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5xzc

Cryo-EM structure of p300-p53 protein complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone acetyltransferase p300

Homo sapiens

UniProt Q09472

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3biy 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j 3i3j

69 assemblies; showing the first 12

Homodimer
4bhw 6ds6 6gyr 6gyr

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1l3e 1p4q 2k8f 2mh0 2mzd 3p57 3t92 6fgn 6fgs 6gyt 7w9v 7xez

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EP300_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–619； UniProt 1046–1664

Cellular tumor antigen p53

Homo sapiens

UniProt P04637

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
2 Protein homooligomer Homooligomer Protein 4 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1uol 1uol 2bim 2bim 2bin 2bio 2bip 2biq 2j1w 2j1w 2j1x 2j1x

251 assemblies; showing the first 12

Homodimer
1a1u 1hs5 3q01 8xcb 8xcb 9g6t

6 assemblies

Homotetramer
1aie 1c26 1olg 1olh 1pes 1pet 1sae 1saf 1sak 1sal 2j0z 2j10

22 assemblies; showing the first 12

Other homooligomers
4rp6 4rp7

2 assemblies

Heteromeric or nucleic-acid complex
1dt7 1gzh 1gzh 1h26 1jsp 1kzy 1ma3 1tsr 1tup 1xqh 1xqh 1ycq

182 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name P53_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–265； UniProt 92–356 Author chain C； PDBConstruct 1–265； UniProt 92–356 Author chain D； PDBConstruct 1–265； UniProt 92–356 Author chain E； PDBConstruct 1–265； UniProt 92–356

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5xzc
Deposition date deposition_date2017-07-12
Structure title titleCryo-EM structure of p300-p53 protein complex
Keywords keywordstranscription factor, autoacetylation, allosteric interaction, catalytically active form, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5xzc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5xzc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5xzc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）35.19 Å
Rg (electron density)35.05 Å
Total Rg35.00 Å
Atom count0
Residues0
Excluded volume87413 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5xzc__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5xzc__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)