7s78

Structure of a cell-entry defective human adenovirus provides insights into precursor proteins and capsid maturation

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hexon protein

OrganismNot specified

UniProt P04133

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Penton protein × 60 (P12538) Pre-hexon-linking protein IIIa × 60 (P12537) Hexon-interlacing protein × 240 (P03281) Pre-hexon-linking protein VIII × 120 (P24936) Pre-protein VI × 540 (P24937) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Penton protein × 5 (P12538) Pre-hexon-linking protein IIIa × 5 (P12537) Hexon-interlacing protein × 20 (P03281) Pre-hexon-linking protein VIII × 10 (P24936) Pre-protein VI × 45 (P24937) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Penton protein × 6 (P12538) Pre-hexon-linking protein IIIa × 6 (P12537) Hexon-interlacing protein × 24 (P03281) Pre-hexon-linking protein VIII × 12 (P24936) Pre-protein VI × 54 (P24937) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAPSH_ADE05
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–952; UniProt 1–952 Author chain B; PDBConstruct 1–952; UniProt 1–952 Author chain C; PDBConstruct 1–952; UniProt 1–952 Author chain D; PDBConstruct 1–952; UniProt 1–952 Author chain E; PDBConstruct 1–952; UniProt 1–952 Author chain F; PDBConstruct 1–952; UniProt 1–952 Author chain G; PDBConstruct 1–952; UniProt 1–952 Author chain H; PDBConstruct 1–952; UniProt 1–952 Author chain I; PDBConstruct 1–952; UniProt 1–952 Author chain J; PDBConstruct 1–952; UniProt 1–952 Author chain K; PDBConstruct 1–952; UniProt 1–952 Author chain L; PDBConstruct 1–952; UniProt 1–952

Penton protein

OrganismNot specified

UniProt P12538

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Hexon protein × 720 (P04133) Pre-hexon-linking protein IIIa × 60 (P12537) Hexon-interlacing protein × 240 (P03281) Pre-hexon-linking protein VIII × 120 (P24936) Pre-protein VI × 540 (P24937) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Hexon protein × 60 (P04133) Pre-hexon-linking protein IIIa × 5 (P12537) Hexon-interlacing protein × 20 (P03281) Pre-hexon-linking protein VIII × 10 (P24936) Pre-protein VI × 45 (P24937) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Hexon protein × 72 (P04133) Pre-hexon-linking protein IIIa × 6 (P12537) Hexon-interlacing protein × 24 (P03281) Pre-hexon-linking protein VIII × 12 (P24936) Pre-protein VI × 54 (P24937) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAPSP_ADE05
Isoform —
PDB entities 2
Chains and sequence ranges Author chain N; PDBConstruct 1–571; UniProt 1–571

Pre-hexon-linking protein IIIa

OrganismNot specified

UniProt P12537

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Hexon protein × 720 (P04133) Penton protein × 60 (P12538) Hexon-interlacing protein × 240 (P03281) Pre-hexon-linking protein VIII × 120 (P24936) Pre-protein VI × 540 (P24937) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Hexon protein × 60 (P04133) Penton protein × 5 (P12538) Hexon-interlacing protein × 20 (P03281) Pre-hexon-linking protein VIII × 10 (P24936) Pre-protein VI × 45 (P24937) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Hexon protein × 72 (P04133) Penton protein × 6 (P12538) Hexon-interlacing protein × 24 (P03281) Pre-hexon-linking protein VIII × 12 (P24936) Pre-protein VI × 54 (P24937) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAP3_ADE05
Isoform —
PDB entities 3
Chains and sequence ranges Author chain M; PDBConstruct 1–585; UniProt 1–585

Hexon-interlacing protein

OrganismNot specified

UniProt P03281

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Hexon protein × 720 (P04133) Penton protein × 60 (P12538) Pre-hexon-linking protein IIIa × 60 (P12537) Pre-hexon-linking protein VIII × 120 (P24936) Pre-protein VI × 540 (P24937) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Hexon protein × 60 (P04133) Penton protein × 5 (P12538) Pre-hexon-linking protein IIIa × 5 (P12537) Pre-hexon-linking protein VIII × 10 (P24936) Pre-protein VI × 45 (P24937) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Hexon protein × 72 (P04133) Penton protein × 6 (P12538) Pre-hexon-linking protein IIIa × 6 (P12537) Pre-hexon-linking protein VIII × 12 (P24936) Pre-protein VI × 54 (P24937) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Pre-hexon-linking protein VIII × 2 (P24936) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAP9_ADE05
Isoform —
PDB entities 4
Chains and sequence ranges Author chain P; PDBConstruct 1–140; UniProt 1–140 Author chain Q; PDBConstruct 1–140; UniProt 1–140 Author chain R; PDBConstruct 1–140; UniProt 1–140 Author chain S; PDBConstruct 1–140; UniProt 1–140

