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8qdv

Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide

Method: X-RAY DIFFRACTION Dmax: 96.8 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

14-3-3 protein zeta/delta

Homo sapiens

UniProt P63104

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain A； UniProt 1–230 Chain B； UniProt 1–230 Not recorded Microtubule-associated protein tau × 1 （P10636） X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350 Resolution 2.50 Å R-free 0.260
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain E； UniProt 1–230 Chain G； UniProt 1–230 Not recorded Microtubule-associated protein tau × 1 （P10636） X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350 Resolution 2.50 Å R-free 0.260

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 8QDV Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1IB1 CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX Deposited 2001-03-26 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded COT COA-S-ACETYL TRYPTAMINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG 4000, magnesium chloride, lithium sulfate, DTT, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.70 Å R-free 0.228
1IB1 CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX Deposited 2001-03-26 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded COT COA-S-ACETYL TRYPTAMINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG 4000, magnesium chloride, lithium sulfate, DTT, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.70 Å R-free 0.228
2C1J Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 Deposited 2005-09-15 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.1 M HEPES PH7.0, 23% ETHYLENE GLYCOL, pH 7.00
Resolution 2.60 Å R-free 0.292
2C1N Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 Deposited 2005-09-16 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；100MM HEPES PH 7.0, 23% ETHYLENE GLYCOL
Resolution 2.00 Å R-free 0.296
2C1N Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 Deposited 2005-09-16 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；100MM HEPES PH 7.0, 23% ETHYLENE GLYCOL
Resolution 2.00 Å R-free 0.296
2O02 Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis Deposited 2006-11-27 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded BEZ BENZOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；285 K；pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 285K
Resolution 1.50 Å R-free 0.212
2WH0 Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon Deposited 2009-04-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.4；16 MG/ML PROTEIN 9% (W/V) POLYETHYLENE GLYCOL 3350, 25 MM CALCIUM ACETATE, 25 MM SODIUM FLUORIDE, pH 7.4
Resolution 2.25 Å R-free 0.235
2WH0 Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon Deposited 2009-04-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.4；16 MG/ML PROTEIN 9% (W/V) POLYETHYLENE GLYCOL 3350, 25 MM CALCIUM ACETATE, 25 MM SODIUM FLUORIDE, pH 7.4
Resolution 2.25 Å R-free 0.235
3CU8 Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Deposited 2008-04-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded MG MAGNESIUM ION × 2 PPI PROPANOIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1M (Sodium propionate, sodium cacodylate, BIS-TRIS propane), 27% PEG 1500, 2mM DTT, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.40 Å R-free 0.259
3NKX Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Deposited 2010-06-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded PPI PROPANOIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1M (Sodium propionate, sodium cacodylate, BIS-TRIS propane), 27% PEG 1500, 2mM DTT, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.40 Å R-free 0.247
3RDH X-ray induced covalent inhibition of 14-3-3 Deposited 2011-04-01 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded 3RD 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid × 2 NI NICKEL (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；25% PEG3350, 100 mM Tris-HCl pH 8.5, 10 mM MgCl2, 1 mM NiCl2, 1% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.39 Å R-free 0.286
3RDH X-ray induced covalent inhibition of 14-3-3 Deposited 2011-04-01 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 1–245（245 aa）
Chain C 1–245（245 aa）
Not recorded 3RD 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid × 2 NI NICKEL (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；25% PEG3350, 100 mM Tris-HCl pH 8.5, 10 mM MgCl2, 1 mM NiCl2, 1% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.39 Å R-free 0.286
3RDH X-ray induced covalent inhibition of 14-3-3 Deposited 2011-04-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded 3RD 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid × 4 NI NICKEL (II) ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；25% PEG3350, 100 mM Tris-HCl pH 8.5, 10 mM MgCl2, 1 mM NiCl2, 1% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.39 Å R-free 0.286
4BG6 14-3-3 interaction with Rnd3 prenyl-phosphorylation motif Deposited 2013-03-23 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded PE4 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 3 FAR FARNESYL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；0.17 M SODIUM ACETATE; 0.085 M TRIS, PH 8.5; 25.5% (W/V) PEG4000, 15% (V/V) GLYCEROL
Resolution 2.30 Å R-free 0.273
4FJ3 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Deposited 2012-06-11 Different construct Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230
Chain B 1–230（230 aa） Fragment：UNP residues 1-230
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M Na-acetate pH 7.0, 0.8 M NaH2PO4 and 1.2 M K2HPO4 , VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.95 Å R-free 0.208
4HKC 14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide Deposited 2012-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1M Na HEPES (pH 7.5), 25% PEG 2000 MME, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.20 Å R-free 0.239
4IHL Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A Deposited 2012-12-19 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230
Chain B 1–230（230 aa） Fragment：UNP residues 1-230
Not recorded K POTASSIUM ION × 2 1F5 (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M NA-ACETATE PH 7.0, 0.8 M NAH2PO4 AND 1.2 M K2HPO4, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.20 Å R-free 0.243
4N7G Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS Deposited 2013-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230
Not recorded P6G HEXAETHYLENE GLYCOL × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；277.15 K；0.2 M sodium chloride, 0.1 M sodium acetate, pH 4.5, 40% v/v PEG300, VAPOR DIFFUSION, temperature 277.15K
Resolution 2.25 Å R-free 0.223
4N7Y Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS Deposited 2013-10-16 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230
Chain B 1–230（230 aa） Fragment：UNP residues 1-230
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；277.15 K；0.09 M HEPES sodium, pH 7.5, 1.26 M sodium citrate, 10% v/v glycerol, VAPOR DIFFUSION, temperature 277.15K
Resolution 2.16 Å R-free 0.256
4N84 Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS Deposited 2013-10-17 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230
Chain B 1–230（230 aa） Fragment：UNP residues 1-230
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；277.15 K；1 M potassium sodium tartrate, 0.1 M sodium chloride, 0.1 M imidazole, pH 8.0, cryoprotectant: 20% glycerol, VAPOR DIFFUSION, temperature 277.15K
Resolution 2.50 Å R-free 0.249
4WRQ Crystal Structure of 14-3-3 zeta with Chibby peptide Deposited 2014-10-24 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；16-20% PEG 3350, ammonium formate
Resolution 2.41 Å R-free 0.256
4ZDR Crystal structure of 14-3-3[zeta]-LKB1 fusion protein Deposited 2015-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–230（230 aa） Fragment：UNP residues 1-230,UNP residues 333-340
Chain B 1–230（230 aa） Fragment：UNP residues 1-230,UNP residues 333-340
Mutation：T240E Mutation：T240E GOL GLYCEROL × 3 SO4 SULFATE ION × 2 TME PROPANE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；1.4 M Li2SO4, 0.1 M BIS-TRIS propane
Resolution 2.90 Å R-free 0.245
5D2D Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 Deposited 2015-08-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；HEPES, NaCl, DTT, Li2SO4, Glycine, K2HPO4
Resolution 2.10 Å R-free 0.220
5D3F Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Deposited 2015-08-06 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded FSC FUSICOCCIN × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；HEPES, NaCl, DTT, PEG6000
Resolution 2.74 Å R-free 0.303
5EWZ Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Deposited 2015-11-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded BEZ BENZOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；1.2 M sodium hydrogen phosphate, 0.8 M dipotassium hydrogen phosphate, 0.2 M lithium sulfate, 0.1 M CAPS
Resolution 2.34 Å R-free 0.244
5EXA Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Deposited 2015-11-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded 5SO Fusicoccin A-THF derivative × 2 BEZ BENZOIC ACID × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；0.17 M ammonium acetate, 0.085 M sodium citrate pH 5.6, 25.5% (w/v) PEG 4000, 15% (v/v) glycerol.
Resolution 1.95 Å R-free 0.234
5J31 Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS Deposited 2016-03-30 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded BEZ BENZOIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；1.26 M Tri-Sodium Citrate, 0.09 M HEPES pH 7.5, 10% Glycerol
Resolution 2.40 Å R-free 0.219
5JM4 Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain Deposited 2016-04-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–229（228 aa）
Chain B 2–229（228 aa）
Not recorded BEZ BENZOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.09 M HEPES sodium salt pH 7.5; 1.26 M tri-Sodium citrate; 10 %(v/v) Glycerol
Resolution 2.34 Å R-free 0.244
5M35 The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Deposited 2016-10-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–230（229 aa）
Chain B 2–230（229 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 2 BEZ BENZOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；277.15 K；0.17 M Ammonium acetate; 0.085 M Sodium citrate pH 5.6; 25.5%(w/v) PEG 4000; 15%(v/v) Glycerol
Resolution 2.38 Å R-free 0.277
5M36 The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Deposited 2016-10-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–230（229 aa）
Chain B 2–230（229 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) 9SZ (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene × 4 BEZ BENZOIC ACID × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；277.15 K；0.17 M Ammonium acetate; 0.085 M Sodium citrate pH 5.6; 25.5% (w/v) PEG 4000; 15% (v/v) Glycerol
Resolution 2.45 Å R-free 0.274
5M37 The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Deposited 2016-10-14 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded 9SZ (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene × 4 BEZ BENZOIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.17 M Ammonium acetate;0.085 M tri-Sodium citrate pH 5.6; 25.5 %(w/v) PEG 4000; 15 %(v/v) Glycerol
Resolution 2.35 Å R-free 0.275
5NAS Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide Deposited 2017-02-28 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；MES, PEG, ethylene glycol
Resolution 2.08 Å R-free 0.231
5ULO Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide Deposited 2017-01-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UNX UNKNOWN LIGAND × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；25% PEG 3350, 0.2 M NaCl, 0.1 M HEPES pH7.5,5%~15% Ethylene Glycol
Resolution 2.14 Å R-free 0.270
5WXN Structure of the LKB1 and 14-3-3 complex Deposited 2017-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；0.15 M ammonium chloride, 18% PEG3350
Resolution 2.93 Å R-free 0.254
5XY9 Structure of the MST4 and 14-3-3 complex Deposited 2017-07-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded GOL GLYCEROL × 1 PE4 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.2M MgCl2, 0.1M Tris pH 8.5, 25% PEG 3350
Resolution 2.30 Å R-free 0.245
6EF5 14-3-3 with peptide Deposited 2018-08-16 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277.15 K；0.1 M Tris pH 8.5, 0.1 M MgCl2, 0.001 M NiCl2 and 22% PEG 3350
Resolution 2.44 Å R-free 0.244
6EF5 14-3-3 with peptide Deposited 2018-08-16 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277.15 K；0.1 M Tris pH 8.5, 0.1 M MgCl2, 0.001 M NiCl2 and 22% PEG 3350
Resolution 2.44 Å R-free 0.244
6EJL Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif Deposited 2017-09-21 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；Morpheus HT-96, condition H12
Resolution 2.38 Å R-free 0.215
6EWW Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif Deposited 2017-11-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；PEG 2000, TRIS-HCl, HEPES, magnesium chloride, sodium fluoride, TCEP
Resolution 2.68 Å R-free 0.234
6EWW Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif Deposited 2017-11-06 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–230（230 aa）
Chain D 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；PEG 2000, TRIS-HCl, HEPES, magnesium chloride, sodium fluoride, TCEP
Resolution 2.68 Å R-free 0.234
6F08 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) Deposited 2017-11-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded 1PE PENTAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.2, 36% (v/v) PEG 300
Resolution 1.90 Å R-free 0.267
6F08 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) Deposited 2017-11-17 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain I 1–230（230 aa）
