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10ou

FGFR2 mutant D650V with compound 12

Method: X-RAY DIFFRACTION Dmax: 91.3 Å Quality: GOOD

SAXS Profile

SAXS profile for 10ou

P(r) Distribution

P(r) distribution for 10ou

1. Structure Basics

entry_id10ou
deposition_date2026-01-29
last_revision2026-04-15
titleFGFR2 mutant D650V with compound 12
keywordsFGFR, FGFR2, Fibroblast growth factor receptor, Tyrosine Kinase, Resistance Mutations, TYRX-0544, TRANSFERASE; TRANSFERASE
methodX-RAY DIFFRACTION

Download Data

2. SAXS Parameters (CRYSOL)

rg_guinier27.50
rg_electron26.92
i0166707000.00
molecular_weight67771.0 kDa
excluded_volume65151 ų
envelope_volume110980 ų
shell_volume34226 ų
envelope_diameter95.7
shell_rg34.37
envelope_rg26.98
shape_rg26.90
total_rg27.49
total_atoms5080
n_residues604
n_harmonics20
q_range— – 0.5000 −1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3

3. P(r) Analysis (GNOM)

dmax91.3
rg_real27.49
rg_real_error0.58
i0_real1.6670e+08
i0_real_error2.2380e+06
rg_reciprocal27.50
i0_reciprocal166700000.0000
total_estimate0.8876
solution_quality GOOD a GOOD solution
n_peaks1
r_peak_primary89.8
skewness0.364
kurtosis-0.337
angular_range— – 0.2900 −1
current_alpha0.0000
highest_alpha44440000.0000
n_real_points59
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.852; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.995; Smooth: 0.985

4. Crystallography & Experiment

5. Entities & Polymer Info (6)

6. Citations (1)

7. Files & Curves (10)