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1jl4

CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN

Mus musculus

UniProt P01910

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K BETA CHAIN × 1 （P06343） OVOTRANSFERRIN × 1 （P02789） T-CELL SURFACE GLYCOPROTEIN CD4 × 1 （P01730） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1d9k 1d9k 1d9k 1d9k 1iak 1jl4 9l1l

7 assemblies

View Construct and Data Evidence
UniProt name HA2K_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–178； UniProt 31–208

H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K BETA CHAIN

Mus musculus

UniProt P06343

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN × 1 （P01910） OVOTRANSFERRIN × 1 （P02789） T-CELL SURFACE GLYCOPROTEIN CD4 × 1 （P01730） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1d9k 1d9k 1d9k 1d9k 1iak 1jl4 9l1l

7 assemblies

View Construct and Data Evidence
UniProt name HB2K_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 3–185； UniProt 34–216

OVOTRANSFERRIN

Gallus gallus

UniProt P02789

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN × 1 （P01910） H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K BETA CHAIN × 1 （P06343） T-CELL SURFACE GLYCOPROTEIN CD4 × 1 （P01730） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1iej 1iq7 1n04 1nft 1nnt 1ovt 1ryx 1tfa 2d3i 8fei

10 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1nft

1 assemblies

Heteromeric or nucleic-acid complex
1aiv 1jl4

2 assemblies

View Construct and Data Evidence
UniProt name TRFE_CHICK
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 4–16； UniProt 153–165

T-CELL SURFACE GLYCOPROTEIN CD4

Homo sapiens

UniProt P01730

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN × 1 （P01910） H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K BETA CHAIN × 1 （P06343） OVOTRANSFERRIN × 1 （P02789） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cdj 1cdu 1cdy 1wbr 1wio 1wio 1wip 1wip 1wiq 1wiq 2klu

11 assemblies

Homodimer
1cdh 1cdi 3cd4

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1g9m 1g9n 1gc1 1jl4 1q68 1rzj 1rzk 2b4c 2b4c 2nxy 2nxz 2ny0

86 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CD4_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–178； UniProt 26–203

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1jl4
Deposition date deposition_date2001-07-15
Structure title titleCRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE
Keywords keywordsPROTEIN-PROTEIN COMPLEX, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1jl4__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1jl4__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1jl4__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.79 Å
Rg (electron density)27.79 Å
Total Rg28.66 Å
Atom count4474
Residues557
Excluded volume79208 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1jl4__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 7 domains

SCOP 2.08 (7 domains)

Domain ID domain_idd1jl4a1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd1jl4a2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.19 — MHC antigen-recognition domain
Superfamily Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
Family Family familyd.19.1.1 — MHC antigen-recognition domain
Domain ID domain_idd1jl4b1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd1jl4b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.19 — MHC antigen-recognition domain
Superfamily Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
Family Family familyd.19.1.1 — MHC antigen-recognition domain
Domain ID domain_idd1jl4b3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd1jl4d1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.1 — V set domains (antibody variable domain-like)
Domain ID domain_idd1jl4d2
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.3 — C2 set domains
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7. Citations (1)