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1shz

Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera

Mus musculus

UniProt P10824

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Rho guanine nucleotide exchange factor 1 × 1 （Q92888） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Rho guanine nucleotide exchange factor 1 × 1 （Q92888） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 4 Rho guanine nucleotide exchange factor 1 × 2 （Q92888） MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-DIPHOSPHATE × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1as0 1as2 1as3 1bh2 1bof 1cip 1gdd 1gfi 1gia 1gil 1git 1svk

26 assemblies; showing the first 12

Homodimer
2zjz

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1agr 1agr 1fqj 1fqj 1fqk 1fqk 1gg2 1gp2 1shz 1shz 1shz 2bcj

31 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBI1_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–27； UniProt 21–47 Author chain A； PDBConstruct 172–197； UniProt 185–210 Author chain A； PDBConstruct 200–217； UniProt 213–230 Author chain A； PDBConstruct 227–340； UniProt 240–353 Author chain D； PDBConstruct 1–27； UniProt 21–47 Author chain D； PDBConstruct 172–197； UniProt 185–210 Author chain D； PDBConstruct 200–217； UniProt 213–230 Author chain D； PDBConstruct 227–340； UniProt 240–353

Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera

Mus musculus

UniProt P27601

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Rho guanine nucleotide exchange factor 1 × 1 （Q92888） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Rho guanine nucleotide exchange factor 1 × 1 （Q92888） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 4 Rho guanine nucleotide exchange factor 1 × 2 （Q92888） MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-DIPHOSPHATE × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1zcb

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1shz 1shz 1shz 3ab3 3ab3 3cx6 3cx7 3cx8

8 assemblies

View Construct and Data Evidence
UniProt name GB13_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 28–171； UniProt 64–207 Author chain A； PDBConstruct 198–199； UniProt 234–235 Author chain A； PDBConstruct 218–226； UniProt 254–262 Author chain D； PDBConstruct 28–171； UniProt 64–207 Author chain D； PDBConstruct 198–199； UniProt 234–235 Author chain D； PDBConstruct 218–226； UniProt 254–262

Rho guanine nucleotide exchange factor 1

Homo sapiens

UniProt Q92888

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera × 1 （P10824,P27601） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera × 1 （P10824,P27601） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 4 Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera × 2 （P10824,P27601） MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-DIPHOSPHATE × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1iap 3odo 3odo 3odw 3odw 3odx 3odx 3p6a 3p6a

9 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1shz 1shz 1shz 3ab3 3ab3

5 assemblies

View Construct and Data Evidence
UniProt name ARHG1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–233； UniProt 7–239 Author chain F； PDBConstruct 1–233； UniProt 7–239

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1shz
Deposition date deposition_date2004-02-26
Structure title titleCrystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera
Keywords keywordsSIGNAL TRANSDUCTION, PROTEIN COMPLEX, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1shz__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1shz__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1shz__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.88 Å
Rg (electron density)33.59 Å
Total Rg34.05 Å
Atom count8518
Residues1037
Excluded volume151320 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1shz__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1shz__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1shz__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd1shza1
Class classa — All alpha proteins
Fold Fold folda.66 — Transducin (alpha subunit), insertion domain
Superfamily Superfamily superfamilya.66.1 — Transducin (alpha subunit), insertion domain
Family Family familya.66.1.1 — Transducin (alpha subunit), insertion domain
Domain ID domain_idd1shza2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1shzc_
Class classa — All alpha proteins
Fold Fold folda.91 — Regulator of G-protein signaling, RGS
Superfamily Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
Family Family familya.91.1.0 — automated matches
Domain ID domain_idd1shzd1
Class classa — All alpha proteins
Fold Fold folda.66 — Transducin (alpha subunit), insertion domain
Superfamily Superfamily superfamilya.66.1 — Transducin (alpha subunit), insertion domain
Family Family familya.66.1.1 — Transducin (alpha subunit), insertion domain
Domain ID domain_idd1shzd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1shzf_
Class classa — All alpha proteins
Fold Fold folda.91 — Regulator of G-protein signaling, RGS
Superfamily Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
Family Family familya.91.1.0 — automated matches

CATH v4.4 (6 domains)

Domain ID domain_id1shzA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1shzA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id1shzC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology167 — Regulator of G-protein Signalling 4; domain 2
Homologous superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
Domain ID domain_id1shzD01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1shzD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id1shzF00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology167 — Regulator of G-protein Signalling 4; domain 2
Homologous superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
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7. Citations (1)