mercaptoethanol, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
分辨率 2.00 Å R-free 0.252
2FAZ Ubiquitin-Like Domain of Human Nuclear Zinc Finger Protein NP95 提交 2005-12-08 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–76(76 aa) 片段:UBIQUITIN-LIKE DOMAIN
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;298 K;Well Solution: 20.0% P3350, 0.2 M tri-Li Citrate; Protein Buffer: 20 mM Tris pH 8.0, 100 mM NaCl, 5 mM beta- mercaptoethanol, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
分辨率 2.00 Å R-free 0.252
2L3R NMR structure of UHRF1 Tandem Tudor Domains in a complex with Histone H3 peptide 提交 2010-09-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 126–285(160 aa) 片段:unp residues 126-285
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 7;298 K;离子强度(mmCIF原始值)250;压力 1
NMR样品组成 0.6 mM [U-100% 15N] protein, 0.6 mM [U-100% 13C] protein, 3 mM protein, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
2LGG Structure of PHD domain of UHRF1 in complex with H3 peptide 提交 2011-07-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–366(69 aa) 片段:UNP RESIDUES 298-366
未记录 ZN ZINC ION × 3 SOLUTION NMR
NMR测量条件 pH 7.4;293 K;离子强度(mmCIF原始值)0.15;压力 ambient
NMR样品组成 1 mM [U-100% 13C; U-100% 15N] entity_1-1, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
2LGK NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide 提交 2011-07-28 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–366(69 aa) 片段:UNP RESIDUES 298-366
未记录 ZN ZINC ION × 3 SOLUTION NMR
NMR测量条件 pH 7;293.13 K;离子强度(mmCIF原始值)150;压力 ambient
NMR样品组成 1.5 mM [U-100% 13C; U-100% 15N] entity_1-1, 1.8 mM entity_2-2, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
2LGL NMR structure of the UHRF1 PHD domain 提交 2011-07-28 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 298–366(69 aa) 片段:PHD domain (UNP RESIDUES 298-366)
未记录 ZN ZINC ION × 3 SOLUTION NMR
NMR测量条件 pH 7;293.15 K;离子强度(mmCIF原始值)0.15;压力 ambient
NMR样品组成 1.5 mM [U-100% 13C; U-100% 15N] entity_1-1, 137 mM sodium chloride-2, 10 mM potassium phosphate-3, 3 mM DTT-4, 2.7 mM potassium chloride-5, 0.1 mM sodium azide-6, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
2PB7 Crystal Structure of the SRA domain of the human UHRF1 protein 提交 2007-03-28 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 408–643(236 aa) 片段:SRA domain
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;295 K;14-19% PEG 3350, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
分辨率 1.90 Å R-free 0.227
3ASK Structure of UHRF1 in complex with histone tail 提交 2010-12-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 134–367(234 aa) 片段:tandem Tudor domain, PHD finger (residues 134-366)
突变:residues 167-175 was deleted. ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.1M Bis-Tris propane, 200mM sodium citrate, 20% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 2.90 Å R-free 0.286
3ASK Structure of UHRF1 in complex with histone tail 提交 2010-12-16 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 134–367(234 aa) 片段:tandem Tudor domain, PHD finger (residues 134-366)
突变:residues 167-175 was deleted. ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.1M Bis-Tris propane, 200mM sodium citrate, 20% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 2.90 Å R-free 0.286
3ASK Structure of UHRF1 in complex with histone tail 提交 2010-12-16 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 134–367(234 aa) 片段:tandem Tudor domain, PHD finger (residues 134-366)
突变:residues 167-175 was deleted. ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.1M Bis-Tris propane, 200mM sodium citrate, 20% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 2.90 Å R-free 0.286
3ASK Structure of UHRF1 in complex with histone tail 提交 2010-12-16 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 134–367(234 aa) 片段:tandem Tudor domain, PHD finger (residues 134-366)
突变:residues 167-175 was deleted. 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.1M Bis-Tris propane, 200mM sodium citrate, 20% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 2.90 Å R-free 0.286
3ASL Structure of UHRF1 in complex with histone tail 提交 2010-12-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:PHD finger domain
