5o9z

Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Pre-mRNA-processing-splicing factor 8

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP8_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–2335； UniProt 1–2335

116 kDa U5 small nuclear ribonucleoprotein component

OrganismNot specified

UniProt Q15029

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	U5S1_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–972； UniProt 1–972

U5 small nuclear ribonucleoprotein 200 kDa helicase

OrganismNot specified

UniProt O75643

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	U520_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–2136； UniProt 1–2136

U5 small nuclear ribonucleoprotein 40 kDa protein

OrganismNot specified

UniProt Q96DI7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SNR40_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–357； UniProt 1–357

U4/U6 small nuclear ribonucleoprotein Prp3

OrganismNot specified

UniProt O43395

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRPF3_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–683； UniProt 1–683

U4/U6 small nuclear ribonucleoprotein Prp4

OrganismNot specified

UniProt O43172

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP4_HUMAN
Isoform	O43172-2
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–521； UniProt 1–521

Pre-mRNA-processing factor 6

OrganismNot specified

UniProt O94906

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP6_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–941； UniProt 1–941

U4/U6 small nuclear ribonucleoprotein Prp31

OrganismNot specified

UniProt Q8WWY3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP31_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–499； UniProt 1–499

Pre-mRNA-splicing factor 38A

OrganismNot specified

UniProt Q8NAV1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PR38A_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–312； UniProt 1–312

Thioredoxin-like protein 4A

OrganismNot specified

UniProt P83876

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TXN4A_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–142； UniProt 1–142

Microfibrillar-associated protein 1

OrganismNot specified

UniProt P55081

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MFAP1_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–439； UniProt 1–439

WD40 repeat-containing protein SMU1

OrganismNot specified

UniProt Q2TAY7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SMU1_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–513； UniProt 1–513

Peptidyl-prolyl cis-trans isomerase H

OrganismNot specified

UniProt O43447

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PPIH_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–177； UniProt 1–177

Zinc finger matrin-type protein 2

OrganismNot specified

UniProt Q96NC0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ZMAT2_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–199； UniProt 1–199

NHP2-like protein 1

OrganismNot specified

UniProt P55769

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NH2L1_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain O； PDBConstruct 1–128； UniProt 1–128

U4/U6.U5 tri-snRNP-associated protein 1

OrganismNot specified

UniProt O43290

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SNUT1_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain P； PDBConstruct 1–800； UniProt 1–800

WW domain-binding protein 4

OrganismNot specified

UniProt O75554

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	WBP4_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain Q； PDBConstruct 1–376； UniProt 1–376

Protein Red

OrganismNot specified

UniProt Q13123

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RED_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain R； PDBConstruct 1–557； UniProt 1–557

Small nuclear ribonucleoprotein Sm D2

OrganismNot specified

UniProt P62316

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SMD2_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain S； PDBConstruct 1–118； UniProt 1–118 Author chain a； PDBConstruct 1–118； UniProt 1–118 Author chain h； PDBConstruct 1–118； UniProt 1–118

Small nuclear ribonucleoprotein F

OrganismNot specified

UniProt P62306

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RUXF_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain T； PDBConstruct 1–86； UniProt 1–86 Author chain b； PDBConstruct 1–86； UniProt 1–86 Author chain i； PDBConstruct 1–86； UniProt 1–86

Small nuclear ribonucleoprotein E

OrganismNot specified

UniProt P62304

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RUXE_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain U； PDBConstruct 1–92； UniProt 1–92 Author chain c； PDBConstruct 1–92； UniProt 1–92 Author chain j； PDBConstruct 1–92； UniProt 1–92

Small nuclear ribonucleoprotein G

OrganismNot specified

UniProt P62308

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RUXG_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain V； PDBConstruct 1–76； UniProt 1–76 Author chain d； PDBConstruct 1–76； UniProt 1–76 Author chain k； PDBConstruct 1–76； UniProt 1–76

Small nuclear ribonucleoprotein Sm D3

OrganismNot specified

UniProt P62318

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SMD3_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain W； PDBConstruct 1–126； UniProt 1–126 Author chain e； PDBConstruct 1–126； UniProt 1–126 Author chain l； PDBConstruct 1–126； UniProt 1–126

;Small nuclear ribonucleoprotein-associated proteins B and B' ;

OrganismNot specified

UniProt P14678

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RSMB_HUMAN
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain X； PDBConstruct 1–240； UniProt 1–240 Author chain f； PDBConstruct 1–240； UniProt 1–240 Author chain m； PDBConstruct 1–240； UniProt 1–240

Small nuclear ribonucleoprotein Sm D1

OrganismNot specified

UniProt P62314

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SMD1_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain Z； PDBConstruct 1–119； UniProt 1–119 Author chain g； PDBConstruct 1–119； UniProt 1–119 Author chain n； PDBConstruct 1–119； UniProt 1–119

U6 snRNA-associated Sm-like protein LSm2

OrganismNot specified

UniProt Q9Y333

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM2_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain o； PDBConstruct 1–95； UniProt 1–95

U6 snRNA-associated Sm-like protein LSm3

OrganismNot specified

UniProt P62310

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM3_HUMAN
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain p； PDBConstruct 1–102； UniProt 1–102

U6 snRNA-associated Sm-like protein LSm4

OrganismNot specified

UniProt Q9Y4Z0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM4_HUMAN
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain q； PDBConstruct 1–139； UniProt 1–139

U6 snRNA-associated Sm-like protein LSm5

OrganismNot specified

UniProt Q9Y4Y9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM5_HUMAN
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain r； PDBConstruct 1–91； UniProt 1–91

U6 snRNA-associated Sm-like protein LSm6

OrganismNot specified

UniProt P62312

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM6_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain s； PDBConstruct 1–80； UniProt 1–80

U6 snRNA-associated Sm-like protein LSm7

OrganismNot specified

UniProt Q9UK45

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM7_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain t； PDBConstruct 1–103； UniProt 1–103

U6 snRNA-associated Sm-like protein LSm8

OrganismNot specified

UniProt O95777

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	LSM8_HUMAN
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain u； PDBConstruct 1–96； UniProt 1–96

Splicing factor 3B subunit 1

OrganismNot specified

UniProt O75533

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SF3B1_HUMAN
Isoform	—
PDB entities	33
Chains and sequence ranges	Author chain v； PDBConstruct 1–1304； UniProt 1–1304

Splicing factor 3B subunit 3 (SF3B3)

OrganismNot specified

UniProt Q15393

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SF3B3_HUMAN
Isoform	—
PDB entities	34
Chains and sequence ranges	Author chain w； PDBConstruct 1–1217； UniProt 1–1217

Splicing factor 3B subunit 5

OrganismNot specified

UniProt Q9BWJ5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SF3B5_HUMAN
Isoform	—
PDB entities	35
Chains and sequence ranges	Author chain x； PDBConstruct 1–86； UniProt 1–86

PHD finger-like domain-containing protein 5A

OrganismNot specified

UniProt Q7RTV0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PHF5A_HUMAN
Isoform	—
PDB entities	36
Chains and sequence ranges	Author chain y； PDBConstruct 1–110； UniProt 1–110

;U2 small nuclear ribonucleoprotein A' ;

OrganismNot specified

UniProt P09661

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein B'' ; × 1 （P08579） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RU2A_HUMAN
Isoform	—
PDB entities	37
Chains and sequence ranges	Author chain z； PDBConstruct 1–256； UniProt 1–255

;U2 small nuclear ribonucleoprotein B'' ;

OrganismNot specified

UniProt P08579

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 52 RNA 5	Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） U5 small nuclear ribonucleoprotein 40 kDa protein × 1 （Q96DI7） U4/U6 small nuclear ribonucleoprotein Prp3 × 1 （O43395） U4/U6 small nuclear ribonucleoprotein Prp4 × 1 （O43172） Pre-mRNA-processing factor 6 × 1 （O94906） U4/U6 small nuclear ribonucleoprotein Prp31 × 1 （Q8WWY3） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Thioredoxin-like protein 4A × 1 （P83876） Microfibrillar-associated protein 1 × 1 （P55081） WD40 repeat-containing protein SMU1 × 1 （Q2TAY7） Peptidyl-prolyl cis-trans isomerase H × 1 （O43447） Zinc finger matrin-type protein 2 × 1 （Q96NC0） NHP2-like protein 1 × 1 （P55769） U4/U6.U5 tri-snRNP-associated protein 1 × 1 （O43290） WW domain-binding protein 4 × 1 （O75554） Protein Red × 1 （Q13123） Small nuclear ribonucleoprotein Sm D2 × 3 （P62316） Small nuclear ribonucleoprotein F × 3 （P62306） Small nuclear ribonucleoprotein E × 3 （P62304） Small nuclear ribonucleoprotein G × 3 （P62308） Small nuclear ribonucleoprotein Sm D3 × 3 （P62318） ;Small nuclear ribonucleoprotein-associated proteins B and B' ; × 3 （P14678） Small nuclear ribonucleoprotein Sm D1 × 3 （P62314） U6 snRNA-associated Sm-like protein LSm2 × 1 （Q9Y333） U6 snRNA-associated Sm-like protein LSm3 × 1 （P62310） U6 snRNA-associated Sm-like protein LSm4 × 1 （Q9Y4Z0） U6 snRNA-associated Sm-like protein LSm5 × 1 （Q9Y4Y9） U6 snRNA-associated Sm-like protein LSm6 × 1 （P62312） U6 snRNA-associated Sm-like protein LSm7 × 1 （Q9UK45） U6 snRNA-associated Sm-like protein LSm8 × 1 （O95777） Splicing factor 3B subunit 1 × 1 （O75533） Splicing factor 3B subunit 3 (SF3B3) × 1 （Q15393） Splicing factor 3B subunit 5 × 1 （Q9BWJ5） PHD finger-like domain-containing protein 5A × 1 （Q7RTV0） ;U2 small nuclear ribonucleoprotein A' ; × 1 （P09661） MINX pre-mRNA × 1 Human gene for small nuclear RNA U2 (snRNA U2) × 1 Homo sapiens U4A snRNA × 1 Homo sapiens U5 A small nuclear RNA × 1 Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RU2B_HUMAN
Isoform	—
PDB entities	38
Chains and sequence ranges	Author chain 1； PDBConstruct 1–225； UniProt 1–225

