SAXSdb — 11cl

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1. Structure Basics

entry_id	11cl
deposition_date	2026-02-17
title	Structure of human TRPV1 in complex with Asivatrep
keywords	;Membrane Protein, Ion Channel, TRPV1, Mavatrep, Asivatrep, JNJ-17203212, CAY10448, Small Molecule, Pain, Thermosensing, GDN, Antagonist ;; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	43.93 Å
rg_electron	43.25 Å
i0	1617870000.00
molecular_weight	230040.0 kDa
excluded_volume	227240 Å³
envelope_volume	437600 Å³
shell_volume	80969 Å³
envelope_diameter	135.7 Å
shell_rg	51.56 Å
envelope_rg	42.10 Å
shape_rg	43.27 Å
total_rg	43.50 Å
total_atoms	17460
n_residues	2124
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	132.8 Å
rg_real	43.59 Å
rg_real_error	0.69 Å
i0_real	1.6180e+09
i0_real_error	2.7840e+07
rg_reciprocal	43.93 Å
i0_reciprocal	1618000000.0000
total_estimate	0.8889
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	59.0 Å
skewness	-0.034
kurtosis	-0.515
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0000
highest_alpha	49210000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.903; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.958; Smooth: 0.885

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Transient receptor potential cation channel subfamily V member 1
formula_weight	124281.5 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,C,D,B
atom_count	17476

MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEKGTLEVLFQGPGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGHHHHHHHGGSGGWSHPQFEK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	(2E)-N-{(1R)-1-[3,5-difluoro-4-(methanesulfonamido)phenyl]ethyl}-3-[2-propyl-6-(trifluoromethyl)pyridin-3-yl]prop-2-enamide
formula_weight	491.5 kDa
src_method	syn
entity_count	4

Entity 3 non-polymer

description	EICOSANE
formula_weight	282.5 kDa
src_method	syn
entity_count	4

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	16

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6. Citations (1)

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resolution	2.10 Å
resolution_method	—
num_particles	476551

fit	/app/data/saxs_computation/1c/11cl/11cl.fit
pddf	/app/data/pr_computation/1c/11cl/11cl.pr.out
profile	/app/data/saxs_computation/1c/11cl/11cl.dat

Structure of human TRPV1 in complex with Asivatrep

SAXS Profile

P(r) Distribution