4cr2

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME COMPONENT PRE3

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB1_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 1； PDBConstruct 1–215； UniProt 1–215

PROTEASOME COMPONENT PUP1

OrganismNot specified

UniProt P25043

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB2_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 2； PDBConstruct 1–261； UniProt 1–261

PROTEASOME COMPONENT PUP3

OrganismNot specified

UniProt P25451

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB3_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 3； PDBConstruct 1–205； UniProt 1–205

PROTEASOME COMPONENT C11

OrganismNot specified

UniProt P22141

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB4_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 4； PDBConstruct 1–198； UniProt 1–198

PROTEASOME COMPONENT PRE2

OrganismNot specified

UniProt P30656

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB5_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 5； PDBConstruct 1–287； UniProt 1–287

PROTEASOME COMPONENT C5

OrganismNot specified

UniProt P23724

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB6_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 6； PDBConstruct 1–241； UniProt 1–241

PROTEASOME COMPONENT PRE4

OrganismNot specified

UniProt P30657

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB7_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain 7； PDBConstruct 1–266； UniProt 1–266

PROTEASOME COMPONENT C7-ALPHA

OrganismNot specified

UniProt P21243

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA1_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain A； PDBConstruct 1–252； UniProt 1–252

PROTEASOME COMPONENT Y7

OrganismNot specified

UniProt P23639

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA2_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain B； PDBConstruct 1–250； UniProt 1–250

PROTEASOME COMPONENT Y13

OrganismNot specified

UniProt P23638

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA3_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain C； PDBConstruct 1–258； UniProt 1–258

PROTEASOME COMPONENT PRE6

OrganismNot specified

UniProt P40303

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA4_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain D； PDBConstruct 1–254； UniProt 1–254

PROTEASOME COMPONENT PUP2

OrganismNot specified

UniProt P32379

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA5_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain E； PDBConstruct 1–260； UniProt 1–260

PROTEASOME COMPONENT PRE5

OrganismNot specified

UniProt P40302

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA6_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain F； PDBConstruct 1–234； UniProt 1–234

PROTEASOME COMPONENT C1

OrganismNot specified

UniProt P21242

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA7_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain G； PDBConstruct 1–288； UniProt 1–288

26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG

OrganismNot specified

UniProt P33299

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS7_YEAST
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain H； PDBConstruct 1–467； UniProt 1–467

26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG

OrganismNot specified

UniProt P40327

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS4_YEAST
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain I； PDBConstruct 1–437； UniProt 1–437

26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG

OrganismNot specified

UniProt Q01939

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS8_YEAST
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain J； PDBConstruct 1–405； UniProt 1–405

26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG

OrganismNot specified

UniProt P33298

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6B_YEAST
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain K； PDBConstruct 1–428； UniProt 1–428

26S PROTEASE SUBUNIT RPT4

OrganismNot specified

UniProt P53549

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS10_YEAST
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain L； PDBConstruct 1–437； UniProt 1–437

26S PROTEASE REGULATORY SUBUNIT 6A

OrganismNot specified

UniProt P33297

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6A_YEAST
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain M； PDBConstruct 1–434； UniProt 1–434

26S PROTEASOME REGULATORY SUBUNIT RPN2

OrganismNot specified

UniProt P32565

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN2_YEAST
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain N； PDBConstruct 1–945； UniProt 1–945

26S PROTEASOME REGULATORY SUBUNIT RPN9

OrganismNot specified

UniProt Q04062

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN9_YEAST
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain O； PDBConstruct 1–393； UniProt 1–393

26S PROTEASOME REGULATORY SUBUNIT RPN5

OrganismNot specified

UniProt Q12250

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN5_YEAST
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain P； PDBConstruct 1–445； UniProt 1–445

26S PROTEASOME REGULATORY SUBUNIT RPN6

OrganismNot specified

UniProt Q12377

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN6_YEAST
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain Q； PDBConstruct 1–434； UniProt 1–434

26S PROTEASOME REGULATORY SUBUNIT RPN7

OrganismNot specified

UniProt Q06103

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN7_YEAST
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain R； PDBConstruct 1–429； UniProt 1–429

26S PROTEASOME REGULATORY SUBUNIT RPN3

OrganismNot specified

UniProt P40016

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN3_YEAST
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain S； PDBConstruct 1–523； UniProt 1–523