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5o9z
Deposition date deposition_date	2017-06-20
Structure title title	Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)
Keywords keywords	Spliceosome, pre-mRNA splicing, macromolecular complex, splicing; SPLICING
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5o9z__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5o9z__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5o9z__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	0.00 Å
Rg (electron density)	117.70 Å
Total Rg	141.10 Å
Atom count	55520
Residues	9464
Excluded volume	1399900 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5o9z__assembly_1__model_1`	57-meric （57）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (43)

Entity 1 Entity 1 polymer

Description description	Pre-mRNA-processing-splicing factor 8
Molecular weight formula_weight	273974.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	59243

MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA

Entity 2 Entity 2 polymer

Description description	116 kDa U5 small nuclear ribonucleoprotein component
Molecular weight formula_weight	109560.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM

Entity 3 Entity 3 polymer

Description description	U5 small nuclear ribonucleoprotein 200 kDa helicase
Molecular weight formula_weight	244823.4 kDa
EC 编号 ec_number	3.6.4.13
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD

Entity 4 Entity 4 polymer

Description description	U5 small nuclear ribonucleoprotein 40 kDa protein
Molecular weight formula_weight	39359.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Entity 5 Entity 5 polymer

Description description	U4/U6 small nuclear ribonucleoprotein Prp3
Molecular weight formula_weight	77669.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD

Entity 6 Entity 6 polymer

Description description	U4/U6 small nuclear ribonucleoprotein Prp4
Molecular weight formula_weight	58408.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MASSRASSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE

Entity 7 Entity 7 polymer

Description description	Pre-mRNA-processing factor 6
Molecular weight formula_weight	107092.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF

Entity 8 Entity 8 polymer

Description description	U4/U6 small nuclear ribonucleoprotein Prp31
Molecular weight formula_weight	55529.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST

Entity 9 Entity 9 polymer

Description description	Pre-mRNA-splicing factor 38A
Molecular weight formula_weight	37563.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE

Entity 10 Entity 10 polymer

Description description	Thioredoxin-like protein 4A
Molecular weight formula_weight	16807.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY

Entity 11 Entity 11 polymer

Description description	Microfibrillar-associated protein 1
Molecular weight formula_weight	52050.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT

Entity 12 Entity 12 polymer

Description description	WD40 repeat-containing protein SMU1
Molecular weight formula_weight	57616.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

Entity 13 Entity 13 polymer

Description description	Peptidyl-prolyl cis-trans isomerase H
Molecular weight formula_weight	19230.1 kDa
EC 编号 ec_number	5.2.1.8
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM

Entity 14 Entity 14 polymer

Description description	Zinc finger matrin-type protein 2
Molecular weight formula_weight	23664.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY

Entity 15 Entity 15 polymer

Description description	NHP2-like protein 1
Molecular weight formula_weight	14191.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV

Entity 16 Entity 16 polymer

Description description	U4/U6.U5 tri-snRNP-associated protein 1
Molecular weight formula_weight	90414.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK

Entity 17 Entity 17 polymer

Description description	WW domain-binding protein 4
Molecular weight formula_weight	42575.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENEYVSTSEADGGGEPKVVFKEKTVTSLGVMADGVAPVFKKRRTENGKSRNLRQRGDDQ

