8tm3

Human proteasome alpha ring assembly intermediate

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-2

OrganismNot specified

UniProt P25787

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–234; UniProt 1–234

Proteasome subunit alpha type-4

OrganismNot specified

UniProt P25789

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA4_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–261; UniProt 1–261

Proteasome subunit alpha type-7

OrganismNot specified

UniProt O14818

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA7_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C; PDBConstruct 1–248; UniProt 1–248

Proteasome subunit alpha type-5

OrganismNot specified

UniProt P28066

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA5_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D; PDBConstruct 1–241; UniProt 1–241

Proteasome subunit alpha type-1

OrganismNot specified

UniProt P25786

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA1_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E; PDBConstruct 1–263; UniProt 1–263

Proteasome subunit alpha type-3

OrganismNot specified

UniProt P25788

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA3_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F; PDBConstruct 1–255; UniProt 1–255

Proteasome subunit alpha type-6

OrganismNot specified

UniProt P60900

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSA6_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain G; PDBConstruct 1–246; UniProt 1–246

Proteasome assembly chaperone 1

OrganismNot specified

UniProt O95456

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSMG1_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain c; PDBConstruct 1–288; UniProt 1–288

Proteasome assembly chaperone 2

OrganismNot specified

UniProt Q969U7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 3 × 1 (Q9BT73) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSMG2_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain d; PDBConstruct 1–264; UniProt 1–264

Proteasome assembly chaperone 3

OrganismNot specified

UniProt Q9BT73

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 4 × 1 (Q5JS54) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSMG3_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain i; PDBConstruct 1–122; UniProt 1–122

Proteasome assembly chaperone 4

OrganismNot specified

UniProt Q5JS54

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 11 Proteasome subunit alpha type-2 × 1 (P25787) Proteasome subunit alpha type-4 × 1 (P25789) Proteasome subunit alpha type-7 × 1 (O14818) Proteasome subunit alpha type-5 × 1 (P28066) Proteasome subunit alpha type-1 × 1 (P25786) Proteasome subunit alpha type-3 × 1 (P25788) Proteasome subunit alpha type-6 × 1 (P60900) Proteasome assembly chaperone 1 × 1 (O95456) Proteasome assembly chaperone 2 × 1 (Q969U7) Proteasome assembly chaperone 3 × 1 (Q9BT73) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PSMG4_HUMAN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain j; PDBConstruct 1–123; UniProt 1–123

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8tm3
Deposition date deposition_date2023-07-28
Structure title titleHuman proteasome alpha ring assembly intermediate
Keywords keywordsproteasome, proteasome assembly, PAC3, PAC4, HYDROLASE; HYDROLASE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8tm3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8tm3__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8tm3__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)40.92 Å
Rg (electron density)40.31 Å
Total Rg40.74 Å
Atom count17562
Residues2381
Excluded volume313280 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8tm3__assembly_1__model_1 undecameric (11) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

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7. Citations (1)