SAXSdb — 11co

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1. Structure Basics

entry_id	11co
deposition_date	2026-02-17
title	Structure of human TRPV1 in Complex with JNJ-17203212
keywords	;Membrane Protein, Ion Channel, TRPV1, Mavatrep, Asivatrep, JNJ-17203212, CAY10448, Small Molecule, Pain, Thermosensing, GDN, Antagonist ;; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	45.21 Å
rg_electron	44.53 Å
i0	1612210000.00
molecular_weight	228820.0 kDa
excluded_volume	225580 Å³
envelope_volume	460090 Å³
shell_volume	83031 Å³
envelope_diameter	138.2 Å
shell_rg	52.53 Å
envelope_rg	43.12 Å
shape_rg	44.55 Å
total_rg	44.76 Å
total_atoms	17364
n_residues	2124
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	136.0 Å
rg_real	44.83 Å
rg_real_error	0.88 Å
i0_real	1.6120e+09
i0_real_error	2.8690e+07
rg_reciprocal	45.21 Å
i0_reciprocal	1613000000.0000
total_estimate	0.8885
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	62.2 Å
skewness	-0.042
kurtosis	-0.519
angular_range	— – 0.1750 Å⁻¹
current_alpha	0.0000
highest_alpha	50800000.0000
n_real_points	36
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.906; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.961; Smooth: 0.866

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	Transient receptor potential cation channel subfamily V member 1
formula_weight	124281.5 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	17364

MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEKGTLEVLFQGPGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGHHHHHHHGGSGGWSHPQFEK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
formula_weight	419.3 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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resolution	2.49 Å
resolution_method	—
num_particles	73728

fit	/app/data/saxs_computation/1c/11co/11co.fit
pddf	/app/data/pr_computation/1c/11co/11co.pr.out
profile	/app/data/saxs_computation/1c/11co/11co.dat

Structure of human TRPV1 in Complex with JNJ-17203212

SAXS Profile

P(r) Distribution