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4gfh

Topoisomerase II-DNA-AMPPNP complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA topoisomerase 2

Saccharomyces cerevisiae

UniProt P06786

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Homooligomer Protein 2 DNA 8 ;DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3') ; × 2 ;DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3') ; × 2 ;DNA (5'-D(P*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*(TSP))-3') ; × 2 ;DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3') ; × 2 MAGNESIUM ION × 2 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1bgw 1bjt 1pvg 1qzr

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2rgr 3l4j 3l4k 4gfh

4 assemblies

View Construct and Data Evidence
UniProt name TOP2_YEAST
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1177； UniProt 1–1177 Author chain F； PDBConstruct 1–1177； UniProt 1–1177

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4gfh
Deposition date deposition_date2012-08-03
Structure title titleTopoisomerase II-DNA-AMPPNP complex
Keywords keywords;TOPOISOMERASE, PROTEIN-DNA COMPLEX, DNA SUPERCOILING, DNA REPLICATION, ATP-BINDING, DNA-BINDING, ISOMERASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, ISOMERASE-DNA COMPLEX ;; Isomerase/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4gfh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4gfh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4gfh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）47.38 Å
Rg (electron density)48.15 Å
Total Rg48.17 Å
Atom count19152
Residues2250
Excluded volume339700 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4gfh__assembly_1__model_1 decameric （10） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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7. Citations (1)