SARM1 TIR with BEXi adduct 6

Method: ELECTRON MICROSCOPY D_max: 85.2 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9tzw
deposition_date	2026-01-24
title	SARM1 TIR with BEXi adduct 6
keywords	NAD(+), hydrolase, SARM1, TIR; HYDROLASE
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	27.49 Å
rg_electron	26.27 Å
i0	66424300.00
molecular_weight	65198.0 kDa
excluded_volume	82191 Å³
envelope_volume	99058 Å³
shell_volume	30924 Å³
envelope_diameter	92.0 Å
shell_rg	34.06 Å
envelope_rg	26.13 Å
shape_rg	26.17 Å
total_rg	27.44 Å
total_atoms	9108
n_residues	552
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	85.2 Å
rg_real	27.35 Å
rg_real_error	0.51 Å
i0_real	6.6420e+07
i0_real_error	9.2950e+05
rg_reciprocal	27.40 Å
i0_reciprocal	66430000.0000
total_estimate	0.9114
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	33.8 Å
skewness	0.137
kurtosis	-0.614
angular_range	— – 0.2900 Å⁻¹
current_alpha	0.0000
highest_alpha	28630000.0000
n_real_points	59
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.949; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.998; Smooth: 0.997

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.30 Å
resolution_method	—
num_particles	110926

description	NAD(+) hydrolase SARM1
formula_weight	16148.5 kDa
ec_number	3.2.2.6,3.2.2.-
src_method	man
entity_count	4

type	polypeptide(L)
strand_id	A,C,D,B
atom_count	9108

SARM1 TIR with BEXi adduct 6

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

description	;[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-[4-[[4-(pyridin-2-ylcarbamoylamino)phenyl]methyl]pyridin-1-yl]oxolan-2-yl]methyl hydrogen phosphate ;
formula_weight	846.7 kDa
src_method	syn
entity_count	4

fit	/app/data/saxs_computation/tz/9tzw/9tzw.fit
pddf	/app/data/pr_computation/tz/9tzw/9tzw.pr.out
profile	/app/data/saxs_computation/tz/9tzw/9tzw.dat