Microtubule-associated protein tau
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count | Chain A； UniProt 1–441 Chain B； UniProt 1–441 Chain C； UniProt 1–441 | Not recorded | No other associated polymer | ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE | Resolution 3.36 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 7QKG | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 10IJ S305I Frontotemporal Lobar Degeneration (FTLD) type I tau filament Deposited 2026-01-21 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 11 PDB declaration: 11-meric |
Chain A
590–696（107 aa）
Chain B
590–696（107 aa）
Chain C
590–696（107 aa）
Chain D
590–696（107 aa）
Chain E
590–696（107 aa）
Chain F
590–696（107 aa）
Chain G
590–696（107 aa）
Chain H
590–696（107 aa）
Chain I
590–696（107 aa）
Chain J
590–696（107 aa）
Chain K
590–696（107 aa）
|
Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 10IK S305I Frontotemporal Lobar Degeneration (FTLD) type II tau filament Deposited 2026-01-21 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
590–696（107 aa）
Chain B
590–696（107 aa）
Chain C
590–696（107 aa）
Chain D
590–696（107 aa）
Chain E
590–696（107 aa）
Chain F
590–696（107 aa）
Chain G
590–696（107 aa）
Chain H
590–696（107 aa）
Chain I
590–696（107 aa）
Chain J
590–696（107 aa）
|
Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 1I8H SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH HUMAN TAU PHOSPHOTHREONINE PEPTIDE Deposited 2001-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
541–553（13 aa）
Fragment：(RESIDUES 541-553)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.4；285 K；Ionic strength (raw mmCIF value) 100 mM NaCl；Pressure ambient
NMR sample composition
sample of 1mM Pin1 WW domain / 11mM tau ligand
buffer of 50 mM deutered Tris-D2O,
pH 6.4, 100 mM NaCl | 90% H2O/10% D2O
|
Resolution not provided |
| 22JY P301L/S320F human tau filaments from mouse brain Deposited 2026-01-14 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
596–646（51 aa）
Chain B
596–646（51 aa）
Chain C
596–646（51 aa）
Chain D
596–646（51 aa）
Chain E
596–646（51 aa）
|
Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.20 Å |
| 2MZ7 Structure of Tau(267-312) bound to Microtubules Deposited 2015-02-06 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
584–629（46 aa）
Fragment：UNP residues 584-629
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.8；278 K；Pressure ambient
NMR sample composition
50 mM sodium phosphate, 1 mM Tau, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
50 mM sodium phosphate, 1 mM Tau, 50 uM microtubules, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 3OVL Structure of an amyloid forming peptide VQIVYK from the TAU protein in complex with orange G Deposited 2010-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
623–628（6 aa）
Fragment：VQIVYK (residues 306-311)
|
Not recorded | ZN ZINC ION × 12 ACY ACETIC ACID × 6 ORA 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；reservoir contained 0.1M Zinc Acetate dihydrate, 18% PEG 3350, vapor diffusion, hanging drop, temperature 291K
|
Resolution 1.81 Å R-free 0.259 |
| 4FL5 Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 Deposited 2012-06-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–536（10 aa）
Fragment：UNP residues 527-536
Chain Q
527–536（10 aa）
Fragment：UNP residues 527-536
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 2 MG MAGNESIUM ION × 4 CA CALCIUM ION × 6 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1 M Hepes/NaOH pH 7.5, 0.2 M CaCl2, 28% PEG 400, 5% glycerol, 2 mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.212 |
| 4NP8 Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) Deposited 2013-11-20 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
623–628（6 aa）
Fragment：UNP residues 623-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；reservoir contained 14% iso-Propanol, 0.07M HEPES-Na pH 7.5, 0.14M Sodium Citrate, and 30% Glycerol, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.51 Å R-free 0.196 |
| 4TQE Structure of tau peptide in complex with Tau5 antibody Fab fragment Deposited 2014-06-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
532–547（16 aa）
Fragment：Residues 532-547
|
Not recorded | SO4 SULFATE ION × 5 NA SODIUM ION × 4 PGE TRIETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.2M lithium sulphate, 30% PEG 4000, 0.1M Tris pH 8.5
|
Resolution 1.60 Å R-free 0.197 |
| 4Y5I Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma Deposited 2015-02-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain F
528–534（7 aa）
Fragment：UNP residues 528-534
Chain G
528–534（7 aa）
Fragment：UNP residues 528-534
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.1；277 K；0.1 M Hepes/NaOH pH 7.1, 0.19 M CaCl2, 24% PEG 400, 5% glycerol
|
Resolution 1.40 Å R-free 0.172 |
| 5MO3 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 8.5 Deposited 2016-12-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
615–628（14 aa）
Fragment：UNP residues 615-628
|
Not recorded | PGE TRIETHYLENE GLYCOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；30% PEG 4000, 0.1 M Tris, 0.2 M LiSO4
|
Resolution 1.69 Å R-free 0.235 |
| 5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
|
Resolution 3.10 Å R-free 0.268 |
| 5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
|
Resolution 3.10 Å R-free 0.268 |
| 5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
|
Resolution 3.10 Å R-free 0.268 |
| 5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
|
Resolution 3.10 Å R-free 0.268 |
| 5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain K
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
|
Resolution 2.31 Å R-free 0.277 |
| 5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
|
Resolution 2.31 Å R-free 0.277 |
| 5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain J
615–628（14 aa）
Fragment：UNP Residues 615-628
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
|
Resolution 2.31 Å R-free 0.277 |
| 5N5A Structure of Tau(254-290) bound to F-actin Deposited 2017-02-13 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
571–607（37 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.8；278 K；Pressure ambient
NMR measurement conditions
pH 6.8；278 K；Pressure ambient
NMR sample composition
800 uM Tau(254-290), 27 uM F-actin, 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
800 uM Tau(254-290), 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5N5B Structure of Tau(292-319) bound to F-actin Deposited 2017-02-13 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
609–636（28 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.8；278 K；Pressure ambient
NMR measurement conditions
pH 6.8；278 K；Pressure ambient
NMR sample composition
800 uM Tau(292-319), 27 uM F-actin, 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
800 uM Tau(254-290), 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5O3L Paired helical filament in Alzheimer's disease brain Deposited 2017-05-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain B
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain C
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain D
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain E
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain F
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain G
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain H
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain I
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain J
623–695（73 aa）
Fragment：UNP Residues 623-695
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 5O3O Pronase-treated paired helical filament in Alzheimer's disease brain Deposited 2017-05-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain B
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain C
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain D
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain E
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain F
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain G
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain H
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain I
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain J
623–695（73 aa）
Fragment：UNP Residues 623-695
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 5O3T Straight filament in Alzheimer's disease brain Deposited 2017-05-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain B
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain C
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain D
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain E
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain F
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain G
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain H
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain I
623–695（73 aa）
Fragment：UNP Residues 623-695
Chain J
623–695（73 aa）
Fragment：UNP Residues 623-695
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 5V5B KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 Deposited 2017-03-13 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric |
Chain A
591–600（10 aa）
Fragment：Repeat 2 peptide (UNP residues 591-600)
|
Not recorded | No recorded non-water small molecule |
ELECTRON CRYSTALLOGRAPHY
cryo-EM buffer
pH 4.2
cryo-EM vitrification conditions
Cryogen ETHANE
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；310 K；0.1 M phosphate citrate, 32% PEG10000
|
Resolution 1.50 Å R-free 0.213 |
| 5V5B KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 Deposited 2017-03-13 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric |
Chain A
591–600（10 aa）
Fragment：Repeat 2 peptide (UNP residues 591-600)
|
Not recorded | No recorded non-water small molecule |
ELECTRON CRYSTALLOGRAPHY
cryo-EM buffer
pH 4.2
cryo-EM vitrification conditions
Cryogen ETHANE
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；310 K；0.1 M phosphate citrate, 32% PEG10000
|
Resolution 1.50 Å R-free 0.213 |
| 5ZV3 Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide Deposited 2018-05-09 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