Chain J 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.2, 36% (v/v) PEG 300
Resolution 1.90 Å R-free 0.267
6F09 Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Deposited 2017-11-17 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 1–230（230 aa）
Chain S 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.4; 40% PEG 300
Resolution 1.59 Å R-free 0.225
6F09 Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Deposited 2017-11-17 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain Q 1–230（230 aa）
Chain R 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.4; 40% PEG 300
Resolution 1.59 Å R-free 0.225
6F09 Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Deposited 2017-11-17 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 1–230（230 aa）
Chain S 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.4; 40% PEG 300
Resolution 1.59 Å R-free 0.225
6F09 Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Deposited 2017-11-17 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain Q 1–230（230 aa）
Chain R 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M phosphate citrate pH 4.4; 40% PEG 300
Resolution 1.59 Å R-free 0.225
6FN9 Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Deposited 2018-02-02 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded DW8 [2-[2-oxidanylidene-2-[[3-[2-[2-[2-[3-oxidanylidene-3-(propylamino)propoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid × 2 BEZ BENZOIC ACID × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.09 M HEPES sodium salt pH 7.5 1.26 M tri-Sodium citrate 10 %(v/v) Glycerol
Resolution 2.27 Å R-free 0.256
6FNA Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Deposited 2018-02-02 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded DWE [2-[2-oxidanylidene-2-[[3-[2-[2-[2-[3-oxidanylidene-3-[2-[3-[2-[2-[2-[[4-[2-(2-phosphonophenoxy)ethanoylamino]phenyl]carbonylamino]ethoxy]ethoxy]ethoxy]propanoylamino]ethylamino]propoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid × 2 BEZ BENZOIC ACID × 2 CA CALCIUM ION × 2 CL CHLORIDE ION × 4 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.18 M Magnesium chloride 0.09 M Sodium HEPES pH 7.5 10% (v/v) Glycerol 27% (v/v) Isopropanol
Resolution 2.12 Å R-free 0.236
6FNB Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Deposited 2018-02-02 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded BEZ BENZOIC ACID × 2 GOL GLYCEROL × 3 CA CALCIUM ION × 2 CL CHLORIDE ION × 4 DWQ [2-[2-oxidanylidene-2-[[3-[2-[5-[3-oxidanylidene-3-[3-[2-[2-[3-[3-[2-[2-[2-[[3-[2-(2-phosphonophenoxy)ethanoylamino]phenyl]carbonylamino]ethoxy]ethoxy]ethoxy]propanoylamino]propoxy]ethoxy]ethoxy]propylamino]propoxy]pentoxy]ethylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.09 M HEPES sodium salt pH 7.5 1.26 M tri-Sodium citrate 10 %(v/v) Glycerol
Resolution 2.30 Å R-free 0.248
6FNC Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Deposited 2018-02-02 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded DWK [2-[2-oxidanylidene-2-[[3-[3-[2-[2-[3-[[4-[2-(2-phosphonophenoxy)ethanoylamino]phenyl]carbonylamino]propoxy]ethoxy]ethoxy]propylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid × 2 BEZ BENZOIC ACID × 2 GOL GLYCEROL × 2 CA CALCIUM ION × 2 CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.18 M Magnesium chloride, 0.09 M Sodium HEPES pH 7.5 10%(v/v) Glycerol 27%(v/v) Isopropanol
Resolution 2.12 Å R-free 0.246
6Q0K Structure of a MAPK pathway complex Deposited 2019-08-01 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain X 1–245（245 aa）
Chain Y 1–245（245 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.80 Å
6RLZ Crystal Structure of 14-3-3zeta in complex with a macrocyclic 8-mer peptide derived from ExoS Deposited 2019-05-03 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；0.2 M Magnesium formate 20% PEG 3350 pH 7.5
Resolution 3.70 Å R-free 0.292
6U2H BRAF dimer bound to 14-3-3 Deposited 2019-08-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded 29L 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；PEG 6000 Tris pH 7.5
Resolution 2.50 Å R-free 0.263
6XAG Apo BRAF dimer bound to 14-3-3 Deposited 2020-06-04 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；289 K；100 mM HEPES pH 7.5, 200 mM ammonium sulfate, 23% (w/v) PEG 3350
Resolution 3.30 Å R-free 0.300
6YMO Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Deposited 2020-04-09 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded SAL 2-HYDROXYBENZOIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 6.8；277.15 K；2.04 M ammonium sulfate, 0.2 M sodium citrate supplemented with 10% of an additive buffer containing 0.33% w/v 3-aminobenzoic acid, 0.33% w/v 3-aminosalicylic acid, 0.33% w/v salicylic acid and 0.02 M HEPES sodium pH 6.8
Resolution 2.02 Å R-free 0.234
6YO8 Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Deposited 2020-04-14 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 8.3；277.15 K；1.29 M MgCl2, 22.5% PEG 3350, 0.1 M Tris pH 8.3, supplemented with 10% of an additive buffer containing 40% v/v of 2,5-Hexanediol
Resolution 2.09 Å R-free 0.238
6YO8 Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Deposited 2020-04-14 Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–230（230 aa）
Chain D 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 8.3；277.15 K；1.29 M MgCl2, 22.5% PEG 3350, 0.1 M Tris pH 8.3, supplemented with 10% of an additive buffer containing 40% v/v of 2,5-Hexanediol
Resolution 2.09 Å R-free 0.238
6YOS Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide Deposited 2020-04-15 Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 6.8；293.15 K；0.35 M MgCl2, 24.4% PEG 3350, 0. 1 M Bis Tris pH 5.5 supplemented with 10% of an additive buffer containing 0.06 M CHAPS, 0.06 M HEPES, 0.06 M Tris, 0.25% w/v Hexamminecobalt(III) chloride and 0.02 M HEPES sodium pH 6.8.
Resolution 2.75 Å R-free 0.261
6ZFD 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–229（229 aa）
Chain B 1–229（229 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；19% PEG4000, 0.1M cacodylate, 20%glycerol as a cryoprotectant
Resolution 1.90 Å R-free 0.207
6ZFG 14-3-3 zeta chimera with 18E6 and fusicoccin Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–229（229 aa）
Chain B 1–229（229 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 FSC FUSICOCCIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；19% PEG4000, 0.1M cacodylate, 20%glycerol as a cryoprotectant
Resolution 1.85 Å R-free 0.219
7D8H CRTC1 pSer64 peptide in complex with 14-3-3 zeta Deposited 2020-10-08 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；200mM Ammonium acetate, 100mM Bis-Tris (pH6.5), 25% (w/v) Polyethylene glycol 3350
Resolution 2.42 Å R-free 0.246
7D8P CRTC1 pSer151 peptide in complex with 14-3-3 zeta Deposited 2020-10-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；200mM Ammonium acetate, 100mM Bis-Tris (pH6.5), 25% (w/v) Polyethylene glycol 3350
Resolution 2.00 Å R-free 0.229
7D9V CRTC1 pSer245 peptide in complex with 14-3-3 zeta Deposited 2020-10-14 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；200mM Ammonium acetate, 100mM Bis-Tris (pH6.5), 25% (w/v) Polyethylene glycol 3350
Resolution 2.21 Å R-free 0.240
7MFD Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved Deposited 2021-04-09 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded ZN ZINC ION × 2 CHU N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
7MFE Autoinhibited BRAF:(14-3-3)2 complex with the BRAF RBD resolved Deposited 2021-04-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–245（245 aa）
Chain C 1–245（245 aa）
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.07 Å
7MFF Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor Deposited 2021-04-09 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded 215 (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.89 Å
7Q16 Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74 Deposited 2021-10-18 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–229（229 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.16 M calcium acetate, 0.08 M sodium cacodylate pH 6.5, 14.4 % w/v PEG 8000, 20 % v/v glycerol
Resolution 2.36 Å R-free 0.241
7ZIT 14-3-3 in complex with SARS-COV2 N phospho-peptide Deposited 2022-04-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded ACT ACETATE ION × 2 GOL GLYCEROL × 1 BEZ BENZOIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；9 0.2 M Sodium acetate 0.1 M Sodium cacodylate pH 6.5 30% (w/v) PEG 8000
Resolution 1.79 Å R-free 0.205
8A9G Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1 Deposited 2022-06-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–230（230 aa）
Chain B 1–230（230 aa）
Not recorded BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2 QJK 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.4 M MgCl2 27% w/v PEG 3350 0.1 M Bis Tris 6.5 pH
Resolution 1.96 Å R-free 0.261
8AH2 Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48 Deposited 2022-07-20 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–229（229 aa）
Mutation：S58A,E75A,K76A,K77A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；0.01 M CoCl2, 0.1 M MES, pH 6.5, 2.2 M (NH4)2SO4
Resolution 2.90 Å R-free 0.323
8AH2 Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48 Deposited 2022-07-20 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 1–229（229 aa）
Mutation：S58A,E75A,K76A,K77A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；0.01 M CoCl2, 0.1 M MES, pH 6.5, 2.2 M (NH4)2SO4
Resolution 2.90 Å R-free 0.323
8VYO Cryo-EM Structure of the BRAF WT monomer Deposited 2024-02-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–230（229 aa）
Chain C 2–230（229 aa）
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 3.74 Å
8VYP Cryo-EM Structure of the BRAF V600E monomer Deposited 2024-02-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 3.29 Å
8VYQ Cryo-EM Structure of the BRAF V600K monomer Deposited 2024-02-09 Different construct Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 4.43 Å
8VYR Cryo-EM Structure of the BRAF V600E monomer bound to GDC0879 Deposited 2024-02-09 Different construct Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–245（245 aa）
Chain C 1–245（245 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 4.32 Å
8VYS Cryo-EM Structure of the BRAF V600E monomer bound to PLX8394 Deposited 2024-02-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 2–245（244 aa）
Chain C 2–245（244 aa）
Not recorded A1AEN (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 3.06 Å
8VYU Cryo-EM Structure of the BRAF WT monomer bound to PLX8394 Deposited 2024-02-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–245（245 aa）
Chain C 1–245（245 aa）
Not recorded A1AEN (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 4.07 Å
8VYV Cryo-EM Structure of the BRAF K601E monomer Deposited 2024-02-09 Different construct Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 5.86 Å
8VYW Cryo-EM Structure of the BRAF D594G monomer Deposited 2024-02-09 Different construct Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Chameleon system (SPT Labtech)
Resolution 4.76 Å
8WE2 14-3-3 zeta complexed with S609 phosphorylated peptide derived from GPIb alpha cytoplasmic domain Deposited 2023-09-16 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.2M Sodium Acetate, 20% PEG 3350
Resolution 2.11 Å R-free 0.238
8WF6 14-3-3 zeta complexed with S559 phosphorylated peptide derived from GPIb alpha cytoplasmic domain Deposited 2023-09-19 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；2% Tacsimate pH7.0, 0.1M Hepes pH7.5, 20% PEG 3350
Resolution 2.47 Å R-free 0.238
8WF6 14-3-3 zeta complexed with S559 phosphorylated peptide derived from GPIb alpha cytoplasmic domain Deposited 2023-09-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded SIN SUCCINIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；2% Tacsimate pH7.0, 0.1M Hepes pH7.5, 20% PEG 3350
Resolution 2.47 Å R-free 0.238
9FUM Dimeric 14-3-3 zeta in complex with MAP2c peptide containing pS435 Deposited 2024-06-26 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded CD CADMIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；100 mM HEPES pH(7.5), 400 mM Sodium acetate, 8mM Cadmium sulfate
Resolution 2.45 Å R-free 0.275
9FVL Dimeric 14-3-3 zeta in complex with unphosphorylated MAP2c peptide Deposited 2024-06-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–245（245 aa）
Chain B 1–245（245 aa）
Not recorded CD CADMIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；100 mM HEPES pH(7.5), 400 mM Sodium acetate, 8mM Cadmium sulfate
Resolution 2.08 Å R-free 0.283
9O2Z Autoinhibited BRAF:(14-3-3)2:MEK complex from Insect cells Deposited 2025-04-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 1–245（245 aa）
Chain D 1–245（245 aa）
Not recorded ZN ZINC ION × 2 CHU N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.83 Å
9SV3 Local refinement of EloB/EloC/VHL/CV2a/14-3-3zeta/ERa from pose 1 Deposited 2025-09-30 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain D 1–245（245 aa）
Chain I 1–245（245 aa）
Not recorded A1JQT ~{N}'-[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]-~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]tridecanediamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
9UJ2 14-3-3 zeta chimera with the S202R peptide of SARS-CoV-2 N (residues 200-213) Deposited 2025-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–229（229 aa）
Chain B 1–229（229 aa）
Mutation：S202R,S58A,E73A,K74A,K75A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S202R,S58A,E73A,K74A,K75A,K157A,K158A,E159A Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 16 PEG DI(HYDROXYETHYL)ETHER × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；288 K；1.8M Ammonium sulfate, 0.1M BIS-TRIS pH 6.5, 2% v/v Polyethylene glycol monomethyl ether 550
Resolution 1.80 Å R-free 0.233

