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1klq

The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A

Homo sapiens

UniProt Q13257

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mad2-binding peptide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1duj 1s2h 2vfx 2vfx 2vfx 2vfx 2vfx 2vfx 2vfx 2vfx 2vfx 2vfx

14 assemblies; showing the first 12

Homodimer
3gmh 3gmh 3gmh 3gmh 3gmh 3gmh

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1go4 1klq 2qyf 2qyf 2v64 2v64 2v64 5khu 5lcw 6f0x 6tlj

11 assemblies

View Construct and Data Evidence
UniProt name MD2L1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–197； UniProt 9–205

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1klq
Deposition date deposition_date2001-12-12
Structure title titleThe Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20
Keywords keywordsprotein-peptide complex, MAD2 FAMILY, CELL CYCLE; CELL CYCLE
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1klq__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1klq__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1klq__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.45 Å
Rg (electron density)16.92 Å
Total Rg18.15 Å
Atom count3371
Residues207
Excluded volume30179 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1klq__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1klqa1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.135 — The spindle assembly checkpoint protein mad2
Superfamily Superfamily superfamilyd.135.1 — The spindle assembly checkpoint protein mad2
Family Family familyd.135.1.1 — The spindle assembly checkpoint protein mad2
Domain ID domain_idd1klqa2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (1 domains)

Domain ID domain_id1klqA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology900 — Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A
Homologous superfamily homologous superfamily10 — HORMA domain
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7. Citations (1)