Pre-hexon-linking protein VIII

OrganismNot specified

UniProt P24936

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Hexon protein × 720 (P04133) Penton protein × 60 (P12538) Pre-hexon-linking protein IIIa × 60 (P12537) Hexon-interlacing protein × 240 (P03281) Pre-protein VI × 540 (P24937) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Hexon protein × 60 (P04133) Penton protein × 5 (P12538) Pre-hexon-linking protein IIIa × 5 (P12537) Hexon-interlacing protein × 20 (P03281) Pre-protein VI × 45 (P24937) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Hexon protein × 72 (P04133) Penton protein × 6 (P12538) Pre-hexon-linking protein IIIa × 6 (P12537) Hexon-interlacing protein × 24 (P03281) Pre-protein VI × 54 (P24937) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-protein VI × 9 (P24937) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAP8_ADE05
Isoform —
PDB entities 5
Chains and sequence ranges Author chain U; PDBConstruct 1–227; UniProt 1–227 Author chain V; PDBConstruct 1–227; UniProt 1–227

Pre-protein VI

OrganismNot specified

UniProt P24937

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1860 Hexon protein × 720 (P04133) Penton protein × 60 (P12538) Pre-hexon-linking protein IIIa × 60 (P12537) Hexon-interlacing protein × 240 (P03281) Pre-hexon-linking protein VIII × 120 (P24936) Unknown-1 × 60 Unknown-2 × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 155 Hexon protein × 60 (P04133) Penton protein × 5 (P12538) Pre-hexon-linking protein IIIa × 5 (P12537) Hexon-interlacing protein × 20 (P03281) Pre-hexon-linking protein VIII × 10 (P24936) Unknown-1 × 5 Unknown-2 × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 186 Hexon protein × 72 (P04133) Penton protein × 6 (P12538) Pre-hexon-linking protein IIIa × 6 (P12537) Hexon-interlacing protein × 24 (P03281) Pre-hexon-linking protein VIII × 12 (P24936) Unknown-1 × 6 Unknown-2 × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 31 Hexon protein × 12 (P04133) Penton protein × 1 (P12538) Pre-hexon-linking protein IIIa × 1 (P12537) Hexon-interlacing protein × 4 (P03281) Pre-hexon-linking protein VIII × 2 (P24936) Unknown-1 × 1 Unknown-2 × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CAP6_ADE05
Isoform —
PDB entities 6
Chains and sequence ranges Author chain 0; PDBConstruct 1–250; UniProt 1–250 Author chain 1; PDBConstruct 1–250; UniProt 1–250 Author chain 2; PDBConstruct 1–250; UniProt 1–250 Author chain 3; PDBConstruct 1–250; UniProt 1–250 Author chain 4; PDBConstruct 1–250; UniProt 1–250 Author chain W; PDBConstruct 1–250; UniProt 1–250 Author chain X; PDBConstruct 1–250; UniProt 1–250 Author chain Y; PDBConstruct 1–250; UniProt 1–250 Author chain Z; PDBConstruct 1–250; UniProt 1–250

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7s78
Deposition date deposition_date2021-09-15
Structure title titleStructure of a cell-entry defective human adenovirus provides insights into precursor proteins and capsid maturation
Keywords keywordsAdenovirus, ts1 mutant, minor protein precursors, virus maturation, VIRUS; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7s78__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7s78__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 1012 1013 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7s78__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)0.00 Å
Rg (electron density)384.40 Å
Total Rg384.50 Å
Atom count6282840
Residues790920
Excluded volume110900000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7s78__assembly_1__model_1 1860-meric (1860) Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7s78__assembly_2__model_1 31-meric (31) Excluded — —
Exclusion reason: Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 7s78__assembly_3__model_1 155-meric (155) Excluded — —
Exclusion reason: Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 7s78__assembly_4__model_1 186-meric (186) Excluded — —
Exclusion reason: Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 7s78__assembly_5__model_1 31-meric (31) Excluded — —
Exclusion reason: Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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7. Citations (1)