未记录 ZN ZINC ION × 4 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;10mM sodium citrate, 42% PEGMME2000, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 1.41 Å R-free 0.196
3BI7 Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1 提交 2007-11-30 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 414–617(204 aa) 片段:SRA Domain: Residues 414-617
非标准单体:是(mmCIF未提供具体位点) SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 4 UNL UNKNOWN LIGAND × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;298 K;1:1 ratio of protein (34 mg/ml) solution and well solution consisting of 1.4 M Ammonium sulfate, 0.1 M Bis-Tris pH 6.0, 0.2 M NaCl, 1 mM TCEP. Crystals cryoprotected by immersion in the well solution mixed in 1:1 ratio with a water solution containing 20% (w/v) Sucrose, 4% (w/v) Glucose, 18% (v/v) Glycerol and 18% (v/v) Ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 1.70 Å R-free 0.197
3CLZ The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA 提交 2008-03-20 Assembly 1 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 A 414–617(204 aa) 片段:SRA DOMAIN (UNP residues 414-617)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;12 % PEG 1500, 0.1 M BIS-TRIS, 0.2 M NACL, 0.001 M TCEP, pH 7.00, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.20 Å R-free 0.231
3CLZ The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA 提交 2008-03-20 Assembly 2 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 B 414–617(204 aa) 片段:SRA DOMAIN (UNP residues 414-617)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;12 % PEG 1500, 0.1 M BIS-TRIS, 0.2 M NACL, 0.001 M TCEP, pH 7.00, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.20 Å R-free 0.231
3CLZ The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA 提交 2008-03-20 Assembly 3 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 C 414–617(204 aa) 片段:SRA DOMAIN (UNP residues 414-617)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;12 % PEG 1500, 0.1 M BIS-TRIS, 0.2 M NACL, 0.001 M TCEP, pH 7.00, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.20 Å R-free 0.231
3CLZ The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA 提交 2008-03-20 Assembly 4 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 D 414–617(204 aa) 片段:SRA DOMAIN (UNP residues 414-617)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;12 % PEG 1500, 0.1 M BIS-TRIS, 0.2 M NACL, 0.001 M TCEP, pH 7.00, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.20 Å R-free 0.231
3DB3 Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 in complex with trimethylated histone H3-K9 peptide 提交 2008-05-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 126–285(160 aa) 片段:Tandem Tudor Domains (UNP residues 126-285)
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5;298 K;3 M SODIUM FORMATE, 0.1 M SODIUM ACETATE, pH 5.00, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.40 Å R-free 0.282
3DB4 Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 提交 2008-05-30 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 126–285(160 aa) 片段:Tandem Tudor Domains (UNP residues 126-285)
非标准单体:是(mmCIF未提供具体位点) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;298 K;10 % PEG 8000, 0.1 M SODIUM CACODYLATE, 0.2 M AMMONIUM SULFATE, 0.001 M TCEP, pH 6.50, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.40 Å R-free 0.285
3DWH Structural and Functional Analysis of SRA domain 提交 2008-07-22 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 414–617(204 aa) 片段:SRA domain, YDG Domain, residues 414-617
未记录 SO4 SULFATE ION × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;298 K;100mM Tris-Hcl 1.2M ammonium Sulfate 0.2M NaCl, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 1.95 Å R-free 0.253
3FL2 Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1 提交 2008-12-18 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 672–793(122 aa) 片段:ring domain (UNP residues 672-793)
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;293 K;27% PEG MME 2000, 0.1 M TRIS-HCL, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 1.75 Å R-free 0.250
3SHB Crystal Structure of PHD Domain of UHRF1 提交 2011-06-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–366(69 aa) 片段:PHD domain (UNP RESIDUES 298-366)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;277 K;0.1M TRIS hydrochloride (pH8.5), 30% w/v Polyethylene glycerol 4000, 0.2M MgCl2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 1.80 Å R-free 0.228
