← Back to search

9u7s

FGFR2 kinase domain with a macrocyclic compound 8r

Method: X-RAY DIFFRACTION D_max: 84.1 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9u7s
deposition_date	2025-03-25
title	FGFR2 kinase domain with a macrocyclic compound 8r
keywords	Fibroblast growth factor receptor 2, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	26.46 Å
rg_electron	25.74 Å
i0	144177000.00
molecular_weight	63197.0 kDa
excluded_volume	60927 Å³
envelope_volume	102880 Å³
shell_volume	32571 Å³
envelope_diameter	89.7 Å
shell_rg	33.66 Å
envelope_rg	25.66 Å
shape_rg	25.73 Å
total_rg	26.36 Å
total_atoms	4751
n_residues	583
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	84.1 Å
rg_real	26.35 Å
rg_real_error	0.44 Å
i0_real	1.4420e+08
i0_real_error	2.1290e+06
rg_reciprocal	26.39 Å
i0_reciprocal	144200000.0000
total_estimate	0.9042
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	32.2 Å
skewness	0.202
kurtosis	-0.480
angular_range	— – 0.3000 Å⁻¹
current_alpha	0.0000
highest_alpha	30120000.0000
n_real_points	61
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.919; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.994

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (4)

Entity 1 polymer

description	Fibroblast growth factor receptor 2
formula_weight	34965.3 kDa
ec_number	2.7.10.1
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	5040

EYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	;(E)-4-methyl-17-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-7,10-dioxa-4-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(1,3)-benzenacyclodecaphan-3-one ;
formula_weight	501.6 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	6

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	276

▶

6. Citations (1)

▶

length_a	60.800 Å
length_b	72.820 Å
length_c	137.880 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	1.990 Å
resolution_low	31.240 Å
r_factor	0.1831
r_work	0.1809
r_free	0.2250

fit	/app/data/saxs_computation/u7/9u7s/9u7s.fit
pddf	/app/data/pr_computation/u7/9u7s/9u7s.pr.out
profile	/app/data/saxs_computation/u7/9u7s/9u7s.dat

FGFR2 kinase domain with a macrocyclic compound 8r

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction