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6axg

Structure of RasGRP4 in complex with HRas

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

RAS guanyl-releasing protein 4

Homo sapiens

UniProt Q8TDF6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 GTPase HRas × 1 （P01112） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6axg 6axg 6axg 6axg 6axg 6axg

6 assemblies

View Construct and Data Evidence
UniProt name GRP4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–418； UniProt 46–460 Author chain C； PDBConstruct 4–418； UniProt 46–460 Author chain E； PDBConstruct 4–418； UniProt 46–460 Author chain G； PDBConstruct 4–418； UniProt 46–460 Author chain I； PDBConstruct 4–418； UniProt 46–460 Author chain K； PDBConstruct 4–418； UniProt 46–460

GTPase HRas

Homo sapiens

UniProt P01112

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 RAS guanyl-releasing protein 4 × 1 （Q8TDF6） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
10dc 1aa9 1clu 1crp 1crq 1crr 1ctq 1iaq 1iaq 1iaq 1ioz 1lf0

156 assemblies; showing the first 12

Homodimer
121p 1agp 1gnp 1gnq 1gnr 1jah 1jai 1plj 1plk 1pll 1q21 221p

24 assemblies; showing the first 12

Homotetramer
6q21

1 assemblies

Other homooligomers
2cl0 3i3s 3lbh 3lbi 3lbn 3oiu 3oiv 3oiw 4dlr 4dls 4dlt 4dlu

18 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1bkd 1k8r 1lfd 1lfd 1nvu 1nvu 1nvv 1nvv 1nvv 1nvv 1nvw 1nvw

126 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RASH_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 5–170； UniProt 1–166 Author chain D； PDBConstruct 5–170； UniProt 1–166 Author chain F； PDBConstruct 5–170； UniProt 1–166 Author chain H； PDBConstruct 5–170； UniProt 1–166 Author chain J； PDBConstruct 5–170； UniProt 1–166 Author chain L； PDBConstruct 5–170； UniProt 1–166

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6axg
Deposition date deposition_date2017-09-06
Structure title titleStructure of RasGRP4 in complex with HRas
Keywords keywordsSIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6axg__assembly_5__model_1

Assembly 5 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6axg__assembly_5__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6axg__assembly_5__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.54 Å
Rg (electron density)25.65 Å
Total Rg26.35 Å
Atom count3864
Residues491
Excluded volume68399 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6axg__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6axg__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6axg__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6axg__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 6axg__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 6axg__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 12 domains

CATH v4.4 (12 domains)

Domain ID domain_id6axgA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology870 — Son of sevenless (SoS) protein; Chain S, domain 1
Homologous superfamily homologous superfamily10 — Son of sevenless (SoS) protein Chain: S domain 1
Domain ID domain_id6axgA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id6axgB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id6axgC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id6axgD00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id6axgE02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id6axgF00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id6axgH00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id6axgI02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id6axgJ00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id6axgK01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id6axgL00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)