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9s9p

Crystal structure of p53 cancer mutant Y220S in complex with rezatapopt

Method: X-RAY DIFFRACTION Dmax: 74.1 Å Quality: REASONABLE

SAXS Profile

SAXS profile for 9s9p

P(r) Distribution

P(r) distribution for 9s9p

1. Structure Basics

entry_id9s9p
deposition_date2025-08-06
titleCrystal structure of p53 cancer mutant Y220S in complex with rezatapopt
keywordsp53, tumor suppressor, protein stability, protein unfolding disease, small-molecule stabilizer, cancer therapy, TRANSCRIPTION; TRANSCRIPTION
methodX-RAY DIFFRACTION

Download Data

2. SAXS Parameters (CRYSOL)

rg_guinier24.13
rg_electron23.38
i073462700.00
molecular_weight43072.0 kDa
excluded_volume40583 ų
envelope_volume69510 ų
shell_volume24808 ų
envelope_diameter77.4
shell_rg30.39
envelope_rg23.21
shape_rg23.37
total_rg23.98
total_atoms3217
n_residues396
n_harmonics20
q_range— – 0.5000 −1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3

3. P(r) Analysis (GNOM)

dmax74.1
rg_real24.04
rg_real_error0.41
i0_real7.3460e+07
i0_real_error9.4570e+05
rg_reciprocal24.07
i0_reciprocal73460000.0000
total_estimate0.7067
solution_quality REASONABLE a REASONABLE solution
n_peaks2
r_peak_primary28.9
skewness0.197
kurtosis-0.576
angular_range— – 0.3300 −1
current_alpha0.0000
highest_alpha6563000.0000
n_real_points65
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.967; Stabil: 1.000; Sysdev: 0.101; Positv: 1.000; Valcen: 1.000; Smooth: 0.980

4. Crystallography & Experiment

5. Entities & Polymer Info (6)

6. Citations (1)

7. Files & Curves (10)