26S PROTEASOME REGULATORY SUBUNIT RPN12

OrganismNot specified

UniProt P32496

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN12_YEAST
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain T； PDBConstruct 1–274； UniProt 1–274

26S PROTEASOME REGULATORY SUBUNIT RPN8

OrganismNot specified

UniProt Q08723

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN8_YEAST
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain U； PDBConstruct 1–338； UniProt 1–338

26S PROTEASOME REGULATORY SUBUNIT RPN11

OrganismNot specified

UniProt P43588

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN11_YEAST
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain V； PDBConstruct 1–306； UniProt 1–306

26S PROTEASOME REGULATORY SUBUNIT RPN10

OrganismNot specified

UniProt P38886

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN10_YEAST
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain W； PDBConstruct 1–268； UniProt 1–268

26S PROTEASOME REGULATORY SUBUNIT RPN13

OrganismNot specified

UniProt O13563

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN13_YEAST
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain X； PDBConstruct 1–156； UniProt 1–156

26S PROTEASOME COMPLEX SUBUNIT SEM1

OrganismNot specified

UniProt O94742

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME REGULATORY SUBUNIT RPN1 × 1 （P38764）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SEM1_YEAST
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain Y； PDBConstruct 1–89； UniProt 1–89

26S PROTEASOME REGULATORY SUBUNIT RPN1

OrganismNot specified

UniProt P38764

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 33	PROTEASOME COMPONENT PRE3 × 1 （P38624） PROTEASOME COMPONENT PUP1 × 1 （P25043） PROTEASOME COMPONENT PUP3 × 1 （P25451） PROTEASOME COMPONENT C11 × 1 （P22141） PROTEASOME COMPONENT PRE2 × 1 （P30656） PROTEASOME COMPONENT C5 × 1 （P23724） PROTEASOME COMPONENT PRE4 × 1 （P30657） PROTEASOME COMPONENT C7-ALPHA × 1 （P21243） PROTEASOME COMPONENT Y7 × 1 （P23639） PROTEASOME COMPONENT Y13 × 1 （P23638） PROTEASOME COMPONENT PRE6 × 1 （P40303） PROTEASOME COMPONENT PUP2 × 1 （P32379） PROTEASOME COMPONENT PRE5 × 1 （P40302） PROTEASOME COMPONENT C1 × 1 （P21242） 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG × 1 （P33299） 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG × 1 （P40327） 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG × 1 （Q01939） 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG × 1 （P33298） 26S PROTEASE SUBUNIT RPT4 × 1 （P53549） 26S PROTEASE REGULATORY SUBUNIT 6A × 1 （P33297） 26S PROTEASOME REGULATORY SUBUNIT RPN2 × 1 （P32565） 26S PROTEASOME REGULATORY SUBUNIT RPN9 × 1 （Q04062） 26S PROTEASOME REGULATORY SUBUNIT RPN5 × 1 （Q12250） 26S PROTEASOME REGULATORY SUBUNIT RPN6 × 1 （Q12377） 26S PROTEASOME REGULATORY SUBUNIT RPN7 × 1 （Q06103） 26S PROTEASOME REGULATORY SUBUNIT RPN3 × 1 （P40016） 26S PROTEASOME REGULATORY SUBUNIT RPN12 × 1 （P32496） 26S PROTEASOME REGULATORY SUBUNIT RPN8 × 1 （Q08723） 26S PROTEASOME REGULATORY SUBUNIT RPN11 × 1 （P43588） 26S PROTEASOME REGULATORY SUBUNIT RPN10 × 1 （P38886） 26S PROTEASOME REGULATORY SUBUNIT RPN13 × 1 （O13563） 26S PROTEASOME COMPLEX SUBUNIT SEM1 × 1 （O94742）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPN1_YEAST
Isoform	—
PDB entities	33
Chains and sequence ranges	Author chain Z； PDBConstruct 1–993； UniProt 1–993

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4cr2
Deposition date deposition_date	2014-02-25
Structure title title	Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
Keywords keywords	HYDROLASE, AAA-ATPASE, ATP-ANALOG, CLASSIFICATION; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4cr2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4cr2__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4cr2__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	79.65 Å
Rg (electron density)	79.65 Å
Total Rg	79.53 Å
Atom count	80139
Residues	10166
Excluded volume	1432900 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4cr2__assembly_1__model_1`	33-meric （33）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (33)

