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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：X5F427 New Search
20PDB entries
21Biological assembly
27chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6TU5 Influenza A/H7N9 polymerase core (apo) Deposited 2020-01-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain CCC 1–128（128 aa）
Chain FFF 1–128（128 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；281 K；Protein at about 9 mg/ml 0.1 M Tris pH 7.0, 8-13% PEG 8K, 0.2 M MgCl2, 0.1 M guanidine hydrochloride
Resolution 3.33 Å R-free 0.268
7QTL Influenza A/H7N9 polymerase elongation complex Deposited 2022-01-14 Assembly 1 Protein–RNA Heteromer；Protein × 3 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Not recorded 2TM 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine × 1 MG MAGNESIUM ION × 2 GTA P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.48 Å
7R0E Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position Deposited 2022-02-01 Assembly 1 Protein–RNA Heteromer；Protein × 3 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Not recorded MG MAGNESIUM ION × 2 GTA P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.51 Å
7Z4O Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A Deposited 2022-03-04 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: pentameric（5） Consistent with all polymers
Chain CCC 1–128（128 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M Tris pH 7.0, 13 % PEG 8K, 0.2 M MgCl2, 0.1 M guanidine hydrochloride
Resolution 3.41 Å R-free 0.273
7Z4O Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A Deposited 2022-03-04 Assembly 2 Protein–RNA Heteromer；Protein × 4 PDB declaration: pentameric（5） Consistent with all polymers
Chain FFF 1–128（128 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M Tris pH 7.0, 13 % PEG 8K, 0.2 M MgCl2, 0.1 M guanidine hydrochloride
Resolution 3.41 Å R-free 0.273
7ZPL Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook Deposited 2022-04-27 Assembly 1 Protein–RNA Heteromer；Protein × 6 PDB declaration: octameric（8） Consistent with all polymers
Chain C 1–759（759 aa）
Chain F 1–759（759 aa）
Not recorded MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
7ZPM Influenza A/H7N9 polymerase apo-protein dimer complex Deposited 2022-04-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 1–759（759 aa）
Chain F 1–759（759 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.81 Å
8BEK Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position Deposited 2022-10-21 Assembly 1 Protein–RNA Heteromer；Protein × 3 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Not recorded MG MAGNESIUM ION × 2 GTA P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.86 Å
8PM0 Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A Deposited 2023-06-27 Assembly 1 Protein–RNA Heteromer；Protein × 5 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Mutation：G74R MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8PNP Influenza A/H7N9 polymerase in pre-initiation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Deposited 2023-06-30 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: pentameric（5） Consistent with all polymers
Chain C 1–759（759 aa）
Mutation：G74R No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.49 Å
8PNQ Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Deposited 2023-06-30 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Mutation：G74R 2KH 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine × 1 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8POH Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) Deposited 2023-07-04 Assembly 1 Protein–RNA Heteromer；Protein × 6 PDB declaration: decameric（10） Consistent with all polymers
Chain C 1–759（759 aa）
Chain G 1–759（759 aa）
Not recorded MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8R3K Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A. Deposited 2023-11-09 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Mutation：G74R POP PYROPHOSPHATE 2- × 1 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.43 Å
8R3L Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A Deposited 2023-11-09 Assembly 1 Protein–RNA Heteromer；Protein × 4 PDB declaration: hexameric（6） Consistent with all polymers
Chain C 1–759（759 aa）
Mutation：G74R No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
8RMP Influenza polymerase A/H7N9-4M (ENDO(R) | Core1) Deposited 2024-01-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–759（759 aa）
Mutation：G74R MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
8RMQ Influenza polymerase A/H7N9-4M (ENDO(R) | Core2) Deposited 2024-01-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–759（759 aa）
Mutation：G74R MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.54 Å
8RMR Influenza polymerase A/H7N9-4M replication complex, an asymmetric polymerase dimer bound to human ANP32A Deposited 2024-01-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain C 1–759（759 aa）
Chain F 1–759（759 aa）
Mutation：G74R Mutation：G74R MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
8RMS Influenza polymerase A/H7N9-4M replicase minus 627(R) (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement) Deposited 2024-01-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–759（759 aa）
Mutation：G74R MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
8RN0 Influenza polymerase A/H7N9-4M encapsidase plus 627(R) / human ANP32A (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement) Deposited 2024-01-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 1–759（759 aa）
Chain F 1–759（759 aa）
Mutation：G74R Mutation：G74R No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
9FYX Influenza A/H7N9 polymerase pre-cleavage cap-snatching complex Deposited 2024-07-04 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 23-meric（23） Consistent with all polymers
Chain c 1–759（759 aa）
Not recorded ZN ZINC ION × 9 G1G 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE × 1 MG MAGNESIUM ION × 2 PO4 PHOSPHATE ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM BICINE pH 8.0 150 mM NaCl 0.1 mM MgCl2 4% glycerol
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9G0A Influenza A/H7N9 polymerase post-cleavage cap-snatching complex Deposited 2024-07-07 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 23-meric（23） Consistent with all polymers
Chain c 1–759（759 aa）
Not recorded ZN ZINC ION × 8 MG MAGNESIUM ION × 2 G1G 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE × 1 PO4 PHOSPHATE ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM BICINE pH 8.0 150 mM NaCl 3 mM MgCl2 4% glycerol
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.