52–71（20 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.085M Tris-HCl, pH 8.5, 0.17M sodium acetate, 25.5% PEG 4000
|
Resolution 2.09 Å R-free 0.251 |
| 6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
703–725（23 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
|
Resolution 2.10 Å R-free 0.270 |
| 6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain Q
703–725（23 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
|
Resolution 2.10 Å R-free 0.270 |
| 6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain R
703–725（23 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
|
Resolution 2.10 Å R-free 0.270 |
| 6DC8 Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 3 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；23% polyethylene glycol 8000, 0.17 M ammonium acetate, and 0.085 M sodium cacodylate trihydrate pH 6.5
|
Resolution 1.80 Å R-free 0.219 |
| 6DC9 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25.5% polyethylene glycol 4000 and 0.17 M ammonium sulfate
|
Resolution 3.00 Å R-free 0.260 |
| 6DC9 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain Q
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25.5% polyethylene glycol 4000 and 0.17 M ammonium sulfate
|
Resolution 3.00 Å R-free 0.260 |
| 6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
|
Resolution 2.60 Å R-free 0.259 |
| 6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain Q
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
|
Resolution 2.60 Å R-free 0.259 |
| 6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain R
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
|
Resolution 2.60 Å R-free 0.259 |
| 6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain S
696–725（30 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
|
Resolution 2.60 Å R-free 0.259 |
| 6GX5 Narrow Pick Filament from Pick's disease brain Deposited 2018-06-26 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
196–289（94 aa）
Chain B
196–289（94 aa）
Chain C
196–289（94 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain I
739–764（26 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
|
Resolution 2.63 Å R-free 0.270 |
| 6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain K
739–764（26 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
|
Resolution 2.63 Å R-free 0.270 |
| 6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain G
739–764（26 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
|
Resolution 2.63 Å R-free 0.270 |
| 6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain J
739–764（26 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
|
Resolution 2.63 Å R-free 0.270 |
| 6HRE Paired helical filament from sporadic Alzheimer's disease brain Deposited 2018-09-26 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 6HRF Straight filament from sporadic Alzheimer's disease brain Deposited 2018-09-26 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 6N4P RQEFEV, crystal structure of the N-terminal segment RQEFEV from protein tau Deposited 2018-11-19 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
5–10（6 aa）
Fragment：UNP residues 5-10
Chain C
5–10（6 aa）
Fragment：UNP residues 5-10
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M ammonium citrate dibasic, 30% PEG3350
|
Resolution 1.85 Å R-free 0.269 |
| 6NK4 KVQIINKKL, crystal structure of a tau protein fragment Deposited 2019-01-04 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
591–599（9 aa）
Fragment：repeat 2 peptide (UNP residues 591-599)
|
Not recorded | No recorded non-water small molecule |
ELECTRON CRYSTALLOGRAPHY
cryo-EM vitrification conditions
Cryogen ETHANE
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M lithium citrate, 20% PEG3350
|
Resolution 1.99 Å R-free 0.299 |
| 6NWP Chronic traumatic encephalopathy Type I Tau filament Deposited 2019-02-07 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 6NWQ Chronic traumatic encephalopathy Type II Tau filament Deposited 2019-02-07 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 6ODG SVQIVY, Crystal Structure of a tau protein fragment Deposited 2019-03-26 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
622–627（6 aa）
Fragment：UNP residues 622-627
Chain B
622–627（6 aa）
Fragment：UNP residues 622-627
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；291 K；3.3 mg/mL SVQIVY, 0.667 M DL-malic acid, pH 7.0, 8% w/v PEG3350
|
Resolution 1.00 Å R-free 0.266 |
| 6PXR Anti-TAU BIIB092 FAB with TAU peptide Deposited 2019-07-26 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
15–22（8 aa）
Fragment：UNP residues 15-22
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；100 mM Tris-HCl, pH 8.5, 20% w/v PEG2000 MME, 200 mM trimethylamine N-oxide, 100 mM non-detergent sulfobetaine 201
|
Resolution 1.56 Å R-free 0.268 |
| 6QJH Cryo-EM structure of heparin-induced 2N4R tau snake filaments Deposited 2019-01-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
243–301（59 aa）
Chain B
243–301（59 aa）
Chain C
243–301（59 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.30 Å |
| 6QJM Cryo-EM structure of heparin-induced 2N4R tau twister filaments Deposited 2019-01-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
274–321（48 aa）
Chain B
274–321（48 aa）
Chain C
274–321（48 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.30 Å |
| 6QJP Cryo-EM structure of heparin-induced 2N4R tau jagged filaments Deposited 2019-01-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
274–321（48 aa）
Chain B
274–321（48 aa）
Chain C
274–321（48 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.50 Å |
| 6QJQ Cryo-EM structure of heparin-induced 2N3R tau filaments Deposited 2019-01-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
214–241（28 aa）
Chain B
214–241（28 aa）
Chain C
214–241（28 aa）
Chain D
214–241（28 aa）
Chain E
214–241（28 aa）
Chain F
214–241（28 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.70 Å |
| 6TJO Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration Deposited 2019-11-26 | Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.20 Å |
| 6TJX Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration Deposited 2019-11-27 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
|
Resolution 3.00 Å |
| 6VH7 Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue Deposited 2020-01-09 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
216–322（107 aa）
Chain B
216–322（107 aa）
Chain C
216–322（107 aa）
Chain E
216–322（107 aa）
Chain F
216–322（107 aa）
Chain G
216–322（107 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 6VHA Singlet Tau Fibril from Corticobasal Degeneration Human Brain Tissue Deposited 2020-01-09 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain E
216–322（107 aa）
Chain F
216–322（107 aa）
Chain G
216–322（107 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.30 Å |
| 6VHL Paired Helical Filament from Alzheimer's Disease Human Brain Tissue Deposited 2020-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
|
Not recorded | GLY GLYCINE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 6VI3 Straight Filament from Alzheimer's Disease Human Brain Tissue Deposited 2020-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
|
Not recorded | GLY GLYCINE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
527–539（13 aa）
Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
|
Resolution 2.00 Å R-free 0.213 |
| 6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
527–539（13 aa）
Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
|
Resolution 2.00 Å R-free 0.213 |
| 6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
527–539（13 aa）
Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
|
Resolution 2.00 Å R-free 0.213 |
| 7NRQ Paired helical filament from primary age-related tauopathy brain Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.76 Å |
| 7NRS Conformation 1 of straight filament from primary age-related tauopathy brain Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.68 Å |
| 7NRT Conformation 2 of straight filament from primary age-related tauopathy brain Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.68 Å |
| 7NRV Paired helical filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain D
1–441（441 aa）
Chain G
1–441（441 aa）
Chain I
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7NRV Paired helical filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain C
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain H
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7NRX Straight filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain D
1–441（441 aa）
Chain F
1–441（441 aa）
Chain H
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.55 Å |
| 7NRX Straight filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain C
1–441（441 aa）
Chain E
1–441（441 aa）
Chain G
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.55 Å |
| 7P65 Progressive supranuclear palsy tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 7P66 Globular glial tauopathy type 1 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 7P67 Globular glial tauopathy type 2 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 7P68 Globular glial tauopathy type 3 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 7P6A Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.90 Å |
| 7P6B Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.20 Å |
| 7P6C Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 7P6D Argyrophilic grain disease type 1 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 7P6E Argyrophilic grain disease type 2 tau filament Deposited 2021-07-15 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
Chain Q
1–441（441 aa）
Chain R
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7PQC tau-microtubule structural ensemble based on CryoEM data Deposited 2021-09-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric |
Chain O
202–395（194 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 7 MG MAGNESIUM ION × 7 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.10 Å |
| 7PQP tau-microtubule structural ensemble based on CryoEM data Deposited 2021-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric |
Chain O
202–395（194 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 7 MG MAGNESIUM ION × 7 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.10 Å |
| 7QJV In vitro assembled tau filaments into Quadruple Helical Filaments type 1 (2c) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
Chain K
1–441（441 aa）
Chain L
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.29 Å |
| 7QJW In vitro assembled tau filaments with structures like chronic traumatic encephalopathy type II (8a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.81 Å |
| 7QJX In vitro assembled 297-394 tau filaments, 700 rpm (34b) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
Chain K
1–441（441 aa）
Chain L
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.99 Å |
| 7QJY In vitro assembled 266/297 - 391 tau filaments with LiCl (9a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 7QJZ In vitro assembled 266/297 - 391 tau filaments with LiCl (9b) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7QK1 In vitro assembled 297-394 tau filaments in PBS (35d) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.03 Å |
| 7QK2 In vitro assembled 300-391 tau filaments in PBS (36a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.61 Å |
| 7QK3 In vitro assembled 258-391 tau filaments, 700 rpm (38a) Deposited 2021-12-17 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.44 Å |
| 7QK5 In vitro assembled 266/297 - 391 tau filaments with KCl (10a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain K
1–441（441 aa）
|
Not recorded | CL CHLORIDE ION × 18 K POTASSIUM ION × 18 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.92 Å |
| 7QK6 In vitro assembled 258-391 tau filaments with heparan sulfate, 700 rpm (40a) Deposited 2021-12-17 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.27 Å |
| 7QKF In vitro assembled 266/297 - 391 tau filaments with CuCl2 (12a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.83 Å |
| 7QKH In vitro assembled 258-391 tau filaments with sodium azide, (41a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain G
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.17 Å |
| 7QKI In vitro assembled 297-408 S396D S400D T403D S404D tau filaments (42a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.13 Å |
| 7QKJ In vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14b) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
Chain K
1–441（441 aa）
Chain L
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.26 Å |
| 7QKK In vitro assembled 258-391 tau filaments with phosphoglycerate, 700 rpm (39a) Deposited 2021-12-17 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 7QKL In vitro assembled 266/297 - 391 tau filaments with ZnCl2 (11a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.07 Å |
| 7QKM In vitro assembled 266-391 S356D tau filaments with NaCl (45a) Deposited 2021-12-17 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.66 Å |
| 7QKU in vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14a) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.57 Å |
| 7QKV In vitro assembled tau filaments with MgSO4 and NaCl (15a) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.23 Å |
| 7QKW In vitro assembled 266-391 S356D tau filaments with KCl (44a) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.32 Å |
| 7QKX In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15b) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain G
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 7QKY In vitro assembled 0N4R tau filaments with phosphoserine (47a) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.86 Å |
| 7QKZ In vitro assembled 305-379 tau filaments (27a) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 7QL0 In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15c) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain c
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.13 Å |
| 7QL1 In vitro assembled 266-391 tau filaments in PBS (23a) Deposited 2021-12-19 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.34 Å |
| 7QL2 In vitro assembled 244-391 tau filaments with Na2P2O7 (20a) Deposited 2021-12-19 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 7QL3 in vitro assembled 266/297 - 391 tau filaments with NaCl (8b) Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.32 Å |
| 7QL4 in vitro assembled tau filaments with structures like Paired Helical Filaments from Alzheimer's Disease Deposited 2021-12-19 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 7R4T In vitro assembled 266/297 - 391 tau filaments with NaHCO3 and NaCl (16a) Deposited 2022-02-09 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.75 Å |
| 7R5H In vitro assembled 266/297 - 391 tau filaments with KCl (10b) Deposited 2022-02-10 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.59 Å |
| 7U0Z High-resolution map of tau filament from progressive supranuclear palsy (PSP) case 1 Deposited 2022-02-19 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
243–352（110 aa）
Fragment：UNP residues 243-352
Chain B
243–352（110 aa）
Fragment：UNP residues 243-352
Chain C
243–352（110 aa）
Fragment：UNP residues 243-352
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.20 Å |
| 7YMN Cryo-EM structure of in vitro PHF fibril Deposited 2022-07-28 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
239–333（95 aa）
Chain B
239–333（95 aa）
Chain C
239–333（95 aa）
Chain D
239–333（95 aa）
Chain E
239–333（95 aa）
Chain F
239–333（95 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.46 Å |
| 7YPG Cryo-EM structure of amyloid fibril formed by tau (297-391) Deposited 2022-08-03 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
268–362（95 aa）
Chain B
268–362（95 aa）
Chain C
268–362（95 aa）
Chain D
268–362（95 aa）
Chain E
268–362（95 aa）
Chain F
268–362（95 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 8AZU Paired helical tau filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | PHF Tau Deposited 2022-09-06 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8BGS Tau Paired Helical Filament from Extracellular Vesicles from Alzheimer's disease brain Deposited 2022-10-28 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain r
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 8BGV Tau Paired Helical Filament from Cellular Fraction of Alzheimer's disease brain Deposited 2022-10-28 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain n
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.27 Å |
| 8BYN Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir Deposited 2022-12-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | S9C 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 8CAQ Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis Deposited 2023-01-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 8CAX Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis Deposited 2023-01-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 8FNZ Acetylated tau repeat 1 and 2 fragment (AcR1R2) Deposited 2022-12-29 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 48 PDB declaration: 48-meric |
Chain A
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain B
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain C
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain D
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain E
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain F
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain G
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain H
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain I
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain J
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain K
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain L
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain M
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain N
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain O
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain P
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain Q
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain R
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain S
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain T
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain U
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain V
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain W
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain X
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain a
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain b
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain c
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain d
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain e
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain f
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain g
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain h
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain i
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain j
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain k
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain l
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain m
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain n
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain o
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain p
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain q
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain r
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain s
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain t
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain u
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain v
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain w
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain x
263–280（18 aa）
Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；This is PBS (1x)
cryo-EM vitrification conditions
Cryogen ETHANE；We used blot-force of -5, and blot-time of 4 seconds.