Entity 1 Entity 1 polymer

Description description	PROTEASOME COMPONENT PRE3
Molecular weight formula_weight	23573.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1
Atom count atom_count	80139

MNGIQVDINRLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL

Entity 2 Entity 2 polymer

Description description	PROTEASOME COMPONENT PUP1
Molecular weight formula_weight	28299.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2

MAGLSFDNYQRNNFLAENSHTQPKATSTGTTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA

Entity 3 Entity 3 polymer

Description description	PROTEASOME COMPONENT PUP3
Molecular weight formula_weight	22627.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD

Entity 4 Entity 4 polymer

Description description	PROTEASOME COMPONENT C11
Molecular weight formula_weight	22545.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ

Entity 5 Entity 5 polymer

Description description	PROTEASOME COMPONENT PRE2
Molecular weight formula_weight	31698.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKRVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG

Entity 6 Entity 6 polymer

Description description	PROTEASOME COMPONENT C5
Molecular weight formula_weight	26905.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MATIASEYSSEASNTPIEHQFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD

Entity 7 Entity 7 polymer

Description description	PROTEASOME COMPONENT PRE4
Molecular weight formula_weight	29471.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI

Entity 8 Entity 8 polymer

Description description	PROTEASOME COMPONENT C7-ALPHA
Molecular weight formula_weight	28033.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD

Entity 9 Entity 9 polymer

Description description	PROTEASOME COMPONENT Y7
Molecular weight formula_weight	27191.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL

Entity 10 Entity 10 polymer

Description description	PROTEASOME COMPONENT Y13
Molecular weight formula_weight	28748.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK

Entity 11 Entity 11 polymer

Description description	PROTEASOME COMPONENT PRE6
Molecular weight formula_weight	28478.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH

Entity 12 Entity 12 polymer

Description description	PROTEASOME COMPONENT PUP2
Molecular weight formula_weight	28649.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGASGEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAAESPEEADVEMS

Entity 13 Entity 13 polymer

Description description	PROTEASOME COMPONENT PRE5
Molecular weight formula_weight	25634.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI

Entity 14 Entity 14 polymer

Description description	PROTEASOME COMPONENT C1
Molecular weight formula_weight	31575.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDSDNVMSSDDENAPVATNANATTDQEGDIHLE

Entity 15 Entity 15 polymer

Description description	26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG
Molecular weight formula_weight	52054.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MPPKEDWEKYKAPLEDDDKKPDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADEDDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRYMQYN

Entity 16 Entity 16 polymer

Description description	26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG
Molecular weight formula_weight	48898.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLLRMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIVTSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKKILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAKERVMKNKVEENLEGLYL

Entity 17 Entity 17 polymer

Description description	26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG
Molecular weight formula_weight	45342.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK

Entity 18 Entity 18 polymer

Description description	26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG
Molecular weight formula_weight	47953.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MEELGIVTPVEKAVEEKPAVKSYASLLAQLNGTVNNNSALSNVNSDIYFKLKKLEKEYELLTLQEDYIKDEQRHLKRELKRAQEEVKRIQSVPLVIGQFLEPIDQNTGIVSSTTGMSYVVRILSTLDRELLKPSMSVALHRHSNALVDILPPDSDSSISVMGENEKPDVTYADVGGLDMQKQEIREAVELPLVQADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKAAFIRVNGSEFVHKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGSDREVQRILIELLTQMDGFDQSTNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFGTIASKMSLAPEADLDSLIIRNDSLSGAVIAAIMQEAGLRAVRKNRYVILQSDLEEAYATQVKTDNTVDKFDFYK

Entity 19 Entity 19 polymer

Description description	26S PROTEASE SUBUNIT RPT4
Molecular weight formula_weight	49480.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MSEEQDPLLAGLGETSGDNHTQQSHEQQPEQPQETEEHHEEEPSRVDPEQEAHNKALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKALQSIGQLIGEVMKELSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILPRETDPLVYNMTSFEQGEITFDGIGGLTEQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLTQMDGFDNLGQTKIIMATNRPDTLDPALLRPGRLDRKVEIPLPNEAGRLEIFKIHTAKVKKTGEFDFEAAVKMSDGFNGADIRNCATEAGFFAIRDDRDHINPDDLMKAVRKVAEVKKLEGTIEYQKL