3SOU Structure of UHRF1 PHD finger in complex with histone H3 1-9 peptide 提交 2011-06-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.80 Å R-free 0.243
3SOU Structure of UHRF1 PHD finger in complex with histone H3 1-9 peptide 提交 2011-06-30 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.80 Å R-free 0.243
3SOU Structure of UHRF1 PHD finger in complex with histone H3 1-9 peptide 提交 2011-06-30 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.80 Å R-free 0.243
3SOW Structure of UHRF1 PHD finger in complex with histone H3K4me3 1-9 peptide 提交 2011-06-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.95 Å R-free 0.247
3SOW Structure of UHRF1 PHD finger in complex with histone H3K4me3 1-9 peptide 提交 2011-06-30 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.95 Å R-free 0.247
3SOW Structure of UHRF1 PHD finger in complex with histone H3K4me3 1-9 peptide 提交 2011-06-30 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;291 K;30% w/v polyethylene glycol 8,000, 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 1.95 Å R-free 0.247
3SOX Structure of UHRF1 PHD finger in the free form 提交 2011-06-30 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;2 M ammonium sulfate, 0.1 M Tris, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.65 Å R-free 0.294
3SOX Structure of UHRF1 PHD finger in the free form 提交 2011-06-30 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;2 M ammonium sulfate, 0.1 M Tris, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.65 Å R-free 0.294
3SOX Structure of UHRF1 PHD finger in the free form 提交 2011-06-30 Assembly 3 蛋白同源多聚体 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;2 M ammonium sulfate, 0.1 M Tris, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.65 Å R-free 0.294
3SOX Structure of UHRF1 PHD finger in the free form 提交 2011-06-30 Assembly 4 蛋白同源多聚体 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 298–367(70 aa) 片段:UHRF1 (UNP Residues 298-367)
未记录 ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;2 M ammonium sulfate, 0.1 M Tris, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.65 Å R-free 0.294
3T6R Structure of UHRF1 in complex with unmodified H3 N-terminal tail 提交 2011-07-29 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 299–364(66 aa) 片段:UNP residues 299-364
未记录 ZN ZINC ION × 4 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;298 K;0.2M MgCl2, 0.1M Tris-HCl, 25% PEG 4000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 1.95 Å R-free 0.229
3T6R Structure of UHRF1 in complex with unmodified H3 N-terminal tail 提交 2011-07-29 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 299–364(66 aa) 片段:UNP residues 299-364
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;298 K;0.2M MgCl2, 0.1M Tris-HCl, 25% PEG 4000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 1.95 Å R-free 0.229
3ZVY PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail 提交 2011-07-28 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 296–367(72 aa) 片段:PHD FINGER, RESIDUES 296-367
未记录 ZN ZINC ION × 4 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;290 K;CRYSTALS WERE OBTAINED AT 17 DEGREES USING THE VAPOR DIFFUSION METHOD BY MIXING A PROTEIN SOLUTION AT A CONCENTRATION OF 606 MICROM (IN 20 MM TRIS PH 7, 150 MM NACL, 0.5 MM TCEP, 25 MICROM ZNCL2 AND 0.1 MM PMSF) AND 10-FOLD EXCESS OF PEPTIDE WITH AN EQUAL VOLUME OF RESERVOIR SOLUTION (0.1 M TRIS PH 8.5, 0.2 M MGCL2, 30 % PEG 4000). CRYSTALS WERE CRYOPROTECTED WITH 15 % MPD AND FLASH FROZEN IN LIQUID NITROGEN.
分辨率 1.95 Å R-free 0.227
3ZVY PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail 提交 2011-07-28 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 296–367(72 aa) 片段:PHD FINGER, RESIDUES 296-367
未记录 ZN ZINC ION × 4 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;290 K;CRYSTALS WERE OBTAINED AT 17 DEGREES USING THE VAPOR DIFFUSION METHOD BY MIXING A PROTEIN SOLUTION AT A CONCENTRATION OF 606 MICROM (IN 20 MM TRIS PH 7, 150 MM NACL, 0.5 MM TCEP, 25 MICROM ZNCL2 AND 0.1 MM PMSF) AND 10-FOLD EXCESS OF PEPTIDE WITH AN EQUAL VOLUME OF RESERVOIR SOLUTION (0.1 M TRIS PH 8.5, 0.2 M MGCL2, 30 % PEG 4000). CRYSTALS WERE CRYOPROTECTED WITH 15 % MPD AND FLASH FROZEN IN LIQUID NITROGEN.
