8r7n

Overall structure of the U11 snRNP

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

OrganismNot specified

UniProt Q9BV90

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNR25_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–132; UniProt 1–132

U11/U12 small nuclear ribonucleoprotein 35 kDa protein

OrganismNot specified

UniProt Q16560

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name U1SBP_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C; PDBConstruct 1–246; UniProt 1–246

Programmed cell death protein 7

OrganismNot specified

UniProt Q8N8D1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PDCD7_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D; PDBConstruct 1–485; UniProt 1–485

Zinc finger matrin-type protein 5

OrganismNot specified

UniProt Q9UDW3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name ZMAT5_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E; PDBConstruct 1–170; UniProt 1–170

U11/U12 small nuclear ribonucleoprotein 48 kDa protein

OrganismNot specified

UniProt Q6IEG0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNR48_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F; PDBConstruct 1–339; UniProt 1–339

Small nuclear ribonucleoprotein Sm D1

OrganismNot specified

UniProt P62314

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD1_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain h; PDBConstruct 1–119; UniProt 1–119

Small nuclear ribonucleoprotein Sm D2

OrganismNot specified

UniProt P62316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD2_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain i; PDBConstruct 1–118; UniProt 1–118

Small nuclear ribonucleoprotein Sm D3

OrganismNot specified

UniProt P62318

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD3_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain j; PDBConstruct 1–126; UniProt 1–126

;Small nuclear ribonucleoprotein-associated proteins B and B' ;

OrganismNot specified

UniProt P14678

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RSMB_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain k; PDBConstruct 1–240; UniProt 1–240

Small nuclear ribonucleoprotein E

OrganismNot specified

UniProt P62304

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein F × 1 (P62306) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXE_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain l; PDBConstruct 1–92; UniProt 1–92

Small nuclear ribonucleoprotein F

OrganismNot specified

UniProt P62306

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein G × 1 (P62308) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXF_HUMAN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain m; PDBConstruct 1–86; UniProt 1–86

Small nuclear ribonucleoprotein G

OrganismNot specified

UniProt P62308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 12 RNA 1 U11 snRNA × 1 U11/U12 small nuclear ribonucleoprotein 25 kDa protein × 1 (Q9BV90) U11/U12 small nuclear ribonucleoprotein 35 kDa protein × 1 (Q16560) Programmed cell death protein 7 × 1 (Q8N8D1) Zinc finger matrin-type protein 5 × 1 (Q9UDW3) U11/U12 small nuclear ribonucleoprotein 48 kDa protein × 1 (Q6IEG0) Small nuclear ribonucleoprotein Sm D1 × 1 (P62314) Small nuclear ribonucleoprotein Sm D2 × 1 (P62316) Small nuclear ribonucleoprotein Sm D3 × 1 (P62318) ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 1 (P14678) Small nuclear ribonucleoprotein E × 1 (P62304) Small nuclear ribonucleoprotein F × 1 (P62306) Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXG_HUMAN
Isoform —
PDB entities 13
Chains and sequence ranges Author chain n; PDBConstruct 1–76; UniProt 1–76

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8r7n
Deposition date deposition_date2023-11-26
Structure title titleOverall structure of the U11 snRNP
Keywords keywordsminor spliceosome, U11 snRNP, RNA-protein complex, SPLICING; SPLICING
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8r7n__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8r7n__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8r7n__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)47.00 Å
Rg (electron density)48.44 Å
Total Rg48.20 Å
Atom count13171
Residues1438
Excluded volume225860 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8r7n__assembly_1__model_1 13-meric (13) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (13)

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7. Citations (1)