|
Resolution 3.88 Å |
| 8FUG Alzheimer's disease paired-helical filament in complex with PET tracer GTP-1 Deposited 2023-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 23 PDB declaration: 23-meric |
Chain A
275–347（73 aa）
Chain B
275–347（73 aa）
Chain C
275–347（73 aa）
Chain D
275–347（73 aa）
Chain E
275–347（73 aa）
Chain F
275–347（73 aa）
Chain G
275–347（73 aa）
Chain H
275–347（73 aa）
Chain I
275–347（73 aa）
Chain J
275–347（73 aa）
Chain K
275–347（73 aa）
Chain L
275–347（73 aa）
Chain M
275–347（73 aa）
Chain N
275–347（73 aa）
Chain O
275–347（73 aa）
Chain P
275–347（73 aa）
Chain Q
275–347（73 aa）
Chain R
275–347（73 aa）
Chain S
275–347（73 aa）
Chain T
275–347（73 aa）
Chain U
275–347（73 aa）
Chain V
275–347（73 aa）
Chain W
275–347（73 aa）
|
Not recorded | Y9H (5S)-2-[4-(2-fluoroethyl)piperidin-1-yl]pyrimido[1,2-a]benzimidazole × 23 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris-HCl, pH 7.4, 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8G54 Temperature-dependent structures of tau aggregates Deposited 2023-02-11 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
198–399（202 aa）
Chain B
198–399（202 aa）
Chain C
198–399（202 aa）
Chain D
198–399（202 aa）
Chain E
198–399（202 aa）
|
Not recorded | No recorded non-water small molecule |
SOLID-STATE NMR
NMR measurement conditions
pH 7.4；295 K；Ionic strength (raw mmCIF value) 135；Pressure 1
NMR sample composition
5 uM [U-13C; U-15N] Microtubule-associated protein tau, 100% H2O | 100% H2O
|
Resolution not provided |
| 8G55 Temperature-dependent structures of tau aggregates Deposited 2023-02-11 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
198–399（202 aa）
Chain B
198–399（202 aa）
Chain C
198–399（202 aa）
Chain D
198–399（202 aa）
Chain E
198–399（202 aa）
Chain F
198–399（202 aa）
Chain G
198–399（202 aa）
Chain H
198–399（202 aa）
Chain I
198–399（202 aa）
Chain J
198–399（202 aa）
|
Not recorded | No recorded non-water small molecule |
SOLID-STATE NMR
NMR measurement conditions
pH 7.4；285 K；Ionic strength (raw mmCIF value) 135；Pressure 1
NMR sample composition
5 uM [U-13C; U-15N] P2R tau, 100% H2O | 100% H2O
|
Resolution not provided |
| 8G58 Tau (297-391) in vitro untwisted fibril Deposited 2023-02-12 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
614–708（95 aa）
Chain B
614–708（95 aa）
Chain C
614–708（95 aa）
Chain D
614–708（95 aa）
Chain E
614–708（95 aa）
Chain F
614–708（95 aa）
Chain G
614–708（95 aa）
Chain H
614–708（95 aa）
Chain I
614–708（95 aa）
Chain J
614–708（95 aa）
|
Not recorded | No recorded non-water small molecule |
SOLID-STATE NMR
NMR measurement conditions
pH 5；287 K；Ionic strength (raw mmCIF value) 0.6；Pressure 1
NMR sample composition
1 uM UCN Tau (297-391), 100% H2O | 100% H2O
NMR sample composition
0.5 uM UCN Tau (297-391), 0.5 uM Tau (297-391), 100% H2O | 100% H2O
NMR sample composition
1 uM 1,3-Glycerol,15N Tau (297-391), 100% H2O | 100% H2O
|
Resolution not provided |
| 8KDX Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Deposited 2023-08-10 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
207–221（15 aa）
Fragment：Tau Peptide 207-221
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293.15 K；1.2 M Sodium citrate tribasic dehydrated, 0.1 M Tris buffer pH8.5
|
Resolution 1.01 Å R-free 0.185 |
| 8OH2 Structure of the Tau-PAM4 Type 1 amyloid fibril Deposited 2023-03-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 36 PDB declaration: 36-meric |
Chain A
666–680（15 aa）
Chain B
666–680（15 aa）
Chain C
666–680（15 aa）
Chain D
666–680（15 aa）
Chain E
666–680（15 aa）
Chain F
666–680（15 aa）
Chain G
666–680（15 aa）
Chain H
666–680（15 aa）
Chain I
666–680（15 aa）
Chain J
666–680（15 aa）
Chain K
666–680（15 aa）
Chain L
666–680（15 aa）
Chain M
666–680（15 aa）
Chain N
666–680（15 aa）
Chain O
666–680（15 aa）
Chain P
666–680（15 aa）
Chain Q
666–680（15 aa）
Chain R
666–680（15 aa）
Chain S
666–680（15 aa）
Chain T
666–680（15 aa）
Chain U
666–680（15 aa）
Chain V
666–680（15 aa）
Chain W
666–680（15 aa）
Chain X
666–680（15 aa）
Chain Y
666–680（15 aa）
Chain Z
666–680（15 aa）
Chain a
666–680（15 aa）
Chain b
666–680（15 aa）
Chain c
666–680（15 aa）
Chain d
666–680（15 aa）
Chain e
666–680（15 aa）
Chain f
666–680（15 aa）
Chain g
666–680（15 aa）
Chain h
666–680（15 aa）
Chain i
666–680（15 aa）
Chain j
666–680（15 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 8OHI Structure of the Fmoc-Tau-PAM4 Type 2 amyloid fibril Deposited 2023-03-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric |
Chain A
667–679（13 aa）
Chain B
667–679（13 aa）
Chain C
667–679（13 aa）
Chain D
667–679（13 aa）
Chain E
667–679（13 aa）
Chain F
667–679（13 aa）
Chain G
667–679（13 aa）
Chain H
667–679（13 aa）
Chain I
667–679（13 aa）
Chain J
667–679（13 aa）
Chain K
667–679（13 aa）
Chain L
667–679（13 aa）
Chain M
667–679（13 aa）
Chain N
667–679（13 aa）
Chain O
667–679（13 aa）
Chain P
667–679（13 aa）
Chain Q
667–679（13 aa）
Chain R
667–679（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 8OHP Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril Deposited 2023-03-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric |
Chain A
667–679（13 aa）
Chain B
667–679（13 aa）
Chain C
667–679（13 aa）
Chain D
667–679（13 aa）
Chain E
667–679（13 aa）
Chain F
667–679（13 aa）
Chain G
667–679（13 aa）
Chain H
667–679（13 aa）
Chain I
667–679（13 aa）
Chain J
667–679（13 aa）
Chain K
667–679（13 aa）
Chain L
667–679（13 aa）
Chain M
667–679（13 aa）
Chain N
667–679（13 aa）
Chain O
667–679（13 aa）
Chain P
667–679（13 aa）
Chain Q
667–679（13 aa）
Chain R
667–679（13 aa）
Chain S
667–679（13 aa）
Chain T
667–679（13 aa）
Chain U
667–679（13 aa）
Chain V
667–679（13 aa）
Chain W
667–679（13 aa）
Chain X
667–679（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8OI0 Structure of the Fmoc-Tau-PAM4 Type 4 amyloid fibril Deposited 2023-03-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric |
Chain A
667–679（13 aa）
Chain B
667–679（13 aa）
Chain C
667–679（13 aa）
Chain D
667–679（13 aa）
Chain E
667–679（13 aa）
Chain F
667–679（13 aa）
Chain G
667–679（13 aa）
Chain H
667–679（13 aa）
Chain I
667–679（13 aa）
Chain J
667–679（13 aa）
Chain K
667–679（13 aa）
Chain L
667–679（13 aa）
Chain M
667–679（13 aa）
Chain N
667–679（13 aa）
Chain O
667–679（13 aa）
Chain P
667–679（13 aa）
Chain Q
667–679（13 aa）
Chain R
667–679（13 aa）
Chain S
667–679（13 aa）
Chain T
667–679（13 aa）
Chain U
667–679（13 aa）
Chain V
667–679（13 aa）
Chain W
667–679（13 aa）
Chain X
667–679（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8ORE Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease Deposited 2023-04-13 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–381（381 aa）
Chain B
1–381（381 aa）
Chain C
1–381（381 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 8ORF Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts Deposited 2023-04-13 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–412（412 aa）
Chain B
1–412（412 aa）
Chain C
1–412（412 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 8ORG Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II) Deposited 2023-04-13 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–412（412 aa）
Chain B
1–412（412 aa）
Chain C
1–412（412 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 8OT6 CTE typeI tau filament from Guam ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.00 Å |
| 8OT9 CTE typeIII tau filament from Guam ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 8OTC CTE typeII tau filament from Guam ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8OTG CTE typeI tau filament from Kii ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.10 Å |
| 8OTH TypeII tau filament from Kii ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 8OTI CTE typeIII tau filament Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8OTJ PHF tau filament from Kii ALS/PDC Deposited 2023-04-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8P34 Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT Deposited 2023-05-17 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
196–289（94 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20 mM Tris-HCL, 100 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.61 Å |
| 8PII VHH Z70 mutant 3 in interaction with PHF6 Tau peptide Deposited 2023-06-21 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
618–631（14 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；1.5M ammonium sulfate, 4.5% isopropanol, 15% glycerol
|
Resolution 2.35 Å R-free 0.263 |
| 8PPO First Intermediate Amyloid (FIA) - Tau Deposited 2023-07-07 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
Chain K
1–441（441 aa）
Chain L
1–441（441 aa）
Chain M
1–441（441 aa）
Chain N
1–441（441 aa）
Chain O
1–441（441 aa）
