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9vrq

Crystal structure of FOXC2/NFAT1 complex bound to ARRE2 DNA

Method: X-RAY DIFFRACTION D_max: 91.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9vrq
deposition_date	2025-07-07
last_revision	2026-05-20
title	Crystal structure of FOXC2/NFAT1 complex bound to ARRE2 DNA
keywords	Transcripton factor, DNA, DNA BINDING PROTEIN/DNA, DNA BINDING PROTEIN-DNA complex; DNA BINDING PROTEIN/DNA
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	27.12 Å
rg_electron	25.61 Å
i0	68654600.00
molecular_weight	56179.0 kDa
excluded_volume	66671 Å³
envelope_volume	87932 Å³
shell_volume	29075 Å³
envelope_diameter	95.7 Å
shell_rg	32.33 Å
envelope_rg	25.65 Å
shape_rg	25.53 Å
total_rg	26.46 Å
total_atoms	3906
n_residues	421
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	91.9 Å
rg_real	27.06 Å
rg_real_error	0.71 Å
i0_real	6.8650e+07
i0_real_error	1.0840e+06
rg_reciprocal	27.08 Å
i0_reciprocal	68660000.0000
total_estimate	0.8863
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	34.9 Å
skewness	0.246
kurtosis	-0.305
angular_range	— – 0.2900 Å⁻¹
current_alpha	0.0000
highest_alpha	5372000.0000
n_real_points	59
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.846; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.995; Smooth: 0.984

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Forkhead box protein C2
formula_weight	12330.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3939

GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKD

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 polymer

description	ARRE2-S
formula_weight	6491.2 kDa
src_method	man
entity_count	1

Polymer

type	polydeoxyribonucleotide
strand_id	C

TTAGGAAAATTTGTTTCATAG

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 3 polymer

description	ARRE2-AS
formula_weight	6389.2 kDa
src_method	man
entity_count	1

Polymer

type	polydeoxyribonucleotide
strand_id	D

AACTATGAAACAAATTTTCCT

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 4 polymer

description	Nuclear factor of activated T-cells, cytoplasmic 2
formula_weight	32514.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	N

ASSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEVPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQAASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	33

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6. Citations (1)

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length_a	65.980 Å
length_b	77.343 Å
length_c	117.058 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	2.800 Å
resolution_low	38.670 Å
r_factor	0.2393
r_work	0.2369
r_free	0.2876

fit	/app/data/saxs_computation/vr/9vrq/9vrq.fit
pddf	/app/data/pr_computation/vr/9vrq/9vrq.pr.out
profile	/app/data/saxs_computation/vr/9vrq/9vrq.dat

Crystal structure of FOXC2/NFAT1 complex bound to ARRE2 DNA

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)