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6b1t

Improved cryoEM structure of human adenovirus type 5 with atomic details of minor proteins VI and VII

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hexon protein

OrganismNot specified

UniProt P04133

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Penton protein × 60 （P12538） Pre-hexon-linking protein IIIa × 60 （P12537） Pre-hexon-linking protein VIII × 120 （P24936） Hexon-interlacing protein × 240 （P03281） Pre-protein VI × 180 （P24937） Pre-histone-like nucleoprotein × 60 （P68951） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Penton protein × 5 （P12538） Pre-hexon-linking protein IIIa × 5 （P12537） Pre-hexon-linking protein VIII × 10 （P24936） Hexon-interlacing protein × 20 （P03281） Pre-protein VI × 15 （P24937） Pre-histone-like nucleoprotein × 5 （P68951） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Penton protein × 6 （P12538） Pre-hexon-linking protein IIIa × 6 （P12537） Pre-hexon-linking protein VIII × 12 （P24936） Hexon-interlacing protein × 24 （P03281） Pre-protein VI × 18 （P24937） Pre-histone-like nucleoprotein × 6 （P68951） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1p30 3tg7 8q7c

3 assemblies

Heteromeric or nucleic-acid complex
4v4u 4v4u 4v4u 5ldn 5ogi 6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv

24 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAPSH_ADE05
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–952； UniProt 1–952 Author chain B； PDBConstruct 1–952； UniProt 1–952 Author chain C； PDBConstruct 1–952； UniProt 1–952 Author chain D； PDBConstruct 1–952； UniProt 1–952 Author chain E； PDBConstruct 1–952； UniProt 1–952 Author chain F； PDBConstruct 1–952； UniProt 1–952 Author chain G； PDBConstruct 1–952； UniProt 1–952 Author chain H； PDBConstruct 1–952； UniProt 1–952 Author chain I； PDBConstruct 1–952； UniProt 1–952 Author chain J； PDBConstruct 1–952； UniProt 1–952 Author chain K； PDBConstruct 1–952； UniProt 1–952 Author chain L； PDBConstruct 1–952； UniProt 1–952

Penton protein

OrganismNot specified

UniProt P12538

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Pre-hexon-linking protein IIIa × 60 （P12537） Pre-hexon-linking protein VIII × 120 （P24936） Hexon-interlacing protein × 240 （P03281） Pre-protein VI × 180 （P24937） Pre-histone-like nucleoprotein × 60 （P68951） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Pre-hexon-linking protein IIIa × 5 （P12537） Pre-hexon-linking protein VIII × 10 （P24936） Hexon-interlacing protein × 20 （P03281） Pre-protein VI × 15 （P24937） Pre-histone-like nucleoprotein × 5 （P68951） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Pre-hexon-linking protein IIIa × 6 （P12537） Pre-hexon-linking protein VIII × 12 （P24936） Hexon-interlacing protein × 24 （P03281） Pre-protein VI × 18 （P24937） Pre-histone-like nucleoprotein × 6 （P68951） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3izo 6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv 6cgv 6cgv 6cgv 6cgv

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAPSP_ADE05
Isoform —
PDB entities 2
Chains and sequence ranges Author chain M； PDBConstruct 1–571； UniProt 1–571

Pre-hexon-linking protein IIIa

OrganismNot specified

UniProt P12537

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Penton protein × 60 （P12538） Pre-hexon-linking protein VIII × 120 （P24936） Hexon-interlacing protein × 240 （P03281） Pre-protein VI × 180 （P24937） Pre-histone-like nucleoprotein × 60 （P68951） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Penton protein × 5 （P12538） Pre-hexon-linking protein VIII × 10 （P24936） Hexon-interlacing protein × 20 （P03281） Pre-protein VI × 15 （P24937） Pre-histone-like nucleoprotein × 5 （P68951） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Penton protein × 6 （P12538） Pre-hexon-linking protein VIII × 12 （P24936） Hexon-interlacing protein × 24 （P03281） Pre-protein VI × 18 （P24937） Pre-histone-like nucleoprotein × 6 （P68951） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv 6cgv 6cgv 6cgv 6cgv 7s78

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAP3_ADE05
Isoform —
PDB entities 3
Chains and sequence ranges Author chain N； PDBConstruct 1–585； UniProt 1–585

Pre-hexon-linking protein VIII

OrganismNot specified

UniProt P24936

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Penton protein × 60 （P12538） Pre-hexon-linking protein IIIa × 60 （P12537） Hexon-interlacing protein × 240 （P03281） Pre-protein VI × 180 （P24937） Pre-histone-like nucleoprotein × 60 （P68951） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Penton protein × 5 （P12538） Pre-hexon-linking protein IIIa × 5 （P12537） Hexon-interlacing protein × 20 （P03281） Pre-protein VI × 15 （P24937） Pre-histone-like nucleoprotein × 5 （P68951） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Penton protein × 6 （P12538） Pre-hexon-linking protein IIIa × 6 （P12537） Hexon-interlacing protein × 24 （P03281） Pre-protein VI × 18 （P24937） Pre-histone-like nucleoprotein × 6 （P68951） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv 6cgv 6cgv 6cgv 6cgv 7s78

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAP8_ADE05
Isoform —
PDB entities 4
Chains and sequence ranges Author chain O； PDBConstruct 1–227； UniProt 1–227 Author chain P； PDBConstruct 1–227； UniProt 1–227

Hexon-interlacing protein

OrganismNot specified

UniProt P03281

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Penton protein × 60 （P12538） Pre-hexon-linking protein IIIa × 60 （P12537） Pre-hexon-linking protein VIII × 120 （P24936） Pre-protein VI × 180 （P24937） Pre-histone-like nucleoprotein × 60 （P68951） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Penton protein × 5 （P12538） Pre-hexon-linking protein IIIa × 5 （P12537） Pre-hexon-linking protein VIII × 10 （P24936） Pre-protein VI × 15 （P24937） Pre-histone-like nucleoprotein × 5 （P68951） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Penton protein × 6 （P12538） Pre-hexon-linking protein IIIa × 6 （P12537） Pre-hexon-linking protein VIII × 12 （P24936） Pre-protein VI × 18 （P24937） Pre-histone-like nucleoprotein × 6 （P68951） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Pre-protein VI × 3 （P24937） Pre-histone-like nucleoprotein × 1 （P68951） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv 6cgv 6cgv 6cgv 6cgv 7s78

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAP9_ADE05
Isoform —
PDB entities 5
Chains and sequence ranges Author chain Q； PDBConstruct 1–140； UniProt 1–140 Author chain R； PDBConstruct 1–140； UniProt 1–140 Author chain S； PDBConstruct 1–140； UniProt 1–140 Author chain T； PDBConstruct 1–140； UniProt 1–140

Pre-protein VI

OrganismNot specified

UniProt P24937

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Penton protein × 60 （P12538） Pre-hexon-linking protein IIIa × 60 （P12537） Pre-hexon-linking protein VIII × 120 （P24936） Hexon-interlacing protein × 240 （P03281） Pre-histone-like nucleoprotein × 60 （P68951） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-histone-like nucleoprotein × 1 （P68951） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Penton protein × 5 （P12538） Pre-hexon-linking protein IIIa × 5 （P12537） Pre-hexon-linking protein VIII × 10 （P24936） Hexon-interlacing protein × 20 （P03281） Pre-histone-like nucleoprotein × 5 （P68951） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Penton protein × 6 （P12538） Pre-hexon-linking protein IIIa × 6 （P12537） Pre-hexon-linking protein VIII × 12 （P24936） Hexon-interlacing protein × 24 （P03281） Pre-histone-like nucleoprotein × 6 （P68951） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-histone-like nucleoprotein × 1 （P68951） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6b1t 6b1t 6b1t 6b1t 6b1t 6cgv 6cgv 6cgv 6cgv 6cgv 6cgv 7s78

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CAP6_ADE05
Isoform —
PDB entities 6, 8
Chains and sequence ranges Author chain U； PDBConstruct 1–33； UniProt 1–33 Author chain V； PDBConstruct 1–33； UniProt 1–33 Author chain Y； PDBConstruct 1–33； UniProt 1–33 Author chain X； PDBConstruct 1–217； UniProt 34–250

Pre-histone-like nucleoprotein

OrganismNot specified

UniProt P68951

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1500 Hexon protein × 720 （P04133） Penton protein × 60 （P12538） Pre-hexon-linking protein IIIa × 60 （P12537） Pre-hexon-linking protein VIII × 120 （P24936） Hexon-interlacing protein × 240 （P03281） Pre-protein VI × 180 （P24937） Pre-protein VI × 60 （P24937） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-protein VI × 1 （P24937） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 125 Hexon protein × 60 （P04133） Penton protein × 5 （P12538） Pre-hexon-linking protein IIIa × 5 （P12537） Pre-hexon-linking protein VIII × 10 （P24936） Hexon-interlacing protein × 20 （P03281） Pre-protein VI × 15 （P24937） Pre-protein VI × 5 （P24937） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 150 Hexon protein × 72 （P04133） Penton protein × 6 （P12538） Pre-hexon-linking protein IIIa × 6 （P12537） Pre-hexon-linking protein VIII × 12 （P24936） Hexon-interlacing protein × 24 （P03281） Pre-protein VI × 18 （P24937） Pre-protein VI × 6 （P24937） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 25 Hexon protein × 12 （P04133） Penton protein × 1 （P12538） Pre-hexon-linking protein IIIa × 1 （P12537） Pre-hexon-linking protein VIII × 2 （P24936） Hexon-interlacing protein × 4 （P03281） Pre-protein VI × 3 （P24937） Pre-protein VI × 1 （P24937） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6b1t 6b1t 6b1t 6b1t 6b1t

5 assemblies

View Construct and Data Evidence
UniProt name NP_ADE05
Isoform —
PDB entities 7
Chains and sequence ranges Author chain W； PDBConstruct 1–11； UniProt 14–24

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6b1t
Deposition date deposition_date2017-09-18
Structure title titleImproved cryoEM structure of human adenovirus type 5 with atomic details of minor proteins VI and VII
Keywords keywordshuman adenovirus, cement protein, dsDNA genome packaging, genome-capsid co-assembly, VIRUS; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6b1t__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6b1t__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 1012 1013 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6b1t__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)378.50 Å
Total Rg378.60 Å
Atom count6008040
Residues752640
Excluded volume106190000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6b1t__assembly_1__model_1 1500-meric （1500） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6b1t__assembly_2__model_1 25-meric （25） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 6b1t__assembly_3__model_1 125-meric （125） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 6b1t__assembly_4__model_1 150-meric （150） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 6b1t__assembly_5__model_1 25-meric （25） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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7. Citations (1)