5a31

Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.

Method: ELECTRON MICROSCOPY

▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

ANAPHASE-PROMOTING COMPLEX SUBUNIT 11

HOMO SAPIENS

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC11_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–84； UniProt 1–84

CELL DIVISION CYCLE PROTEIN 23 HOMOLOG

HOMO SAPIENS

UniProt Q9UJX2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC23_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–597； UniProt 1–597 Author chain P； PDBConstruct 1–597； UniProt 1–597

ANAPHASE-PROMOTING COMPLEX SUBUNIT 15

HOMO SAPIENS

UniProt P60006

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC15_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 6–121； UniProt 6–121

ANAPHASE-PROMOTING COMPLEX SUBUNIT 16

HOMO SAPIENS

UniProt Q96DE5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC16_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–110； UniProt 1–110

ANAPHASE-PROMOTING COMPLEX SUBUNIT 3

HOMO SAPIENS

UniProt P30260

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC27_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–824； UniProt 1–824 Author chain H； PDBConstruct 1–824； UniProt 1–824

ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26

HOMO SAPIENS

UniProt Q8NHZ8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC26_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–85； UniProt 1–85 Author chain W； PDBConstruct 1–85； UniProt 1–85

ANAPHASE-PROMOTING COMPLEX SUBUNIT 4

HOMO SAPIENS

UniProt Q9UJX5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC4_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain I； PDBConstruct 1–808； UniProt 1–808

ANAPHASE-PROMOTING COMPLEX SUBUNIT 6

HOMO SAPIENS

UniProt Q13042

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC16_HUMAN
Isoform	—
PDB entities	9, 10
Chains and sequence ranges	Author chain J； PDBConstruct 1–620； UniProt 1–620 Author chain K； PDBConstruct 1–620； UniProt 1–620

ANAPHASE-PROMOTING COMPLEX SUBUNIT 10

HOMO SAPIENS

UniProt Q9UM13

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC10_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain L； PDBConstruct 1–185； UniProt 1–185

ANAPHASE-PROMOTING COMPLEX SUBUNIT 13

HOMO SAPIENS

UniProt Q2NKV2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC13_BOVIN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain M； PDBConstruct 1–74； UniProt 1–74

ANAPHASE-PROMOTING COMPLEX SUBUNIT 5

HOMO SAPIENS

UniProt Q9UJX4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 × 2 （Q9UJX3） ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC5_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain O； PDBConstruct 1–755； UniProt 1–755

ANAPHASE-PROMOTING COMPLEX SUBUNIT 7

HOMO SAPIENS

UniProt Q9UJX3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 24	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 × 1 （Q9NYG5） CELL DIVISION CYCLE PROTEIN 23 HOMOLOG × 2 （Q9UJX2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 × 1 （P60006） ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 × 1 （Q96DE5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 × 2 （P30260） ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 × 2 （Q8NHZ8） ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 × 1 （Q9UJX5） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 × 1 （Q13042） ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 × 1 （Q9UM13） ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 × 1 （Q2NKV2） ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 × 1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 × 1 （Q9UJX4） FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN R × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN T × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN U × 1 THE ANAPHASE-PROMOTING COMPLEX CHAIN V × 1 ZINC ION × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	APC7_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain X； PDBConstruct 1–599； UniProt 1–599 Author chain Y； PDBConstruct 1–599； UniProt 1–599

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id	5a31
Deposition date deposition_date	2015-05-26
Structure title title	Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.
Keywords keywords	UBIQUITINATION, CELL CYCLE, APC/C; CELL CYCLE
Experimental Method method	ELECTRON MICROSCOPY

▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5a31__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5a31__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5a31__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	73.67 Å
Rg (electron density)	73.41 Å
Total Rg	73.54 Å
Atom count	67670
Residues	8624
Excluded volume	1209300 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5a31__assembly_1__model_1`	24-meric （24）	Success	4.1.3-1-20251215 (887e7ef)	View Download

▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (21)

Entity 1 Entity 1 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1
Molecular weight formula_weight	159616.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	67685

MIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASEXXXXXXXXXXXKESWQLRKAVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISEVEKCICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSPLPTMFSMLHPLDEITPLVCKAQYVVDHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKAEEEXXXXXXXXXGGFXXXXPIVPELCIDHLWAAAQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESTALIFGSVTNIPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPATYIHSIRDPVHNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGASYHSEWNLFVTCLMNMMGYTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLASEPPSIYQWVSSCLKGEGAPPYPYLPGICERSRLVVLSIALYILSSLAERLVVWMTNVGFILRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSAADDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSEHEFIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYATDRESYSLAAGLALGMVCLGHGSNLIGMSALNVPEQLYQYMVGGHSPSYQIKEGDTLNVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVLYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLTQHLKSILSKDGVLYVKLRAGQLSYKEDASEARAFKSAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSPLESQLSMLACFAVYHSVPAPXXXXXXXXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 2 Entity 2 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 11
Molecular weight formula_weight	9866.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MKVKIKCWNGVALWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 3 Entity 3 polymer

Description description	CELL DIVISION CYCLE PROTEIN 23 HOMOLOG
Molecular weight formula_weight	68905.0 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,P

MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKLHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 4 Entity 4 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 15
Molecular weight formula_weight	14302.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MSTLYPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 5 Entity 5 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 16
Molecular weight formula_weight	11678.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 6 Entity 6 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 3
Molecular weight formula_weight	92005.1 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,H

MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLSLCSYNCKESINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 7 Entity 7 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26
Molecular weight formula_weight	9794.0 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,W

MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQMINDRIGYKPQPKPNNRSSQFGSLEF

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 8 Entity 8 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 4
Molecular weight formula_weight	92205.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTDDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKPADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQYVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESEAENQQAGAAALAPEIVIKVEKLDPELDS

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 9 Entity 9 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 6
Molecular weight formula_weight	71631.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVNGLEKNLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVASEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIAMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 10 Entity 10 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 6
Molecular weight formula_weight	71806.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLEKNLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHKSCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 11 Entity 11 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
Molecular weight formula_weight	21282.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMMYRSIR

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 12 Entity 12 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 13
Molecular weight formula_weight	8528.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 13 Entity 13 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
Molecular weight formula_weight	79116.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWFVEVLQNDLQANISPEFWXXXXXXXXXXXXXXXXXXXXXXXXXXXPYXXXLXXXXXXXXXXXXXXXXXXGLREEVHTMLRGVLFFAAPRTFQEMIQRLYGCFLRVYMQSKRKGXXXXXXELDSRYARRRYYRLXXXXXWCRQALEQFHQLSQVLHRLSLLARVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVIDPSMVILEVACEPIRRYLRTREDTVRQIVAGLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSADIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLP

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 14 Entity 14 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 5
Molecular weight formula_weight	85087.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLSEMSRTGEGAVSLVERRRLNQQLLPLLQGPDITVSKLLKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 15 Entity 15 polymer

Description description	FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S
Molecular weight formula_weight	17793.4 kDa
EC 编号 ec_number	2.3.2.23, 2.3.2.24, 2.3.2.23
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

GPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 16 Entity 16 polymer

Description description	THE ANAPHASE-PROMOTING COMPLEX CHAIN R
Molecular weight formula_weight	42944.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

SKHGDRFIPSRAGANWSVNFHRINENGLAYSALLKNELLGAGIEKVQKGLFTYSLSPYSLSPVSNKSQKLLRSRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLFTRIR

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 17 Entity 17 polymer

Description description	THE ANAPHASE-PROMOTING COMPLEX CHAIN T
Molecular weight formula_weight	1876.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

XXXXXQLXXXXXXXXXXXXXX

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 18 Entity 18 polymer

Description description	THE ANAPHASE-PROMOTING COMPLEX CHAIN U
Molecular weight formula_weight	2060.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

XXXXXXXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 19 Entity 19 polymer

Description description	THE ANAPHASE-PROMOTING COMPLEX CHAIN V
Molecular weight formula_weight	1421.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

AAFRIALKSVQKS

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 20 Entity 20 polymer

Description description	ANAPHASE-PROMOTING COMPLEX SUBUNIT 7
Molecular weight formula_weight	66832.2 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X,Y

MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLLLTLSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKLAECYTVLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLNKALTQEPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ

Source Source

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	TRICHOPLUSIA NI

Entity 21 Entity 21 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	3

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.300 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	4.30 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	19939

Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.

1. Protein Identity and Related Structures Protein Identity & Related Structures

ANAPHASE-PROMOTING COMPLEX SUBUNIT 11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

CELL DIVISION CYCLE PROTEIN 23 HOMOLOG

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 15

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 16

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 10

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ANAPHASE-PROMOTING COMPLEX SUBUNIT 13

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer