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6r8f

Cryo-EM structure of the Human BRISC-SHMT2 complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Lys-63-specific deubiquitinase BRCC36

Homo sapiens

UniProt P46736

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 BRISC complex subunit Abraxas 2 × 2 （Q15018） Serine hydroxymethyltransferase, mitochondrial × 2 （P34897） BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2) × 2 （Q9NXR7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6h3c 6r8f 8pvy 8py2

4 assemblies

View Construct and Data Evidence
UniProt name BRCC3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–316； UniProt 1–316 Author chain C； PDBConstruct 1–316； UniProt 1–316

BRISC complex subunit Abraxas 2

Homo sapiens

UniProt Q15018

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Lys-63-specific deubiquitinase BRCC36 × 2 （P46736） Serine hydroxymethyltransferase, mitochondrial × 2 （P34897） BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2) × 2 （Q9NXR7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6h3c 6r8f 8pvy 8py2

4 assemblies

View Construct and Data Evidence
UniProt name ABRX2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–267； UniProt 1–267 Author chain D； PDBConstruct 1–267； UniProt 1–267

Serine hydroxymethyltransferase, mitochondrial

Homo sapiens

UniProt P34897

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Lys-63-specific deubiquitinase BRCC36 × 2 （P46736） BRISC complex subunit Abraxas 2 × 2 （Q15018） BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2) × 2 （Q9NXR7） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6dk3

1 assemblies

Homodimer
5v7i 5x3v 6dk3 6m5o 6qvg 6qvl 7byi 8fjt 8fju 8xna 9box 9box

12 assemblies

Homotetramer
4pvf 8aql 8gks 8gkt 8gku 8gkw 8gky 8gkz 8qi7 8ssj 8t4o 8t4p

14 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex
6h3c 6r8f

2 assemblies

View Construct and Data Evidence
UniProt name GLYM_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain K； PDBConstruct 1–504； UniProt 1–504 Author chain L； PDBConstruct 1–504； UniProt 1–504

BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2)

Homo sapiens

UniProt Q9NXR7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Lys-63-specific deubiquitinase BRCC36 × 2 （P46736） BRISC complex subunit Abraxas 2 × 2 （Q15018） Serine hydroxymethyltransferase, mitochondrial × 2 （P34897） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6h3c 6r8f 8pvy 8py2

4 assemblies

View Construct and Data Evidence
UniProt name BABA2_HUMAN
Isoform Q9NXR7-1
PDB entities 4
Chains and sequence ranges Author chain E； PDBConstruct 3–133； UniProt 1–131 Author chain G； PDBConstruct 3–133； UniProt 1–131

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6r8f
Deposition date deposition_date2019-04-01
Structure title titleCryo-EM structure of the Human BRISC-SHMT2 complex
Keywords keywordsComplex, Deubiquitylation, Ubiquitin, Immune signalling, signaling protein; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6r8f__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6r8f__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6r8f__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）45.62 Å
Rg (electron density)44.73 Å
Total Rg45.01 Å
Atom count15810
Residues2164
Excluded volume278740 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6r8f__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)