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6rx2

Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

14-3-3 protein sigma

Homo sapiens

UniProt P31947

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Cellular tumor antigen p53 × 2 （P04637） MAGNESIUM ION × 6 CALCIUM ION × 2 7-[[(2~{S})-1-azanylpropan-2-yl]amino]-1-benzothiophene-2-carboximidamide × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1yz5 3t0l 3t0m 3u9x 4dhm 4dhn 4dho 4dhp 4dhq 4dhr 4dhs 4dht

21 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ywt 1ywt 3iqj 3iqu 3iqv 3lw1 3mhr 3o8i 3p1n 3p1o 3p1p 3p1q

523 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 1433S_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–253； UniProt 1–248

Cellular tumor antigen p53

OrganismNot specified

UniProt P04637

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 14-3-3 protein sigma × 2 （P31947） MAGNESIUM ION × 6 CALCIUM ION × 2 7-[[(2~{S})-1-azanylpropan-2-yl]amino]-1-benzothiophene-2-carboximidamide × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1uol 1uol 2bim 2bim 2bin 2bio 2bip 2biq 2j1w 2j1w 2j1x 2j1x

251 assemblies; showing the first 12

Homodimer
1a1u 1hs5 3q01 8xcb 8xcb 9g6t

6 assemblies

Homotetramer
1aie 1c26 1olg 1olh 1pes 1pet 1sae 1saf 1sak 1sal 2j0z 2j10

22 assemblies; showing the first 12

Other homooligomers
4rp6 4rp7

2 assemblies

Heteromeric or nucleic-acid complex
1dt7 1gzh 1gzh 1h26 1jsp 1kzy 1ma3 1tsr 1tup 1xqh 1xqh 1ycq

182 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name P53_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain P； PDBConstruct 1–12； UniProt 382–393

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6rx2
Deposition date deposition_date2019-06-07
Structure title titleFragment AZ-005 binding at the p53pT387/14-3-3 sigma interface
Keywords keywordsprotein protein interaction, fragment soaking, stabilization, PEPTIDE BINDING PROTEIN; PEPTIDE BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6rx2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6rx2__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6rx2__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.28 Å
Rg (electron density)26.32 Å
Total Rg27.05 Å
Atom count3664
Residues458
Excluded volume65061 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6rx2__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)