3jcr

3D structure determination of the human*U4/U6.U5* tri-snRNP complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

hPrp6

OrganismNot specified

UniProt O94906

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP6_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain G; PDBConstruct 1–941; UniProt 1–941

U5-40K

OrganismNot specified

UniProt Q96DI7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNR40_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D; PDBConstruct 1–357; UniProt 1–357

hBrr2

OrganismNot specified

UniProt O75643

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name U520_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C; PDBConstruct 1–2136; UniProt 1–2136

hDim1

OrganismNot specified

UniProt P83876

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TXN4A_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–142; UniProt 1–142

hPrp8

OrganismNot specified

UniProt Q6P2Q9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP8_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain A; PDBConstruct 1–2335; UniProt 1–2335

hPrp28

OrganismNot specified

UniProt Q9BUQ8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DDX23_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F; PDBConstruct 1–820; UniProt 1–820

hSnu114

OrganismNot specified

UniProt Q15029

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name U5S1_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain B; PDBConstruct 1–972; UniProt 1–972

SmB

OrganismNot specified

UniProt P14678

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RSMB_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain O; PDBConstruct 1–240; UniProt 1–240 Author chain o; PDBConstruct 1–240; UniProt 1–240

SmD1

OrganismNot specified

UniProt P62314

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD1_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain P; PDBConstruct 1–119; UniProt 1–119 Author chain p; PDBConstruct 1–119; UniProt 1–119

SmD2

OrganismNot specified

UniProt P62316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD2_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain Q; PDBConstruct 1–118; UniProt 1–118 Author chain q; PDBConstruct 1–118; UniProt 1–118

SmD3

OrganismNot specified

UniProt P62318

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMD3_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain R; PDBConstruct 1–126; UniProt 1–126 Author chain r; PDBConstruct 1–126; UniProt 1–126

SmE

OrganismNot specified

UniProt P62304

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXE_HUMAN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain S; PDBConstruct 1–92; UniProt 1–92 Author chain s; PDBConstruct 1–92; UniProt 1–92

SmF

OrganismNot specified

UniProt P62306

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXF_HUMAN
Isoform —
PDB entities 13
Chains and sequence ranges Author chain T; PDBConstruct 1–86; UniProt 1–86 Author chain t; PDBConstruct 1–86; UniProt 1–86

SmG

OrganismNot specified

UniProt P62308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RUXG_HUMAN
Isoform —
PDB entities 14
Chains and sequence ranges Author chain U; PDBConstruct 1–76; UniProt 1–76 Author chain u; PDBConstruct 1–76; UniProt 1–76

LSm8

OrganismNot specified

UniProt O95777

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM8_HUMAN
Isoform —
PDB entities 15
Chains and sequence ranges Author chain 8; PDBConstruct 1–96; UniProt 1–96

LSm6

OrganismNot specified

UniProt P62312

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM6_HUMAN
Isoform —
PDB entities 16
Chains and sequence ranges Author chain 6; PDBConstruct 1–80; UniProt 1–80

LSm5

OrganismNot specified

UniProt Q9Y4Y9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM5_HUMAN
Isoform —
PDB entities 17
Chains and sequence ranges Author chain 5; PDBConstruct 1–91; UniProt 1–91

LSm4

OrganismNot specified

UniProt Q9Y4Z0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM4_HUMAN
Isoform —
PDB entities 18
Chains and sequence ranges Author chain 4; PDBConstruct 1–139; UniProt 1–139

LSm3

OrganismNot specified

UniProt P62310

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM3_HUMAN
Isoform —
PDB entities 19
Chains and sequence ranges Author chain 3; PDBConstruct 1–102; UniProt 1–102

LSm2

OrganismNot specified

UniProt Q9Y333

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM2_HUMAN
Isoform —
PDB entities 20
Chains and sequence ranges Author chain 2; PDBConstruct 1–95; UniProt 1–95

LSm7

OrganismNot specified

UniProt Q9UK45

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name LSM7_HUMAN
Isoform —
PDB entities 21
Chains and sequence ranges Author chain 7; PDBConstruct 1–103; UniProt 1–103

hPrp3

OrganismNot specified

UniProt O43395

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRPF3_HUMAN
Isoform —
PDB entities 22
Chains and sequence ranges Author chain K; PDBConstruct 1–683; UniProt 1–683

hPrp4

OrganismNot specified

UniProt Q5T1M7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name Q5T1M7_HUMAN
Isoform —
PDB entities 23
Chains and sequence ranges Author chain L; PDBConstruct 1–521; UniProt 1–521

hPrp31

OrganismNot specified

UniProt Q8WWY3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hSnu13 × 1 (P55769) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PRP31_HUMAN
Isoform —
PDB entities 24
Chains and sequence ranges Author chain J; PDBConstruct 1–499; UniProt 1–499

hSnu13

OrganismNot specified

UniProt P55769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSad1 × 1 (Q53GS9) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name NH2L1_HUMAN
Isoform —
PDB entities 25
Chains and sequence ranges Author chain I; PDBConstruct 1–128; UniProt 1–128

hSad1

OrganismNot specified

UniProt Q53GS9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 33 RNA 3 hPrp6 × 1 (O94906) U5-40K × 1 (Q96DI7) hBrr2 × 1 (O75643) hDim1 × 1 (P83876) hPrp8 × 1 (Q6P2Q9) hPrp28 × 1 (Q9BUQ8) hSnu114 × 1 (Q15029) SmB × 2 (P14678) SmD1 × 2 (P62314) SmD2 × 2 (P62316) SmD3 × 2 (P62318) SmE × 2 (P62304) SmF × 2 (P62306) SmG × 2 (P62308) LSm8 × 1 (O95777) LSm6 × 1 (P62312) LSm5 × 1 (Q9Y4Y9) LSm4 × 1 (Q9Y4Z0) LSm3 × 1 (P62310) LSm2 × 1 (Q9Y333) LSm7 × 1 (Q9UK45) hPrp3 × 1 (O43395) hPrp4 × 1 (Q5T1M7) hPrp31 × 1 (Q8WWY3) hSnu13 × 1 (P55769) U4 snRNA × 1 U6 snRNA × 1 U5 snRNA × 1 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNUT2_HUMAN
Isoform —
PDB entities 26
Chains and sequence ranges Author chain V; PDBConstruct 1–565; UniProt 1–565

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3jcr
Deposition date deposition_date2016-01-21
Structure title title3D structure determination of the human*U4/U6.U5* tri-snRNP complex
Keywords keywordssnRNP, splicing, spliceosome, human; SPLICING
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3jcr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3jcr__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3jcr__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)87.81 Å
Rg (electron density)87.49 Å
Total Rg87.38 Å
Atom count203
Residues203
Excluded volume1298600 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3jcr__assembly_1__model_1 36-meric (36) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (29)

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7. Citations (1)