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2mtp

The structure of Filamin repeat 21 bound to integrin

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Filamin-A

Homo sapiens

UniProt P21333

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Integrin alpha-IIb × 1 （P08514） Integrin beta-3 × 1 （P05106） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2aav 2j3s 2j3s 2k3t 2k7p 2k7q 3hoc 3hoc 3hop 3hop 3hor 3hor

20 assemblies; showing the first 12

Homodimer
2wfn 3cnk 3hoc

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2bp3 2bp3 2brq 2jf1 2mtp 2w0p 3isw 4p3w 4p3w 4p3w 4p3w 4p3w

19 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FLNA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–95； UniProt 2236–2330

Integrin alpha-IIb

Homo sapiens

UniProt P08514

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Filamin-A × 1 （P21333） Integrin beta-3 × 1 （P05106） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1dpk 1dpq 1s4w 2k1a

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kup 1kuz 1m8o 1tye 1tye 1tye 2k9j 2knc 2mtp 2n9y 2vc2 2vdk

113 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ITA2B_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–21； UniProt 1019–1039

Integrin beta-3

Homo sapiens

UniProt P05106

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Filamin-A × 1 （P21333） Integrin alpha-IIb × 1 （P08514） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1s4x 2kv9 2l91 2ljd 2lje 2ljf 2rmz 2rn0

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kup 1kuz 1l5g 1m1x 1m8o 1miz 1mk7 1mk7 1mk9 1mk9 1mk9 1mk9

169 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ITB3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–47； UniProt 742–788

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2mtp
Deposition date deposition_date2014-08-28
Structure title titleThe structure of Filamin repeat 21 bound to integrin
Keywords keywordsintegrin, filamin, PROTEIN BINDING-Cell Adhesion complex; PROTEIN BINDING/Cell Adhesion
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2mtp__assembly_1__model_15

Assembly 1 · Model 15 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2mtp__assembly_1__model_15 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2mtp__assembly_1__model_15 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.07 Å
Rg (electron density)16.86 Å
Total Rg17.94 Å
Atom count2464
Residues163
Excluded volume22225 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2mtp__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2mtp__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2mtp__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2mtp__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2mtp__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2mtp__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2mtp__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2mtp__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2mtp__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2mtp__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2mtp__assembly_1__model_11 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2mtp__assembly_1__model_12 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2mtp__assembly_1__model_13 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2mtp__assembly_1__model_14 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2mtp__assembly_1__model_15 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2mtp__assembly_1__model_16 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2mtp__assembly_1__model_17 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2mtp__assembly_1__model_18 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2mtp__assembly_1__model_19 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2mtp__assembly_1__model_20 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2mtpa_
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.18 — E set domains
Family Family familyb.1.18.10 — Filamin repeat (rod domain)

CATH v4.4 (1 domains)

Domain ID domain_id2mtpA00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)