73 other PDB entries and 87 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name 1433Z_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–230； UniProt 1–230 Author chain B； PDBConstruct 1–230； UniProt 1–230 Author chain E； PDBConstruct 1–230； UniProt 1–230 Author chain G； PDBConstruct 1–230； UniProt 1–230

Microtubule-associated protein tau

OrganismNot specified

UniProt P10636

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain C； UniProt 527–539 Chain C； UniProt 635–648 Non-standard monomer：Yes (specific site not provided by mmCIF) 14-3-3 protein zeta/delta × 2 （P63104） X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350 Resolution 2.50 Å R-free 0.260
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain F； UniProt 527–539 Chain F； UniProt 635–648 Non-standard monomer：Yes (specific site not provided by mmCIF) 14-3-3 protein zeta/delta × 2 （P63104） X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Sodium Fluoride, 0.1M bis-tris propane pH 6.5, 20% w/v PEG 3350 Resolution 2.50 Å R-free 0.260

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 8QDV Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
10IJ S305I Frontotemporal Lobar Degeneration (FTLD) type I tau filament Deposited 2026-01-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 11 PDB declaration: 11-meric
Chain A 590–696（107 aa）
Chain B 590–696（107 aa）
Chain C 590–696（107 aa）
Chain D 590–696（107 aa）
Chain E 590–696（107 aa）
Chain F 590–696（107 aa）
Chain G 590–696（107 aa）
Chain H 590–696（107 aa）
Chain I 590–696（107 aa）
Chain J 590–696（107 aa）
Chain K 590–696（107 aa）
Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
10IK S305I Frontotemporal Lobar Degeneration (FTLD) type II tau filament Deposited 2026-01-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 590–696（107 aa）
Chain B 590–696（107 aa）
Chain C 590–696（107 aa）
Chain D 590–696（107 aa）
Chain E 590–696（107 aa）
Chain F 590–696（107 aa）
Chain G 590–696（107 aa）
Chain H 590–696（107 aa）
Chain I 590–696（107 aa）
Chain J 590–696（107 aa）
Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I Mutation：S305I No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
1I8H SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH HUMAN TAU PHOSPHOTHREONINE PEPTIDE Deposited 2001-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 541–553（13 aa） Fragment：(RESIDUES 541-553)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.4；285 K；Ionic strength (raw mmCIF value) 100 mM NaCl；Pressure ambient
NMR sample composition sample of 1mM Pin1 WW domain / 11mM tau ligand buffer of 50 mM deutered Tris-D2O, pH 6.4, 100 mM NaCl | 90% H2O/10% D2O
Resolution not provided
22JY P301L/S320F human tau filaments from mouse brain Deposited 2026-01-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 596–646（51 aa）
Chain B 596–646（51 aa）
Chain C 596–646（51 aa）
Chain D 596–646（51 aa）
Chain E 596–646（51 aa）
Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F Mutation：P301L, S320F No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
2MZ7 Structure of Tau(267-312) bound to Microtubules Deposited 2015-02-06 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 584–629（46 aa） Fragment：UNP residues 584-629
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；278 K；Pressure ambient
NMR sample composition 50 mM sodium phosphate, 1 mM Tau, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 50 mM sodium phosphate, 1 mM Tau, 50 uM microtubules, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3OVL Structure of an amyloid forming peptide VQIVYK from the TAU protein in complex with orange G Deposited 2010-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 623–628（6 aa） Fragment：VQIVYK (residues 306-311)
Not recorded ZN ZINC ION × 12 ACY ACETIC ACID × 6 ORA 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；reservoir contained 0.1M Zinc Acetate dihydrate, 18% PEG 3350, vapor diffusion, hanging drop, temperature 291K
Resolution 1.81 Å R-free 0.259
4FL5 Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 Deposited 2012-06-14 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–536（10 aa） Fragment：UNP residues 527-536
Chain Q 527–536（10 aa） Fragment：UNP residues 527-536
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 MG MAGNESIUM ION × 4 CA CALCIUM ION × 6 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1 M Hepes/NaOH pH 7.5, 0.2 M CaCl2, 28% PEG 400, 5% glycerol, 2 mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.90 Å R-free 0.212
4NP8 Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) Deposited 2013-11-20 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric
Chain A 623–628（6 aa） Fragment：UNP residues 623-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；reservoir contained 14% iso-Propanol, 0.07M HEPES-Na pH 7.5, 0.14M Sodium Citrate, and 30% Glycerol, vapor diffusion, hanging drop, temperature 298K
Resolution 1.51 Å R-free 0.196
4TQE Structure of tau peptide in complex with Tau5 antibody Fab fragment Deposited 2014-06-11 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 532–547（16 aa） Fragment：Residues 532-547
Not recorded SO4 SULFATE ION × 5 NA SODIUM ION × 4 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；0.2M lithium sulphate, 30% PEG 4000, 0.1M Tris pH 8.5
Resolution 1.60 Å R-free 0.197
4Y5I Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma Deposited 2015-02-11 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 528–534（7 aa） Fragment：UNP residues 528-534
Chain G 528–534（7 aa） Fragment：UNP residues 528-534
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.1；277 K；0.1 M Hepes/NaOH pH 7.1, 0.19 M CaCl2, 24% PEG 400, 5% glycerol
Resolution 1.40 Å R-free 0.172
5MO3 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 8.5 Deposited 2016-12-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 615–628（14 aa） Fragment：UNP residues 615-628
Not recorded PGE TRIETHYLENE GLYCOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；30% PEG 4000, 0.1 M Tris, 0.2 M LiSO4
Resolution 1.69 Å R-free 0.235
5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
Resolution 3.10 Å R-free 0.268
5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
Resolution 3.10 Å R-free 0.268
5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
Resolution 3.10 Å R-free 0.268
5MP1 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 4000; 10% 2-Propanol, 0.1 M Na-HEPES
Resolution 3.10 Å R-free 0.268
5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain K 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
Resolution 2.31 Å R-free 0.277
5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
Resolution 2.31 Å R-free 0.277
5MP5 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 Deposited 2016-12-15 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain J 615–628（14 aa） Fragment：UNP Residues 615-628
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20% PEG 8000, 0.1 M Na-cacodylate, 0.2 M Mg-acetate
Resolution 2.31 Å R-free 0.277
5N5A Structure of Tau(254-290) bound to F-actin Deposited 2017-02-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 571–607（37 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；278 K；Pressure ambient
NMR measurement conditions pH 6.8；278 K；Pressure ambient
NMR sample composition 800 uM Tau(254-290), 27 uM F-actin, 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 800 uM Tau(254-290), 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
5N5B Structure of Tau(292-319) bound to F-actin Deposited 2017-02-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 609–636（28 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；278 K；Pressure ambient
NMR measurement conditions pH 6.8；278 K；Pressure ambient
NMR sample composition 800 uM Tau(292-319), 27 uM F-actin, 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 800 uM Tau(254-290), 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
5O3L Paired helical filament in Alzheimer's disease brain Deposited 2017-05-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 623–695（73 aa） Fragment：UNP Residues 623-695
Chain B 623–695（73 aa） Fragment：UNP Residues 623-695
Chain C 623–695（73 aa） Fragment：UNP Residues 623-695
Chain D 623–695（73 aa） Fragment：UNP Residues 623-695
Chain E 623–695（73 aa） Fragment：UNP Residues 623-695
Chain F 623–695（73 aa） Fragment：UNP Residues 623-695
Chain G 623–695（73 aa） Fragment：UNP Residues 623-695
Chain H 623–695（73 aa） Fragment：UNP Residues 623-695
Chain I 623–695（73 aa） Fragment：UNP Residues 623-695
Chain J 623–695（73 aa） Fragment：UNP Residues 623-695
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
5O3O Pronase-treated paired helical filament in Alzheimer's disease brain Deposited 2017-05-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 623–695（73 aa） Fragment：UNP Residues 623-695
Chain B 623–695（73 aa） Fragment：UNP Residues 623-695
Chain C 623–695（73 aa） Fragment：UNP Residues 623-695
Chain D 623–695（73 aa） Fragment：UNP Residues 623-695
Chain E 623–695（73 aa） Fragment：UNP Residues 623-695
Chain F 623–695（73 aa） Fragment：UNP Residues 623-695
Chain G 623–695（73 aa） Fragment：UNP Residues 623-695
Chain H 623–695（73 aa） Fragment：UNP Residues 623-695
Chain I 623–695（73 aa） Fragment：UNP Residues 623-695
Chain J 623–695（73 aa） Fragment：UNP Residues 623-695
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
5O3T Straight filament in Alzheimer's disease brain Deposited 2017-05-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 623–695（73 aa） Fragment：UNP Residues 623-695
Chain B 623–695（73 aa） Fragment：UNP Residues 623-695
Chain C 623–695（73 aa） Fragment：UNP Residues 623-695
Chain D 623–695（73 aa） Fragment：UNP Residues 623-695
Chain E 623–695（73 aa） Fragment：UNP Residues 623-695
Chain F 623–695（73 aa） Fragment：UNP Residues 623-695
Chain G 623–695（73 aa） Fragment：UNP Residues 623-695
Chain H 623–695（73 aa） Fragment：UNP Residues 623-695
Chain I 623–695（73 aa） Fragment：UNP Residues 623-695
Chain J 623–695（73 aa） Fragment：UNP Residues 623-695
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris-HCl pH 7.4 containing 100 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
5V5B KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 Deposited 2017-03-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric
Chain A 591–600（10 aa） Fragment：Repeat 2 peptide (UNP residues 591-600)
Not recorded No recorded non-water small molecule ELECTRON CRYSTALLOGRAPHY
cryo-EM buffer pH 4.2
cryo-EM vitrification conditions Cryogen ETHANE
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.2；310 K；0.1 M phosphate citrate, 32% PEG10000
Resolution 1.50 Å R-free 0.213
5V5B KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 Deposited 2017-03-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric
Chain A 591–600（10 aa） Fragment：Repeat 2 peptide (UNP residues 591-600)
Not recorded No recorded non-water small molecule ELECTRON CRYSTALLOGRAPHY
cryo-EM buffer pH 4.2
cryo-EM vitrification conditions Cryogen ETHANE
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.2；310 K；0.1 M phosphate citrate, 32% PEG10000
Resolution 1.50 Å R-free 0.213
5ZV3 Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide Deposited 2018-05-09 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 52–71（20 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.085M Tris-HCl, pH 8.5, 0.17M sodium acetate, 25.5% PEG 4000
Resolution 2.09 Å R-free 0.251
6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 703–725（23 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
Resolution 2.10 Å R-free 0.270
6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain Q 703–725（23 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
Resolution 2.10 Å R-free 0.270
6BB4 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. Deposited 2017-10-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain R 703–725（23 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25.5% polyethylene glycol 4000, 0.17 M ammonium sulfate, 15% glycerol
Resolution 2.10 Å R-free 0.270
6DC8 Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 3 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；23% polyethylene glycol 8000, 0.17 M ammonium acetate, and 0.085 M sodium cacodylate trihydrate pH 6.5
Resolution 1.80 Å R-free 0.219
6DC9 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；25.5% polyethylene glycol 4000 and 0.17 M ammonium sulfate
Resolution 3.00 Å R-free 0.260
6DC9 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain Q 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；25.5% polyethylene glycol 4000 and 0.17 M ammonium sulfate
Resolution 3.00 Å R-free 0.260
6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
Resolution 2.60 Å R-free 0.259
6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain Q 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
Resolution 2.60 Å R-free 0.259
6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain R 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
Resolution 2.60 Å R-free 0.259
6DCA Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. Deposited 2018-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain S 696–725（30 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2M ammonium sulfate
Resolution 2.60 Å R-free 0.259
6GX5 Narrow Pick Filament from Pick's disease brain Deposited 2018-06-26 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 196–289（94 aa）
Chain B 196–289（94 aa）
Chain C 196–289（94 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain I 739–764（26 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
Resolution 2.63 Å R-free 0.270
6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain K 739–764（26 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
Resolution 2.63 Å R-free 0.270
6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 739–764（26 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
Resolution 2.63 Å R-free 0.270
6H06 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 Deposited 2018-07-06 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain J 739–764（26 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.20 M KCl, 0.10 M Hepes/NaOH pH=7, 21.2 % (w/v) PEG 5K MME
Resolution 2.63 Å R-free 0.270
6HRE Paired helical filament from sporadic Alzheimer's disease brain Deposited 2018-09-26 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
6HRF Straight filament from sporadic Alzheimer's disease brain Deposited 2018-09-26 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
6N4P RQEFEV, crystal structure of the N-terminal segment RQEFEV from protein tau Deposited 2018-11-19 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 5–10（6 aa） Fragment：UNP residues 5-10
Chain C 5–10（6 aa） Fragment：UNP residues 5-10
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M ammonium citrate dibasic, 30% PEG3350
Resolution 1.85 Å R-free 0.269
6NK4 KVQIINKKL, crystal structure of a tau protein fragment Deposited 2019-01-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 591–599（9 aa） Fragment：repeat 2 peptide (UNP residues 591-599)
Not recorded No recorded non-water small molecule ELECTRON CRYSTALLOGRAPHY
cryo-EM vitrification conditions Cryogen ETHANE
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M lithium citrate, 20% PEG3350
Resolution 1.99 Å R-free 0.299
6NWP Chronic traumatic encephalopathy Type I Tau filament Deposited 2019-02-07 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
6NWQ Chronic traumatic encephalopathy Type II Tau filament Deposited 2019-02-07 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
6ODG SVQIVY, Crystal Structure of a tau protein fragment Deposited 2019-03-26 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 622–627（6 aa） Fragment：UNP residues 622-627
Chain B 622–627（6 aa） Fragment：UNP residues 622-627
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；3.3 mg/mL SVQIVY, 0.667 M DL-malic acid, pH 7.0, 8% w/v PEG3350
Resolution 1.00 Å R-free 0.266
6PXR Anti-TAU BIIB092 FAB with TAU peptide Deposited 2019-07-26 Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 15–22（8 aa） Fragment：UNP residues 15-22
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；100 mM Tris-HCl, pH 8.5, 20% w/v PEG2000 MME, 200 mM trimethylamine N-oxide, 100 mM non-detergent sulfobetaine 201
Resolution 1.56 Å R-free 0.268
6QJH Cryo-EM structure of heparin-induced 2N4R tau snake filaments Deposited 2019-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 243–301（59 aa）
Chain B 243–301（59 aa）
Chain C 243–301（59 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.30 Å
6QJM Cryo-EM structure of heparin-induced 2N4R tau twister filaments Deposited 2019-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 274–321（48 aa）
Chain B 274–321（48 aa）
Chain C 274–321（48 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.30 Å
6QJP Cryo-EM structure of heparin-induced 2N4R tau jagged filaments Deposited 2019-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 274–321（48 aa）
Chain B 274–321（48 aa）
Chain C 274–321（48 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.50 Å
6QJQ Cryo-EM structure of heparin-induced 2N3R tau filaments Deposited 2019-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 214–241（28 aa）
Chain B 214–241（28 aa）
Chain C 214–241（28 aa）
Chain D 214–241（28 aa）
Chain E 214–241（28 aa）
Chain F 214–241（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.70 Å
6TJO Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration Deposited 2019-11-26 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.20 Å
6TJX Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration Deposited 2019-11-27 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris, pH 7.4, 100mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；Blot force: -12 ; Blot time: 4s
Resolution 3.00 Å
6VH7 Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue Deposited 2020-01-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 216–322（107 aa）
Chain B 216–322（107 aa）
Chain C 216–322（107 aa）
Chain E 216–322（107 aa）
Chain F 216–322（107 aa）
Chain G 216–322（107 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6VHA Singlet Tau Fibril from Corticobasal Degeneration Human Brain Tissue Deposited 2020-01-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain E 216–322（107 aa）
Chain F 216–322（107 aa）
Chain G 216–322（107 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6VHL Paired Helical Filament from Alzheimer's Disease Human Brain Tissue Deposited 2020-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Not recorded GLY GLYCINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
6VI3 Straight Filament from Alzheimer's Disease Human Brain Tissue Deposited 2020-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Not recorded GLY GLYCINE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 527–539（13 aa） Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
Resolution 2.00 Å R-free 0.213
6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 527–539（13 aa） Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
Resolution 2.00 Å R-free 0.213
6XLI CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE Deposited 2020-06-28 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 527–539（13 aa） Fragment：residues 210-222 of Tau, phosporylated on T212 and T217
Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；20% PEG 3350, 0.2 M NH4H2PO4
Resolution 2.00 Å R-free 0.213
7NRQ Paired helical filament from primary age-related tauopathy brain Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.76 Å
7NRS Conformation 1 of straight filament from primary age-related tauopathy brain Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.68 Å
7NRT Conformation 2 of straight filament from primary age-related tauopathy brain Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.68 Å
7NRV Paired helical filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain D 1–441（441 aa）
Chain G 1–441（441 aa）
Chain I 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7NRV Paired helical filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain C 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain H 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7NRX Straight filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain D 1–441（441 aa）
Chain F 1–441（441 aa）
Chain H 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.55 Å
7NRX Straight filament from Alzheimer's disease with PET ligand APN-1607 Deposited 2021-03-04 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain C 1–441（441 aa）
Chain E 1–441（441 aa）
Chain G 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.55 Å
7P65 Progressive supranuclear palsy tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
7P66 Globular glial tauopathy type 1 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7P67 Globular glial tauopathy type 2 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7P68 Globular glial tauopathy type 3 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
7P6A Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.90 Å
7P6B Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
7P6C Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
7P6D Argyrophilic grain disease type 1 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7P6E Argyrophilic grain disease type 2 tau filament Deposited 2021-07-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Chain Q 1–441（441 aa）
Chain R 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7PQC tau-microtubule structural ensemble based on CryoEM data Deposited 2021-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain O 202–395（194 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 7 MG MAGNESIUM ION × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7PQP tau-microtubule structural ensemble based on CryoEM data Deposited 2021-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain O 202–395（194 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 7 MG MAGNESIUM ION × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7QJV In vitro assembled tau filaments into Quadruple Helical Filaments type 1 (2c) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Chain K 1–441（441 aa）
Chain L 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.29 Å
7QJW In vitro assembled tau filaments with structures like chronic traumatic encephalopathy type II (8a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.81 Å
7QJX In vitro assembled 297-394 tau filaments, 700 rpm (34b) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Chain K 1–441（441 aa）
Chain L 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.99 Å
7QJY In vitro assembled 266/297 - 391 tau filaments with LiCl (9a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.14 Å
7QJZ In vitro assembled 266/297 - 391 tau filaments with LiCl (9b) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7QK1 In vitro assembled 297-394 tau filaments in PBS (35d) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.03 Å
7QK2 In vitro assembled 300-391 tau filaments in PBS (36a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å
7QK3 In vitro assembled 258-391 tau filaments, 700 rpm (38a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.44 Å
7QK5 In vitro assembled 266/297 - 391 tau filaments with KCl (10a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain K 1–441（441 aa）
Not recorded CL CHLORIDE ION × 18 K POTASSIUM ION × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.92 Å
7QK6 In vitro assembled 258-391 tau filaments with heparan sulfate, 700 rpm (40a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.27 Å
7QKF In vitro assembled 266/297 - 391 tau filaments with CuCl2 (12a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.83 Å
7QKG In vitro assembled 258-391 tau filaments with phosphoglycerate, 700 rpm (39a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
7QKH In vitro assembled 258-391 tau filaments with sodium azide, (41a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain G 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å
7QKI In vitro assembled 297-408 S396D S400D T403D S404D tau filaments (42a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
7QKJ In vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14b) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Chain K 1–441（441 aa）
Chain L 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.26 Å
7QKK In vitro assembled 258-391 tau filaments with phosphoglycerate, 700 rpm (39a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
7QKL In vitro assembled 266/297 - 391 tau filaments with ZnCl2 (11a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.07 Å
7QKM In vitro assembled 266-391 S356D tau filaments with NaCl (45a) Deposited 2021-12-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.66 Å
7QKU in vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.57 Å
7QKV In vitro assembled tau filaments with MgSO4 and NaCl (15a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.23 Å
7QKW In vitro assembled 266-391 S356D tau filaments with KCl (44a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.32 Å
7QKX In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15b) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain G 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.16 Å
7QKY In vitro assembled 0N4R tau filaments with phosphoserine (47a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.86 Å
7QKZ In vitro assembled 305-379 tau filaments (27a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.65 Å
7QL0 In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15c) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain c 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
7QL1 In vitro assembled 266-391 tau filaments in PBS (23a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.34 Å
7QL2 In vitro assembled 244-391 tau filaments with Na2P2O7 (20a) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
7QL3 in vitro assembled 266/297 - 391 tau filaments with NaCl (8b) Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.32 Å
7QL4 in vitro assembled tau filaments with structures like Paired Helical Filaments from Alzheimer's Disease Deposited 2021-12-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
7R4T In vitro assembled 266/297 - 391 tau filaments with NaHCO3 and NaCl (16a) Deposited 2022-02-09 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.75 Å
7R5H In vitro assembled 266/297 - 391 tau filaments with KCl (10b) Deposited 2022-02-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.59 Å
7U0Z High-resolution map of tau filament from progressive supranuclear palsy (PSP) case 1 Deposited 2022-02-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 243–352（110 aa） Fragment：UNP residues 243-352
Chain B 243–352（110 aa） Fragment：UNP residues 243-352
Chain C 243–352（110 aa） Fragment：UNP residues 243-352
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
7YMN Cryo-EM structure of in vitro PHF fibril Deposited 2022-07-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 239–333（95 aa）
Chain B 239–333（95 aa）
Chain C 239–333（95 aa）
Chain D 239–333（95 aa）
Chain E 239–333（95 aa）
Chain F 239–333（95 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
7YPG Cryo-EM structure of amyloid fibril formed by tau (297-391) Deposited 2022-08-03 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 268–362（95 aa）
Chain B 268–362（95 aa）
Chain C 268–362（95 aa）
Chain D 268–362（95 aa）
Chain E 268–362（95 aa）
Chain F 268–362（95 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8AZU Paired helical tau filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | PHF Tau Deposited 2022-09-06 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain C 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8BGS Tau Paired Helical Filament from Extracellular Vesicles from Alzheimer's disease brain Deposited 2022-10-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain r 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.16 Å
8BGV Tau Paired Helical Filament from Cellular Fraction of Alzheimer's disease brain Deposited 2022-10-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain n 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å
8BYN Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir Deposited 2022-12-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded S9C 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
8CAQ Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis Deposited 2023-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
8CAX Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis Deposited 2023-01-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8FNZ Acetylated tau repeat 1 and 2 fragment (AcR1R2) Deposited 2022-12-29 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 48 PDB declaration: 48-meric
Chain A 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain B 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain C 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain D 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain E 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain F 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain G 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain H 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain I 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain J 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain K 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain L 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain M 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain N 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain O 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain P 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain Q 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain R 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain S 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain T 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain U 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain V 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain W 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain X 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain a 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain b 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain c 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain d 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain e 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain f 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain g 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain h 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain i 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain j 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain k 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain l 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain m 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain n 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain o 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain p 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain q 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain r 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain s 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain t 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain u 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain v 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain w 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Chain x 263–280（18 aa） Fragment：acetylated repeat 1 and 2 fragment (AcR1R2)
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；This is PBS (1x)
cryo-EM vitrification conditions Cryogen ETHANE；We used blot-force of -5, and blot-time of 4 seconds.
Resolution 3.88 Å
8FUG Alzheimer's disease paired-helical filament in complex with PET tracer GTP-1 Deposited 2023-01-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 23 PDB declaration: 23-meric
Chain A 275–347（73 aa）
Chain B 275–347（73 aa）
Chain C 275–347（73 aa）
Chain D 275–347（73 aa）
Chain E 275–347（73 aa）
Chain F 275–347（73 aa）
Chain G 275–347（73 aa）
Chain H 275–347（73 aa）
Chain I 275–347（73 aa）
Chain J 275–347（73 aa）
Chain K 275–347（73 aa）
Chain L 275–347（73 aa）
Chain M 275–347（73 aa）
Chain N 275–347（73 aa）
Chain O 275–347（73 aa）
Chain P 275–347（73 aa）
Chain Q 275–347（73 aa）
Chain R 275–347（73 aa）
Chain S 275–347（73 aa）
Chain T 275–347（73 aa）
Chain U 275–347（73 aa）
Chain V 275–347（73 aa）
Chain W 275–347（73 aa）
Not recorded Y9H (5S)-2-[4-(2-fluoroethyl)piperidin-1-yl]pyrimido[1,2-a]benzimidazole × 23 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris-HCl, pH 7.4, 100 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8G54 Temperature-dependent structures of tau aggregates Deposited 2023-02-11 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 198–399（202 aa）
Chain B 198–399（202 aa）
Chain C 198–399（202 aa）
Chain D 198–399（202 aa）
Chain E 198–399（202 aa）
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 7.4；295 K；Ionic strength (raw mmCIF value) 135；Pressure 1
NMR sample composition 5 uM [U-13C; U-15N] Microtubule-associated protein tau, 100% H2O | 100% H2O
Resolution not provided
8G55 Temperature-dependent structures of tau aggregates Deposited 2023-02-11 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 198–399（202 aa）
Chain B 198–399（202 aa）
Chain C 198–399（202 aa）
Chain D 198–399（202 aa）
Chain E 198–399（202 aa）
Chain F 198–399（202 aa）
Chain G 198–399（202 aa）
Chain H 198–399（202 aa）
Chain I 198–399（202 aa）
Chain J 198–399（202 aa）
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 7.4；285 K；Ionic strength (raw mmCIF value) 135；Pressure 1
NMR sample composition 5 uM [U-13C; U-15N] P2R tau, 100% H2O | 100% H2O
Resolution not provided
8G58 Tau (297-391) in vitro untwisted fibril Deposited 2023-02-12 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 614–708（95 aa）
Chain B 614–708（95 aa）
Chain C 614–708（95 aa）
Chain D 614–708（95 aa）
Chain E 614–708（95 aa）
Chain F 614–708（95 aa）
Chain G 614–708（95 aa）
Chain H 614–708（95 aa）
Chain I 614–708（95 aa）
Chain J 614–708（95 aa）
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 5；287 K；Ionic strength (raw mmCIF value) 0.6；Pressure 1
NMR sample composition 1 uM UCN Tau (297-391), 100% H2O | 100% H2O
NMR sample composition 0.5 uM UCN Tau (297-391), 0.5 uM Tau (297-391), 100% H2O | 100% H2O
NMR sample composition 1 uM 1,3-Glycerol,15N Tau (297-391), 100% H2O | 100% H2O
Resolution not provided
8KDX Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Deposited 2023-08-10 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 207–221（15 aa） Fragment：Tau Peptide 207-221
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293.15 K；1.2 M Sodium citrate tribasic dehydrated, 0.1 M Tris buffer pH8.5
Resolution 1.01 Å R-free 0.185
8OH2 Structure of the Tau-PAM4 Type 1 amyloid fibril Deposited 2023-03-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 36 PDB declaration: 36-meric
Chain A 666–680（15 aa）
Chain B 666–680（15 aa）
Chain C 666–680（15 aa）
Chain D 666–680（15 aa）
Chain E 666–680（15 aa）
Chain F 666–680（15 aa）
Chain G 666–680（15 aa）
Chain H 666–680（15 aa）
Chain I 666–680（15 aa）
Chain J 666–680（15 aa）
Chain K 666–680（15 aa）
Chain L 666–680（15 aa）
Chain M 666–680（15 aa）
Chain N 666–680（15 aa）
Chain O 666–680（15 aa）
Chain P 666–680（15 aa）
Chain Q 666–680（15 aa）
Chain R 666–680（15 aa）
Chain S 666–680（15 aa）
Chain T 666–680（15 aa）
Chain U 666–680（15 aa）
Chain V 666–680（15 aa）
Chain W 666–680（15 aa）
Chain X 666–680（15 aa）
Chain Y 666–680（15 aa）
Chain Z 666–680（15 aa）
Chain a 666–680（15 aa）
Chain b 666–680（15 aa）
Chain c 666–680（15 aa）
Chain d 666–680（15 aa）
Chain e 666–680（15 aa）
Chain f 666–680（15 aa）
Chain g 666–680（15 aa）
Chain h 666–680（15 aa）
Chain i 666–680（15 aa）
Chain j 666–680（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
8OHI Structure of the Fmoc-Tau-PAM4 Type 2 amyloid fibril Deposited 2023-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 18 PDB declaration: octadecameric
Chain A 667–679（13 aa）
Chain B 667–679（13 aa）
Chain C 667–679（13 aa）
Chain D 667–679（13 aa）
Chain E 667–679（13 aa）
Chain F 667–679（13 aa）
Chain G 667–679（13 aa）
Chain H 667–679（13 aa）
Chain I 667–679（13 aa）
Chain J 667–679（13 aa）
Chain K 667–679（13 aa）
Chain L 667–679（13 aa）
Chain M 667–679（13 aa）
Chain N 667–679（13 aa）
Chain O 667–679（13 aa）
Chain P 667–679（13 aa）
Chain Q 667–679（13 aa）
Chain R 667–679（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
8OHP Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril Deposited 2023-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric
Chain A 667–679（13 aa）
Chain B 667–679（13 aa）
Chain C 667–679（13 aa）
Chain D 667–679（13 aa）
Chain E 667–679（13 aa）
Chain F 667–679（13 aa）
Chain G 667–679（13 aa）
Chain H 667–679（13 aa）
Chain I 667–679（13 aa）
Chain J 667–679（13 aa）
Chain K 667–679（13 aa）
Chain L 667–679（13 aa）
Chain M 667–679（13 aa）
Chain N 667–679（13 aa）
Chain O 667–679（13 aa）
Chain P 667–679（13 aa）
Chain Q 667–679（13 aa）
Chain R 667–679（13 aa）
Chain S 667–679（13 aa）
Chain T 667–679（13 aa）
Chain U 667–679（13 aa）
Chain V 667–679（13 aa）
Chain W 667–679（13 aa）
Chain X 667–679（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8OI0 Structure of the Fmoc-Tau-PAM4 Type 4 amyloid fibril Deposited 2023-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric
Chain A 667–679（13 aa）
Chain B 667–679（13 aa）
Chain C 667–679（13 aa）
Chain D 667–679（13 aa）
Chain E 667–679（13 aa）
Chain F 667–679（13 aa）
Chain G 667–679（13 aa）
Chain H 667–679（13 aa）
Chain I 667–679（13 aa）
Chain J 667–679（13 aa）
Chain K 667–679（13 aa）
Chain L 667–679（13 aa）
Chain M 667–679（13 aa）
Chain N 667–679（13 aa）
Chain O 667–679（13 aa）
Chain P 667–679（13 aa）
Chain Q 667–679（13 aa）
Chain R 667–679（13 aa）
Chain S 667–679（13 aa）
Chain T 667–679（13 aa）
Chain U 667–679（13 aa）
Chain V 667–679（13 aa）
Chain W 667–679（13 aa）
Chain X 667–679（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；Peptide resuspended in MilliQ water for aggregation reaction
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8ORE Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease Deposited 2023-04-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–381（381 aa）
Chain B 1–381（381 aa）
Chain C 1–381（381 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8ORF Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts Deposited 2023-04-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–412（412 aa）
Chain B 1–412（412 aa）
Chain C 1–412（412 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8ORG Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II) Deposited 2023-04-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–412（412 aa）
Chain B 1–412（412 aa）
Chain C 1–412（412 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
8OT6 CTE typeI tau filament from Guam ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.00 Å
8OT9 CTE typeIII tau filament from Guam ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8OTC CTE typeII tau filament from Guam ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8OTG CTE typeI tau filament from Kii ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.10 Å
8OTH TypeII tau filament from Kii ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8OTI CTE typeIII tau filament Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8OTJ PHF tau filament from Kii ALS/PDC Deposited 2023-04-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8P34 Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT Deposited 2023-05-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 196–289（94 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM Tris-HCL, 100 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å
8PII VHH Z70 mutant 3 in interaction with PHF6 Tau peptide Deposited 2023-06-21 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 618–631（14 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；1.5M ammonium sulfate, 4.5% isopropanol, 15% glycerol
Resolution 2.35 Å R-free 0.263
8PPO First Intermediate Amyloid (FIA) - Tau Deposited 2023-07-07 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Chain K 1–441（441 aa）
Chain L 1–441（441 aa）
Chain M 1–441（441 aa）
Chain N 1–441（441 aa）
Chain O 1–441（441 aa）
Chain P 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.00 Å
8Q27 Tau: AD-MIA1 Deposited 2023-08-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.02 Å
8Q2J Tau - AD-MIA2 Deposited 2023-08-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.23 Å
8Q2K Tau - AD-MIA3 Deposited 2023-08-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8Q2L Tau - AD-MIA4 Deposited 2023-08-02 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
8Q7F Tau - AD-MIA5 Deposited 2023-08-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.72 Å
8Q7L Tau - AD-MIA6 (tau intermediate amyloid) Deposited 2023-08-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.82 Å
8Q7M Tau - AD-MIA7 (tau intermediate amyloid) Deposited 2023-08-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Chain G 1–383（383 aa）
Chain H 1–383（383 aa）
Chain I 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.26 Å
8Q7P Tau - AD-MIA8 (intermediate amyloid) Deposited 2023-08-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.28 Å
8Q7T Tau - AD-MIA11 Deposited 2023-08-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Chain G 1–383（383 aa）
Chain H 1–383（383 aa）
Chain I 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8Q88 Tau - AD-LIA2 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
8Q8C Tau - AD-MIA10 (intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.92 Å
8Q8D Tau - AD-LIA6 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
8Q8E Tau - AD-LIA4 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: 12-meric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Chain G 1–383（383 aa）
Chain H 1–383（383 aa）
Chain I 1–383（383 aa）
Chain J 1–383（383 aa）
Chain K 1–383（383 aa）
Chain L 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.81 Å
8Q8F Tau - AD-LIA5 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.93 Å
8Q8L Tau - AD-LIA7 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
8Q8M Tau - AD-PHF long crossover Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
8Q8R Tau - AD-PHF Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.10 Å
8Q8S Tau - AD-THF Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Chain G 1–383（383 aa）
Chain H 1–383（383 aa）
Chain I 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.68 Å
8Q8U Tau - CTE-MIA1 (tau intermediate amyloid) Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8Q8V Tau - CTE-MIA3 Deposited 2023-08-18 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8Q8W Tau - CTE-MIA4 (tau intermediate amyloid) Deposited 2023-08-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.85 Å
8Q8X Tau - CTE-MIA5 (tau intermediate amyloid) Deposited 2023-08-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.54 Å
8Q8Y Tau - CTE-MIA6 (tau intermediate amyloid) Deposited 2023-08-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8Q8Z Tau - CTE-MIA7 (tau intermediate amyloid) Deposited 2023-08-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.16 Å
8Q92 P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line Deposited 2023-08-19 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 588–681（94 aa）
Chain B 588–681（94 aa）
Chain C 588–681（94 aa）
Mutation：P301S Mutation：P301S Mutation：P301S No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.05 Å
8Q97 Tau - CTE-MIA9 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.99 Å
8Q98 Tau - CTE-MIA8 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.75 Å
8Q99 Tau - CTE-MIA10 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8Q9A Tau - CTE-MIA11 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
8Q9B Tau - CTE-MIA13 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8Q9C Tau - CTE-MIA14 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8Q9D Tau - CTE-MIA15 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.16 Å
8Q9E Tau - CTE-MIA18 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.97 Å
8Q9F Tau - CTE-LIA3 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain c 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.91 Å
8Q9G Tau - CTE-LIA5 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.65 Å
8Q9H Tau - CTE-LIA4 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain G 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.18 Å
8Q9I Tau - CTE-LIA6 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–383（383 aa）
Chain C 1–383（383 aa）
Chain E 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.56 Å
8Q9J Tau - CTE-LIA7 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
8Q9K Tau - CTE-LIA13 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8Q9L Tau - CTE-LIA14 (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Chain G 1–383（383 aa）
Chain H 1–383（383 aa）
Chain I 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.76 Å
8Q9M Tau - CTE-type I (tau intermediate amyloid) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain G 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.65 Å
8Q9O CTE tau intermediate amyloid (LIA-17) Deposited 2023-08-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain G 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8QCP Tau - AD-LIA8 (tau intermediate amyloid) Deposited 2023-08-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
8QCR Tau - CTE-MIA12 (tau intermediate amyloid) Deposited 2023-08-28 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–383（383 aa）
Chain C 1–383（383 aa）
Chain E 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.75 Å
8QJJ CTE type II (tau intermediate amyloid) Deposited 2023-09-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.35 Å
8R3T Cofactor-free Tau 4R2N isoform Deposited 2023-11-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8SEH PHF Tau from Down Syndrome Deposited 2023-04-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 275–347（73 aa）
Chain B 275–347（73 aa）
Chain C 275–347（73 aa）
Chain D 275–347（73 aa）
Chain E 275–347（73 aa）
Chain F 275–347（73 aa）
Chain G 275–347（73 aa）
Chain H 275–347（73 aa）
Chain I 275–347（73 aa）
Chain J 275–347（73 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8SEI SF Tau from Down Syndrome Deposited 2023-04-10 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 623–695（73 aa）
Chain B 623–695（73 aa）
Chain C 623–695（73 aa）
Chain D 623–695（73 aa）
Chain E 623–695（73 aa）
Chain F 623–695（73 aa）
Chain G 623–695（73 aa）
Chain H 623–695（73 aa）
Chain I 623–695（73 aa）
Chain J 623–695（73 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8TTL AT8-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S202E, T205E, S208E) Deposited 2023-08-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Chain F 1–383（383 aa）
Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E Mutation：S202E, T205E, S208E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8；50 mM K2HPO4 buffer, pH 6.8, containing 300 mM NaCl, 5 mM DTT, and 1x cOmplete protease inhibitor cocktail tablet (Roche) per 40 ml fibrillization buffer.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
8TTN PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E) Deposited 2023-08-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–383（383 aa）
Chain B 1–383（383 aa）
Chain C 1–383（383 aa）
Chain D 1–383（383 aa）
Chain E 1–383（383 aa）
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8；50 mM K2HPO4 buffer, pH 6.8, containing 300 mM NaCl, 5 mM DTT, and 1x cOmplete protease inhibitor cocktail tablet (Roche) per 40 ml fibrillization buffer.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
8UQ7 Alzheimer's disease PHF complexed with PET ligand MK-6240 Deposited 2023-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 622–696（75 aa）
Chain B 622–696（75 aa）
Chain C 622–696（75 aa）
Chain D 622–696（75 aa）
Chain E 622–696（75 aa）
Chain F 622–696（75 aa）
Not recorded X6R 6-fluoro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.31 Å
8V1N Cryo-EM structure of tau filaments made from jR2R3-P301L peptides induced with heparin Deposited 2023-11-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric
Chain A 612–630（19 aa）
Chain B 612–630（19 aa）
Chain C 612–630（19 aa）
Chain D 612–630（19 aa）
Chain E 612–630（19 aa）
Chain F 612–630（19 aa）
Chain G 612–630（19 aa）
Chain H 612–630（19 aa）
Chain I 612–630（19 aa）
Chain J 612–630（19 aa）
Chain K 612–630（19 aa）
Chain L 612–630（19 aa）
Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L Mutation：P618L No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20mM ammoniium acetate, 50mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8ZWL Heparin bound Tau fibril polymorph 3 Deposited 2024-06-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8ZWM Heparin bound Tau fibril polymorph 4 Deposited 2024-06-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8ZX6 Heparin bound Tau fibril PHF Deposited 2024-06-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9B3A filament of type 1 KD-mxyl miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric
Chain A 612–630（19 aa）
Chain C 612–630（19 aa）
Chain E 612–630（19 aa）
Chain G 612–630（19 aa）
Chain I 612–630（19 aa）
Chain K 612–630（19 aa）
Chain M 612–630（19 aa）
Chain O 612–630（19 aa）
Chain Q 612–630（19 aa）
Chain S 612–630（19 aa）
Chain U 612–630（19 aa）
Chain W 612–630（19 aa）
Chain Y 612–630（19 aa）
Chain a 612–630（19 aa）
Chain c 612–630（19 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) NH2 AMINO GROUP × 15 8VH 1,3-dimethylbenzene × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9B3C type 2 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric
Chain A 612–630（19 aa）
Chain C 612–630（19 aa）
Chain E 612–630（19 aa）
Chain G 612–630（19 aa）
Chain I 612–630（19 aa）
Chain K 612–630（19 aa）
Chain M 612–630（19 aa）
Chain O 612–630（19 aa）
Chain Q 612–630（19 aa）
Chain S 612–630（19 aa）
Chain U 612–630（19 aa）
Chain W 612–630（19 aa）
Chain Y 612–630（19 aa）
Chain a 612–630（19 aa）
Chain c 612–630（19 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) NH2 AMINO GROUP × 15 8VH 1,3-dimethylbenzene × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
9B4L Filament of Tau in complex with D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric
Chain 0 1–758（758 aa）
Chain 1 1–758（758 aa）
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain M 1–758（758 aa）
Chain N 1–758（758 aa）
Chain O 1–758（758 aa）
Chain P 1–758（758 aa）
Chain Y 1–758（758 aa）
Chain Z 1–758（758 aa）
Not recorded EDT {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9B4M Filament of Tau in complex with D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-20 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Chain H 1–758（758 aa）
Chain I 1–758（758 aa）
Chain J 1–758（758 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9B4N Filament of Tau in complex with D-TLKIVWR, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM Deposited 2024-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Chain H 1–758（758 aa）
Chain I 1–758（758 aa）
Chain J 1–758（758 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9B4O Alzheimer's Tau Paired Helical Filaments, determined by CryoEM, before addition of D-peptide disaggregants Deposited 2024-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Chain H 1–758（758 aa）
Chain I 1–758（758 aa）
Chain J 1–758（758 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9BBL THF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Deposited 2024-04-06 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 9 PDB declaration: nonameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；The pH was tuned to pH 7.5-8 using 5M NaOH after mixing phosphate buffer and MgCl2, and precipitation was formed.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9BBM PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Deposited 2024-04-06 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E Mutation：S396E, S400E, T403E, S404E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；The pH was tuned to pH 7.5-8 using 5M NaOH after mixing phosphate buffer and MgCl2, and precipitation was formed.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9BXI Paired Helical Filament of tau amyloids found in Down Syndrome individuals Deposited 2024-05-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 275–351（77 aa）
Chain B 275–351（77 aa）
Chain C 275–351（77 aa）
Chain D 275–351（77 aa）
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9BXO Straight Filament of tau amyloids found in Down Syndrome individuals Deposited 2024-05-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 275–351（77 aa）
Chain B 275–351（77 aa）
Chain C 275–351（77 aa）
Chain D 275–351（77 aa）
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9BXQ Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids Deposited 2024-05-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain C 275–351（77 aa）
Chain D 275–351（77 aa）
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Chain G 275–351（77 aa）
Chain H 275–351（77 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9BXR Straight Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids Deposited 2024-05-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain C 275–351（77 aa）
Chain D 275–351（77 aa）
Chain E 275–351（77 aa）
Chain F 275–351（77 aa）
Chain G 275–351（77 aa）
Chain H 275–351（77 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9CGX Alzheimer's Disease Seeded 0N3R Tau Fibrils Deposited 2024-07-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Chain E 1–352（352 aa）
Chain F 1–352（352 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.97 Å
9CGZ Alzheimer's Disease Seeded Mixed 0N4R and 0N3R Tau Fibrils Deposited 2024-07-01 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Chain E 1–352（352 aa）
Chain F 1–352（352 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.69 Å
9CZI Paired helical tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques Deposited 2024-08-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 275–347（73 aa） Fragment：UNP residues 275-347
Chain B 275–347（73 aa） Fragment：UNP residues 275-347
Chain C 275–347（73 aa） Fragment：UNP residues 275-347
Chain D 275–347（73 aa） Fragment：UNP residues 275-347
Chain E 275–347（73 aa） Fragment：UNP residues 275-347
Chain F 275–347（73 aa） Fragment：UNP residues 275-347
Chain G 275–347（73 aa） Fragment：UNP residues 275-347
Chain H 275–347（73 aa） Fragment：UNP residues 275-347
Chain I 275–347（73 aa） Fragment：UNP residues 275-347
Chain J 275–347（73 aa） Fragment：UNP residues 275-347
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9CZL Straight tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques Deposited 2024-08-05 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 274–347（74 aa） Fragment：UNP residues 274-347
Chain B 274–347（74 aa） Fragment：UNP residues 274-347
Chain C 274–347（74 aa） Fragment：UNP residues 274-347
Chain D 274–347（74 aa） Fragment：UNP residues 274-347
Chain E 274–347（74 aa） Fragment：UNP residues 274-347
Chain F 274–347（74 aa） Fragment：UNP residues 274-347
Chain G 274–347（74 aa） Fragment：UNP residues 274-347
Chain H 274–347（74 aa） Fragment：UNP residues 274-347
Chain I 274–347（74 aa） Fragment：UNP residues 274-347
Chain J 274–347（74 aa） Fragment：UNP residues 274-347
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9DA8 Tau-Microtubule structure in the presence of ATP Deposited 2024-08-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–758（758 aa）
Chain N 1–758（758 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 4 TA1 TAXOL × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
9DME Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold Deposited 2024-09-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: pentadecameric
Chain A 612–630（19 aa）
Chain B 612–630（19 aa）
Chain C 612–630（19 aa）
Chain D 612–630（19 aa）
Chain E 612–630（19 aa）
Chain F 612–630（19 aa）
Chain G 612–630（19 aa）
Chain H 612–630（19 aa）
Chain I 612–630（19 aa）
Chain J 612–630（19 aa）
Chain K 612–630（19 aa）
Chain L 612–630（19 aa）
Chain M 612–630（19 aa）
Chain N 612–630（19 aa）
Chain O 612–630（19 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) 8VH 1,3-dimethylbenzene × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9EO7 PHF type tau filament from V337M mutant Deposited 2024-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9EO9 SF type tau filament from V337M mutant Deposited 2024-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: tetrameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9EOE TF type tau filament from V337M mutant Deposited 2024-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: dimeric
Chain A 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
9EOG PHF type tau filament from R406W mutant Deposited 2024-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9EOH PHF type tau filament from in vitro V337M mutant Deposited 2024-03-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9ERM CTE type I tau filament from vacuolar tauopathy Deposited 2024-03-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
9ERN CTE type II tau filament from vacuolar tauopathy Deposited 2024-03-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9ERO CTE type III tau filament from vacuolar tauopathy Deposited 2024-03-24 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9FH6 Cryo-EM Structure of Tau Filaments from Individuals Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation Deposited 2024-05-26 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 623–695（73 aa）
Chain B 623–695（73 aa）
Chain C 623–695（73 aa）
Chain D 623–695（73 aa）
Chain E 623–695（73 aa）
Chain F 623–695（73 aa）
Chain G 623–695（73 aa）
Chain H 623–695（73 aa）
Chain I 623–695（73 aa）
Chain J 623–695（73 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9FS4 Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD12 Deposited 2024-06-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) TJ8 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.60 Å R-free 0.198
9FVG Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer AO184 Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IF3 1-(3-bromanyl-4-methyl-phenyl)-2-(4-ethylphenyl)imidazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.45 Å R-free 0.193