Entity 18 Entity 18 polymer

Description description	Protein Red
Molecular weight formula_weight	65731.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKAYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRDRERERERDRERERERDREREEEKKRHSYFEKPKVDDEPMDVDKGPGSTKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYPATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGIKMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKKMEADGVEVKRPKY

Entity 19 Entity 19 polymer

Description description	Small nuclear ribonucleoprotein Sm D2
Molecular weight formula_weight	13551.9 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a,h,S

MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK

Entity 20 Entity 20 polymer

Description description	Small nuclear ribonucleoprotein F
Molecular weight formula_weight	9734.2 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b,i,T

MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEEDGEMRE

Entity 21 Entity 21 polymer

Description description	Small nuclear ribonucleoprotein E
Molecular weight formula_weight	10817.6 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c,j,U

MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN

Entity 22 Entity 22 polymer

Description description	Small nuclear ribonucleoprotein G
Molecular weight formula_weight	8508.1 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d,k,V

MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV

Entity 23 Entity 23 polymer

Description description	Small nuclear ribonucleoprotein Sm D3
Molecular weight formula_weight	13940.3 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e,l,W

MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR

Entity 24 Entity 24 polymer

Description description	;Small nuclear ribonucleoprotein-associated proteins B and B' ;
Molecular weight formula_weight	24642.1 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f,m,X

MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGPPPPGMRPPRP

Entity 25 Entity 25 polymer

Description description	Small nuclear ribonucleoprotein Sm D1
Molecular weight formula_weight	13310.7 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g,n,Z

MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR

Entity 26 Entity 26 polymer

Description description	U6 snRNA-associated Sm-like protein LSm2
Molecular weight formula_weight	10847.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	o

MLFYSFFKSLVGKDVVVELKNDLSICGTLHSVDQYLNIKLTDISVTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ

Entity 27 Entity 27 polymer

Description description	U6 snRNA-associated Sm-like protein LSm3
Molecular weight formula_weight	11859.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	p

MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLHAYDQHLNMILGDVEETVTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG

Entity 28 Entity 28 polymer

Description description	U6 snRNA-associated Sm-like protein LSm4
Molecular weight formula_weight	15375.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	q

MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Entity 29 Entity 29 polymer

Description description	U6 snRNA-associated Sm-like protein LSm5
Molecular weight formula_weight	9945.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r

MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Entity 30 Entity 30 polymer

Description description	U6 snRNA-associated Sm-like protein LSm6
Molecular weight formula_weight	9139.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	s

MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM

Entity 31 Entity 31 polymer

Description description	U6 snRNA-associated Sm-like protein LSm7
Molecular weight formula_weight	11617.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	t

MADKEKKKKESILDLSKYIDKTIRVKFQGGREASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNPFIQQQDA

Entity 32 Entity 32 polymer

Description description	U6 snRNA-associated Sm-like protein LSm8
Molecular weight formula_weight	10410.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	u

MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH

Entity 33 Entity 33 polymer

Description description	Splicing factor 3B subunit 1
Molecular weight formula_weight	146024.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	v

MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL

Entity 34 Entity 34 polymer

Description description	Splicing factor 3B subunit 3 (SF3B3)
Molecular weight formula_weight	135718.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	w

MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF

Entity 35 Entity 35 polymer

Description description	Splicing factor 3B subunit 5
Molecular weight formula_weight	10149.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	x

MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN

Entity 36 Entity 36 polymer

Description description	PHD finger-like domain-containing protein 5A
Molecular weight formula_weight	12427.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	y

MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR

Entity 37 Entity 37 polymer

Description description	;U2 small nuclear ribonucleoprotein A' ;
Molecular weight formula_weight	28631.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	z

MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPDLTELILTNNSLVELGDLDPLASLKSLTYLCILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKFLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS

Entity 38 Entity 38 polymer

Description description	;U2 small nuclear ribonucleoprotein B'' ;
Molecular weight formula_weight	25524.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1

MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK

Entity 39 Entity 39 polymer

Description description	MINX pre-mRNA
Molecular weight formula_weight	103979.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	Y

GGGAGACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCCGAUAUCCGUACACCAUCAGGGUACGAGCUAGCCCAUGGCGUACACCAUCAGGGUACGACUAGUAGAUCUCGUACACCAUCAGGGUACGGAAUUCUCUAGA

Entity 40 Entity 40 polymer

Description description	Human gene for small nuclear RNA U2 (snRNA U2)
Molecular weight formula_weight	60186.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	2

AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC

Entity 41 Entity 41 polymer

Description description	Homo sapiens U4A snRNA
Molecular weight formula_weight	46528.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	4

