SAXSdb — 11cn

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1. Structure Basics

entry_id	11cn
deposition_date	2026-02-17
title	Structure of human TRPV1 in complex with Mavatrep
keywords	;Membrane Protein, Ion Channel, TRPV1, Mavatrep, Asivatrep, JNJ-17203212, CAY10448, Small Molecule, Pain, Thermosensing, GDN, Antagonist ;; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	43.82 Å
rg_electron	43.14 Å
i0	1603680000.00
molecular_weight	228810.0 kDa
excluded_volume	225910 Å³
envelope_volume	429780 Å³
shell_volume	79798 Å³
envelope_diameter	136.5 Å
shell_rg	51.30 Å
envelope_rg	41.99 Å
shape_rg	43.14 Å
total_rg	43.39 Å
total_atoms	17372
n_residues	2124
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	132.3 Å
rg_real	43.48 Å
rg_real_error	0.81 Å
i0_real	1.6040e+09
i0_real_error	2.4540e+07
rg_reciprocal	43.82 Å
i0_reciprocal	1604000000.0000
total_estimate	0.8889
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	58.8 Å
skewness	-0.031
kurtosis	-0.508
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0000
highest_alpha	47310000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.905; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.958; Smooth: 0.878

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Transient receptor potential cation channel subfamily V member 1
formula_weight	124281.5 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,C,B,D
atom_count	17376

MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEKGTLEVLFQGPGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGHHHHHHHGGSGGWSHPQFEK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	2-[(2P)-2-(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethen-1-yl}-1H-1,3-benzimidazol-5-yl)phenyl]propan-2-ol
formula_weight	422.4 kDa
src_method	syn
entity_count	4

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	4

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6. Citations (1)

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resolution	2.37 Å
resolution_method	—
num_particles	198931

fit	/app/data/saxs_computation/1c/11cn/11cn.fit
pddf	/app/data/pr_computation/1c/11cn/11cn.pr.out
profile	/app/data/saxs_computation/1c/11cn/11cn.dat

Structure of human TRPV1 in complex with Mavatrep

SAXS Profile

P(r) Distribution