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6ukt

Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)

Rattus norvegicus

UniProt B1H241

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Guanine nucleotide-binding protein G(i) subunit alpha-1 × 1 （P10824） NB8109 × 1 NB8117 × 1 NB8119 × 1 NB9156 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6nmg 6nmg 6nmj 6nmj

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6tyl 6tyl 6ukt 6vu8 8alh

5 assemblies

View Construct and Data Evidence
UniProt name B1H241_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–492； UniProt 1–491

Guanine nucleotide-binding protein G(i) subunit alpha-1

Rattus norvegicus

UniProt P10824

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) × 1 （B1H241） NB8109 × 1 NB8117 × 1 NB8119 × 1 NB9156 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1as0 1as2 1as3 1bh2 1bof 1cip 1gdd 1gfi 1gia 1gil 1git 1svk

26 assemblies; showing the first 12

Homodimer
2zjz

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1agr 1agr 1fqj 1fqj 1fqk 1fqk 1gg2 1gp2 1shz 1shz 1shz 2bcj

31 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GNAI1_RAT
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–323； UniProt 32–354

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6ukt
Deposition date deposition_date2019-10-05
Structure title titleCryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex
Keywords keywordsRic-8A, G protein, GEF, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6ukt__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6ukt__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6ukt__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）39.32 Å
Rg (electron density)38.23 Å
Total Rg38.56 Å
Atom count8979
Residues1202
Excluded volume157880 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6ukt__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id6uktA01
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
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7. Citations (1)