分辨率 1.95 Å R-free 0.227
3ZVZ PHD finger of human UHRF1 提交 2011-07-28 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 314–367(54 aa) 片段:PHD FINGER, RESIDUES 314-367
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.45 Å R-free 0.197
4GY5 Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 提交 2012-09-05 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 134–366(233 aa) 片段:Tudor PHD domain, UNP residues 134-366
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;291 K;20% PEG 3350, 200mM Ammonium Tartrate, 100mM Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.96 Å R-free 0.288
4GY5 Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 提交 2012-09-05 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 134–366(233 aa) 片段:Tudor PHD domain, UNP residues 134-366
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;291 K;20% PEG 3350, 200mM Ammonium Tartrate, 100mM Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.96 Å R-free 0.288
4GY5 Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 提交 2012-09-05 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 134–366(233 aa) 片段:Tudor PHD domain, UNP residues 134-366
未记录 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;291 K;20% PEG 3350, 200mM Ammonium Tartrate, 100mM Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.96 Å R-free 0.288
4GY5 Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 提交 2012-09-05 Assembly 4 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 134–366(233 aa) 片段:Tudor PHD domain, UNP residues 134-366
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;291 K;20% PEG 3350, 200mM Ammonium Tartrate, 100mM Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.96 Å R-free 0.288
4QQD Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule 提交 2014-06-27 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 126–285(160 aa) 片段:unp residues 126-285
未记录 36X 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine × 2 UNX UNKNOWN LIGAND × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;20% PEG-3350, 0.2 M magnesium nitrate, vapor diffusion, sitting drop
分辨率 2.28 Å R-free 0.250
4QQD Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule 提交 2014-06-27 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 126–285(160 aa) 片段:unp residues 126-285
未记录 36X 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine × 1 UNX UNKNOWN LIGAND × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;20% PEG-3350, 0.2 M magnesium nitrate, vapor diffusion, sitting drop
分辨率 2.28 Å R-free 0.250
5C6D Crystal structure of USP7 in complex with UHRF1 提交 2015-06-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 634–665(32 aa) 片段:UNP residues 634-665
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;293 K;100 mM CHES (pH 9.0), 20% PEG8000
分辨率 2.29 Å R-free 0.234
5C6D Crystal structure of USP7 in complex with UHRF1 提交 2015-06-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 634–665(32 aa) 片段:UNP residues 634-665
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;293 K;100 mM CHES (pH 9.0), 20% PEG8000
分辨率 2.29 Å R-free 0.234
5IAY NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide 提交 2016-02-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 134–285(152 aa) 片段:UNP residues 134-285
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 7.4;297.15 K
NMR样品组成 1.0 mM [U-13C; U-15N] TTD, 1.2 mM Spacer, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR样品组成 1.0 mM [U-15N] Spacer, TTD, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
5XPI Structure of UHRF1 TTD in complex with NV01 提交 2017-06-02 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 127–283(157 aa) 片段:UNP residues 127-283
未记录 8C3 N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2,6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.2;293 K;2.7 M Na formate and 0.1 M Na acetate pH 5.2
分辨率 2.20 Å R-free 0.219
5YY9 Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 提交 2017-12-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 123–285(163 aa) 片段:Tandem Tudor Domain
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;293 K;00 mM Tris-HCl (pH 7.0), 200 mM tri-potassium phosphate and 20% (w/v) PEG 3350
分辨率 2.65 Å R-free 0.288