Entity 20 Entity 20 polymer

Description description	26S PROTEASE REGULATORY SUBUNIT 6A
Molecular weight formula_weight	48315.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MATLEELDAQTLPGDDELDQEILNLSTQELQTRAKLLDNEIRIFRSELQRLSHENNVMLEKIKDNKEKIKNNRQLPYLVANVVEVMDMNEIEDKENSESTTQGGNVNLDNTAVGKAAVVKTSSRQTVFLPMVGLVDPDKLKPNDLVGVNKDSYLILDTLPSEFDSRVKAMEVDEKPTETYSDVGGLDKQIEELVEAIVLPMKRADKFKDMGIRAPKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLVQMYIGEGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPSEDSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGISEVQARKSKSVSFYA

Entity 21 Entity 21 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN2
Molecular weight formula_weight	104351.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MSLTTAAPLLALLRENQDSVKTYALESINNVVDQLWSEISNELPDIEALYDDDTFSDREMAALIASKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKDEQFYTKDIIDPKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQDSTSENVKIINYLLTLAITTVTNSKFRSSILRKSFDFLMNMPNCDYLTLNKVVVNLNDAGLALQLFKKLKEENDEGLSAQIAFDLVSSASQQLLEILVTELTAQGYDPALLNILSGLPTCDYYNTFLLNNKNIDIGLLNKSKSSLDGKFSLFHTAVSVANGFMHAGTTDNSFIKANLPWLGKAQNWAKFTATASLGVIHKGNLLEGKKVMAPYLPGSRASSRFIKGGSLYGLGLIYAGFGRDTTDYLKNIIVENSGTSGDEDVDVLLHGASLGIGLAAMGSANIEVYEALKEVLYNDSATSGEAAALGMGLCMLGTGKPEAIHDMFTYSQETQHGNITRGLAVGLALINYGRQELADDLITKMLASDESLLRYGGAFTIALAYAGTGNNSAVKRLLHVAVSDSNDDVRRAAVIALGFVLLRDYTTVPRIVQLLSKSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTKDPVDFVRQAAMIALSMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVTIQLENADTGTLDTKSVVGLVMFSQFWYWFPLAHFLSLSFTPTTVIGIRGSDQAIPKFQMNCYAKEDAFSYPRMYEEASGKEVEKVATAVLSTTARAKARAKKTKKEKGPNEEEKKKEHEEKEKERETNKKGIKETKENDEEFYKNKYSSKPYKVDNMTRILPQQSRYISFIKDDRFVPVRKFKGNNGVVVLRDREPKEPVALIETVRQMKDVNAPLPTPFKVDDNVDFPSA

Entity 22 Entity 22 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN9
Molecular weight formula_weight	45839.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MFNNHEIDTILSTLRMEADPSLHPLFEQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQLSVVKYLLASLKDSKDFDESLKYLDDLKAQFQELDSKKQRNNGSKDHGDGILLIDSEIARTYLLKNDLVKARDLLDDLEKTLDKKDSIPLRITNSFYSTNSQYFKFKNDFNSFYYTSLLYLSTLEPSTSITLAERQQLAYDLSISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKFDSLIKVQISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWNDQVEKLGKKMEARGQSIWV

Entity 23 Entity 23 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN5
Molecular weight formula_weight	51840.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMHGLQAK

Entity 24 Entity 24 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN6
Molecular weight formula_weight	49839.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MSLPGSKLEEARRLVNEKQYNEAEQVYLSLLDKDSSQSSAAAGASVDDKRRNEQETSILELGQLYVTMGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTLIEKFEQVPDSLDDQIFVCEKSIEFAKREKRVFLKHSLSIKLATLHYQKKQYKDSLALINDLLREFKKLDDKPSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYHNLTTHNSYEKACQVLKYMLLSKIMLNLIDDVKNILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLDFNTALKQYEKELMGDELTRSHFNALYDTLLESNLCKIIEPFECVEISHISKIIGLDTQQVEGKLSQMILDKIFYGVLDQGNGWLYVYETPNQDATYDSALELVGQLNKVVDQLFEKASVLY

