← Back to search
8sv1

Caspase-1 complex with interleukin-18

Method: ELECTRON MICROSCOPY
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Caspase-1

Homo sapiens

UniProt P29466

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Interleukin-18 × 2 （Q14116） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8wra

1 assemblies

Homodimer
1bmq 1sc1 3e4c 3ns7 5mmv 5mtk 6f6r 6pzp 8wra

9 assemblies

Homotetramer
1bmq 1rwk 1rwm 1rwn 1rwo 1rwp 1rwv 1rww 1rwx 1sc3 1sc4 2fqq

14 assemblies; showing the first 12

Other homooligomers
5fna 9wz6 9wzi

3 assemblies

Heteromeric or nucleic-acid complex
1ibc 1ice 2h48 2h4w 2h4y 2h51 2h54 2hbq 2hbr 2hby 2hbz 3d6f

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CASP1_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–148； UniProt 150–297 Author chain a； PDBConstruct 1–148； UniProt 150–297 Author chain B； PDBConstruct 1–88； UniProt 317–404 Author chain b； PDBConstruct 1–88； UniProt 317–404

Interleukin-18

Homo sapiens

UniProt Q14116

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Caspase-1 × 2 （P29466） Caspase-1 × 2 （P29466） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1j0s 3wo2 3wo2 3wo2 3wo2 4xfs 4xfs 4xft 4xft 4xfu 4xfu 8urv

14 assemblies; showing the first 12

Homodimer
4xfs 4xft 4xfu

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2vxt 3f62 3wo3 3wo3 3wo3 3wo3 3wo3 3wo3 3wo4 4eee 4ekx 4ekx

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name IL18_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–188； UniProt 6–193 Author chain c； PDBConstruct 1–188； UniProt 6–193

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id8sv1
Deposition date deposition_date2023-05-15
Structure title titleCaspase-1 complex with interleukin-18
Keywords keywordsInnate immune, Complex, HYDROLASE, IMMUNE SYSTEM; HYDROLASE, IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8sv1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8sv1__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8sv1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.57 Å
Rg (electron density)33.61 Å
Total Rg33.98 Å
Atom count6330
Residues792
Excluded volume112870 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8sv1__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (3)

▶

7. Citations (1)