5YY9 Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 提交 2017-12-08 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 123–285(163 aa) 片段:Tandem Tudor Domain
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;293 K;00 mM Tris-HCl (pH 7.0), 200 mM tri-potassium phosphate and 20% (w/v) PEG 3350
分辨率 2.65 Å R-free 0.288
5YYA Crystal structure of Tandem Tudor Domain of human UHRF1 提交 2017-12-08 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 123–285(163 aa) 片段:Tandem Tudor Domain
未记录 EDO 1,2-ETHANEDIOL × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.1 M Bis-Tris (pH 6.5), 200 mM ammonium acetate, 25% (w/v) polyethylene glycol (PEG) 3350
分辨率 1.70 Å R-free 0.205
6B9M Crystal structure of UHRF1 TTD domain in complex with the polybasic region 提交 2017-10-10 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 D 638–678(41 aa) 片段:unp residues 638-678
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;277 K;0.1M Succinic acid pH7.0, 15% (v/v) Polyethylene glycol 3350
分辨率 1.68 Å R-free 0.207
6IIW Crystal structure of human UHRF1 PHD finger in complex with PAF15 提交 2018-10-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 299–366(68 aa)
未记录 ZN ZINC ION × 4 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277 K;0.1 M HEPES (pH 7.5), 70% (v/v) MPD
分辨率 1.70 Å R-free 0.189
6VCS SRA domain of UHRF1 in complex with DNA 提交 2019-12-22 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 4 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 427–630(204 aa)
链 B 427–630(204 aa)
链 E 427–630(204 aa)
未记录 UNX UNKNOWN LIGAND × 66 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;291 K;0.1M sodium malonate, 12% PEG3350
分辨率 1.70 Å R-free 0.258
6VED Solution structure of the TTD and linker region of UHRF1 提交 2019-12-31 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 146–313(168 aa)
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 7.5;303 K;离子强度(mmCIF原始值)150;压力 1
NMR样品组成 250 uM [U-99% 13C; U-99% 15N] TTD-linker, 150 mM sodium chloride, 25 mM sodium phosphate, 5 mM DTT, 2 mM beta-mercaptoethanol, 2 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
分辨率未提供
6VYJ Human UHRF1 TTD domain in complex with a fragment 提交 2020-02-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 122–283(162 aa)
未记录 RVV 2,4-dimethylpyridine × 2 BGC beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;277 K;50 mM Bis-Tris, pH 5.75, 35 % w/v PEG 3350. The crystals were cryo-preserved by 25% glucose
分辨率 1.39 Å R-free 0.226
6W92 Human UHRF1 TTD domain 提交 2020-03-21 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 135–296(162 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.75;295 K;0.1 M Bis-Tris, pH = 5.5, 25 % w/v PEG 3350
分辨率 1.30 Å R-free 0.185
7FB7 Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine 提交 2021-07-08 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 123–285(163 aa)
未记录 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 8NF 5-amino-2,4-dimethylpyridine × 1 DMS DIMETHYL SULFOXIDE × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277 K;0.1 M HEPES (pH7.5), 45% v/v MPD, 0.2 M Ammonium acetate
分辨率 1.45 Å R-free 0.173
7FB7 Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine 提交 2021-07-08 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 123–285(163 aa)
未记录 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 8NF 5-amino-2,4-dimethylpyridine × 1 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277 K;0.1 M HEPES (pH7.5), 45% v/v MPD, 0.2 M Ammonium acetate
分辨率 1.45 Å R-free 0.173
8JIG A Novel UHRF1-Targeted Compound 提交 2023-05-26 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 414–617(204 aa)
未记录 8JA N-[2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]-N'-oxidanyl-octanediamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291 K;0.1 M Bris-Tris, pH 6.0, 0.2M NaCl, 1mM TCEP, 2.2-2.4mM ammonium sulfate
分辨率 2.40 Å R-free 0.244
8JIG A Novel UHRF1-Targeted Compound 提交 2023-05-26 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 414–617(204 aa)
未记录 8JA N-[2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]-N'-oxidanyl-octanediamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291 K;0.1 M Bris-Tris, pH 6.0, 0.2M NaCl, 1mM TCEP, 2.2-2.4mM ammonium sulfate
分辨率 2.40 Å R-free 0.244
8WMS Crystal structure of human DPPA3 in complex with human UHRF1 PHD domain 提交 2023-10-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 299–366(68 aa)
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;100 mM Tris-HCl (pH 7.0), 200 mM tri-potassium phosphate and 20% (w/v) PEG3,350
分辨率 2.40 Å R-free 0.266
8XV4 Crystal structure of TTD-PHD domain of UHRF1 in complex with mStella peptide (residues 85-119) 提交 2024-01-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.6 M NaCl, 0.1 M MES pH6.5, 20% PEG4000
分辨率 3.20 Å R-free 0.266
8XV4 Crystal structure of TTD-PHD domain of UHRF1 in complex with mStella peptide (residues 85-119) 提交 2024-01-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.6 M NaCl, 0.1 M MES pH6.5, 20% PEG4000
分辨率 3.20 Å R-free 0.266
8XV6 Crystal structure of PHD domain of UHRF1 in complex with mStella peptide (residues 85-119) 提交 2024-01-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:PHD domain
未记录 SCN THIOCYANATE ION × 3 GOL GLYCEROL × 1 ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.1 M Potassium thiocyanate, 30% PEG MME2000
分辨率 1.60 Å R-free 0.168
8XV6 Crystal structure of PHD domain of UHRF1 in complex with mStella peptide (residues 85-119) 提交 2024-01-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 298–367(70 aa) 片段:PHD domain
未记录 SCN THIOCYANATE ION × 3 ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.1 M Potassium thiocyanate, 30% PEG MME2000
分辨率 1.60 Å R-free 0.168
8XV7 Crystal structure of TTD-PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 3 GOL GLYCEROL × 2 ACY ACETIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;4% v/v Tacsimate pH 7.0, 12% PEG 3350
分辨率 2.25 Å R-free 0.226
8XV7 Crystal structure of TTD-PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;4% v/v Tacsimate pH 7.0, 12% PEG 3350
分辨率 2.25 Å R-free 0.226
8XV7 Crystal structure of TTD-PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;4% v/v Tacsimate pH 7.0, 12% PEG 3350
分辨率 2.25 Å R-free 0.226
8XV7 Crystal structure of TTD-PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 134–366(233 aa) 片段:TTD-PHD domain
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;4% v/v Tacsimate pH 7.0, 12% PEG 3350
分辨率 2.25 Å R-free 0.226
8XV8 Crystal structure of PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 298–367(70 aa) 片段:PHD domain
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.2 M Ammonium acetate, 0.1 M HEPES pH 7.5, 25% PEG 3350
分辨率 2.05 Å R-free 0.207
8XV8 Crystal structure of PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 298–367(70 aa) 片段:PHD domain
未记录 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.2 M Ammonium acetate, 0.1 M HEPES pH 7.5, 25% PEG 3350
分辨率 2.05 Å R-free 0.207
8XV8 Crystal structure of PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 298–367(70 aa) 片段:PHD domain
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.2 M Ammonium acetate, 0.1 M HEPES pH 7.5, 25% PEG 3350
分辨率 2.05 Å R-free 0.207
8XV8 Crystal structure of PHD domain of UHRF1 in complex with hStella peptide (residues 75-121) 提交 2024-01-14 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 298–367(70 aa) 片段:PHD domain
未记录 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.2 M Ammonium acetate, 0.1 M HEPES pH 7.5, 25% PEG 3350
分辨率 2.05 Å R-free 0.207
9LN6 Structure of human NLRP14-UHRF1 complex 提交 2025-01-20 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–78(78 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.49 Å
9LPK Structure of human PADI6-UHRF1-UBE2D3 complex 提交 2025-01-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–793(793 aa)
链 F 1–793(793 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 OTHER
分辨率 3.03 Å
9M76 UHRF1 bound to a mononucleosome in its pre-active state, with the RING domain bound to the SRA domain. 提交 2025-03-09 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 9 PDB 声明:undecameric(11) 与全部聚合物一致
链 K 1–793(793 aa)
未记录 ZN ZINC ION × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.10 Å
9M77 The activated state of human UHRF1 bound to a mononucleosome, with the finger loop ordered and linker 4 disordered. 提交 2025-03-09 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 9 PDB 声明:undecameric(11) 与全部聚合物一致
链 K 1–793(793 aa)
未记录 ZN ZINC ION × 3 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.70 Å