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9z70

Crystal structure of shorter construct of SHP2 unbound N-SH2 domain (Y66 in blocking conformation)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11

Homo sapiens

UniProt Q06124

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2shp 2shp 3b7o 3mow 3o5x 3zm0 3zm1 3zm2 3zm3 4dgp 4dgx 4gwf

164 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3tkz 3tl0 4je4 4jeg 4jmg 4qsy 5df6 5x7b 5x94 5x94 6r5g 6roy

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PTN11_HUMAN
Isoform Q06124-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–104； UniProt 4–103

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9z70
Deposition date deposition_date2025-11-14
Last revision last_revision2026-01-07
Structure title titleCrystal structure of shorter construct of SHP2 unbound N-SH2 domain (Y66 in blocking conformation)
Keywords keywordsSHP2, phosphatase, SH2, allostery, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9z70__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9z70__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9z70__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.38 Å
Rg (electron density)12.78 Å
Total Rg14.12 Å
Atom count1645
Residues104
Excluded volume14686 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9z70__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (2)