Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein monomer | Monomer | Protein 1 | water × 1 | Consistent with protein count |
| UniProt name | PTN11_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–528； UniProt 1–532 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 4dgp |
| Deposition date deposition_date | 2012-01-26 |
| Structure title title | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) |
| Keywords keywords | HYDROLASE; HYDROLASE |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 25.97 Å |
| Rg (electron density) | 24.91 Å |
| Total Rg | 25.75 Å |
| Atom count | 4024 |
| Residues | 499 |
| Excluded volume | 71026 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | d4dgpa1 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.93 — SH2-like |
| Superfamily Superfamily superfamily | d.93.1 — SH2 domain |
| Family Family family | d.93.1.0 — automated matches |
| Domain ID domain_id | d4dgpa2 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.93 — SH2-like |
| Superfamily Superfamily superfamily | d.93.1 — SH2 domain |
| Family Family family | d.93.1.0 — automated matches |
| Domain ID domain_id | d4dgpa3 |
| Class class | c — Alpha and beta proteins (a/b) |
| Fold Fold fold | c.45 — (Phosphotyrosine protein) phosphatases II |
| Superfamily Superfamily superfamily | c.45.1 — (Phosphotyrosine protein) phosphatases II |
| Family Family family | c.45.1.2 — Higher-molecular-weight phosphotyrosine protein phosphatases |
| Domain ID domain_id | 4dgpA01 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 505 — SHC Adaptor Protein |
| Homologous superfamily homologous superfamily | 10 — SH2 domain |
| Domain ID domain_id | 4dgpA02 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 505 — SHC Adaptor Protein |
| Homologous superfamily homologous superfamily | 10 — SH2 domain |
| Domain ID domain_id | 4dgpA03 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 90 — Alpha-Beta Complex |
| Topology topology | 190 — Protein-Tyrosine Phosphatase; Chain A |
| Homologous superfamily homologous superfamily | 10 — Protein tyrosine phosphatase superfamily |