当前蛋白身份:Q9HBE5 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 1 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 NI NICKEL (II) ION × 1 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 2 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 3 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 NI NICKEL (II) ION × 1 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 4 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 NI NICKEL (II) ION × 1 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 5 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 I 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 6 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 K 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 7 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 M 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
3TGX IL-21:IL21R complex 提交 2011-08-18 Assembly 8 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 O 20–232(213 aa) 片段:Interleukin 21 receptor extracellular domain
突变:N78Q, N85Q, N106D, N116Q MAN alpha-D-mannopyranose × 1 NI NICKEL (II) ION × 1 SO4 SULFATE ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.3 K;1,8-1,9 M di-Ammonium sulphate and 0.1 M Sodium acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291.3K
分辨率 2.80 Å R-free 0.273
4NZD Interleukin 21 receptor 提交 2013-12-12 Assembly 1 其他组合 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 20–232(213 aa)
未记录 MAN alpha-D-mannopyranose × 1 NA SODIUM ION × 3 CL CHLORIDE ION × 4 TLA L(+)-TARTARIC ACID × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;278 K;5 mg/ml Protein in 10 mM Hepes, 150 mM NaCl, pH7.5 Crystalized in 1M Potassium sodium tartrate tetrahydrate, 3% W/V Peg5000 and 0.1 M tris Ph 8.5. Drops were 1:1, VAPOR DIFFUSION, SITTING DROP, temperature 278K
分辨率 2.75 Å R-free 0.275
4NZD Interleukin 21 receptor 提交 2013-12-12 Assembly 2 其他组合 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 20–232(213 aa)
未记录 MAN alpha-D-mannopyranose × 1 CL CHLORIDE ION × 5 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;278 K;5 mg/ml Protein in 10 mM Hepes, 150 mM NaCl, pH7.5 Crystalized in 1M Potassium sodium tartrate tetrahydrate, 3% W/V Peg5000 and 0.1 M tris Ph 8.5. Drops were 1:1, VAPOR DIFFUSION, SITTING DROP, temperature 278K
分辨率 2.75 Å R-free 0.275
4NZD Interleukin 21 receptor 提交 2013-12-12 Assembly 3 其他组合 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 20–232(213 aa)
未记录 MAN alpha-D-mannopyranose × 1 NA SODIUM ION × 2 CL CHLORIDE ION × 2 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;278 K;5 mg/ml Protein in 10 mM Hepes, 150 mM NaCl, pH7.5 Crystalized in 1M Potassium sodium tartrate tetrahydrate, 3% W/V Peg5000 and 0.1 M tris Ph 8.5. Drops were 1:1, VAPOR DIFFUSION, SITTING DROP, temperature 278K
分辨率 2.75 Å R-free 0.275
4NZD Interleukin 21 receptor 提交 2013-12-12 Assembly 4 其他组合 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 20–232(213 aa)
链 B 20–232(213 aa)
链 C 20–232(213 aa)
未记录 MAN alpha-D-mannopyranose × 6 NA SODIUM ION × 10 CL CHLORIDE ION × 22 TLA L(+)-TARTARIC ACID × 6 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;278 K;5 mg/ml Protein in 10 mM Hepes, 150 mM NaCl, pH7.5 Crystalized in 1M Potassium sodium tartrate tetrahydrate, 3% W/V Peg5000 and 0.1 M tris Ph 8.5. Drops were 1:1, VAPOR DIFFUSION, SITTING DROP, temperature 278K
分辨率 2.75 Å R-free 0.275
6PLH FAB fragment complexed with C-mannosylated tryptophan peptide 提交 2019-06-30 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 202–232(31 aa) 片段:UNP Residues 202-232
未记录 PO4 PHOSPHATE ION × 1 MAN alpha-D-mannopyranose × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;25% (w/v) polyethylene glycol 1500, 0.1 M succinate-phosphate-glycine, pH 7.0
分辨率 1.60 Å R-free 0.221
7KQ7 Crystal structure of IL21R in complex with an antibody Fab fragment 提交 2020-11-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 20–233(214 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;300 K;10% PEG MME 5000 and 0.1M MES, pH 6.5
分辨率 2.20 Å R-free 0.240
8ENT Interleukin-21 signaling complex with IL-21R and IL-2Rg 提交 2022-09-30 Assembly 1 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 20–229(210 aa)
突变:N78Q, N85Q, N106D, N116Q NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;295 K;0.1M Tris pH 8, 20% PEG 6000
分辨率 2.83 Å R-free 0.300
8ENT Interleukin-21 signaling complex with IL-21R and IL-2Rg 提交 2022-09-30 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 20–229(210 aa)
突变:N78Q, N85Q, N106D, N116Q NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;295 K;0.1M Tris pH 8, 20% PEG 6000
分辨率 2.83 Å R-free 0.300
8ENT Interleukin-21 signaling complex with IL-21R and IL-2Rg 提交 2022-09-30 Assembly 3 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 H 20–229(210 aa)
突变:N78Q, N85Q, N106D, N116Q NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;295 K;0.1M Tris pH 8, 20% PEG 6000
分辨率 2.83 Å R-free 0.300
8ENT Interleukin-21 signaling complex with IL-21R and IL-2Rg 提交 2022-09-30 Assembly 4 其他组合 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 K 20–229(210 aa)
突变:N78Q, N85Q, N106D, N116Q EDO 1,2-ETHANEDIOL × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;295 K;0.1M Tris pH 8, 20% PEG 6000
分辨率 2.83 Å R-free 0.300
9E2T Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg 提交 2024-10-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 20–228(209 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 EDO 1,2-ETHANEDIOL × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;0.2M Potassium thiocyanate, 0.1M Bis-Tris propane, pH 6.5, 20% w/v PEG 3350
分辨率 2.28 Å R-free 0.242
9E2T Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg 提交 2024-10-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 20–228(209 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;0.2M Potassium thiocyanate, 0.1M Bis-Tris propane, pH 6.5, 20% w/v PEG 3350
分辨率 2.28 Å R-free 0.242
9E2T Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg 提交 2024-10-22 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 H 20–228(209 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;0.2M Potassium thiocyanate, 0.1M Bis-Tris propane, pH 6.5, 20% w/v PEG 3350
分辨率 2.28 Å R-free 0.242
9E2T Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg 提交 2024-10-22 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 J 20–228(209 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;0.2M Potassium thiocyanate, 0.1M Bis-Tris propane, pH 6.5, 20% w/v PEG 3350
分辨率 2.28 Å R-free 0.242