Chain P
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.00 Å |
| 8Q27 Tau: AD-MIA1 Deposited 2023-08-01 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.02 Å |
| 8Q2J Tau - AD-MIA2 Deposited 2023-08-02 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.23 Å |
| 8Q2K Tau - AD-MIA3 Deposited 2023-08-02 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.88 Å |
| 8Q2L Tau - AD-MIA4 Deposited 2023-08-02 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.20 Å |
| 8Q7F Tau - AD-MIA5 Deposited 2023-08-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.72 Å |
| 8Q7L Tau - AD-MIA6 (tau intermediate amyloid) Deposited 2023-08-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.82 Å |
| 8Q7M Tau - AD-MIA7 (tau intermediate amyloid) Deposited 2023-08-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
Chain G
1–383（383 aa）
Chain H
1–383（383 aa）
Chain I
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.26 Å |
| 8Q7P Tau - AD-MIA8 (intermediate amyloid) Deposited 2023-08-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.28 Å |
| 8Q7T Tau - AD-MIA11 Deposited 2023-08-17 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
Chain G
1–383（383 aa）
Chain H
1–383（383 aa）
Chain I
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8Q88 Tau - AD-LIA2 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 8Q8C Tau - AD-MIA10 (intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.92 Å |
| 8Q8D Tau - AD-LIA6 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 8Q8E Tau - AD-LIA4 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: 12-meric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
Chain G
1–383（383 aa）
Chain H
1–383（383 aa）
Chain I
1–383（383 aa）
Chain J
1–383（383 aa）
Chain K
1–383（383 aa）
Chain L
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.81 Å |
| 8Q8F Tau - AD-LIA5 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.93 Å |
| 8Q8L Tau - AD-LIA7 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 8Q8M Tau - AD-PHF long crossover Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 8Q8R Tau - AD-PHF Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.10 Å |
| 8Q8S Tau - AD-THF Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
Chain G
1–383（383 aa）
Chain H
1–383（383 aa）
Chain I
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.68 Å |
| 8Q8U Tau - CTE-MIA1 (tau intermediate amyloid) Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8Q8V Tau - CTE-MIA3 Deposited 2023-08-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 8Q8W Tau - CTE-MIA4 (tau intermediate amyloid) Deposited 2023-08-19 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.85 Å |
| 8Q8X Tau - CTE-MIA5 (tau intermediate amyloid) Deposited 2023-08-19 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.54 Å |
| 8Q8Y Tau - CTE-MIA6 (tau intermediate amyloid) Deposited 2023-08-19 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.88 Å |
| 8Q8Z Tau - CTE-MIA7 (tau intermediate amyloid) Deposited 2023-08-19 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 8Q92 P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line Deposited 2023-08-19 | Different construct Different mutation/modification Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
588–681（94 aa）
Chain B
588–681（94 aa）
Chain C
588–681（94 aa）
|
Mutation：P301S Mutation：P301S Mutation：P301S | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.05 Å |
| 8Q97 Tau - CTE-MIA9 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.99 Å |
| 8Q98 Tau - CTE-MIA8 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.75 Å |
| 8Q99 Tau - CTE-MIA10 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8Q9A Tau - CTE-MIA11 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 8Q9B Tau - CTE-MIA13 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8Q9C Tau - CTE-MIA14 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 8Q9D Tau - CTE-MIA15 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 8Q9E Tau - CTE-MIA18 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 8Q9F Tau - CTE-LIA3 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain c
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 1.91 Å |
| 8Q9G Tau - CTE-LIA5 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 8Q9H Tau - CTE-LIA4 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain G
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.18 Å |
| 8Q9I Tau - CTE-LIA6 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–383（383 aa）
Chain C
1–383（383 aa）
Chain E
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.56 Å |
| 8Q9J Tau - CTE-LIA7 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.96 Å |
| 8Q9K Tau - CTE-LIA13 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8Q9L Tau - CTE-LIA14 (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
Chain G
1–383（383 aa）
Chain H
1–383（383 aa）
Chain I
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.76 Å |
| 8Q9M Tau - CTE-type I (tau intermediate amyloid) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain G
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 8Q9O CTE tau intermediate amyloid (LIA-17) Deposited 2023-08-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain G
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8QCP Tau - AD-LIA8 (tau intermediate amyloid) Deposited 2023-08-28 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 8QCR Tau - CTE-MIA12 (tau intermediate amyloid) Deposited 2023-08-28 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–383（383 aa）
Chain C
1–383（383 aa）
Chain E
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.75 Å |
| 8QDV Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide Deposited 2023-08-30 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
527–539（13 aa）
Chain C
635–648（14 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350
|
Resolution 2.50 Å R-free 0.260 |
| 8QDV Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide Deposited 2023-08-30 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
527–539（13 aa）
Chain F
635–648（14 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350
|
Resolution 2.50 Å R-free 0.260 |
| 8QJJ CTE type II (tau intermediate amyloid) Deposited 2023-09-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 8R3T Cofactor-free Tau 4R2N isoform Deposited 2023-11-10 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8SEH PHF Tau from Down Syndrome Deposited 2023-04-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
275–347（73 aa）
Chain B
275–347（73 aa）
Chain C
275–347（73 aa）
Chain D
275–347（73 aa）
Chain E
275–347（73 aa）
Chain F
275–347（73 aa）
Chain G
275–347（73 aa）
Chain H
275–347（73 aa）
Chain I
275–347（73 aa）
Chain J
275–347（73 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8SEI SF Tau from Down Syndrome Deposited 2023-04-10 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
623–695（73 aa）
Chain B
623–695（73 aa）
Chain C
623–695（73 aa）
Chain D
623–695（73 aa）
Chain E
623–695（73 aa）
Chain F
623–695（73 aa）
Chain G
623–695（73 aa）
Chain H
623–695（73 aa）
Chain I
623–695（73 aa）
Chain J
623–695（73 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8TTL AT8-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S202E, T205E, S208E) Deposited 2023-08-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
Chain F
1–383（383 aa）
|
Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.8；50 mM K2HPO4 buffer, pH 6.8, containing 300 mM NaCl, 5 mM DTT, and 1x cOmplete protease inhibitor cocktail tablet (Roche) per 40 ml fibrillization buffer.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 8TTN PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E) Deposited 2023-08-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–383（383 aa）
Chain B
1–383（383 aa）
Chain C
1–383（383 aa）
Chain D
1–383（383 aa）
Chain E
1–383（383 aa）
|
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.8；50 mM K2HPO4 buffer, pH 6.8, containing 300 mM NaCl, 5 mM DTT, and 1x cOmplete protease inhibitor cocktail tablet (Roche) per 40 ml fibrillization buffer.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.40 Å |
| 8UQ7 Alzheimer's disease PHF complexed with PET ligand MK-6240 Deposited 2023-10-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
622–696（75 aa）
Chain B
622–696（75 aa）
Chain C
622–696（75 aa）
Chain D
622–696（75 aa）
Chain E
622–696（75 aa）
Chain F
622–696（75 aa）
|
Not recorded | X6R 6-fluoro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.31 Å |
| 8V1N Cryo-EM structure of tau filaments made from jR2R3-P301L peptides induced with heparin Deposited 2023-11-20 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
