SAXSdb — 8p2l

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1. Protein Identity and Related Structures Protein Identity & Related Structures

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Homooligomer	Protein 16	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 8	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SARM1_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 28–564； UniProt 26–562 Author chain B； PDBConstruct 28–564； UniProt 26–562 Author chain C； PDBConstruct 28–564； UniProt 26–562 Author chain D； PDBConstruct 28–564； UniProt 26–562 Author chain E； PDBConstruct 28–564； UniProt 26–562 Author chain F； PDBConstruct 28–564； UniProt 26–562 Author chain G； PDBConstruct 28–564； UniProt 26–562 Author chain H； PDBConstruct 28–564； UniProt 26–562 Author chain I； PDBConstruct 28–564； UniProt 26–562 Author chain J； PDBConstruct 28–564； UniProt 26–562 Author chain K； PDBConstruct 28–564； UniProt 26–562 Author chain L； PDBConstruct 28–564； UniProt 26–562 Author chain M； PDBConstruct 28–564； UniProt 26–562 Author chain N； PDBConstruct 28–564； UniProt 26–562 Author chain O； PDBConstruct 28–564； UniProt 26–562 Author chain P； PDBConstruct 28–564； UniProt 26–562

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

Homo sapiens

UniProt Q86DA5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Homooligomer	Protein 16	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 8	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SARM1_CAEEL
Isoform	Q86DA5-4
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 565–728； UniProt 125–288 Author chain B； PDBConstruct 565–728； UniProt 125–288 Author chain C； PDBConstruct 565–728； UniProt 125–288 Author chain D； PDBConstruct 565–728； UniProt 125–288 Author chain E； PDBConstruct 565–728； UniProt 125–288 Author chain F； PDBConstruct 565–728； UniProt 125–288 Author chain G； PDBConstruct 565–728； UniProt 125–288 Author chain H； PDBConstruct 565–728； UniProt 125–288 Author chain I； PDBConstruct 565–728； UniProt 125–288 Author chain J； PDBConstruct 565–728； UniProt 125–288 Author chain K； PDBConstruct 565–728； UniProt 125–288 Author chain L； PDBConstruct 565–728； UniProt 125–288 Author chain M； PDBConstruct 565–728； UniProt 125–288 Author chain N； PDBConstruct 565–728； UniProt 125–288 Author chain O； PDBConstruct 565–728； UniProt 125–288 Author chain P； PDBConstruct 565–728； UniProt 125–288

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8p2l
Deposition date deposition_date	2023-05-16
Last revision last_revision	2023-09-06
Structure title title	A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.
Keywords keywords	SARM1; TIR-1; C. elegans; neurodegeneration; cryo-EM; structural biology; NAD+ metabolism; axon Wallerian degeneration, HYDROLASE; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8p2l__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8p2l__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8p2l__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	66.86 Å
Rg (electron density)	66.86 Å
Total Rg	66.89 Å
Atom count	40776
Residues	5152
Excluded volume	726330 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8p2l__assembly_1__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Description description	NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1
Molecular weight formula_weight	81070.7 kDa
EC 编号 ec_number	3.2.2.6,3.2.2.-,3.2.2.6
Source method src_method	man
Copy count entity_count	16

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,J,I,K,L,M,N,O,P
Atom count atom_count	40776

MSYHHHHHHDYDIPTTENLYFQGAMGSERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 2 Entity 2 non-polymer

Description description	NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Molecular weight formula_weight	663.4 kDa
Source method src_method	syn
Copy count entity_count	8

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.680 Å
Low-resolution limit resolution_low	252.000 Å
R factor r_factor	—
R_work r_work	0.4560
R_free r_free	—

Resolution resolution	2.68 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	136346

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

1. Protein Identity and Related Structures Protein Identity & Related Structures

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

State in the Current Structure

Other States of the Same Protein in the Database

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8p2l__assembly_1__model_1

8p2l__assembly_1__model_1 | I(q)

8p2l__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

7. Citations (1)

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

1. Protein Identity and Related Structures Protein Identity & Related Structures

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8p2l__assembly_1__model_1

8p2l__assembly_1__model_1 | I(q)

8p2l__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

7. Citations (1)