Entity 25 Entity 25 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN7
Molecular weight formula_weight	49016.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MVDVEEKSQEVEYVDPTVNRVPNYEVSEKAFLLTQSKVSIEQRKEAAEFVLAKIKEEEMAPYYKYLCEEYLVNNGQSDLEHDEKSDSLNEWIKFDQELYNELCKKNESKIKELNEKIQKLEEDDEGELEQAQAWINLGEYYAQIGDKDNAEKTLGKSLSKAISTGAKIDVMLTIARLGFFYNDQLYVKEKLEAVNSMIEKGGDWERRNRYKTYYGIHCLAVRNFKEAAKLLVDSLATFTSIELTSYESIATYASVTGLFTLERTDLKSKVIDSPELLSLISTTAALQSISSLTISLYASDYASYFPYLLETYANVLIPCKYLNRHADFFVREMRRKVYAQLLESYKTLSLKSMASAFGVSVAFLDNDLGKFIPNKQLNCVIDRVNGIVETNRPDNKNAQYHLLVKQGDGLLTKLQKYGAAVRLTGSDRV

Entity 26 Entity 26 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN3
Molecular weight formula_weight	60464.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDLSSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYSVNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEYLVSMRYPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDLDDLGFL

Entity 27 Entity 27 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN12
Molecular weight formula_weight	31952.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MPSLAELTKSLSIAFENGDYAACEKLLPPIKIELIKNNLLIPDLSIQNDIYLNDLMITKRILEVGALASIQTFNFDSFENYFNQLKPYYFSNNHKLSESDKKSKLISLYLLNLLSQNNTTKFHSELQYLDKHIKNLEDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNISEFDSFTDILKSAIRDEIAKNTELSYDFLPLSNIKALLFFNNEKETEKFALERNWPIVNSKVYFNNQSKEKADYEDEMMHEEDQKTNIIEKAMDYAISIENIV

Entity 28 Entity 28 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN8
Molecular weight formula_weight	38365.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MSLQHEKVTIAPLVLLSALDHYERTQTKENKRCVGVILGDANSSTIRVTNSFALPFEEDEKNSDVWFLDHNYIENMNEMCKKINAKEKLIGWYHSGPKLRASDLKINELFKKYTQNNPLLLIVDVKQQGVGLPTDAYVAIEQVKDDGTSTEKTFLHLPCTIEAEEAEEIGVEHLLRDVRDQAAGGLSIRLTNQLKSLKGLQSKLKDVVEYLDKVINKELPINHTILGKLQDVFNLLPNLGTPDDDEIDVENHDRINISNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKDKQSKVSDDSESESGDKEATAPLIQRKNKKN

Entity 29 Entity 29 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN11
Molecular weight formula_weight	34442.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

MERLQRLMMNSKVGSADTGRDDTKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLEPRQTTSNTGLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLHKEQWQSGLKMYDYEEKEESNLAATKSMVKIAEQYSKRIEEEKELTEEELKTRYVGRQDPKKHLSETADETLENNIVSVLTAGVNSVAIK

Entity 30 Entity 30 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN10
Molecular weight formula_weight	29776.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MVLEATVLVIDNSEYSRNGDFPRTRFEAQIDSVEFIFQAKRNSNPENTVGLISGAGANPRVLSTFTAEFGKILAGLHDTQIEGKLHMATALQIAQLTLKHRQNKVQHQRIVAFVCSPISDSRDELIRLAKTLKKNNVAVDIINFGEIEQNTELLDEFIAAVNNPQEETSHLLTVTPGPRLLYENIASSPIILEEGSSGMGAFGGSGGDSDANGTFMDFGVDPSMDPELAMALRLSMEEEQQRQERLRQQQQQQDQPEQSEQPEQHQDK

Entity 31 Entity 31 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN13
Molecular weight formula_weight	17919.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRELDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKEIYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD

Entity 32 Entity 32 polymer

Description description	26S PROTEASOME COMPLEX SUBUNIT SEM1
Molecular weight formula_weight	10397.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

MSTDVAAAQAQSKIDLTKKKNEEINKKSLEEDDEFEDFPIDTWANGETIKSNAVTQTNIWEENWDDVEVDDDFTNELKAELDRYKRENQ

Entity 33 Entity 33 polymer

Description description	26S PROTEASOME REGULATORY SUBUNIT RPN1
Molecular weight formula_weight	109601.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MVDESDKKQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLKEDDSSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLSILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVASIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADEEETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGKNDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLRQLASYYSREQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAVGLVSPSFMLKHHQLFYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNHGERAELETDEYISYTSHIEGVVILKKNPDYREEE

▼

6. Fold Classification (SCOP + CATH) 58 domains

SCOP 2.08 (58 domains)