612–630（19 aa）
Chain B
612–630（19 aa）
Chain C
612–630（19 aa）
Chain D
612–630（19 aa）
Chain E
612–630（19 aa）
Chain F
612–630（19 aa）
Chain G
612–630（19 aa）
Chain H
612–630（19 aa）
Chain I
612–630（19 aa）
Chain J
612–630（19 aa）
Chain K
612–630（19 aa）
Chain L
612–630（19 aa）
|
Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；20mM ammoniium acetate, 50mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8ZWL Heparin bound Tau fibril polymorph 3 Deposited 2024-06-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 8ZWM Heparin bound Tau fibril polymorph 4 Deposited 2024-06-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8ZX6 Heparin bound Tau fibril PHF Deposited 2024-06-13 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9B3A filament of type 1 KD-mxyl miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-03-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric |
Chain A
612–630（19 aa）
Chain C
612–630（19 aa）
Chain E
612–630（19 aa）
Chain G
612–630（19 aa）
Chain I
612–630（19 aa）
Chain K
612–630（19 aa）
Chain M
612–630（19 aa）
Chain O
612–630（19 aa）
Chain Q
612–630（19 aa）
Chain S
612–630（19 aa）
Chain U
612–630（19 aa）
Chain W
612–630（19 aa）
Chain Y
612–630（19 aa）
Chain a
612–630（19 aa）
Chain c
612–630（19 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NH2 AMINO GROUP × 15 8VH 1,3-dimethylbenzene × 15 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9B3C type 2 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-03-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric |
Chain A
612–630（19 aa）
Chain C
612–630（19 aa）
Chain E
612–630（19 aa）
Chain G
612–630（19 aa）
Chain I
612–630（19 aa）
Chain K
612–630（19 aa）
Chain M
612–630（19 aa）
Chain O
612–630（19 aa）
Chain Q
612–630（19 aa）
Chain S
612–630（19 aa）
Chain U
612–630（19 aa）
Chain W
612–630（19 aa）
Chain Y
612–630（19 aa）
Chain a
612–630（19 aa）
Chain c
612–630（19 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NH2 AMINO GROUP × 15 8VH 1,3-dimethylbenzene × 15 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 9B4L Filament of Tau in complex with D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric |
Chain 0
1–758（758 aa）
Chain 1
1–758（758 aa）
Chain A
1–758（758 aa）
Chain B
1–758（758 aa）
Chain C
1–758（758 aa）
Chain D
1–758（758 aa）
Chain M
1–758（758 aa）
Chain N
1–758（758 aa）
Chain O
1–758（758 aa）
Chain P
1–758（758 aa）
Chain Y
1–758（758 aa）
Chain Z
1–758（758 aa）
|
Not recorded | EDT {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9B4M Filament of Tau in complex with D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-20 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–758（758 aa）
Chain B
1–758（758 aa）
Chain C
1–758（758 aa）
Chain D
1–758（758 aa）
Chain E
1–758（758 aa）
Chain F
1–758（758 aa）
Chain G
1–758（758 aa）
Chain H
1–758（758 aa）
Chain I
1–758（758 aa）
Chain J
1–758（758 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9B4N Filament of Tau in complex with D-TLKIVWR, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-21 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–758（758 aa）
Chain B
1–758（758 aa）
Chain C
1–758（758 aa）
Chain D
1–758（758 aa）
Chain E
1–758（758 aa）
Chain F
1–758（758 aa）
Chain G
1–758（758 aa）
Chain H
1–758（758 aa）
Chain I
1–758（758 aa）
Chain J
1–758（758 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9B4O Alzheimer's Tau Paired Helical Filaments, determined by CryoEM, before addition of D-peptide disaggregants Deposited 2024-03-21 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–758（758 aa）
Chain B
1–758（758 aa）
Chain C
1–758（758 aa）
Chain D
1–758（758 aa）
Chain E
1–758（758 aa）
Chain F
1–758（758 aa）
Chain G
1–758（758 aa）
Chain H
1–758（758 aa）
Chain I
1–758（758 aa）
Chain J
1–758（758 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9BBL THF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Deposited 2024-04-06 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
|
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；The pH was tuned to pH 7.5-8 using 5M NaOH after mixing phosphate buffer and MgCl2, and precipitation was formed.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 9BBM PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Deposited 2024-04-06 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；The pH was tuned to pH 7.5-8 using 5M NaOH after mixing phosphate buffer and MgCl2, and precipitation was formed.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9BXI Paired Helical Filament of tau amyloids found in Down Syndrome individuals Deposited 2024-05-22 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
275–351（77 aa）
Chain B
275–351（77 aa）
Chain C
275–351（77 aa）
Chain D
275–351（77 aa）
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 9BXO Straight Filament of tau amyloids found in Down Syndrome individuals Deposited 2024-05-22 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
275–351（77 aa）
Chain B
275–351（77 aa）
Chain C
275–351（77 aa）
Chain D
275–351（77 aa）
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9BXQ Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids Deposited 2024-05-22 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
275–351（77 aa）
Chain D
275–351（77 aa）
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
Chain G
275–351（77 aa）
Chain H
275–351（77 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9BXR Straight Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids Deposited 2024-05-22 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
275–351（77 aa）
Chain D
275–351（77 aa）
Chain E
275–351（77 aa）
Chain F
275–351（77 aa）
Chain G
275–351（77 aa）
Chain H
275–351（77 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9CGX Alzheimer's Disease Seeded 0N3R Tau Fibrils Deposited 2024-07-01 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–352（352 aa）
Chain B
1–352（352 aa）
Chain C
1–352（352 aa）
Chain D
1–352（352 aa）
Chain E
1–352（352 aa）
Chain F
1–352（352 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 9CGZ Alzheimer's Disease Seeded Mixed 0N4R and 0N3R Tau Fibrils Deposited 2024-07-01 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–352（352 aa）
Chain B
1–352（352 aa）
Chain C
1–352（352 aa）
Chain D
1–352（352 aa）
Chain E
1–352（352 aa）
Chain F
1–352（352 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.69 Å |
| 9CZI Paired helical tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques Deposited 2024-08-05 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
275–347（73 aa）
Fragment：UNP residues 275-347
Chain B
275–347（73 aa）
Fragment：UNP residues 275-347
Chain C
275–347（73 aa）
Fragment：UNP residues 275-347
Chain D
275–347（73 aa）
Fragment：UNP residues 275-347
Chain E
275–347（73 aa）
Fragment：UNP residues 275-347
Chain F
275–347（73 aa）
Fragment：UNP residues 275-347
Chain G
275–347（73 aa）
Fragment：UNP residues 275-347
Chain H
275–347（73 aa）
Fragment：UNP residues 275-347
Chain I
275–347（73 aa）
Fragment：UNP residues 275-347
Chain J
275–347（73 aa）
Fragment：UNP residues 275-347
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9CZL Straight tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques Deposited 2024-08-05 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
274–347（74 aa）
Fragment：UNP residues 274-347
Chain B
274–347（74 aa）
Fragment：UNP residues 274-347
Chain C
274–347（74 aa）
Fragment：UNP residues 274-347
Chain D
274–347（74 aa）
Fragment：UNP residues 274-347
Chain E
274–347（74 aa）
Fragment：UNP residues 274-347
Chain F
274–347（74 aa）
Fragment：UNP residues 274-347
Chain G
274–347（74 aa）
Fragment：UNP residues 274-347
Chain H
274–347（74 aa）
Fragment：UNP residues 274-347
Chain I
274–347（74 aa）
Fragment：UNP residues 274-347
Chain J
274–347（74 aa）
Fragment：UNP residues 274-347
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9DA8 Tau-Microtubule structure in the presence of ATP Deposited 2024-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain D
1–758（758 aa）
Chain N
1–758（758 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 4 TA1 TAXOL × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.94 Å |
| 9DME Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-09-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: pentadecameric |
Chain A
612–630（19 aa）
Chain B
612–630（19 aa）
Chain C
612–630（19 aa）
Chain D
612–630（19 aa）
Chain E
612–630（19 aa）
Chain F
612–630（19 aa）
Chain G
612–630（19 aa）
Chain H
612–630（19 aa）
Chain I
612–630（19 aa）
Chain J
612–630（19 aa）
Chain K
612–630（19 aa）
Chain L
612–630（19 aa）
Chain M
612–630（19 aa）
Chain N
612–630（19 aa）
Chain O
