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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9C000 New Search
12PDB entries
19Biological assembly
79chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1PN5 NMR structure of the NALP1 Pyrin domain (PYD) Deposited 2003-06-12 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–93（93 aa） Fragment：Pyrin domain (PYD)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；293 K；Pressure 1
NMR sample composition 1mM NALP1 PYD U-15N,13C; 50mM Na / PO4 - Buffer; 50mM NaCl; 1mM CHAPS; 20mM DTT (D10); 0.02% NaN3; 0.1mM EDTA; protease inhibitor cocktail (Complete, Roche); 95% H2O, 5% D2O | 95% H2O/5% D2O
Resolution not provided
3KAT Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E Deposited 2009-10-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1371–1467（97 aa） Fragment：CARD domain
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；Protein solution: 100mM NaCl, 5mM DTT, 0.02% NaN3, 10mM Tris-HCl (pH 7.5) . Reservoir solution: 18% PEG3350 and 150 mM sodium formate., VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.10 Å R-free 0.260
3KAT Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E Deposited 2009-10-19 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1371–1467（97 aa） Fragment：CARD domain
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；Protein solution: 100mM NaCl, 5mM DTT, 0.02% NaN3, 10mM Tris-HCl (pH 7.5) . Reservoir solution: 18% PEG3350 and 150 mM sodium formate., VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.10 Å R-free 0.260
4IFP X-ray Crystal Structure of Human NLRP1 CARD Domain Deposited 2012-12-14 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1335–1418（84 aa） Fragment：NLRP1-CARD
Not recorded MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；1.4 M Malonate, 100 mM HEPES 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.99 Å R-free 0.208
4IFP X-ray Crystal Structure of Human NLRP1 CARD Domain Deposited 2012-12-14 Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1335–1418（84 aa） Fragment：NLRP1-CARD
Not recorded MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；1.4 M Malonate, 100 mM HEPES 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.99 Å R-free 0.208
4IFP X-ray Crystal Structure of Human NLRP1 CARD Domain Deposited 2012-12-14 Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1335–1418（84 aa） Fragment：NLRP1-CARD
Not recorded MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；1.4 M Malonate, 100 mM HEPES 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.99 Å R-free 0.208
4IM6 LRR domain from human NLRP1 Deposited 2013-01-02 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 791–990（200 aa） Fragment：LRR domain (UNP Residues 791-990)
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1 M Tris pH 8.0, 0.02 M MgCl2, 25 % (w/v) PAA 5100, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.65 Å R-free 0.183
4IM6 LRR domain from human NLRP1 Deposited 2013-01-02 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 791–990（200 aa） Fragment：LRR domain (UNP Residues 791-990)
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1 M Tris pH 8.0, 0.02 M MgCl2, 25 % (w/v) PAA 5100, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.65 Å R-free 0.183
5Y3S Crystal structure of human NLRP1 leucine rich repeat domain Deposited 2017-07-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 790–990（201 aa） Fragment：UNP residues 790-990
Not recorded PO4 PHOSPHATE ION × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；1.6M Sodium Potassium Phosphate, 100mM HEPES, pH 6.4
Resolution 2.45 Å R-free 0.259
5Y3S Crystal structure of human NLRP1 leucine rich repeat domain Deposited 2017-07-30 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 790–990（201 aa） Fragment：UNP residues 790-990
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；1.6M Sodium Potassium Phosphate, 100mM HEPES, pH 6.4
Resolution 2.45 Å R-free 0.259
5Y3S Crystal structure of human NLRP1 leucine rich repeat domain Deposited 2017-07-30 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 790–990（201 aa） Fragment：UNP residues 790-990
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；1.6M Sodium Potassium Phosphate, 100mM HEPES, pH 6.4
Resolution 2.45 Å R-free 0.259
5Y3S Crystal structure of human NLRP1 leucine rich repeat domain Deposited 2017-07-30 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 790–990（201 aa） Fragment：UNP residues 790-990
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；1.6M Sodium Potassium Phosphate, 100mM HEPES, pH 6.4
Resolution 2.45 Å R-free 0.259
6K7V Structure of NLRP1 CARD filament Deposited 2019-06-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1379–1466（88 aa）
Chain B 1379–1466（88 aa）
Chain C 1379–1466（88 aa）
Chain D 1379–1466（88 aa）
Chain E 1379–1466（88 aa）
Chain F 1379–1466（88 aa）
Chain G 1379–1466（88 aa）
Chain H 1379–1466（88 aa）
Chain I 1379–1466（88 aa）
Chain J 1379–1466（88 aa）
Chain K 1379–1466（88 aa）
Chain L 1379–1466（88 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å R-free 0.285
6X6A Cryo-EM structure of NLRP1-DPP9 complex Deposited 2020-05-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–1212（1212 aa）
Chain C 1213–1473（261 aa）
Chain E 1–1212（1212 aa）
Chain F 1213–1473（261 aa）
Chain G 1213–1473（261 aa）
Chain I 1213–1473（261 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6X6C Cryo-EM structure of NLRP1-DPP9-VbP complex Deposited 2020-05-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain E 1–1473（1473 aa）
Chain F 1–1473（1473 aa）
Not recorded GK2 [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
6XKK Cryo-EM structure of the NLRP1-CARD filament Deposited 2020-06-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 44 PDB declaration: 44-meric（44） Consistent with protein count
Chain A 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain B 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain C 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain D 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain E 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain F 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain G 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain H 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain I 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain J 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain K 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain L 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain M 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain N 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain O 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain P 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain Q 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain R 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain S 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain T 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain U 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain V 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain a 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain b 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain c 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain d 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain e 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain f 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain g 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain h 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain i 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain j 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain k 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain l 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain m 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain n 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain o 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain p 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain q 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain r 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain s 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain t 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain u 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Chain v 1305–1399（95 aa） Fragment：CARD domain (UNP residues 1305-1399)
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.72 Å
7WGE Human NLRP1 complexed with thioredoxin Deposited 2021-12-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 95–994（900 aa）
Not recorded AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8ZGD The Crystal Structure of the NLRP1_LRR domain from Biortus. Deposited 2024-05-09 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 791–990（200 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20mM MgCl2, 0.1M Tris pH 8.0, 19% polyacrylic acid 5100
Resolution 2.05 Å R-free 0.221
9BJ9 Human CRL-2 ZYG11B binding to human NLRP1 Gly/N degron Deposited 2024-04-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain P 131–139（9 aa） Fragment：residues 131-139 (Uniprot numbering)
Not recorded ZN ZINC ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.