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9czo

Ca2+ bound intermediate state of hSlo1 + beta2N-beta4 channel in nanodisc.

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 5 of Calcium-activated potassium channel subunit alpha-1

Homo sapiens

UniProt Q12791

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 8 Large-conductance Ca2+-activated K+ channel beta2 subunit,Calcium-activated potassium channel subunit beta-4 × 4 （B5BNX0,Q86W47） CALCIUM ION × 8 POTASSIUM ION × 4 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 11 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2k44 6v5a

2 assemblies

Homodimer

None

Homotetramer
10ad 3naf 6nd0 6v38 6v3g 8gh9 8ghf 8ghg 8v60 8v63 8v64 8z3s

14 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex
6v22 6v35 8vav 8vaz 9czh 9czj 9czk 9czm 9czo 9czq 9d18 9d19

12 assemblies

View Construct and Data Evidence
UniProt name KCMA1_HUMAN
Isoform Q12791-5
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1056； UniProt 66–1121 Author chain B； PDBConstruct 1–1056； UniProt 66–1121 Author chain C； PDBConstruct 1–1056； UniProt 66–1121 Author chain D； PDBConstruct 1–1056； UniProt 66–1121

Large-conductance Ca2+-activated K+ channel beta2 subunit,Calcium-activated potassium channel subunit beta-4

Homo sapiens

UniProt B5BNX0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 8 Isoform 5 of Calcium-activated potassium channel subunit alpha-1 × 4 （Q12791） CALCIUM ION × 8 POTASSIUM ION × 4 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 11 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
9czh 9czj 9czk 9czm 9czo 9czq 9d18 9d19

8 assemblies

View Construct and Data Evidence
UniProt name B5BNX0_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–43； UniProt 2–44 Author chain F； PDBConstruct 1–43； UniProt 2–44 Author chain G； PDBConstruct 1–43； UniProt 2–44 Author chain H； PDBConstruct 1–43； UniProt 2–44

Large-conductance Ca2+-activated K+ channel beta2 subunit,Calcium-activated potassium channel subunit beta-4

Homo sapiens

UniProt Q86W47

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 8 Isoform 5 of Calcium-activated potassium channel subunit alpha-1 × 4 （Q12791） CALCIUM ION × 8 POTASSIUM ION × 4 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 11 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5y7l

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6v22 6v35 9czh 9czj 9czk 9czm 9czo 9czq 9d18 9d19

10 assemblies

View Construct and Data Evidence
UniProt name KCMB4_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 44–239； UniProt 15–210 Author chain F； PDBConstruct 44–239； UniProt 15–210 Author chain G； PDBConstruct 44–239； UniProt 15–210 Author chain H； PDBConstruct 44–239； UniProt 15–210

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9czo
Deposition date deposition_date2024-08-05
Structure title titleCa2+ bound intermediate state of hSlo1 + beta2N-beta4 channel in nanodisc.
Keywords keywords;Potassium ion channel, calcium and voltage gated ion channel, big potassium channel, human BK, hSlo1, intermediate hSlo1, ball and chain inactivation, hSlo1 inactivating subunit complex, nanodisc, membrane protein, beta2, beta4 ;; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9czo__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9czo__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9czo__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）56.78 Å
Rg (electron density)55.67 Å
Total Rg55.91 Å
Atom count69351
Residues4344
Excluded volume630690 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9czo__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)