Domain ID domain_id	d4cr21_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr22_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr23_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr24_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr25_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr26_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr27_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2a_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2b_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2c_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2d1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2d2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d4cr2e_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2f_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2g_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4cr2h1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2h2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2h3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2i1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2i2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2i3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2j1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2j2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2j3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2k1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2k2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2k3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2l1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2l2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2l3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2m1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2m2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2m3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family family	c.37.1.20 — Extended AAA-ATPase domain

Domain ID domain_id	d4cr2n1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.1 — ARM repeat
Family Family family	a.118.1.28 — Proteasome/cyclosome repeat (PC repeat)

Domain ID domain_id	d4cr2n2
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.28 — Proteasome regulatory subunit Rpn2 N-terminal domain-like
Family Family family	a.118.28.1 — Proteasome regulatory subunit Rpn2, N-terminal domain-like

Domain ID domain_id	d4cr2n3
Class class	b — All beta proteins
Fold Fold fold	b.3 — Prealbumin-like
Superfamily Superfamily superfamily	b.3.8 — Proteasome regulatory subunit Rpn2 C-terminal domain-like
Family Family family	b.3.8.1 — Proteasome regulatory subunit Rpn2, C-terminal domain-like

Domain ID domain_id	d4cr2o1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2o2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2p1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2p2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2q1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2q2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2r1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2r2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2s1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2s2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2t1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.9 — TPR-like repeats from PCI (proteasome / COP9 signalosome / eIF3) domains

Domain ID domain_id	d4cr2t2
Class class	a — All alpha proteins
Fold Fold fold	a.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamily	a.4.5 — 'Winged helix' DNA-binding domain
Family Family family	a.4.5.47 — C-terminal part of PCI (proteasome COP9/signalosome eIF3) domains (PINT motif)

Domain ID domain_id	d4cr2u1
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.97 — Cytidine deaminase-like
Superfamily Superfamily superfamily	c.97.3 — JAB1/MPN domain
Family Family family	c.97.3.1 — JAB1/MPN domain

Domain ID domain_id	d4cr2u2
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2v1
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.97 — Cytidine deaminase-like
Superfamily Superfamily superfamily	c.97.3 — JAB1/MPN domain
Family Family family	c.97.3.1 — JAB1/MPN domain

Domain ID domain_id	d4cr2v2
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.39 — Proteasome regulatory subunits coiled coil regions
Family Family family	h.1.39.1 — Proteasome regulatory subunits coiled coil regions

Domain ID domain_id	d4cr2w_
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.62 — vWA-like
Superfamily Superfamily superfamily	c.62.1 — vWA-like
Family Family family	c.62.1.1 — Integrin A (or I) domain

Domain ID domain_id	d4cr2x_
Class class	b — All beta proteins
Fold Fold fold	b.55 — PH domain-like barrel
Superfamily Superfamily superfamily	b.55.3 — Pleckstrin-like receptor for ubiquitin (Pru) domain
Family Family family	b.55.3.1 — Pleckstrin-like receptor for ubiquitin (Pru) domain

Domain ID domain_id	d4cr2y_
Class class	j — Peptides
Fold Fold fold	j.136 — SEM1 fragments
Superfamily Superfamily superfamily	j.136.1 — SEM1 fragments
Family Family family	j.136.1.1 — SEM1 fragments

Domain ID domain_id	d4cr2z1
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.1 — ARM repeat
Family Family family	a.118.1.28 — Proteasome/cyclosome repeat (PC repeat)

Domain ID domain_id	d4cr2z2
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.28 — Proteasome regulatory subunit Rpn2 N-terminal domain-like
Family Family family	a.118.28.1 — Proteasome regulatory subunit Rpn2, N-terminal domain-like

Domain ID domain_id	d4cr2z3
Class class	b — All beta proteins
Fold Fold fold	b.3 — Prealbumin-like
Superfamily Superfamily superfamily	b.3.8 — Proteasome regulatory subunit Rpn2 C-terminal domain-like
Family Family family	b.3.8.1 — Proteasome regulatory subunit Rpn2, C-terminal domain-like

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	7.700 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	7.70 Å
Resolution测定Method resolution_method	PROJECTION MATCHING
颗粒数 num_particles	1300000

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME COMPONENT PRE3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT PUP1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT PUP3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT C11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT PRE2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT C5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT PRE4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT C7-ALPHA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT Y7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT Y13

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer