INSULIN
Sus scrofa
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain E； UniProt 25–53 Chain E； UniProt 88–108 Chain F； UniProt 25–53 Chain F； UniProt 88–108 | Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 2 | Protein homooligomer Homooligomer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count | Chain E； UniProt 25–53 Chain E； UniProt 88–108 Chain F； UniProt 25–53 Chain F； UniProt 88–108 | Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 6INS | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2C PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.26 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.26；pH 6.26
|
Resolution 1.80 Å R-free 0.223 |
| 1B2C PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.26 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.26；pH 6.26
|
Resolution 1.80 Å R-free 0.223 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2F PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.98 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.98；pH 6.98
|
Resolution 1.90 Å R-free 0.244 |
| 1B2F PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.98 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.98；pH 6.98
|
Resolution 1.90 Å R-free 0.244 |
| 1B2G PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 9.00 COORDINATES) Deposited 1998-11-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 9；pH 9.00
|
Resolution 1.80 Å R-free 0.226 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–47（23 aa）
Chain C
88–108（21 aa）
Chain D
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state | Assembly 7 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different mutation/modification Different oligomeric state | Assembly 8 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1M5A Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution Deposited 2002-07-09 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | CO COBALT (II) ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SLOW COOLING；pH 6.3；300 K；cobalt acetate, trisodium citrate, acetone, hydrochloric acid, pH 6.3, SLOW COOLING, temperature 300K
|
Resolution 1.20 Å R-free 0.241 |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1SDB PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN Deposited 1996-01-29 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
27–49（23 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.65 Å R-free 0.220 |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 10 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 11 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 12 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | IPH PHENOL × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 6 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1ZEI CROSS-LINKED B28 ASP INSULIN Deposited 1998-07-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–51（51 aa）
Chain B
1–51（51 aa）
Chain C
1–51（51 aa）
Chain D
1–51（51 aa）
Chain E
1–51（51 aa）
Chain F
1–51（51 aa）
|
Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D | CRS M-CRESOL × 8 ZN ZINC ION × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.4；pH 6.4
|
Resolution 1.90 Å R-free 0.232 |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 9 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 9 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 2EFA Neutron crystal structure of cubic insulin at pD6.6 Deposited 2007-02-22 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain
Chain B
25–54（30 aa）
Fragment：Insulin B chain
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 6.6；298 K；0.2M Sodium phosphate, 8mM 3NaEDTA, pH 6.6(PD), MICRODIALYSIS, temperature 298K
|
Resolution 2.70 Å R-free 0.291 |
| 2EFA Neutron crystal structure of cubic insulin at pD6.6 Deposited 2007-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain
Chain B
25–54（30 aa）
Fragment：Insulin B chain
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 6.6；298 K；0.2M Sodium phosphate, 8mM 3NaEDTA, pH 6.6(PD), MICRODIALYSIS, temperature 298K
|
Resolution 2.70 Å R-free 0.291 |
| 2G4M Insulin collected at 2.0 A wavelength Deposited 2006-02-22 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.223 |
| 2G4M Insulin collected at 2.0 A wavelength Deposited 2006-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.223 |
| 2TCI X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SCN THIOCYANATE ION × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 2TCI X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 2ZPP Neutron crystal structure of cubic insulin at pD9 Deposited 2008-07-26 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 9；298 K；0.2M sodium phosphate, 10mM 3NaEDTA, pH 9.0, MICRODIALYSIS, temperature 298K
|
Resolution 2.50 Å R-free 0.260 |
| 3FHP A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution Deposited 2008-12-09 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Fragment：UNP residues 88-108
Chain B
25–54（30 aa）
Fragment：UNP residues 25-54
Chain C
88–108（21 aa）
Fragment：UNP residues 88-108
Chain D
25–54（30 aa）
Fragment：UNP residues 25-54
|
Not recorded | ZN ZINC ION × 6 |
NEUTRON DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.3；293 K；2.3mg/ml insulin, 50mM sodium citrate, 6mM zinc acetate, 17% acetone, pH6.3, LIQUID DIFFUSION, temperature 293K
|
Resolution 2.00 Å R-free 0.247 |
| 3GKY The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape Deposited 2009-03-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 CL CHLORIDE ION × 6 IPH PHENOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.1；298 K；0.02 M Tris, 0.05 M sodium citrate, 5% acetone, 0.03% phenol, 0.01% zinc acetate, pH 8.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.253 |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different construct Different oligomeric state Different experimental method Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different construct Different oligomeric state Different experimental method Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 3 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 3 ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3RTO Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure Deposited 2011-05-03 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain (UNP residues 88-108)
Chain B
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
Chain C
88–108（21 aa）
Fragment：Insulin A chain (UNP residues 88-108)
Chain D
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
|
Not recorded | ZN ZINC ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6；Microcrystals are obtained by dissolving 0.025 g protein in 5 mL of crystallizing solution (200 mL 0.02 M HCl, 100 mL 0.20 M sodium citrate, 60 mL acetone, 20 mL water, 20 mL 0.12 M zinc sulfate) at 315K. The solution is then rapidly quenched to 293K by immersing it in a cool water bath. Quenching speed determines the resulting crystal size. 20-micron crystals are obtained by quenching in a 293K water bath, 10-micron crystals by quenching in a 283K water bath, and 5-micron crystals by quenching in ice water. pH 6.0, SMALL TUBES
|
Resolution 1.80 Å R-free 0.223 |
| 3T2A TMAO-grown cubic insulin (porcine) Deposited 2011-07-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | TMO trimethylamine oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；Protein: 10 mg/mL in 50 mM CAPS pH 11;
Well: 1.2 M TMAO, 0.1 M malate, pH 5.5
, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.223 |
| 3T2A TMAO-grown cubic insulin (porcine) Deposited 2011-07-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | TMO trimethylamine oxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；Protein: 10 mg/mL in 50 mM CAPS pH 11;
Well: 1.2 M TMAO, 0.1 M malate, pH 5.5
, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.223 |
| 4A7E X-ray crystal structure of porcine insulin flash-cooled at high pressure Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 10；0.5 M SODIUM PHOSPHATE, 0.01 M EDTA, PH 10.0
|
Resolution 1.86 Å R-free 0.217 |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different oligomeric state Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different oligomeric state Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different construct Different oligomeric state Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 5D52 In meso in situ serial X-ray crystallography structure of insulin at room temperature Deposited 2015-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.80 Å R-free 0.214 |
| 5D53 In meso in situ serial X-ray crystallography structure of insulin at 100 K Deposited 2015-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.50 Å R-free 0.170 |
| 5D54 In meso X-ray crystallography structure of insulin at 100 K Deposited 2015-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.50 Å R-free 0.188 |
| 5D5E In meso in situ serial X-ray crystallography structure of insulin by sulfur-SAD at 100 K Deposited 2015-08-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 2.41 Å R-free 0.220 |
| 5FB6 Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering Deposited 2015-12-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.6 M Na2HPO4 0.01 M EDTA
|
Resolution 1.90 Å R-free 0.173 |
| 5LIS Insulin solved by Native SAD from a dataset collected in one second Deposited 2016-07-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；30% ethylene glycol
|
Resolution 2.29 Å R-free 0.262 |
| 6Z7Z Porcine insulin in complex with the analytical antibody OXI-005 Fab Deposited 2020-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium chloride, 20 % (w/v) PEG 3350
|
Resolution 2.40 Å R-free 0.259 |
| 6Z7Z Porcine insulin in complex with the analytical antibody OXI-005 Fab Deposited 2020-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium chloride, 20 % (w/v) PEG 3350
|
Resolution 2.40 Å R-free 0.259 |
| 7AC4 Structure of insulin collected by rotation serial crystallography on a COC membrane at a synchrotron source Deposited 2020-09-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PGR R-1,2-PROPANEDIOL × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；50mM Na2HPO4, 10mM EDTA pH 10.8
|
Resolution 1.46 Å R-free 0.180 |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 10 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
25–54（30 aa）
Chain D
25–54（30 aa）
Chain F
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 11 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 2 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different ligand/ion | Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different ligand/ion | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different ligand/ion | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 4 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 6 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 5 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 3 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different oligomeric state Different ligand/ion | Assembly 6 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 4 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 7 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 8 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain B
25–54（30 aa）
Chain D
25–54（30 aa）
Chain F
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 7INS STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Deposited 1991-09-03 | Different construct Different oligomeric state Different ligand/ion | Assembly 9 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | CRS M-CRESOL × 2 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 9INS MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS Deposited 1991-10-23 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 9INS MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS Deposited 1991-10-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
41 other PDB entries and 125 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | INS_PIG |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain E； PDBConstruct 1–29； UniProt 25–53 Author chain E； PDBConstruct 30–50； UniProt 88–108 Author chain F； PDBConstruct 1–29； UniProt 25–53 Author chain F； PDBConstruct 30–50； UniProt 88–108 |