612–630（19 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | 8VH 1,3-dimethylbenzene × 15 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9EO7 PHF type tau filament from V337M mutant Deposited 2024-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9EO9 SF type tau filament from V337M mutant Deposited 2024-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9EOE TF type tau filament from V337M mutant Deposited 2024-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: dimeric |
Chain A
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 9EOG PHF type tau filament from R406W mutant Deposited 2024-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9EOH PHF type tau filament from in vitro V337M mutant Deposited 2024-03-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9ERM CTE type I tau filament from vacuolar tauopathy Deposited 2024-03-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 9ERN CTE type II tau filament from vacuolar tauopathy Deposited 2024-03-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 9ERO CTE type III tau filament from vacuolar tauopathy Deposited 2024-03-24 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9FH6 Cryo-EM Structure of Tau Filaments from Individuals Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation Deposited 2024-05-26 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
623–695（73 aa）
Chain B
623–695（73 aa）
Chain C
623–695（73 aa）
Chain D
623–695（73 aa）
Chain E
623–695（73 aa）
Chain F
623–695（73 aa）
Chain G
623–695（73 aa）
Chain H
623–695（73 aa）
Chain I
623–695（73 aa）
Chain J
623–695（73 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9FS4 Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD12 Deposited 2024-06-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | TJ8 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.60 Å R-free 0.198 |
| 9FVG Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer AO184 Deposited 2024-06-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IF3 1-(3-bromanyl-4-methyl-phenyl)-2-(4-ethylphenyl)imidazole × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.45 Å R-free 0.193 |
| 9FVH Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS17 Deposited 2024-06-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IF5 2-bromanyl-4-[2-(2-methylphenyl)imidazol-1-yl]benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.45 Å R-free 0.176 |
| 9FVI Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS18 Deposited 2024-06-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IF4 1-(3-bromanyl-4-methyl-phenyl)-2-(3-methylphenyl)imidazole × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.55 Å R-free 0.211 |
| 9FVN Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer NZ4 Deposited 2024-06-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IGH 2-[4-[1-(3-bromanyl-4-methyl-phenyl)benzimidazol-2-yl]phenoxy]ethanol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.50 Å R-free 0.209 |
| 9FVP Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS24 Deposited 2024-06-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IGF 1-(3-bromanyl-4-methyl-phenyl)-2-(4-methylphenyl)imidazole × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.58 Å R-free 0.205 |
| 9G13 VHH H3-2 in complex with Tau C-terminal peptide Deposited 2024-07-09 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
369–381（13 aa）
Chain D
369–381（13 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；23% PEG-MME 2000, 0.1 M potassium acetate
|
Resolution 1.80 Å R-free 0.231 |
| 9G13 VHH H3-2 in complex with Tau C-terminal peptide Deposited 2024-07-09 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain F
369–381（13 aa）
Chain H
369–381（13 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；23% PEG-MME 2000, 0.1 M potassium acetate
|
Resolution 1.80 Å R-free 0.231 |
| 9GFA Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD33 Deposited 2024-08-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IKN 3-(3-bromanyl-4-methyl-phenyl)-2-pyridin-3-yl-1,2-dihydrobenzimidazole × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 1.60 Å R-free 0.196 |
| 9GG0 P301L tau filaments from human brain Deposited 2024-08-12 | Different construct Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
213–319（107 aa）
Chain B
213–319（107 aa）
Chain C
213–319（107 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.81 Å |
| 9GG1 P301T type I tau filaments from human brain Deposited 2024-08-12 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
215–321（107 aa）
Chain B
215–321（107 aa）
Chain C
215–321（107 aa）
Chain D
215–321（107 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.26 Å |
| 9GG6 P301T type II tau filaments from human brain Deposited 2024-08-13 | Different construct | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
269–364（96 aa）
Chain B
269–364（96 aa）
Chain C
269–364（96 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.36 Å |
| 9GG7 Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS324 peptide and covalent stabilizer 187 Deposited 2024-08-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
653–666（14 aa）
Chain P
653–666（14 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | TW8 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；Cocrystalization of 12 mg/ml protein, 2eq peptide and 1.8mM compound in 20 mM Sodium HEPES pH 7.5, 2 mM MgCl2, and 1.5 mM TCEP.
Crystallization buffer: 0.19 M Calcium chloride dihydrate, 0.095 M Sodium HEPES pH 7.1, 5% glycerol, and28% PEG 400, mixed 1:1 with cocrystal mix
|
Resolution 1.24 Å R-free 0.242 |
| 9GG8 Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS214 peptide and covalent stabilizer 187 Deposited 2024-08-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | TW8 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；Cocrystalization of 12 mg/ml protein, 2eq peptide and 1.8mM compound in 20 mM Sodium HEPES pH 7.5, 2 mM MgCl2, and 1.5 mM TCEP.
Crystallization buffer: 0.19 M Calcium chloride dihydrate, 0.095 M Sodium HEPES pH 7.1, 5% glycerol, and28% PEG 400, mixed 1:1 with cocrystal mix
|
Resolution 1.10 Å R-free 0.203 |
| 9GGA Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer FM089 Deposited 2024-08-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
527–539（13 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | A1IKS 2-bromanyl-4-[[(3~{R})-3-oxidanyl-3,4-dihydro-2~{H}-quinolin-1-yl]sulfonyl]benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol
compound soaked
|
Resolution 2.24 Å R-free 0.199 |
| 9H5G PAD12 0N3R:0N4R tau PHF Deposited 2024-10-22 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–352（352 aa）
Chain B
1–352（352 aa）
Chain C
1–352（352 aa）
Chain D
1–352（352 aa）
Chain E
1–352（352 aa）
Chain F
1–352（352 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.28
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.48 Å |
| 9H5J PAD12 0N3R tau PHF seeded by AD Deposited 2024-10-22 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–352（352 aa）
Chain B
1–352（352 aa）
Chain C
1–352（352 aa）
Chain D
1–352（352 aa）
Chain E
1–352（352 aa）
Chain F
1–352（352 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.28
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.72 Å |
| 9HBB Recombinant tau PHF filaments (peptide synthesis 291-391) Deposited 2024-11-06 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
291–391（101 aa）
Chain B
291–391（101 aa）
Chain C
291–391（101 aa）
Chain D
291–391（101 aa）
Chain E
291–391（101 aa）
Chain F
291–391（101 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9MC2 Cryo-EM structure of dopaminated Tau fibril Deposited 2025-03-17 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
561–689（129 aa）
Chain B
561–689（129 aa）
Chain C
561–689（129 aa）
Chain D
561–689（129 aa）
Chain E
561–689（129 aa）
Chain F
561–689（129 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.55 Å |
| 9MR8 Structure of D421-Truncated Tau Fibril Deposited 2025-01-07 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 30 PDB declaration: 30-meric |
Chain C
590–679（90 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9MR8 Structure of D421-Truncated Tau Fibril Deposited 2025-01-07 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
590–679（90 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9O6V Recombinant AD PHF complexed with SW-MK-NBD (PHF2) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain F
622–696（75 aa）
Chain G
622–696（75 aa）
Chain H
622–696（75 aa）
Chain I
622–696（75 aa）
Chain J
622–696（75 aa）
Chain N
622–696（75 aa）
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Y
622–696（75 aa）
Chain Z
