8pkp

Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Anaphase-promoting complex subunit 1

Homo sapiens

UniProt Q9H1A4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC1_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–1944; UniProt 1–1944

Anaphase-promoting complex subunit 15

Homo sapiens

UniProt P60006

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC15_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 D; PDB构建体 1–121; UniProt 1–121

Anaphase-promoting complex subunit CDC26

Homo sapiens

UniProt Q8NHZ8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC26_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 G; PDB构建体 1–85; UniProt 1–85 作者链 W; PDB构建体 1–85; UniProt 1–85

Anaphase-promoting complex subunit 16

Homo sapiens

UniProt Q96DE5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC16_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 H; PDB构建体 1–110; UniProt 1–110

Cell division cycle protein 27 homolog

Homo sapiens

UniProt P30260

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC27_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 J; PDB构建体 1–824; UniProt 1–824 作者链 P; PDB构建体 1–824; UniProt 1–824

Cell division cycle protein 16 homolog

Homo sapiens

UniProt Q13042

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC16_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 K; PDB构建体 1–620; UniProt 1–620 作者链 Q; PDB构建体 1–620; UniProt 1–620

Anaphase-promoting complex subunit 10

Homo sapiens

UniProt Q9UM13

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC10_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 L; PDB构建体 1–185; UniProt 1–185

Anaphase-promoting complex subunit 13

Homo sapiens

UniProt Q9BS18

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC13_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 M; PDB构建体 1–74; UniProt 1–74

Anaphase-promoting complex subunit 5

Homo sapiens

UniProt Q9UJX4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC5_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 O; PDB构建体 1–755; UniProt 1–755

Cell division cycle protein 23 homolog

Homo sapiens

UniProt Q9UJX2

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC23_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 U; PDB构建体 1–597; UniProt 1–597 作者链 V; PDB构建体 1–597; UniProt 1–597

Anaphase-promoting complex subunit 7

Homo sapiens

UniProt Q9UJX3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC7_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 Y; PDB构建体 1–565; UniProt 1–565 作者链 Z; PDB构建体 1–565; UniProt 1–565

Anaphase-promoting complex subunit 4

Homo sapiens

UniProt Q9UJX5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC4_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 I; PDB构建体 1–808; UniProt 1–808

Anaphase-promoting complex subunit 2

Homo sapiens

UniProt Q9UJX6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 11 × 1 (Q9NYG5) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ANC2_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 N; PDB构建体 1–822; UniProt 1–822

Anaphase-promoting complex subunit 11

Homo sapiens

UniProt Q9NYG5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 19 Anaphase-promoting complex subunit 1 × 1 (Q9H1A4) Anaphase-promoting complex subunit 15 × 1 (P60006) Anaphase-promoting complex subunit CDC26 × 2 (Q8NHZ8) Anaphase-promoting complex subunit 16 × 1 (Q96DE5) Cell division cycle protein 27 homolog × 2 (P30260) Cell division cycle protein 16 homolog × 2 (Q13042) Anaphase-promoting complex subunit 10 × 1 (Q9UM13) Anaphase-promoting complex subunit 13 × 1 (Q9BS18) Anaphase-promoting complex subunit 5 × 1 (Q9UJX4) Cell division cycle protein 23 homolog × 2 (Q9UJX2) Anaphase-promoting complex subunit 7 × 2 (Q9UJX3) Anaphase-promoting complex subunit 4 × 1 (Q9UJX5) Anaphase-promoting complex subunit 2 × 1 (Q9UJX6) ZINC ION × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 APC11_HUMAN
Isoform —
PDB实体 14
链与序列区间 作者链 C; PDB构建体 1–84; UniProt 1–84

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id8pkp
沉积日期 deposition_date2023-06-27
结构标题 titleCryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution
关键词 keywordsAPC/C, cyclosome, Cdc20, Cdh1, ubiquitination, Emi1, mitosis, Cell cycle; CELL CYCLE
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

8pkp__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

8pkp__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

8pkp__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)75.00 Å
Rg(电子密度)74.82 Å
总 Rg74.92 Å
原子数63725
残基数8076
排除体积1138900 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 8pkp__assembly_1__model_1 19-meric (19) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (15)

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6. 折叠分类 (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

结构域编号 domain_id8pkpK01
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily10 — Tetratricopeptide repeat domain
结构域编号 domain_id8pkpQ01
类 Class class1 — Mainly Alpha
架构 Architecture architecture25 — Alpha Horseshoe
拓扑 Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
同源超家族 H-superfamily homologous superfamily10 — Tetratricopeptide repeat domain
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7. 引用文献 (1)