AGCUUUGCGCAGUGGCAGUAUCGUAGCCAAUGAGGUUUAUCCGAGGCGCGAUUAUUGCUAAUUGAAAACUUUUCCCAAUACCCCGCCGUGACGACUUGCAAUAUAGUCGGCAUUGGCAAUUUUUGACAGUCUCUACGGAGACUGG

Entity 42 Entity 42 polymer

Description description	Homo sapiens U5 A small nuclear RNA
Molecular weight formula_weight	36908.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	5

AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGGAGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA

Entity 43 Entity 43 polymer

Description description	Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA
Molecular weight formula_weight	34098.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	6

GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGCCCCUGCGCAAGGAUGACACGCAAAUUCGUGAAGCGUUCCAUAUUUU

▼

6. Fold Classification (SCOP + CATH) 11 domains

SCOP 2.08 (11 domains)

Domain ID domain_id	d5o9ze1
Class class	j — Peptides
Fold Fold fold	j.144 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp3 N-terminal domain-like
Superfamily Superfamily superfamily	j.144.1 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp3 N-terminal domain-like
Family Family family	j.144.1.1 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp3 N-terminal domain-like

Domain ID domain_id	d5o9ze2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.10 — Acylphosphatase/BLUF domain-like
Family Family family	d.58.10.3 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp3 C-terminal domain-like

Domain ID domain_id	d5o9zg_
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.8 — TPR-like
Family Family family	a.118.8.1 — Tetratricopeptide repeat (TPR)

Domain ID domain_id	d5o9zh1
Class class	j — Peptides
Fold Fold fold	j.149 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp31 C-terminal domain-like
Superfamily Superfamily superfamily	j.149.1 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp31 C-terminal domain-like
Family Family family	j.149.1.1 — Spliceosomal U4/U6 small nuclear ribonucleoprotein Prp31 C-terminal domain-like

Domain ID domain_id	d5o9zh2
Class class	a — All alpha proteins
Fold Fold fold	a.183 — Nop domain
Superfamily Superfamily superfamily	a.183.1 — Nop domain
Family Family family	a.183.1.1 — Nop domain

Domain ID domain_id	d5o9zi_
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.30 — Pre-mRNA splicing factor Prp38 N-terminal-like
Family Family family	a.118.30.1 — Pre-mRNA splicing factor Prp38-like

Domain ID domain_id	d5o9zk_
Class class	j — Peptides
Fold Fold fold	j.145 — Microfibrillar-associated protein 1 fragment
Superfamily Superfamily superfamily	j.145.1 — Microfibrillar-associated protein 1 fragment
Family Family family	j.145.1.1 — Microfibrillar-associated protein 1 fragment

Domain ID domain_id	d5o9zp_
Class class	j — Peptides
Fold Fold fold	j.143 — Pre-mRNA splicing factor Snu66-like
Superfamily Superfamily superfamily	j.143.1 — Pre-mRNA splicing factor Snu66-like
Family Family family	j.143.1.1 — Pre-mRNA splicing factor Sart1 / Snu66-like

Domain ID domain_id	d5o9zv_
Class class	a — All alpha proteins
Fold Fold fold	a.118 — alpha-alpha superhelix
Superfamily Superfamily superfamily	a.118.1 — ARM repeat
Family Family family	a.118.1.2 — HEAT repeat

Domain ID domain_id	d5o9zx_
Class class	j — Peptides
Fold Fold fold	j.146 — Splicing factor 3B subunit 5 fragment
Superfamily Superfamily superfamily	j.146.1 — Splicing factor 3B subunit 5 fragment
Family Family family	j.146.1.1 — Splicing factor 3B subunit 5 fragment

Domain ID domain_id	d5o9zy_
Class class	g — Small proteins
Fold Fold fold	g.101 — Triquetra knot
Superfamily Superfamily superfamily	g.101.1 — Pre-mRNA splicing factor Phf5-like
Family Family family	g.101.1.1 — Pre-mRNA splicing factor Phf5-like

▶

Resolution resolution	4.50 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	44629

Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)

1. Protein Identity and Related Structures Protein Identity & Related Structures

Pre-mRNA-processing-splicing factor 8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

116 kDa U5 small nuclear ribonucleoprotein component

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

U5 small nuclear ribonucleoprotein 200 kDa helicase

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

U5 small nuclear ribonucleoprotein 40 kDa protein

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

U4/U6 small nuclear ribonucleoprotein Prp3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

U4/U6 small nuclear ribonucleoprotein Prp4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Pre-mRNA-processing factor 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

U4/U6 small nuclear ribonucleoprotein Prp31

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Pre-mRNA-splicing factor 38A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Thioredoxin-like protein 4A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer