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3c4m

Structure of human parathyroid hormone in complex with the extracellular domain of its G-protein-coupled receptor (PTH1R)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor

Homo sapiens

UniProt P0AEX9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 其他Polymer 1 Parathyroid hormone × 1 （P01270） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 其他Polymer 1 Parathyroid hormone × 1 （P01270） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2d21 2h25 2klf 2mv0 2n44 2n45 3csb 3csg 3kjt 5aq9 5aq9 5gxt

18 assemblies; showing the first 12

Homodimer
2obg

1 assemblies

Homotetramer

None

Other homooligomers
9wy8

1 assemblies

Heteromeric or nucleic-acid complex
21dh 21dh 21dh 21dh 21dh 21dh 2ok2 2r6g 2zxt 3a3c 3c4m 3c4m

472 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MALE_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–368； UniProt 26–392 Author chain B； PDBConstruct 2–368； UniProt 26–392

Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor

Homo sapiens

UniProt Q03431

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 其他Polymer 1 Parathyroid hormone × 1 （P01270） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 其他Polymer 1 Parathyroid hormone × 1 （P01270） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bl1

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
25nv 25nx 3c4m 3c4m 3h3g 3l2j 6fj3 6nbf 6nbh 6nbi 7uzp 7vvj

44 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PTHR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 375–533； UniProt 29–187 Author chain B； PDBConstruct 375–533； UniProt 29–187

Parathyroid hormone

OrganismNot specified

UniProt P01270

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 其他Polymer 1 Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor × 1 （P0AEX9,Q03431） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 其他Polymer 1 Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor × 1 （P0AEX9,Q03431） alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bwx 1fvy 1hph 1hpy 1hth 1zwa 1zwb 1zwd 1zwe 1zwf 1zwg 2l1x

12 assemblies

Homodimer
1et1

1 assemblies

Homotetramer

None

Other homooligomers
8t5f

1 assemblies

Heteromeric or nucleic-acid complex
3c4m 3c4m 7vvk 7vvl 7vvm 7vvn 7vvo 7y36 8flq 8ha0 8hao 9jr2

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PTHY_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–20； UniProt 46–65 Author chain D； PDBConstruct 1–20； UniProt 46–65

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3c4m
Deposition date deposition_date2008-01-30
Structure title titleStructure of human parathyroid hormone in complex with the extracellular domain of its G-protein-coupled receptor (PTH1R)
Keywords keywords;parathyroid hormone, G-protein-coupled receptor, Sugar transport, Transport, Cleavage on pair of basic residues, Disease mutation, Secreted, Dwarfism, Glycoprotein, Membrane, Receptor, Transducer, Transmembrane, MEMBRANE PROTEIN ;; MEMBRANE PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3c4m__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3c4m__assembly_2__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3c4m__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.30 Å
Rg (electron density)26.33 Å
Total Rg27.17 Å
Atom count3883
Residues489
Excluded volume69159 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3c4m__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3c4m__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd3c4mc1
Class classj — Peptides
Fold Fold foldj.15 — Parathyroid hormone fragments (residues between 1 and 39)
Superfamily Superfamily superfamilyj.15.1 — Parathyroid hormone fragments (residues between 1 and 39)
Family Family familyj.15.1.1 — Parathyroid hormone fragments (residues between 1 and 39)
Domain ID domain_idd3c4md1
Class classj — Peptides
Fold Fold foldj.15 — Parathyroid hormone fragments (residues between 1 and 39)
Superfamily Superfamily superfamilyj.15.1 — Parathyroid hormone fragments (residues between 1 and 39)
Family Family familyj.15.1.1 — Parathyroid hormone fragments (residues between 1 and 39)

CATH v4.4 (6 domains)

Domain ID domain_id3c4mA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily10 — Periplasmic binding protein-like II
Domain ID domain_id3c4mA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily10 — Periplasmic binding protein-like II
Domain ID domain_id3c4mA03
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology1240 — Hormone receptor fold
Homologous superfamily homologous superfamily10 — GPCR, family 2, extracellular hormone receptor domain
Domain ID domain_id3c4mB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily10 — Periplasmic binding protein-like II
Domain ID domain_id3c4mB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily10 — Periplasmic binding protein-like II
Domain ID domain_id3c4mB03
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology1240 — Hormone receptor fold
Homologous superfamily homologous superfamily10 — GPCR, family 2, extracellular hormone receptor domain
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7. Citations (1)