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6jk8

Cryo-EM structure of the full-length human IGF-1R in complex with insulin

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Insulin-like growth factor 1 receptor

Homo sapiens

UniProt P08069

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 4 其他Polymer 5 Insulin × 2 （P01308） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ;alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jqh 1jqh 1jqh 1m7n 1m7n 1p4o 1p4o 2oj9 2zm3 2zm3 2zm3 2zm3

71 assemblies; showing the first 12

Homodimer
1p4o 3d94 7xgd 7xlc

4 assemblies

Homotetramer

None

Other homooligomers
2zm3 3f5p

2 assemblies

Heteromeric or nucleic-acid complex
1igr 1k3a 5u8q 5u8r 6jk8 6vwg 6vwh 6vwi 6vwj 7s0q 7s8v 7u23

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name IGF1R_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1367； UniProt 1–1367 Author chain B； PDBConstruct 1–1367； UniProt 1–1367

Insulin

Homo sapiens

UniProt P01308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 4 其他Polymer 5 Insulin-like growth factor 1 receptor × 2 （P08069） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ;alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1efe 1sju 1t0c 2jzq 2kqp 2lwz 4efx 4efx 4efx 4efx 5wbt 8pi6

16 assemblies; showing the first 12

Homodimer
1a7f 1ben 1ben 1guj 1guj 1hiq 1his 1hit 1hls 1hui 1iog 1ioh

155 assemblies; showing the first 12

Homotetramer
1b9e 1b9e 1fub 1lph 1lph 1trz 1trz 1tyl 1tyl 1tym 1tym 1xda

69 assemblies; showing the first 12

Other homooligomers
1ai0 1aiy 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben

244 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2g54 2g54 2g56 2g56 2wby 2wby 2wc0 2wc0 3utq 3uts 3uts 3utt

100 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name INS_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–110； UniProt 1–110 Author chain D； PDBConstruct 1–110； UniProt 1–110

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6jk8
Deposition date deposition_date2019-02-27
Structure title titleCryo-EM structure of the full-length human IGF-1R in complex with insulin
Keywords keywordshuman type 1 insulin-like growth factor receptor; insulin, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6jk8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6jk8__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6jk8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）48.92 Å
Rg (electron density)48.78 Å
Total Rg48.86 Å
Atom count13646
Residues1670
Excluded volume241790 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6jk8__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)