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2mwo

Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tumor suppressor p53-binding protein 1

Homo sapiens

UniProt Q12888

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Cellular tumor antigen p53 × 1 （P04637） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1xni 1xni 1xni 1xni 1xni 1xni 1xni 1xni 1xni 1xni 2g3r 5z78

21 assemblies; showing the first 12

Homodimer
2g3r 4rg2 6mxx 6mxx 6mxx 6mxx 6mxx 6mxy 6mxz 6mxz 6mxz 6mxz

20 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1gzh 1gzh 1kzy 2ig0 2lvm 2mwo 2mwp 3lgf 3lgf 3lgl 3lh0 3lh0

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TP53B_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–123； UniProt 1484–1603

Cellular tumor antigen p53

OrganismNot specified

UniProt P04637

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Tumor suppressor p53-binding protein 1 × 1 （Q12888） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1uol 1uol 2bim 2bim 2bin 2bio 2bip 2biq 2j1w 2j1w 2j1x 2j1x

251 assemblies; showing the first 12

Homodimer
1a1u 1hs5 3q01 8xcb 8xcb 9g6t

6 assemblies

Homotetramer
1aie 1c26 1olg 1olh 1pes 1pet 1sae 1saf 1sak 1sal 2j0z 2j10

22 assemblies; showing the first 12

Other homooligomers
4rp6 4rp7

2 assemblies

Heteromeric or nucleic-acid complex
1dt7 1gzh 1gzh 1h26 1jsp 1kzy 1ma3 1tsr 1tup 1xqh 1xqh 1ycq

182 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name P53_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–15； UniProt 363–377

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2mwo
Deposition date deposition_date2014-11-15
Structure title titleSolution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide
Keywords keywordsCell cycle, DNA damage response, TRANSCRIPTION-ANTITUMOR PROTEIN complex; TRANSCRIPTION/ANTITUMOR PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2mwo__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2mwo__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2mwo__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.11 Å
Rg (electron density)14.66 Å
Total Rg15.91 Å
Atom count2191
Residues137
Excluded volume19518 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2mwo__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2mwo__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2mwo__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2mwo__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2mwo__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2mwo__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2mwo__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2mwo__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2mwo__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2mwo__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2mwo__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2mwo__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2mwo__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2mwo__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2mwo__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2mwo__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2mwo__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2mwo__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2mwo__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2mwo__assembly_1__model_20 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id2mwoA01
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily140 —
Domain ID domain_id2mwoA02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily30 —
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7. Citations (1)