9FVH Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS17 Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IF5 2-bromanyl-4-[2-(2-methylphenyl)imidazol-1-yl]benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.45 Å R-free 0.176
9FVI Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS18 Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IF4 1-(3-bromanyl-4-methyl-phenyl)-2-(3-methylphenyl)imidazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.55 Å R-free 0.211
9FVN Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer NZ4 Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IGH 2-[4-[1-(3-bromanyl-4-methyl-phenyl)benzimidazol-2-yl]phenoxy]ethanol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.50 Å R-free 0.209
9FVP Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS24 Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IGF 1-(3-bromanyl-4-methyl-phenyl)-2-(4-methylphenyl)imidazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.58 Å R-free 0.205
9G13 VHH H3-2 in complex with Tau C-terminal peptide Deposited 2024-07-09 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 369–381（13 aa）
Chain D 369–381（13 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；23% PEG-MME 2000, 0.1 M potassium acetate
Resolution 1.80 Å R-free 0.231
9G13 VHH H3-2 in complex with Tau C-terminal peptide Deposited 2024-07-09 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain F 369–381（13 aa）
Chain H 369–381（13 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；23% PEG-MME 2000, 0.1 M potassium acetate
Resolution 1.80 Å R-free 0.231
9GFA Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD33 Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IKN 3-(3-bromanyl-4-methyl-phenyl)-2-pyridin-3-yl-1,2-dihydrobenzimidazole × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 1.60 Å R-free 0.196
9GG0 P301L tau filaments from human brain Deposited 2024-08-12 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 213–319（107 aa）
Chain B 213–319（107 aa）
Chain C 213–319（107 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.81 Å
9GG1 P301T type I tau filaments from human brain Deposited 2024-08-12 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 215–321（107 aa）
Chain B 215–321（107 aa）
Chain C 215–321（107 aa）
Chain D 215–321（107 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.26 Å
9GG6 P301T type II tau filaments from human brain Deposited 2024-08-13 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 269–364（96 aa）
Chain B 269–364（96 aa）
Chain C 269–364（96 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
9GG7 Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS324 peptide and covalent stabilizer 187 Deposited 2024-08-13 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 653–666（14 aa）
Chain P 653–666（14 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) TW8 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；Cocrystalization of 12 mg/ml protein, 2eq peptide and 1.8mM compound in 20 mM Sodium HEPES pH 7.5, 2 mM MgCl2, and 1.5 mM TCEP. Crystallization buffer: 0.19 M Calcium chloride dihydrate, 0.095 M Sodium HEPES pH 7.1, 5% glycerol, and28% PEG 400, mixed 1:1 with cocrystal mix
Resolution 1.24 Å R-free 0.242
9GG8 Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS214 peptide and covalent stabilizer 187 Deposited 2024-08-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) TW8 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；Cocrystalization of 12 mg/ml protein, 2eq peptide and 1.8mM compound in 20 mM Sodium HEPES pH 7.5, 2 mM MgCl2, and 1.5 mM TCEP. Crystallization buffer: 0.19 M Calcium chloride dihydrate, 0.095 M Sodium HEPES pH 7.1, 5% glycerol, and28% PEG 400, mixed 1:1 with cocrystal mix
Resolution 1.10 Å R-free 0.203
9GGA Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer FM089 Deposited 2024-08-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 527–539（13 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) A1IKS 2-bromanyl-4-[[(3~{R})-3-oxidanyl-3,4-dihydro-2~{H}-quinolin-1-yl]sulfonyl]benzaldehyde × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；10mg/mL 14-3-3sigma delta C, 1.5eq peptide, 0.095 M HEPES pH 7.1, 28% PEG400, 0.19 M CaCl2, 5% (v/v) glycerol compound soaked
Resolution 2.24 Å R-free 0.199
9H5G PAD12 0N3R:0N4R tau PHF Deposited 2024-10-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Chain E 1–352（352 aa）
Chain F 1–352（352 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.28
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.48 Å
9H5J PAD12 0N3R tau PHF seeded by AD Deposited 2024-10-22 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Chain E 1–352（352 aa）
Chain F 1–352（352 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.28
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
9HBB Recombinant tau PHF filaments (peptide synthesis 291-391) Deposited 2024-11-06 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 291–391（101 aa）
Chain B 291–391（101 aa）
Chain C 291–391（101 aa）
Chain D 291–391（101 aa）
Chain E 291–391（101 aa）
Chain F 291–391（101 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9MC2 Cryo-EM structure of dopaminated Tau fibril Deposited 2025-03-17 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 561–689（129 aa）
Chain B 561–689（129 aa）
Chain C 561–689（129 aa）
Chain D 561–689（129 aa）
Chain E 561–689（129 aa）
Chain F 561–689（129 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.55 Å
9MR8 Structure of D421-Truncated Tau Fibril Deposited 2025-01-07 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 30 PDB declaration: 30-meric
Chain C 590–679（90 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9MR8 Structure of D421-Truncated Tau Fibril Deposited 2025-01-07 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 590–679（90 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9O6V Recombinant AD PHF complexed with SW-MK-NBD (PHF2) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain F 622–696（75 aa）
Chain G 622–696（75 aa）
Chain H 622–696（75 aa）
Chain I 622–696（75 aa）
Chain J 622–696（75 aa）
Chain N 622–696（75 aa）
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Y 622–696（75 aa）
Chain Z 622–696（75 aa）
Not recorded A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
9O6W Recombinant AD PHF complexed with SW-MK-NBD (Non Symmetric Binding Site) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain F 622–696（75 aa）
Chain G 622–696（75 aa）
Chain H 622–696（75 aa）
Chain I 622–696（75 aa）
Chain J 622–696（75 aa）
Chain N 622–696（75 aa）
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Q 622–696（75 aa）
Chain R 622–696（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.67 Å
9O6X Recombinant AD THF incubated with SW-MK-NBD (Non-Symmetric Binding) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric
Chain R 622–696（75 aa）
Chain S 622–696（75 aa）
Chain T 622–696（75 aa）
Chain U 622–696（75 aa）
Chain V 622–696（75 aa）
Chain W 622–696（75 aa）
Chain X 622–696（75 aa）
Chain Y 622–696（75 aa）
Chain Z 622–696（75 aa）
Chain a 622–696（75 aa）
Chain e 622–696（75 aa）
Chain f 622–696（75 aa）
Chain g 622–696（75 aa）
Chain h 622–696（75 aa）
Chain i 622–696（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9O6Y Recombinant AD PHF complexed with SW-MK-NBD Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain K 622–696（75 aa）
Chain L 622–696（75 aa）
Chain M 622–696（75 aa）
Chain N 622–696（75 aa）
Chain O 622–696（75 aa）
Chain R 622–696（75 aa）
Chain S 622–696（75 aa）
Chain Z 622–696（75 aa）
Chain a 622–696（75 aa）
Chain b 622–696（75 aa）
Not recorded A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
9O6Z Recombinant AD THF with SW-MK-NBD complexed in AD-related Binding Site Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: pentadecameric
Chain N 622–696（75 aa）
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Q 622–696（75 aa）
Chain R 622–696（75 aa）
Chain V 622–696（75 aa）
Chain W 622–696（75 aa）
Chain X 622–696（75 aa）
Chain Y 622–696（75 aa）
Chain Z 622–696（75 aa）
Chain b 622–696（75 aa）
Chain c 622–696（75 aa）
Chain d 622–696（75 aa）
Chain e 622–696（75 aa）
Chain f 622–696（75 aa）
Not recorded A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.31 Å
9O76 Recombinant AD THF complexed with SW-MK-NBD (Secondary Binding Site) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Q 622–696（75 aa）
Chain R 622–696（75 aa）
Chain S 622–696（75 aa）
Chain V 622–696（75 aa）
Chain W 622–696（75 aa）
Chain X 622–696（75 aa）
Chain Y 622–696（75 aa）
Chain Z 622–696（75 aa）
Chain b 622–696（75 aa）
Chain c 622–696（75 aa）
Chain d 622–696（75 aa）
Chain e 622–696（75 aa）
Chain f 622–696（75 aa）
Not recorded A1B91 7-nitro-N-[2-(2-{[(3P)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-7-yl]oxy}ethoxy)ethyl]-2,1,3-benzoxadiazol-4-amine × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9O79 Recombinant AD PHF incubated with DMSO (Kinked Backbone E342) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain F 622–696（75 aa）
Chain G 622–696（75 aa）
Chain H 622–696（75 aa）
Chain I 622–696（75 aa）
Chain J 622–696（75 aa）
Chain N 622–696（75 aa）
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Q 622–696（75 aa）
Chain R 622–696（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.55 Å
9O7B Recombinant AD THF incubated with DMSO (Kinked Backbone E342) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric
Chain O 622–696（75 aa）
Chain P 622–696（75 aa）
Chain Q 622–696（75 aa）
Chain R 622–696（75 aa）
Chain S 622–696（75 aa）
Chain W 622–696（75 aa）
Chain X 622–696（75 aa）
Chain Y 622–696（75 aa）
Chain Z 622–696（75 aa）
Chain a 622–696（75 aa）
Chain d 622–696（75 aa）
Chain e 622–696（75 aa）
Chain f 622–696（75 aa）
Chain g 622–696（75 aa）
Chain h 622–696（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.31 Å
9O7C Recombinant AD THF incubated with DMSO (Flat Backbone E342) Deposited 2025-04-14 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 15 PDB declaration: 15-meric
Chain S 622–696（75 aa）
Chain T 622–696（75 aa）
Chain U 622–696（75 aa）
Chain V 622–696（75 aa）
Chain W 622–696（75 aa）
Chain i 622–696（75 aa）
Chain j 622–696（75 aa）
Chain k 622–696（75 aa）
Chain l 622–696（75 aa）
Chain m 622–696（75 aa）
Chain n 622–696（75 aa）
Chain o 622–696（75 aa）
Chain p 622–696（75 aa）
Chain q 622–696（75 aa）
Chain r 622–696（75 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10 mM Phosphate buffer, pH 7.4, with 10 mM DTT and 200 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.31 Å
9O8E amyloid fibril of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer's disease tau fibrils Deposited 2025-04-15 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O8H amyloid fibril of recombinant full-length 2N4R tau complexed with mouse liver 18S ribosomal RNA Deposited 2025-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Chain I 1–441（441 aa）
Chain J 1–441（441 aa）
Not recorded CL CHLORIDE ION × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9OFW 328-363 tau mutant S341L_S352I Deposited 2025-04-30 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 20 PDB declaration: 20-meric
Chain A 666–680（15 aa）
Chain B 666–680（15 aa）
Chain C 666–680（15 aa）
Chain D 666–680（15 aa）
Chain E 666–680（15 aa）
Chain F 666–680（15 aa）
Chain G 666–680（15 aa）
Chain H 666–680（15 aa）
Chain I 666–680（15 aa）
Chain J 666–680（15 aa）
Chain K 666–680（15 aa）
Chain L 666–680（15 aa）
Chain M 666–680（15 aa）
Chain N 666–680（15 aa）
Chain O 666–680（15 aa）
Chain P 666–680（15 aa）
Chain Q 666–680（15 aa）
Chain R 666–680（15 aa）
Chain S 666–680（15 aa）
Chain T 666–680（15 aa）
Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I Mutation：S352I No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；10mM NaPO4, 200mM MgCl2, pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9PGO Cryo-EM structure of brain-derived Tau fibril from Alzheimers disease patient tissue Deposited 2025-07-08 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: 12-meric
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Chain H 1–758（758 aa）
Chain I 1–758（758 aa）
Chain J 1–758（758 aa）
Chain K 1–758（758 aa）
Chain L 1–758（758 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.29 Å
9QNK Tau pT245 phosphopeptide binding to 14-3-3sigma Deposited 2025-03-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain P 558–566（9 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M HEPES pH=7.1-7.7 0.19 M CaCl2 5% glycerol 24-29% PEG400
Resolution 1.60 Å R-free 0.196
9R2F Tau filaments seeded by AD homogenate using 0N3R C322A Deposited 2025-04-30 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 218–289（72 aa）
Chain B 218–289（72 aa）
Chain C 218–289（72 aa）
Chain D 218–289（72 aa）
Chain E 218–289（72 aa）
Chain F 218–289（72 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9R2H Tau filaments seeded by AD homogenate using 0N3R C322S Deposited 2025-04-30 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 248–383（136 aa）
Chain B 248–383（136 aa）
Chain C 248–383（136 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
9R88 CTE Type I tau filament from the brain of a football player Deposited 2025-05-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
9R89 CTE Type II tau filament from the brain of a football player Deposited 2025-05-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9R8A PHF tau filament from the brain of a football player Deposited 2025-05-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9R8D SF tau filament from the brain of a football player Deposited 2025-05-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Chain F 1–441（441 aa）
Chain G 1–441（441 aa）
Chain H 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9S2B 297-441 delta392-395 tau filaments Deposited 2025-07-21 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 614–635（22 aa）
Chain B 614–635（22 aa）
Chain C 614–635（22 aa）
Chain D 614–635（22 aa）
Chain E 614–635（22 aa）
Chain F 614–635（22 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9SHS Head to Head tau filament with the Alzheimer's fold Deposited 2025-08-27 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 246–321（76 aa）
Chain B 246–321（76 aa）
Chain C 246–321（76 aa）
Chain D 246–321（76 aa）
Chain E 246–321（76 aa）
Chain G 246–321（76 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9TZX Cryo-EM structure of a tau filament Deposited 2026-01-25 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 1–441（441 aa）
Chain B 1–441（441 aa）
Chain C 1–441（441 aa）
Chain D 1–441（441 aa）
Chain E 1–441（441 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.75 Å

248 other PDB entries and 269 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TAU_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–13； UniProt 527–539 Author chain C； PDBConstruct 25–38； UniProt 635–648 Author chain F； PDBConstruct 1–13； UniProt 527–539 Author chain F； PDBConstruct 25–38； UniProt 635–648

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 8qdv

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 8qdv
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2. Structure Basics 2. Structure Basics

Entry ID entry_id8qdv
Deposition date deposition_date2023-08-30
Structure title titleStructure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide
Keywords keywords14-3-3 zeta, tau, protein-protein interaction, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier34.68 Å
Radius of gyration Rg (electron density) rg_electron33.70 Å
Forward intensity I(0) i0172769000.00
Molecular weight molecular_weight102880.0 kDa
Excluded volume excluded_volume127980 ų
Envelope volume envelope_volume184070 ų
Hydration-shell volume shell_volume44920 ų
Envelope diameter envelope_diameter94.2 Å
Shell Rg shell_rg41.81 Å
Envelope Rg envelope_rg31.56 Å
Shape Rg shape_rg33.71 Å
Total Rg total_rg34.35 Å
Total atoms total_atoms7225
Residues n_residues940
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax96.8 Å
Rg (real space) rg_real34.40 Å
Rg uncertainty (real space) rg_real_error0.60 Å
I(0) (real space) i0_real1.7280e+08
I(0) uncertainty (real space) i0_real_error2.6950e+06
Rg (reciprocal space) rg_reciprocal34.58 Å
I(0) (reciprocal space) i0_reciprocal172800000.0000
Solution quality estimate total_estimate0.8898
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary54.7 Å
Skewness Skewness skewness-0.179
Kurtosis Kurtosis kurtosis-0.738
Angular range angular_range— – 0.2300 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha15430000.0000
Real-space data points n_real_points47
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.931; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.771
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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8. Citations (1)

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9. Files and Curves (10)