← Back to search
3p57

Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Myocyte-specific enhancer factor 2A

Homo sapiens

UniProt Q02078

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 7 DNA 6 ;DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3') ; × 3 ;DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3') ; × 3 Histone acetyltransferase p300 × 1 （Q09472） ZINC ION × 3 water × 13 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1c7u 1egw 1egw 1lew 3kov 3kov 3mu6 3mu6 3p57 6byy 6byy 6bz1

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MEF2A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–90； UniProt 2–91 Author chain B； PDBConstruct 1–90； UniProt 2–91 Author chain C； PDBConstruct 1–90； UniProt 2–91 Author chain D； PDBConstruct 1–90； UniProt 2–91 Author chain I； PDBConstruct 1–90； UniProt 2–91 Author chain J； PDBConstruct 1–90； UniProt 2–91

Histone acetyltransferase p300

Homo sapiens

UniProt Q09472

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 7 DNA 6 Myocyte-specific enhancer factor 2A × 6 （Q02078） ;DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3') ; × 3 ;DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3') ; × 3 ZINC ION × 3 water × 13 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
3biy 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j

69 assemblies; showing the first 12

Homodimer
4bhw 6ds6 6gyr 6gyr

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1l3e 1p4q 2k8f 2mh0 2mzd 3p57 3t92 6fgn 6fgs 6gyt 7w9v 7xez

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EP300_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain P； PDBConstruct 3–112； UniProt 1726–1835

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id3p57
Deposition date deposition_date2010-10-08
Structure title titleCrystal structure of the p300 TAZ2 domain bound to MEF2 on DNA
Keywords keywords;protein-DNA complex, transcription factor, transcriptional activation, p300, zinc finger, TRANSFERASE-TRANSCRIPTION ACTIVATOR-DNA complex ;; TRANSFERASE/TRANSCRIPTION ACTIVATOR/DNA
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3p57__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3p57__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3p57__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）40.35 Å
Rg (electron density)38.29 Å
Total Rg38.75 Å
Atom count7084
Residues733
Excluded volume121500 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3p57__assembly_1__model_1 tridecameric （13） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (6)

▼

6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd3p57j_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.88 — SRF-like
Superfamily Superfamily superfamilyd.88.1 — SRF-like
Family Family familyd.88.1.1 — SRF-like

CATH v4.4 (7 domains)

Domain ID domain_id3p57A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57B01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57C01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57D01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57I01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57J01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1810 — SRF-like
Homologous superfamily homologous superfamily10 — Transcription factor, MADS-box
Domain ID domain_id3p57P00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1020 — CREB-binding Protein; Chain A
Homologous superfamily homologous superfamily10 — TAZ domain
▶

7. Citations (1)