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6o8b

Crystal structure of STING CTD in complex with TBK1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Stimulator of interferon genes protein

Homo sapiens

UniProt Q86WV6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Serine/threonine-protein kinase TBK1 × 2 （Q9UHD2） N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8b2j 8b2j 9kya

3 assemblies

Homodimer
4ef4 4ef5 4emt 4emu 4f5d 4f5e 4f5w 4f5y 4f9e 4f9g 4ksy 4loh

65 assemblies; showing the first 12

Homotetramer
4emt 4emu 7sii 8flk 8flm 9ct3 9ct4 9dan 9dat 9dav 9daw 9jw6

14 assemblies; showing the first 12

Other homooligomers
9ct5 9ct6 9swr

3 assemblies

Heteromeric or nucleic-acid complex
5jej 6o8b 6o8c 7r4h 8ik3 8ywb

6 assemblies

View Construct and Data Evidence
UniProt name STING_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain D； PDBConstruct 2–226； UniProt 155–379 Author chain E； PDBConstruct 2–226； UniProt 155–379

Serine/threonine-protein kinase TBK1

Homo sapiens

UniProt Q9UHD2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Stimulator of interferon genes protein × 2 （Q86WV6） N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4efo 4efo 4im2 4iwq 6bny 6bod 6boe 6cq0 6cq4 6cq5 6rsu

11 assemblies

Homodimer
4eut 4euu 4im0 4im2 4im3 4iw0 4iwo 4iwp 4iwq 5w5v 6rsr 6rst

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5eoa 5eof 5ep6 5ep6 6nt9 6o8b

6 assemblies

View Construct and Data Evidence
UniProt name TBK1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain A； PDBConstruct 10–665； UniProt 2–657 Author chain B； PDBConstruct 10–665； UniProt 2–657

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6o8b
Deposition date deposition_date2019-03-09
Structure title titleCrystal structure of STING CTD in complex with TBK1
Keywords keywordsAdaptor, Kinase, Complex, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6o8b__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6o8b__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6o8b__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）39.70 Å
Rg (electron density)39.49 Å
Total Rg39.77 Å
Atom count10897
Residues1336
Excluded volume194620 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6o8b__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id6o8bA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id6o8bA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id6o8bA03
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Domain ID domain_id6o8bA04
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1270 — Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homologous superfamily homologous superfamily420 —
Domain ID domain_id6o8bB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id6o8bB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id6o8bB03
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Domain ID domain_id6o8bB04
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1270 — Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homologous superfamily homologous superfamily420 —
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7. Citations (1)