622–696（75 aa）
|
Not recorded | A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 10 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.72 Å |
| 9O6W Recombinant AD PHF complexed with SW-MK-NBD (Non Symmetric Binding Site) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain F
622–696（75 aa）
Chain G
622–696（75 aa）
Chain H
622–696（75 aa）
Chain I
622–696（75 aa）
Chain J
622–696（75 aa）
Chain N
622–696（75 aa）
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Q
622–696（75 aa）
Chain R
622–696（75 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.67 Å |
| 9O6X Recombinant AD THF incubated with SW-MK-NBD (Non-Symmetric Binding) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric |
Chain R
622–696（75 aa）
Chain S
622–696（75 aa）
Chain T
622–696（75 aa）
Chain U
622–696（75 aa）
Chain V
622–696（75 aa）
Chain W
622–696（75 aa）
Chain X
622–696（75 aa）
Chain Y
622–696（75 aa）
Chain Z
622–696（75 aa）
Chain a
622–696（75 aa）
Chain e
622–696（75 aa）
Chain f
622–696（75 aa）
Chain g
622–696（75 aa）
Chain h
622–696（75 aa）
Chain i
622–696（75 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.58 Å |
| 9O6Y Recombinant AD PHF complexed with SW-MK-NBD Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain K
622–696（75 aa）
Chain L
622–696（75 aa）
Chain M
622–696（75 aa）
Chain N
622–696（75 aa）
Chain O
622–696（75 aa）
Chain R
622–696（75 aa）
Chain S
622–696（75 aa）
Chain Z
622–696（75 aa）
Chain a
622–696（75 aa）
Chain b
622–696（75 aa）
|
Not recorded | A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 10 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.72 Å |
| 9O6Z Recombinant AD THF with SW-MK-NBD complexed in AD-related Binding Site Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: pentadecameric |
Chain N
622–696（75 aa）
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Q
622–696（75 aa）
Chain R
622–696（75 aa）
Chain V
622–696（75 aa）
Chain W
622–696（75 aa）
Chain X
622–696（75 aa）
Chain Y
622–696（75 aa）
Chain Z
622–696（75 aa）
Chain b
622–696（75 aa）
Chain c
622–696（75 aa）
Chain d
622–696（75 aa）
Chain e
622–696（75 aa）
Chain f
622–696（75 aa）
|
Not recorded | A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.31 Å |
| 9O76 Recombinant AD THF complexed with SW-MK-NBD (Secondary Binding Site) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric |
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Q
622–696（75 aa）
Chain R
622–696（75 aa）
Chain S
622–696（75 aa）
Chain V
622–696（75 aa）
Chain W
622–696（75 aa）
Chain X
622–696（75 aa）
Chain Y
622–696（75 aa）
Chain Z
622–696（75 aa）
Chain b
622–696（75 aa）
Chain c
622–696（75 aa）
Chain d
622–696（75 aa）
Chain e
622–696（75 aa）
Chain f
622–696（75 aa）
|
Not recorded | A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.58 Å |
| 9O79 Recombinant AD PHF incubated with DMSO (Kinked Backbone E342) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain F
622–696（75 aa）
Chain G
622–696（75 aa）
Chain H
622–696（75 aa）
Chain I
622–696（75 aa）
Chain J
622–696（75 aa）
Chain N
622–696（75 aa）
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Q
622–696（75 aa）
Chain R
622–696（75 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.55 Å |
| 9O7B Recombinant AD THF incubated with DMSO (Kinked Backbone E342) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric |
Chain O
622–696（75 aa）
Chain P
622–696（75 aa）
Chain Q
622–696（75 aa）
Chain R
622–696（75 aa）
Chain S
622–696（75 aa）
Chain W
622–696（75 aa）
Chain X
622–696（75 aa）
Chain Y
622–696（75 aa）
Chain Z
622–696（75 aa）
Chain a
622–696（75 aa）
Chain d
622–696（75 aa）
Chain e
622–696（75 aa）
Chain f
622–696（75 aa）
Chain g
622–696（75 aa）
Chain h
622–696（75 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.31 Å |
| 9O7C Recombinant AD THF incubated with DMSO (Flat Backbone E342) Deposited 2025-04-14 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric |
Chain S
622–696（75 aa）
Chain T
622–696（75 aa）
Chain U
622–696（75 aa）
Chain V
622–696（75 aa）
Chain W
622–696（75 aa）
Chain i
622–696（75 aa）
Chain j
622–696（75 aa）
Chain k
622–696（75 aa）
Chain l
622–696（75 aa）
Chain m
622–696（75 aa）
Chain n
622–696（75 aa）
Chain o
622–696（75 aa）
Chain p
622–696（75 aa）
Chain q
622–696（75 aa）
Chain r
622–696（75 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.31 Å |
| 9O8E amyloid fibril of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer's disease tau fibrils Deposited 2025-04-15 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9O8H amyloid fibril of recombinant full-length 2N4R tau complexed with mouse liver 18S ribosomal RNA Deposited 2025-04-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
Chain I
1–441（441 aa）
Chain J
1–441（441 aa）
|
Not recorded | CL CHLORIDE ION × 10 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9OFW 328-363 tau mutant S341L_S352I Deposited 2025-04-30 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 20 PDB declaration: 20-meric |
Chain A
666–680（15 aa）
Chain B
666–680（15 aa）
Chain C
666–680（15 aa）
Chain D
666–680（15 aa）
Chain E
666–680（15 aa）
Chain F
666–680（15 aa）
Chain G
666–680（15 aa）
Chain H
666–680（15 aa）
Chain I
666–680（15 aa）
Chain J
666–680（15 aa）
Chain K
666–680（15 aa）
Chain L
666–680（15 aa）
Chain M
666–680（15 aa）
Chain N
666–680（15 aa）
Chain O
666–680（15 aa）
Chain P
666–680（15 aa）
Chain Q
666–680（15 aa）
Chain R
666–680（15 aa）
Chain S
666–680（15 aa）
Chain T
666–680（15 aa）
|
Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；10mM NaPO4, 200mM MgCl2, pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 9PGO Cryo-EM structure of brain-derived Tau fibril from Alzheimers disease patient tissue Deposited 2025-07-08 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: 12-meric |
Chain A
1–758（758 aa）
Chain B
1–758（758 aa）
Chain C
1–758（758 aa）
Chain D
1–758（758 aa）
Chain E
1–758（758 aa）
Chain F
1–758（758 aa）
Chain G
1–758（758 aa）
Chain H
1–758（758 aa）
Chain I
1–758（758 aa）
Chain J
1–758（758 aa）
Chain K
1–758（758 aa）
Chain L
1–758（758 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.29 Å |
| 9QNK Tau pT245 phosphopeptide binding to 14-3-3sigma Deposited 2025-03-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
558–566（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M HEPES pH=7.1-7.7
0.19 M CaCl2
5% glycerol
24-29% PEG400
|
Resolution 1.60 Å R-free 0.196 |
| 9R2F Tau filaments seeded by AD homogenate using 0N3R C322A Deposited 2025-04-30 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
218–289（72 aa）
Chain B
218–289（72 aa）
Chain C
218–289（72 aa）
Chain D
218–289（72 aa）
Chain E
218–289（72 aa）
Chain F
218–289（72 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9R2H Tau filaments seeded by AD homogenate using 0N3R C322S Deposited 2025-04-30 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
248–383（136 aa）
Chain B
248–383（136 aa）
Chain C
248–383（136 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 9R88 CTE Type I tau filament from the brain of a football player Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.60 Å |
| 9R89 CTE Type II tau filament from the brain of a football player Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9R8A PHF tau filament from the brain of a football player Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.50 Å |
| 9R8D SF tau filament from the brain of a football player Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
Chain F
1–441（441 aa）
Chain G
1–441（441 aa）
Chain H
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9S2B 297-441 delta392-395 tau filaments Deposited 2025-07-21 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
614–635（22 aa）
Chain B
614–635（22 aa）
Chain C
614–635（22 aa）
Chain D
614–635（22 aa）
Chain E
614–635（22 aa）
Chain F
614–635（22 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9SHS Head to Head tau filament with the Alzheimer's fold Deposited 2025-08-27 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
246–321（76 aa）
Chain B
246–321（76 aa）
Chain C
246–321（76 aa）
Chain D
246–321（76 aa）
Chain E
246–321（76 aa）
Chain G
246–321（76 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9TZX Cryo-EM structure of a tau filament Deposited 2026-01-25 | Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–441（441 aa）
Chain B
1–441（441 aa）
Chain C
1–441（441 aa）
Chain D
1–441（441 aa）
Chain E
1–441（441 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.75 Å |
248 other PDB entries and 270 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TAU_HUMAN |
| Isoform | P10636-8 |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–441； UniProt 1–441 Author chain B； PDBConstruct 1–441； UniProt 1–441 Author chain C； PDBConstruct 1–441； UniProt 1–441 |
