9r3d

Cryo-EM structure of the human pre-Bact-OTS complex (whole map)

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

U5 small nuclear ribonucleoprotein 200 kDa helicase

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	U520_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain B； PDBConstruct 1–2136； UniProt 1–2136

116 kDa U5 small nuclear ribonucleoprotein component

OrganismNot specified

UniProt Q15029

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	U5S1_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain C； PDBConstruct 1–972； UniProt 1–972

Pre-mRNA-splicing factor 38A

OrganismNot specified

UniProt Q8NAV1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PR38A_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain I； PDBConstruct 1–312； UniProt 1–312

Microfibrillar-associated protein 1

OrganismNot specified

UniProt P55081

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MFAP1_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain K； PDBConstruct 1–439； UniProt 1–439

Protein BUD31 homolog

OrganismNot specified

UniProt P41223

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	BUD31_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain Q； PDBConstruct 1–144； UniProt 1–144

Transcription elongation regulator 1

OrganismNot specified

UniProt O14776

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCRG1_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain T； PDBConstruct 1–1098； UniProt 1–1098

WW domain-binding protein 11

OrganismNot specified

UniProt Q9Y2W2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	WBP11_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain X； PDBConstruct 1–641； UniProt 1–641

Ubiquitin-like protein 5

OrganismNot specified

UniProt Q9BZL1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	UBL5_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain q； PDBConstruct 1–73； UniProt 1–73

Zinc finger matrin-type protein 2

OrganismNot specified

UniProt Q96NC0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ZMAT2_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain r； PDBConstruct 1–199； UniProt 1–199

Pre-mRNA-processing factor 17

OrganismNot specified

UniProt O60508

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP17_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain P7； PDBConstruct 1–579； UniProt 1–579

Pre-mRNA-processing-splicing factor 8

OrganismNot specified

UniProt Q6P2Q9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRP8_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain A； PDBConstruct 1–2335； UniProt 1–2335

Pre-mRNA-splicing factor RBM22

OrganismNot specified

UniProt Q9NW64

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RBM22_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain P； PDBConstruct 1–420； UniProt 1–420

RING-type E3 ubiquitin-protein ligase PPIL2

OrganismNot specified

UniProt Q13356

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） SNW domain-containing protein 1 × 1 （Q13573） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PPIL2_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain t； PDBConstruct 1–520； UniProt 1–520

SNW domain-containing protein 1

OrganismNot specified

UniProt Q13573

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 14 RNA 3	U5 snRNA × 1 U6 snRNA × 1 U5 small nuclear ribonucleoprotein 200 kDa helicase × 1 （O75643） 116 kDa U5 small nuclear ribonucleoprotein component × 1 （Q15029） Pre-mRNA-splicing factor 38A × 1 （Q8NAV1） Microfibrillar-associated protein 1 × 1 （P55081） Protein BUD31 homolog × 1 （P41223） Transcription elongation regulator 1 × 1 （O14776） WW domain-binding protein 11 × 1 （Q9Y2W2） pre-mRNA × 1 Ubiquitin-like protein 5 × 1 （Q9BZL1） Zinc finger matrin-type protein 2 × 1 （Q96NC0） Pre-mRNA-processing factor 17 × 1 （O60508） Pre-mRNA-processing-splicing factor 8 × 1 （Q6P2Q9） Pre-mRNA-splicing factor RBM22 × 1 （Q9NW64） RING-type E3 ubiquitin-protein ligase PPIL2 × 1 （Q13356） INOSITOL HEXAKISPHOSPHATE × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SNW1_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain S1； PDBConstruct 1–526； UniProt 1–526

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9r3d
Deposition date deposition_date	2025-05-04
Structure title title	Cryo-EM structure of the human pre-Bact-OTS complex (whole map)
Keywords keywords	spliceosome, SPLICING; SPLICING
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9r3d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9r3d__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9r3d__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	65.15 Å
Rg (electron density)	65.21 Å
Total Rg	64.67 Å
Atom count	41855
Residues	5336
Excluded volume	720810 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9r3d__assembly_1__model_1`	17-meric （17）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (18)

Entity 1 Entity 1 polymer

Description description	U5 snRNA
Molecular weight formula_weight	24496.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	5
Atom count atom_count	41862

ACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGGAGAGGAACAACUCUGAGUC

Entity 2 Entity 2 polymer

Description description	U6 snRNA
Molecular weight formula_weight	27447.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	6

GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGCCCCUGCGCAAGGAUGACACGCAAAA

Entity 3 Entity 3 polymer

Description description	U5 small nuclear ribonucleoprotein 200 kDa helicase
Molecular weight formula_weight	244823.4 kDa
EC 编号 ec_number	3.6.4.13
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD

Entity 4 Entity 4 polymer

Description description	116 kDa U5 small nuclear ribonucleoprotein component
Molecular weight formula_weight	109560.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM

Entity 5 Entity 5 polymer

Description description	Pre-mRNA-splicing factor 38A
Molecular weight formula_weight	37563.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE

Entity 6 Entity 6 polymer

Description description	Microfibrillar-associated protein 1
Molecular weight formula_weight	52050.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT

Entity 7 Entity 7 polymer

Description description	Protein BUD31 homolog
Molecular weight formula_weight	17032.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG

Entity 8 Entity 8 polymer

Description description	Transcription elongation regulator 1
Molecular weight formula_weight	124083.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK

Entity 9 Entity 9 polymer

Description description	WW domain-binding protein 11
Molecular weight formula_weight	70098.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL

Entity 10 Entity 10 polymer

Description description	pre-mRNA
Molecular weight formula_weight	9307.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	Z

GCCGCCAAGGUAUGUAUCAAGCUUACAAG

Entity 11 Entity 11 polymer

Description description	Ubiquitin-like protein 5
Molecular weight formula_weight	8560.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	q

MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ

Entity 12 Entity 12 polymer

Description description	Zinc finger matrin-type protein 2
Molecular weight formula_weight	23664.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r

MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY

Entity 13 Entity 13 polymer

Description description	Pre-mRNA-processing factor 17
Molecular weight formula_weight	65612.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P7

MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD

Entity 14 Entity 14 polymer

Description description	Pre-mRNA-processing-splicing factor 8
Molecular weight formula_weight	273974.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA

Entity 15 Entity 15 polymer

Description description	Pre-mRNA-splicing factor RBM22
Molecular weight formula_weight	46959.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP

Entity 16 Entity 16 polymer

Description description	RING-type E3 ubiquitin-protein ligase PPIL2
Molecular weight formula_weight	58910.4 kDa
EC 编号 ec_number	2.3.2.27
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	t

MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATKRAAEEEPSTSATVPMSKKKPSRGFGDFSSW

Entity 17 Entity 17 polymer

Description description	SNW domain-containing protein 1
Molecular weight formula_weight	60326.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S1

MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEH

Entity 18 Entity 18 non-polymer

Description description	INOSITOL HEXAKISPHOSPHATE
Molecular weight formula_weight	660.0 kDa
Source method src_method	syn
Copy count entity_count	1

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.12 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	35015

Cryo-EM structure of the human pre-Bact-OTS complex (whole map)

1. Protein Identity and Related Structures Protein Identity & Related Structures

U5 small nuclear ribonucleoprotein 200 kDa helicase

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

116 kDa U5 small nuclear ribonucleoprotein component

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Pre-mRNA-splicing factor 38A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Microfibrillar-associated protein 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Protein BUD31 homolog

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Transcription elongation regulator 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

WW domain-binding protein 11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Ubiquitin-like protein 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Zinc finger matrin-type protein 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Pre-mRNA-processing factor 17

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer